CH622487A5 - - Google Patents

Download PDF

Info

Publication number
CH622487A5
CH622487A5 CH1630375A CH1630375A CH622487A5 CH 622487 A5 CH622487 A5 CH 622487A5 CH 1630375 A CH1630375 A CH 1630375A CH 1630375 A CH1630375 A CH 1630375A CH 622487 A5 CH622487 A5 CH 622487A5
Authority
CH
Switzerland
Prior art keywords
formula
propanol
phenoxy
compounds
preparation
Prior art date
Application number
CH1630375A
Other languages
German (de)
English (en)
Inventor
Helmut Dr Grill
Rainer Hans Dr Zschocke
Josef Dr Wagner
Gernot Dr Hofrichter
P Stefan Dr Janiak
Original Assignee
Klinge Co Chem Pharm Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Co Chem Pharm Fab filed Critical Klinge Co Chem Pharm Fab
Publication of CH622487A5 publication Critical patent/CH622487A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
CH1630375A 1974-12-20 1975-12-16 CH622487A5 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2460689A DE2460689C3 (de) 1974-12-20 1974-12-20 13-disubstituierte Propanol-(2)-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
CH622487A5 true CH622487A5 (nl) 1981-04-15

Family

ID=5934146

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1630375A CH622487A5 (nl) 1974-12-20 1975-12-16

Country Status (21)

Country Link
US (1) US4073935A (nl)
JP (1) JPS51125238A (nl)
AR (1) AR213397A1 (nl)
AT (1) AT352699B (nl)
AU (1) AU498719B2 (nl)
BE (1) BE836870A (nl)
CA (1) CA1065870A (nl)
CH (1) CH622487A5 (nl)
DD (1) DD123597A5 (nl)
DE (1) DE2460689C3 (nl)
DK (1) DK573275A (nl)
ES (1) ES443616A1 (nl)
FR (1) FR2294691A1 (nl)
GB (1) GB1516747A (nl)
HU (1) HU173345B (nl)
IT (1) IT1051847B (nl)
LU (1) LU74050A1 (nl)
NL (1) NL171356C (nl)
PL (1) PL97422B1 (nl)
SE (1) SE7514271L (nl)
ZA (1) ZA757912B (nl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260816A (en) * 1975-12-09 1981-04-07 American Cyanamid Company Naphthyloxyalkylaminobenzoic acids, salts and esters thereof
EP0025331B1 (en) * 1979-09-06 1983-03-02 Beecham Group Plc Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them
EP0056172B1 (en) * 1981-01-09 1985-04-03 FISONS plc Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them
US4567201A (en) * 1981-11-25 1986-01-28 Takeda Chemical Industries, Ltd. Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
US5105017A (en) * 1983-07-18 1992-04-14 Eli Lilly And Company Leukotriene antagonist intermediates
DE3326164A1 (de) * 1983-07-20 1985-01-31 Klinge Pharma GmbH, 8000 München Neue p-oxibenzoesaeure-derivate, sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CH671402A5 (nl) * 1985-10-02 1989-08-31 Sandoz Ag
US4778925A (en) * 1985-12-30 1988-10-18 Klinge Pharma Gmbh New benzoic acid derivatives, as well as processes for their production and their use as pharmaceuticals
EP0393607B1 (en) * 1989-04-19 1996-02-21 Otsuka Pharmaceutical Co., Ltd. Phenylcarboxylic acid derivatives having a hetero ring
DE4032037A1 (de) * 1990-10-09 1992-04-16 Klinge Co Chem Pharm Fab Neue p-oxibenzoesaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE4119055A1 (de) * 1991-06-10 1992-12-17 Klinge Co Chem Pharm Fab Verfahren zur herstellung der reinen enantiomere des lifibrol und seiner alkylester
DE4127800A1 (de) * 1991-08-22 1993-02-25 Klinge Co Chem Pharm Fab Neue p-oxibenzoesaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA2632078C (en) * 2002-03-04 2012-08-14 Sloan-Kettering Institute For Cancer Research Methods of inducing terminal differentiation
EP2100877B1 (en) 2003-09-19 2012-01-25 Janssen Pharmaceutica N.V. 4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs
JO3006B1 (ar) * 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
UY30288A1 (es) * 2006-04-18 2007-08-31 Janssen Pharmaceutica Nv Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738351A (en) * 1952-08-02 1956-03-13 Bristol Lab Inc Substituted glycerol ethers

