CH626092A5 - - Google Patents
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- Publication number
- CH626092A5 CH626092A5 CH94577A CH94577A CH626092A5 CH 626092 A5 CH626092 A5 CH 626092A5 CH 94577 A CH94577 A CH 94577A CH 94577 A CH94577 A CH 94577A CH 626092 A5 CH626092 A5 CH 626092A5
- Authority
- CH
- Switzerland
- Prior art keywords
- groups
- protein
- group
- reacted
- solution
- Prior art date
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- 102000004169 proteins and genes Human genes 0.000 claims description 66
- 108090000623 proteins and genes Proteins 0.000 claims description 66
- 238000000034 method Methods 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 20
- -1 imino ester Chemical class 0.000 claims description 20
- 230000001588 bifunctional effect Effects 0.000 claims description 19
- 239000003153 chemical reaction reagent Substances 0.000 claims description 18
- 125000003156 secondary amide group Chemical group 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 15
- 239000004952 Polyamide Substances 0.000 claims description 14
- 229920002647 polyamide Polymers 0.000 claims description 14
- 239000012320 chlorinating reagent Substances 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 239000012876 carrier material Substances 0.000 claims description 10
- 125000002947 alkylene group Chemical group 0.000 claims description 6
- 125000005442 diisocyanate group Chemical group 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 125000003368 amide group Chemical group 0.000 claims description 5
- 239000003125 aqueous solvent Substances 0.000 claims description 4
- 125000004185 ester group Chemical group 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 125000005037 alkyl phenyl group Chemical group 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims description 3
- 150000001336 alkenes Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 239000007795 chemical reaction product Substances 0.000 claims description 2
- 125000006165 cyclic alkyl group Chemical group 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 230000003100 immobilizing effect Effects 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 2
- 229920003192 poly(bis maleimide) Polymers 0.000 claims description 2
- 125000001302 tertiary amino group Chemical group 0.000 claims description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 2
- XQUPVDVFXZDTLT-UHFFFAOYSA-N 1-[4-[[4-(2,5-dioxopyrrol-1-yl)phenyl]methyl]phenyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C(C=C1)=CC=C1CC1=CC=C(N2C(C=CC2=O)=O)C=C1 XQUPVDVFXZDTLT-UHFFFAOYSA-N 0.000 claims 1
- ZETHHMPKDUSZQQ-UHFFFAOYSA-N Betulafolienepentol Natural products C1C=C(C)CCC(C(C)CCC=C(C)C)C2C(OC)OC(OC)C2=C1 ZETHHMPKDUSZQQ-UHFFFAOYSA-N 0.000 claims 1
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical group N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- PCSMJKASWLYICJ-UHFFFAOYSA-N Succinic aldehyde Chemical compound O=CCCC=O PCSMJKASWLYICJ-UHFFFAOYSA-N 0.000 claims 1
- 125000004036 acetal group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- HEOKFDGOFROELJ-UHFFFAOYSA-N diacetal Natural products COc1ccc(C=C/c2cc(O)cc(OC3OC(COC(=O)c4cc(O)c(O)c(O)c4)C(O)C(O)C3O)c2)cc1O HEOKFDGOFROELJ-UHFFFAOYSA-N 0.000 claims 1
- 125000002560 nitrile group Chemical group 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 55
- 239000000243 solution Substances 0.000 description 43
- 239000008363 phosphate buffer Substances 0.000 description 18
- 230000000694 effects Effects 0.000 description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 16
- 239000004677 Nylon Substances 0.000 description 14
- 229920001778 nylon Polymers 0.000 description 14
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- 108010015776 Glucose oxidase Proteins 0.000 description 12
- 239000004366 Glucose oxidase Substances 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 12
- 229940116332 glucose oxidase Drugs 0.000 description 12
- 235000019420 glucose oxidase Nutrition 0.000 description 12
- 239000008187 granular material Substances 0.000 description 12
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 9
- 229920002292 Nylon 6 Polymers 0.000 description 9
- 125000003277 amino group Chemical group 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 239000000872 buffer Substances 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 6
- 150000004985 diamines Chemical class 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 125000006850 spacer group Chemical group 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 102100024078 Plasma serine protease inhibitor Human genes 0.000 description 4
- 101710183733 Plasma serine protease inhibitor Proteins 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N Vilsmeier-Haack reagent Natural products CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 238000013146 percutaneous coronary intervention Methods 0.000 description 4
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 3
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 235000019253 formic acid Nutrition 0.000 description 3
- 125000001841 imino group Chemical group [H]N=* 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 239000004927 clay Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N dihydromaleimide Natural products O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
- SWRGUMCEJHQWEE-UHFFFAOYSA-N ethanedihydrazide Chemical compound NNC(=O)C(=O)NN SWRGUMCEJHQWEE-UHFFFAOYSA-N 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 150000002466 imines Chemical class 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 229960002317 succinimide Drugs 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- MPTQLFFTNNKMRP-UHFFFAOYSA-N 3,4-dihydroxypyrrolidine-2,5-dione Chemical class OC1C(O)C(=O)NC1=O MPTQLFFTNNKMRP-UHFFFAOYSA-N 0.000 description 1
- HVCNXQOWACZAFN-UHFFFAOYSA-N 4-ethylmorpholine Chemical compound CCN1CCOCC1 HVCNXQOWACZAFN-UHFFFAOYSA-N 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 1
- 102000057621 Glycerol kinases Human genes 0.000 description 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical group NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 1
- 101710163410 Probable glycerol kinase Proteins 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- HCOMFAYPHBFMKU-UHFFFAOYSA-N butanedihydrazide Chemical compound NNC(=O)CCC(=O)NN HCOMFAYPHBFMKU-UHFFFAOYSA-N 0.000 description 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 125000002993 cycloalkylene group Chemical group 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 150000001990 dicarboxylic acid derivatives Chemical class 0.000 description 1
- RZVGUUMNWCDIBV-UHFFFAOYSA-N diethyl propanediimidate Chemical compound CCOC(=N)CC(=N)OCC RZVGUUMNWCDIBV-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- CEIPQQODRKXDSB-UHFFFAOYSA-N ethyl 3-(6-hydroxynaphthalen-2-yl)-1H-indazole-5-carboximidate dihydrochloride Chemical compound Cl.Cl.C1=C(O)C=CC2=CC(C3=NNC4=CC=C(C=C43)C(=N)OCC)=CC=C21 CEIPQQODRKXDSB-UHFFFAOYSA-N 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000002140 halogenating effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 150000002463 imidates Chemical class 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 239000002991 molded plastic Substances 0.000 description 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical group ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 108010011110 polyarginine Proteins 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C12N11/096—Polyesters; Polyamides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Landscapes
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Polyamides (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2603319A DE2603319C3 (de) | 1976-01-29 | 1976-01-29 | Verfahren zur Fixierung von biologisch aktiven Proteinen an Trägern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH626092A5 true CH626092A5 (OSRAM) | 1981-10-30 |
Family
ID=5968538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH94577A CH626092A5 (OSRAM) | 1976-01-29 | 1977-01-26 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4119589A (OSRAM) |
| JP (1) | JPS5294489A (OSRAM) |
| AT (1) | AT359021B (OSRAM) |
| AU (1) | AU509729B2 (OSRAM) |
| BE (1) | BE850717A (OSRAM) |
| CA (1) | CA1087608A (OSRAM) |
| CH (1) | CH626092A5 (OSRAM) |
| DD (1) | DD128404A5 (OSRAM) |
| DE (1) | DE2603319C3 (OSRAM) |
| DK (1) | DK36377A (OSRAM) |
| FR (1) | FR2339620A1 (OSRAM) |
| GB (1) | GB1521243A (OSRAM) |
| HU (1) | HU176482B (OSRAM) |
| IL (1) | IL51126A (OSRAM) |
| IT (1) | IT1065504B (OSRAM) |
| NL (1) | NL7614014A (OSRAM) |
| SE (1) | SE7700761L (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2528806A (en) * | 1945-11-09 | 1950-11-07 | Deere & Co | Beet harvester |
| DE2708018A1 (de) | 1977-02-24 | 1978-09-07 | Boehringer Mannheim Gmbh | An polyamid fixiertes biologisch aktives protein und verfahren zu seiner herstellung |
| US4415490A (en) * | 1979-07-24 | 1983-11-15 | Nippon Zeon Co., Ltd. | Non-thrombogenic material |
| US4279787A (en) * | 1979-07-30 | 1981-07-21 | Tetra Consultants Inc. | Method of binding antigens to insoluble polymeric substances |
| WO1981001145A1 (en) * | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| JPS5670028A (en) * | 1979-11-12 | 1981-06-11 | Teijin Ltd | Polymer bonding with albumin |
| FI76888C (fi) * | 1981-04-29 | 1988-12-12 | Ciba Geigy Ag | Nya medel och foerpackningar foer immunologiska analyser. |
| IL66094A0 (en) * | 1982-06-22 | 1982-09-30 | Yeda Res & Dev | Synthesis with multipolymer systems |
| US4595656A (en) * | 1984-01-06 | 1986-06-17 | Becton Dickinson & Company | Coupling agents and products produced therefrom |
| US4615985A (en) * | 1984-04-16 | 1986-10-07 | Genetic Diagnostics Corporation | Immobilized protein on nylon for immunoassay |
| WO1986002654A1 (en) * | 1984-10-29 | 1986-05-09 | Memtec Limited | Sulphuryl chloride/polyamide derivatives |
| US5108923A (en) * | 1986-04-25 | 1992-04-28 | Collaborative Research, Inc. | Bioadhesives for cell and tissue adhesion |
| US4952519A (en) * | 1988-05-02 | 1990-08-28 | E. I. Du Pont De Nemours And Company | Protein immobilization with poly(ethyleneimine) derivatized with a hydroprobic group |
| ATE102074T1 (de) * | 1989-09-29 | 1994-03-15 | Rohm & Haas | Ligand enthaltendes medium fuer chromatographische trennung, verfahren zur dessen herstellung und dessen verwendung zur isolierung von synthetischen oder natuerlichen molekuelen von einer fluidmischung. |
| WO1992008790A1 (en) * | 1990-11-14 | 1992-05-29 | Cargill, Incorporated | Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins |
| US5424219A (en) * | 1991-10-25 | 1995-06-13 | Cytech Biomedical, Inc. | Method of performing assays for biomolecules and solid supports for use in such methods |
| US6048735A (en) * | 1996-12-05 | 2000-04-11 | Idego Aps | Sensor laminates and multi-sectioned fluid delivery devices for detecting by immunoassay target molecules in biological fluids |
| US20160324269A1 (en) | 2015-05-08 | 2016-11-10 | Under Armour, Inc. | Footwear Including an Adaptable and Adjustable Lacing System |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1171774A (en) * | 1966-02-10 | 1969-11-26 | Dunlop Co Ltd | Improvements in and relating to Bonding. |
| US3639558A (en) * | 1968-02-19 | 1972-02-01 | Louis Csizmas | Immunological reagent particles having proteinaceous materials covalently bonded thereto |
| AT317424B (de) * | 1971-06-09 | 1974-08-26 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von trägergebundenen Proteinen |
| US3830699A (en) * | 1972-03-16 | 1974-08-20 | Exxon Research Engineering Co | Insolubilized enzymes |
| IL42516A (en) * | 1973-06-15 | 1976-11-30 | Mordechai Sokolovsky | Polyamides are converted by aldehyde and isonitrile groups and a process for their preparation |
| FR2234311B1 (OSRAM) * | 1973-06-21 | 1976-04-30 | Air Liquide | |
| GB1485122A (en) * | 1973-08-06 | 1977-09-08 | Nat Res Dev | Biologically active matrices |
| US3985617A (en) * | 1974-10-29 | 1976-10-12 | Ajinomoto Co., Inc. | Immobilization of biologically active proteins with a polypeptide azide |
| US4007089A (en) * | 1975-04-30 | 1977-02-08 | Nelson Research & Development Company | Method for binding biologically active compounds |
| US4045384A (en) * | 1976-07-23 | 1977-08-30 | The Dow Chemical Company | Method for forming an amide bond between a latex and protein |
-
1976
- 1976-01-29 DE DE2603319A patent/DE2603319C3/de not_active Expired
- 1976-11-24 AT AT872676A patent/AT359021B/de not_active IP Right Cessation
- 1976-12-13 CA CA267,721A patent/CA1087608A/en not_active Expired
- 1976-12-17 NL NL7614014A patent/NL7614014A/xx not_active Application Discontinuation
- 1976-12-17 IL IL51126A patent/IL51126A/xx unknown
- 1976-12-23 IT IT30848/76A patent/IT1065504B/it active
-
1977
- 1977-01-18 US US05/760,296 patent/US4119589A/en not_active Expired - Lifetime
- 1977-01-25 BE BE174350A patent/BE850717A/xx not_active IP Right Cessation
- 1977-01-25 FR FR7702049A patent/FR2339620A1/fr active Granted
- 1977-01-25 SE SE7700761A patent/SE7700761L/xx not_active Application Discontinuation
- 1977-01-26 GB GB3147/77A patent/GB1521243A/en not_active Expired
- 1977-01-26 CH CH94577A patent/CH626092A5/de not_active IP Right Cessation
- 1977-01-27 DD DD7700197116A patent/DD128404A5/xx unknown
- 1977-01-27 AU AU21737/77A patent/AU509729B2/en not_active Expired
- 1977-01-28 HU HU77BO1651A patent/HU176482B/hu unknown
- 1977-01-28 DK DK36377A patent/DK36377A/da not_active Application Discontinuation
- 1977-01-28 JP JP857577A patent/JPS5294489A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2173777A (en) | 1978-08-03 |
| AT359021B (de) | 1980-10-10 |
| FR2339620A1 (fr) | 1977-08-26 |
| SE7700761L (sv) | 1977-07-30 |
| HU176482B (en) | 1981-03-28 |
| FR2339620B1 (OSRAM) | 1981-07-24 |
| DD128404A5 (de) | 1977-11-16 |
| US4119589A (en) | 1978-10-10 |
| AU509729B2 (en) | 1980-05-22 |
| GB1521243A (en) | 1978-08-16 |
| ATA872676A (de) | 1980-03-15 |
| BE850717A (fr) | 1977-07-25 |
| DE2603319C3 (de) | 1979-08-23 |
| IL51126A0 (en) | 1977-02-28 |
| NL7614014A (nl) | 1977-08-02 |
| IL51126A (en) | 1979-11-30 |
| IT1065504B (it) | 1985-02-25 |
| DK36377A (da) | 1977-07-30 |
| CA1087608A (en) | 1980-10-14 |
| DE2603319A1 (de) | 1977-08-11 |
| DE2603319B2 (de) | 1978-12-21 |
| JPS5294489A (en) | 1977-08-09 |
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| Date | Code | Title | Description |
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| PL | Patent ceased | ||
| PL | Patent ceased |