CH617703A5 - Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel antibiotically active 7 beta -acylamino-ceph-3-em-4-carboxylic acids - Google Patents

Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel antibiotically active 7 beta -acylamino-ceph-3-em-4-carboxylic acids Download PDF

Info

Publication number
CH617703A5
CH617703A5 CH1708674A CH1708674A CH617703A5 CH 617703 A5 CH617703 A5 CH 617703A5 CH 1708674 A CH1708674 A CH 1708674A CH 1708674 A CH1708674 A CH 1708674A CH 617703 A5 CH617703 A5 CH 617703A5
Authority
CH
Switzerland
Prior art keywords
acid
formula
ceph
solution
compound
Prior art date
Application number
CH1708674A
Other languages
German (de)
English (en)
Inventor
Janice Bradshaw
Martin Christopher Cook
Gordon Ian Gregory
John Derek Cocker
Derek Ronald Sutherland
Original Assignee
Glaxo Operations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB59517/73A external-priority patent/GB1496757A/en
Application filed by Glaxo Operations Ltd filed Critical Glaxo Operations Ltd
Publication of CH617703A5 publication Critical patent/CH617703A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CH1708674A 1973-12-21 1974-12-20 Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel antibiotically active 7 beta -acylamino-ceph-3-em-4-carboxylic acids CH617703A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB59517/73A GB1496757A (en) 1973-12-21 1973-12-21 Cephalosporin derivatives
GB4300574 1974-10-03

Publications (1)

Publication Number Publication Date
CH617703A5 true CH617703A5 (en) 1980-06-13

Family

ID=26265028

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1708674A CH617703A5 (en) 1973-12-21 1974-12-20 Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel antibiotically active 7 beta -acylamino-ceph-3-em-4-carboxylic acids

Country Status (15)

Country Link
JP (1) JPS5844675B2 (no)
AT (1) AT344888B (no)
CH (1) CH617703A5 (no)
DE (1) DE2460537C2 (no)
DK (1) DK674674A (no)
ES (2) ES433226A1 (no)
FI (1) FI65258C (no)
FR (1) FR2255076B1 (no)
HU (1) HU172234B (no)
IE (1) IE42144B1 (no)
IL (1) IL46302A (no)
LU (1) LU71550A1 (no)
NL (1) NL7416665A (no)
NO (1) NO744621L (no)
SE (1) SE7416195L (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144392A (en) 1973-12-21 1979-03-13 Glaxo Laboratories Limited Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile
US4144393A (en) 1973-12-21 1979-03-13 Glaxo Laboratories Limited 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group
GB1555471A (en) * 1975-06-19 1979-11-14 Glaxo Lab Ltd 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof
CA1093549A (en) * 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics
US4165430A (en) 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
US4304770A (en) 1976-04-12 1981-12-08 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US4066762A (en) * 1976-07-12 1978-01-03 Smithkline Corporation Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid
US4278670A (en) * 1976-07-12 1981-07-14 Smithkline Corporation 7-Alpha-oxyiminoacylcephalosporins
GB1591439A (en) 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
GB1596278A (en) 1976-11-30 1981-08-26 Glaxo Operations Ltd 7-(-oxyimino-acetamino)cephalosporin derivatives
PH17188A (en) 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2943427A1 (de) * 1978-10-27 1980-05-08 Glaxo Group Ltd Cephalosporinverbindungen
FR2457296A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
FR2552432B2 (fr) * 1983-09-27 1985-10-25 Roussel Uclaf Nouvelles oximes derivees de l'acide 2-amino thiazol- 4-yl acetique, procede de preparation
US20040166434A1 (en) 2003-02-21 2004-08-26 Dammel Ralph R. Photoresist composition for deep ultraviolet lithography

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
GB1348984A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Antibiotics and processes for their production
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds

Also Published As

Publication number Publication date
NO744621L (no) 1975-07-21
IE42144B1 (en) 1980-06-18
FI65258B (fi) 1983-12-30
DE2460537C2 (de) 1987-01-22
NL7416665A (nl) 1975-06-24
AT344888B (de) 1978-08-10
FI65258C (fi) 1984-04-10
IE42144L (en) 1975-06-21
FI371374A (no) 1975-06-22
ATA1020174A (de) 1977-12-15
ES451604A1 (es) 1977-12-16
IL46302A (en) 1978-09-29
AU7673574A (en) 1976-06-24
HU172234B (hu) 1978-07-28
IL46302A0 (en) 1975-03-13
LU71550A1 (no) 1976-04-13
JPS50105689A (no) 1975-08-20
FR2255076A1 (no) 1975-07-18
DE2460537A1 (de) 1975-07-03
DK674674A (no) 1975-09-08
ES433226A1 (es) 1977-07-01
FR2255076B1 (no) 1978-11-10
SE7416195L (sv) 1975-09-22
JPS5844675B2 (ja) 1983-10-04

Similar Documents

Publication Publication Date Title
DE2461478C2 (de) Cephalosporinderivate und Verfahren zu deren Herstellung
NO155347B (no) Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt (6r,7r)-7-((z)-2-(2-amino-tiazol-4-yl)-2-(2-karboksy-prop-2-oksyimino)-acetamido)-3-(1-pyridiniummetyl)cef-3-em-4-karboksylat.
DE2223375A1 (de) Antibiotika und Verfahren zu ihrer Herstellung
CH617703A5 (en) Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel antibiotically active 7 beta -acylamino-ceph-3-em-4-carboxylic acids
FR2540875A1 (fr) Nouveaux derives de la cephalosporine et leur procede de preparation
KR830000835B1 (ko) 세팔로스포린 항생제의 제조방법
CH615436A5 (en) Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel 7-alpha-substituted 7-beta-acylaminoceph-3-em-4-carboxylic acids
DE2204060A1 (de) Cephalosporin- und Penicillin-Antibiotika
DE2439880A1 (de) Antibiotika und verfahren zu ihrer herstellung
EP0002765B1 (de) Cephalosporinderivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate sowie deren Herstellung
CH625526A5 (no)
EP0009008A2 (de) Cephalosporinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
CH626370A5 (en) Process for the preparation of the syn isomer or of a mixture of syn and anti isomers of 7beta-acylamidoceph-3-em-4-carboxylic acids with antibiotic activity
NL7907882A (nl) Nieuwe cefalosporine-antibiotica, werkwijze voor de bereiding daarvan alsmede farmaceutisch preparaat dat deze bevat.
EP0295630A2 (de) Cephalosporinderivate
CH637139A5 (de) Verfahren zur herstellung von cephalosporinverbindungen.
DE3011038A1 (de) Cephalosporinantibiotika
CH618440A5 (no)
US4103085A (en) 7-(Syn-α-alkoxy-iminofurylacetamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids
EP0035161B1 (de) Cephalosporine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE69033952T2 (de) Antibakterielle Cephalosporin-Derivate
CH627758A5 (en) Process for the preparation of the syn isomer or a mixture of the syn isomer and anti isomer of 7beta-acylamidoceph-3-em-4-carboxylic acids with the antibiotic activity
DE2943437A1 (de) Cephalosporinverbindungen
DE3115935A1 (de) Substituierte 7-((alpha)-oxyimino-acetamido)-cephalosporine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische oder veterinaermedizinische mittel
CH671765A5 (no)

Legal Events

Date Code Title Description
PL Patent ceased