Also Published As

Publication number Publication date
AT352699B (de) 1979-10-10
NL7514696A (nl) 1976-06-22
DE2460689B2 (de) 1979-10-18
IT1051847B (it) 1981-05-20
DE2460689A1 (de) 1976-07-01
CA1065870A (en) 1979-11-06
AU498719B2 (en) 1979-03-22
FR2294691B1 (nl) 1978-07-28
JPS51125238A (en) 1976-11-01
NL171356C (nl) 1983-03-16
LU74050A1 (nl) 1976-07-20
US4073935A (en) 1978-02-14
BE836870A (fr) 1976-04-16
ATA964375A (de) 1979-03-15
SE7514271L (sv) 1976-06-21
GB1516747A (en) 1978-07-05
ES443616A1 (es) 1977-05-01
DK573275A (da) 1976-06-21
NL171356B (nl) 1982-10-18
AR213397A1 (es) 1979-01-31
AU8762375A (en) 1977-06-23
DE2460689C3 (de) 1980-06-26
PL97422B1 (pl) 1978-02-28
FR2294691A1 (fr) 1976-07-16
HU173345B (hu) 1979-04-28
DD123597A5 (nl) 1977-01-05
ZA757912B (en) 1976-12-29

Similar Documents

Publication Publication Date Title
CH622487A5 (nl)
DD146179A5 (de) Verfahren zur herstellung von neuen(dl)-16-phenoxy-9-keto-prostatriensaeuren und deren derivaten
DE2556474C2 (de) Substituierte p-Benzyloxyphenylessigsäuren, ihre Herstellung sowie diese enthaltende Arzneimittel
EP0133935B1 (de) p-Oxibenzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln mit hypolipämischer Wirkung
CH635060A5 (de) 1,3-diphenoxypropan-2-on-derivate, verfahren zu ihrer herstellung und daraus hergestellte arzneimittel.
AT343104B (de) Verfahren zur herstellung von neuen naphthalinderivaten
DE2535343C2 (de) 2-(6'-Carboxy-n-hexyl)-3-n-hexyl-cyclopentanole und -derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
CH646935A5 (de) 2-(4-dimethylvinylphenyl)-propionsaeure.
DE2625688A1 (de) Neue substituierte 1,3-diphenoxypropanol-(2)-derivate sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3026924A1 (de) 1,3-diphenoxypropan-2-ol-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE1668809C3 (de) Prostaglandinverbindungen, Verfahren zu deren Herstellung und sie enthaltende therapeutische Mittel
DE2331081A1 (de) Neue cyclopentanderivate und verfahren zu ihrer herstellung
CH643250A5 (de) (3-alkylamino-2-hydroxypropoxy)-furan-2-carbonsaeureanilide.
DE3028776A1 (de) Neue 1,3-diphenoxypropan-2-on-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE2625689C3 (de) 1,3-Diphenoxypropanol-(2)-Derivate sowie Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CH643843A5 (de) Phenthiazin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
AT371798B (de) Verfahren zur herstellung von neuen indan-1carbons[ure-derivaten und deren salzen
AT337682B (de) Verfahren zur herstellung von neuen benzocycloalkencarbonsauren sowie ihren estern und salzen
AT277226B (de) Verfahren zur herstellung von neuen pyrrolderivaten und ihren salzen
AT336612B (de) Verfahren zur herstellung von neuen thianthren-, thioxanthen- und phenoxathiinderivaten sowie ihren salzen und optischen isomeren
DE1593901C3 (de) Basisch substituierte Benzofurane oder Indole und Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE4032037A1 (de) Neue p-oxibenzoesaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2402742A1 (de) Synthetische prostaglandine
EP0286703A1 (de) Neue Benzoesäure-Derivate, sowie Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE3546324A1 (de) Neue benzoesaeure-derivate, sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Legal Events

Date Code Title Description
PL Patent ceased