CH628906A5 - Semi-synthetic derivatives of 4''-erythromycin A and medicinal products containing them - Google Patents
Semi-synthetic derivatives of 4''-erythromycin A and medicinal products containing them Download PDFInfo
- Publication number
- CH628906A5 CH628906A5 CH106178A CH106178A CH628906A5 CH 628906 A5 CH628906 A5 CH 628906A5 CH 106178 A CH106178 A CH 106178A CH 106178 A CH106178 A CH 106178A CH 628906 A5 CH628906 A5 CH 628906A5
- Authority
- CH
- Switzerland
- Prior art keywords
- deoxy
- formulas
- erythromycin
- product
- compound
- Prior art date
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- 229940126601 medicinal product Drugs 0.000 title 1
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- 238000006243 chemical reaction Methods 0.000 claims description 36
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- 239000011541 reaction mixture Substances 0.000 claims description 22
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 claims description 20
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 claims description 18
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- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000006140 methanolysis reaction Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000021962 pH elevation Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 229940051027 pasteurella multocida Drugs 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 238000010956 selective crystallization Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76548077A | 1977-02-04 | 1977-02-04 | |
| US05/856,479 US4150220A (en) | 1977-02-04 | 1977-12-01 | Semi-synthetic 4"-erythromycin A derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH628906A5 true CH628906A5 (en) | 1982-03-31 |
Family
ID=27117613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH106178A CH628906A5 (en) | 1977-02-04 | 1978-01-31 | Semi-synthetic derivatives of 4''-erythromycin A and medicinal products containing them |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS5827798B2 (hu) |
| AR (1) | AR222147A1 (hu) |
| AU (1) | AU501298B1 (hu) |
| BG (2) | BG33159A3 (hu) |
| CA (1) | CA1106367A (hu) |
| CH (1) | CH628906A5 (hu) |
| CS (1) | CS221801B2 (hu) |
| DD (1) | DD140048A5 (hu) |
| DE (1) | DE2804507C2 (hu) |
| DK (1) | DK148036C (hu) |
| ES (2) | ES466057A1 (hu) |
| FI (1) | FI780354A (hu) |
| FR (2) | FR2379550A1 (hu) |
| GB (2) | GB1585316A (hu) |
| GR (1) | GR68691B (hu) |
| HU (1) | HU182559B (hu) |
| IE (1) | IE46661B1 (hu) |
| IL (2) | IL53968A0 (hu) |
| IT (1) | IT1094209B (hu) |
| LU (1) | LU79004A1 (hu) |
| NL (1) | NL176174C (hu) |
| NO (2) | NO146472C (hu) |
| NZ (1) | NZ186385A (hu) |
| PH (2) | PH14421A (hu) |
| PL (1) | PL116228B1 (hu) |
| PT (1) | PT67568B (hu) |
| RO (4) | RO81622B (hu) |
| SE (2) | SE445223B (hu) |
| SU (1) | SU927122A3 (hu) |
| YU (3) | YU40913B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4124755A (en) * | 1978-01-03 | 1978-11-07 | Pfizer Inc. | 11-Alkanoyl-4"-deoxy-4"-isonitrilo-oleandomycin derivatives |
| US4133950A (en) * | 1978-01-03 | 1979-01-09 | Pfizer Inc. | 4"-Deoxy-4"-carbamate and dithiocarbamate derivatives of oleandomycin and its esters |
| US4382085A (en) * | 1982-03-01 | 1983-05-03 | Pfizer Inc. | 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents |
| US4518590A (en) * | 1984-04-13 | 1985-05-21 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method |
| HN1998000074A (es) * | 1997-06-11 | 1999-01-08 | Pfizer Prod Inc | Derivados de macrolidos c-4 sustituidos |
| US6407074B1 (en) | 1997-06-11 | 2002-06-18 | Pfizer Inc | C-4″-substituted macrolide derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3836519A (en) * | 1973-05-04 | 1974-09-17 | Abbott Lab | Sulfonyl derivatives of erythromycin |
| US3884903A (en) * | 1973-06-21 | 1975-05-20 | Abbott Lab | 4{41 -Deoxy-4{41 -oxoerythromycin B derivatives |
-
1978
- 1978-01-10 SE SE7800270A patent/SE445223B/sv not_active IP Right Cessation
- 1978-01-13 PH PH20662A patent/PH14421A/en unknown
- 1978-01-17 ES ES466057A patent/ES466057A1/es not_active Expired
- 1978-01-18 AR AR270752A patent/AR222147A1/es active
- 1978-01-18 YU YU73/78A patent/YU40913B/xx unknown
- 1978-01-23 PT PT67568A patent/PT67568B/pt unknown
- 1978-01-31 CH CH106178A patent/CH628906A5/fr not_active IP Right Cessation
- 1978-02-02 RO RO105255A patent/RO81622B/ro unknown
- 1978-02-02 RO RO78101651A patent/RO79687A7/ro unknown
- 1978-02-02 GB GB34309/79A patent/GB1585316A/en not_active Expired
- 1978-02-02 RO RO78101650A patent/RO79686A7/ro unknown
- 1978-02-02 CS CS78703A patent/CS221801B2/cs unknown
- 1978-02-02 CA CA296,037A patent/CA1106367A/en not_active Expired
- 1978-02-02 RO RO7893080A patent/RO77345A/ro unknown
- 1978-02-02 GB GB4165/78A patent/GB1585315A/en not_active Expired
- 1978-02-02 GR GR55330A patent/GR68691B/el unknown
- 1978-02-02 DE DE2804507A patent/DE2804507C2/de not_active Expired
- 1978-02-03 DD DD78203547A patent/DD140048A5/de unknown
- 1978-02-03 AU AU32990/78A patent/AU501298B1/en not_active Expired
- 1978-02-03 IE IE239/78A patent/IE46661B1/en not_active IP Right Cessation
- 1978-02-03 PL PL1978204428A patent/PL116228B1/pl unknown
- 1978-02-03 JP JP53011352A patent/JPS5827798B2/ja not_active Expired
- 1978-02-03 BG BG040069A patent/BG33159A3/xx unknown
- 1978-02-03 IL IL53968A patent/IL53968A0/xx not_active IP Right Cessation
- 1978-02-03 FR FR7803066A patent/FR2379550A1/fr active Granted
- 1978-02-03 NL NLAANVRAGE7801262,A patent/NL176174C/xx not_active IP Right Cessation
- 1978-02-03 DK DK51878A patent/DK148036C/da not_active IP Right Cessation
- 1978-02-03 NO NO780389A patent/NO146472C/no unknown
- 1978-02-03 SU SU782573754A patent/SU927122A3/ru active
- 1978-02-03 BG BG038579A patent/BG32718A3/xx unknown
- 1978-02-03 LU LU79004A patent/LU79004A1/xx unknown
- 1978-02-03 NZ NZ186385A patent/NZ186385A/xx unknown
- 1978-02-03 IT IT20005/78A patent/IT1094209B/it active
- 1978-02-03 FI FI780354A patent/FI780354A/fi not_active Application Discontinuation
- 1978-02-03 HU HU78PI611A patent/HU182559B/hu not_active IP Right Cessation
- 1978-07-07 FR FR7820334A patent/FR2385735A1/fr active Granted
- 1978-08-08 ES ES472429A patent/ES472429A1/es not_active Expired
- 1978-09-01 PH PH21555A patent/PH16675A/en unknown
-
1981
- 1981-01-27 IL IL61997A patent/IL61997A0/xx unknown
- 1981-06-05 NO NO811913A patent/NO150484C/no unknown
-
1983
- 1983-02-07 YU YU265/83A patent/YU40798B/xx unknown
- 1983-02-16 SE SE8300870A patent/SE457086B/xx not_active IP Right Cessation
- 1983-11-21 YU YU2279/83A patent/YU40799B/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |