CH618959A5 - - Google Patents
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- Publication number
- CH618959A5 CH618959A5 CH389775A CH389775A CH618959A5 CH 618959 A5 CH618959 A5 CH 618959A5 CH 389775 A CH389775 A CH 389775A CH 389775 A CH389775 A CH 389775A CH 618959 A5 CH618959 A5 CH 618959A5
- Authority
- CH
- Switzerland
- Prior art keywords
- phe
- arg
- gly
- tyr
- ala
- Prior art date
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- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- WHQSYGRFZMUQGQ-UHFFFAOYSA-N n,n-dimethylformamide;hydrate Chemical compound O.CN(C)C=O WHQSYGRFZMUQGQ-UHFFFAOYSA-N 0.000 description 1
- VTDLJMATIHSOTR-RSAXXLAASA-N n-cyclohexylcyclohexanamine;(2s)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoic acid Chemical compound C1CCCCC1NC1CCCCC1.CC(C)(C)OC(=O)NCCCC[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 VTDLJMATIHSOTR-RSAXXLAASA-N 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 1
- PTVIBIVJSXWMPT-FGSANIJTSA-N octadecaneuropeptide Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)O PTVIBIVJSXWMPT-FGSANIJTSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- NPKKRSHVJIQBKU-UHFFFAOYSA-N ornogenin Natural products CC(OC(=O)C=Cc1ccccc1)C2(O)CCC3(O)C4(O)CC=C5CC(O)CCC5(C)C4CC(OC(=O)C=Cc6ccccc6)C23C NPKKRSHVJIQBKU-UHFFFAOYSA-N 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 150000003012 phosphoric acid amides Chemical class 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920005990 polystyrene resin Polymers 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 238000003797 solvolysis reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 108010078580 tyrosylleucine Proteins 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- BZPCSFNCKORLQG-NSHDSACASA-N z-arg(no2)-oh Chemical compound [O-][N+](=O)NC(N)=NCCC[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 BZPCSFNCKORLQG-NSHDSACASA-N 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3416174A JPS5724777B2 (en, 2012) | 1974-03-26 | 1974-03-26 | |
| JP50010878A JPS5850212B2 (ja) | 1975-01-24 | 1975-01-24 | ポリペプチドノセイゾウホウ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH618959A5 true CH618959A5 (en, 2012) | 1980-08-29 |
Family
ID=26346233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH389775A CH618959A5 (en, 2012) | 1974-03-26 | 1975-03-26 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4001199A (en, 2012) |
| AT (1) | AT348153B (en, 2012) |
| CA (1) | CA1059993A (en, 2012) |
| CH (1) | CH618959A5 (en, 2012) |
| CS (1) | CS189694B2 (en, 2012) |
| DE (1) | DE2513057A1 (en, 2012) |
| DK (1) | DK126275A (en, 2012) |
| ES (1) | ES435990A1 (en, 2012) |
| FI (1) | FI750925A7 (en, 2012) |
| FR (1) | FR2274604A1 (en, 2012) |
| GB (1) | GB1499764A (en, 2012) |
| HU (1) | HU175306B (en, 2012) |
| IE (1) | IE40877B1 (en, 2012) |
| NL (1) | NL7503519A (en, 2012) |
| NO (1) | NO751044L (en, 2012) |
| SE (1) | SE7503471L (en, 2012) |
| SU (1) | SU577975A3 (en, 2012) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4073890A (en) * | 1974-03-26 | 1978-02-14 | Takeda Chemical Industries, Ltd. | Novel polypeptides |
| US4089821A (en) * | 1976-03-31 | 1978-05-16 | Armour Pharmaceutical Company | Synthesis of peptide amides |
| DE3146598A1 (de) * | 1981-11-25 | 1983-07-07 | Hoechst Ag, 6230 Frankfurt | "neue peptide und verfahren zu ihrer herstellung" |
| US5447995A (en) | 1994-05-27 | 1995-09-05 | Shell Oil Company | Method for producing asymmetric radial polymers |
| AU4394201A (en) * | 2000-03-31 | 2001-10-08 | Metabolic Pharm Ltd | Insulin potentiating peptides |
| AUPQ661800A0 (en) * | 2000-03-31 | 2000-05-04 | Metabolic Pharmaceuticals Limited | Insulin-potentiating compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3778426A (en) * | 1970-12-16 | 1973-12-11 | Research Corp | Therapeutically useful polypeptides |
| US3891616A (en) * | 1974-04-17 | 1975-06-24 | Squibb & Sons Inc | Hypotensive {62 -homoaminoacid nonapeptides |
-
1975
- 1975-03-19 US US05/560,092 patent/US4001199A/en not_active Expired - Lifetime
- 1975-03-22 CS CS751971A patent/CS189694B2/cs unknown
- 1975-03-24 AT AT223975A patent/AT348153B/de not_active IP Right Cessation
- 1975-03-24 IE IE651/75A patent/IE40877B1/xx unknown
- 1975-03-24 NL NL7503519A patent/NL7503519A/xx not_active Application Discontinuation
- 1975-03-24 FR FR7509114A patent/FR2274604A1/fr active Granted
- 1975-03-25 GB GB12365/75A patent/GB1499764A/en not_active Expired
- 1975-03-25 SE SE7503471A patent/SE7503471L/xx unknown
- 1975-03-25 DK DK126275A patent/DK126275A/da unknown
- 1975-03-25 ES ES435990A patent/ES435990A1/es not_active Expired
- 1975-03-25 NO NO751044A patent/NO751044L/no unknown
- 1975-03-25 CA CA223,059A patent/CA1059993A/en not_active Expired
- 1975-03-25 DE DE19752513057 patent/DE2513057A1/de not_active Withdrawn
- 1975-03-26 HU HU75TA1351A patent/HU175306B/hu unknown
- 1975-03-26 FI FI750925A patent/FI750925A7/fi not_active Application Discontinuation
- 1975-03-26 SU SU7502127597A patent/SU577975A3/ru active
- 1975-03-26 CH CH389775A patent/CH618959A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO751044L (en, 2012) | 1975-09-29 |
| NL7503519A (nl) | 1975-09-30 |
| IE40877B1 (en) | 1979-08-29 |
| HU175306B (hu) | 1980-06-28 |
| DE2513057A1 (de) | 1975-10-09 |
| CA1059993A (en) | 1979-08-07 |
| FR2274604A1 (fr) | 1976-01-09 |
| SU577975A3 (ru) | 1977-10-25 |
| SE7503471L (en, 2012) | 1975-09-29 |
| ATA223975A (de) | 1978-06-15 |
| AU7904675A (en) | 1976-09-16 |
| AT348153B (de) | 1979-02-12 |
| DK126275A (en, 2012) | 1975-09-27 |
| IE40877L (en) | 1975-09-26 |
| FI750925A7 (en, 2012) | 1975-09-27 |
| GB1499764A (en) | 1978-02-01 |
| ES435990A1 (es) | 1976-12-16 |
| US4001199A (en) | 1977-01-04 |
| FR2274604B1 (en, 2012) | 1979-09-28 |
| CS189694B2 (en) | 1979-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |