CH605872A5 - - Google Patents
Info
- Publication number
- CH605872A5 CH605872A5 CH1790773A CH1790773A CH605872A5 CH 605872 A5 CH605872 A5 CH 605872A5 CH 1790773 A CH1790773 A CH 1790773A CH 1790773 A CH1790773 A CH 1790773A CH 605872 A5 CH605872 A5 CH 605872A5
- Authority
- CH
- Switzerland
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2263211A DE2263211A1 (de) | 1972-12-23 | 1972-12-23 | Neue arylpiperazine und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH605872A5 true CH605872A5 (es) | 1978-10-13 |
Family
ID=5865328
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1790773A CH605872A5 (es) | 1972-12-23 | 1973-12-20 | |
| CH1516877A CH616667A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517177A CH616670A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1516777A CH616673A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1516977A CH616668A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517377A CH616675A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517077A CH616669A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517277A CH616674A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517577A CH616677A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517477A CH616676A5 (es) | 1972-12-23 | 1977-12-09 |
Family Applications After (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1516877A CH616667A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517177A CH616670A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1516777A CH616673A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1516977A CH616668A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517377A CH616675A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517077A CH616669A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517277A CH616674A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517577A CH616677A5 (es) | 1972-12-23 | 1977-12-09 | |
| CH1517477A CH616676A5 (es) | 1972-12-23 | 1977-12-09 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3941789A (es) |
| JP (4) | JPS4994688A (es) |
| AT (1) | AT338271B (es) |
| BE (1) | BE809041A (es) |
| CH (10) | CH605872A5 (es) |
| DE (1) | DE2263211A1 (es) |
| ES (10) | ES421751A1 (es) |
| FI (1) | FI59990C (es) |
| FR (1) | FR2211252B1 (es) |
| GB (1) | GB1456253A (es) |
| IE (1) | IE38679B1 (es) |
| LU (1) | LU69064A1 (es) |
| NL (1) | NL7317469A (es) |
| NO (1) | NO140381C (es) |
| SE (1) | SE417516B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4075208A (en) * | 1972-08-24 | 1978-02-21 | Ciba-Geigy Corporation | 1-Substituted-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine |
| US4038279A (en) * | 1972-12-23 | 1977-07-26 | Boehringer Ingelheim Gmbh | N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof |
| US4100282A (en) * | 1972-12-23 | 1978-07-11 | Boehringer Ingelheim Gmbh | N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof |
| US4440774A (en) * | 1975-03-03 | 1984-04-03 | Merck & Co., Inc. | 3-Amino-2-hydroxypropoxyaryl imidazole derivatives |
| GB1518559A (en) * | 1976-04-12 | 1978-07-19 | Science Union & Cie | Naphthyl derivatives processes for their preparation an pharmaceutical compositions containing them |
| US4052399A (en) * | 1976-09-13 | 1977-10-04 | Morton-Norwich Products, Inc. | 1-[2-(Hexahydro-1H-azepino)ethyl]-2(1H)pyrimidone dihydrochloride |
| US4052400A (en) * | 1976-10-29 | 1977-10-04 | Morton-Norwich Products, Inc. | Hypertensive 1-substituted 2(1h)-pyrimidones |
| DE2960178D1 (en) * | 1978-06-06 | 1981-04-09 | Hoechst Ag | New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation |
| DE2834114A1 (de) * | 1978-08-01 | 1980-02-14 | Schering Ag | Polyalkoxyphenylpyrrolidone iii, verfahren zu ihrer herstellung und ihre verwendung |
| DE3005287A1 (de) * | 1980-02-13 | 1981-08-20 | Basf Ag, 6700 Ludwigshafen | Phenylpiperazinderivate von 1,3,4-oxadiazolylphenolen, ihre herstellung und diese enthaltende therapeutische mittel |
| DE3101456A1 (de) | 1981-01-19 | 1982-09-02 | Basf Ag, 6700 Ludwigshafen | Phenylpiperazinyl-propanole von hetarylphenolen, ihre herstellung und diese enthaltende therapeutische mittel |
| DE3101502A1 (de) * | 1981-01-19 | 1982-08-26 | Basf Ag, 6700 Ludwigshafen | Phenylpiperazinderivate von hetarylphenolen und hetarylanilinen, ihre hersttellung und diese enthaltendetherapeutische mittel |
| CH653021A5 (fr) * | 1981-04-24 | 1985-12-13 | Delalande Sa | Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant. |
| US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
| US4450272A (en) * | 1982-05-06 | 1984-05-22 | American Cyanamid Company | Antiatherosclerotic 1-piperazine-thicarboxamides |
| US4452798A (en) * | 1982-06-22 | 1984-06-05 | Warner-Lambert Company | 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents |
| EP0138754B1 (de) * | 1983-08-15 | 1988-05-25 | Ciba-Geigy Ag | Photohärtbare Gemische |
| US4593039A (en) * | 1984-04-02 | 1986-06-03 | Merck & Co., Inc. | 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols |
| US4539318A (en) * | 1984-06-04 | 1985-09-03 | Merck & Co., Inc. | Tertiary aminohydroxypropoxy substituted thiadiazoles, pharmaceutical compositions and use |
| US4616017A (en) * | 1984-06-04 | 1986-10-07 | Merck & Co., Inc. | Aminohydroxypropoxy substituted aryl compounds |
| DE3424685A1 (de) * | 1984-07-05 | 1986-02-06 | Beiersdorf Ag, 2000 Hamburg | Neue substituierte phenylpiperazinyl-propanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen |
| GB8603120D0 (en) * | 1986-02-07 | 1986-03-12 | Pfizer Ltd | Anti-dysrhythmia agents |
| US4732895A (en) * | 1986-05-02 | 1988-03-22 | American Cyanamid Company | α-[5-methyl-2-(pyridinyl)-1H-imidazol-4-yl]substituted-1-piperazineethanols useful for treating hypertension |
| JPH0788357B2 (ja) * | 1986-10-27 | 1995-09-27 | 吉富製薬株式会社 | ピペラジン化合物 |
| DE3803860A1 (de) * | 1988-02-09 | 1989-08-17 | Basf Ag | N,n'-disubstituierte piperazine |
| US5382583A (en) * | 1989-04-22 | 1995-01-17 | John Wyeth & Brother, Limited | Piperazine derivatives |
| US5364849A (en) * | 1989-04-22 | 1994-11-15 | John Wyeth & Brother, Limited | 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives |
| US5166148A (en) * | 1990-07-09 | 1992-11-24 | The Du Pont Merck Pharmaceutical Company | 2-amino-1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
| WO1994018172A1 (en) * | 1993-02-01 | 1994-08-18 | Yoshitomi Pharmaceutical Industries, Ltd. | Imidazolylbenzene compound and use thereof as medicine |
| IL114027A (en) | 1994-06-08 | 1999-11-30 | Lundbeck & Co As H | 4-Phenyl piperazine (piperidine or tetrahydropyridine) derivatives serotinin 5-HT1A and dopamin D2 receptor ligand pharmaceutical compositions containing them |
| WO1996014297A1 (fr) * | 1994-11-04 | 1996-05-17 | Sumitomo Pharmaceuticals Company, Limited | Nouveaux derives de lactame |
| PT889889E (pt) * | 1996-03-29 | 2007-01-31 | Duphar Int Res | Composto de piperazina e piperidina |
| JP4349320B2 (ja) | 2005-05-12 | 2009-10-21 | パナソニック株式会社 | マニピュレータ型ロボット |
| US7943605B2 (en) | 2005-10-27 | 2011-05-17 | Ucb Pharma S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| US10126380B2 (en) * | 2015-06-15 | 2018-11-13 | Norell, Inc. | Closure and system for NMR sample containers with a secondary locking seal |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL274491A (es) * | 1961-02-08 | |||
| US3562277A (en) * | 1967-09-06 | 1971-02-09 | Shulton Inc | Ketonic derivatives of phenyl piperazines |
| BE788280A (fr) * | 1971-09-04 | 1973-02-28 | Pfizer | Nouvelles 1-(3-trifluoro-methyl-phenyl)-4-((amido cyclique)- alkyl) piperazines et composition pharmaceutique les contenant |
-
1972
- 1972-12-23 DE DE2263211A patent/DE2263211A1/de not_active Withdrawn
-
1973
- 1973-12-20 NL NL7317469A patent/NL7317469A/xx not_active Application Discontinuation
- 1973-12-20 CH CH1790773A patent/CH605872A5/xx not_active IP Right Cessation
- 1973-12-20 FI FI3940/73A patent/FI59990C/fi active
- 1973-12-20 GB GB5919473A patent/GB1456253A/en not_active Expired
- 1973-12-21 NO NO4936/73A patent/NO140381C/no unknown
- 1973-12-21 SE SE7317423A patent/SE417516B/xx unknown
- 1973-12-21 AT AT1072773A patent/AT338271B/de not_active IP Right Cessation
- 1973-12-21 FR FR7346112A patent/FR2211252B1/fr not_active Expired
- 1973-12-21 BE BE139227A patent/BE809041A/xx not_active IP Right Cessation
- 1973-12-21 LU LU69064A patent/LU69064A1/xx unknown
- 1973-12-21 US US05/427,367 patent/US3941789A/en not_active Expired - Lifetime
- 1973-12-21 JP JP49004699A patent/JPS4994688A/ja active Pending
- 1973-12-22 ES ES421751A patent/ES421751A1/es not_active Expired
- 1973-12-28 IE IE2338/73A patent/IE38679B1/xx unknown
-
1976
- 1976-01-29 ES ES444734A patent/ES444734A1/es not_active Expired
- 1976-01-29 ES ES444733A patent/ES444733A1/es not_active Expired
- 1976-01-29 ES ES444735A patent/ES444735A1/es not_active Expired
- 1976-01-29 ES ES444731A patent/ES444731A1/es not_active Expired
- 1976-01-29 ES ES444736A patent/ES444736A1/es not_active Expired
- 1976-01-29 ES ES444737A patent/ES444737A1/es not_active Expired
- 1976-01-29 ES ES444738A patent/ES444738A1/es not_active Expired
- 1976-01-29 ES ES444730A patent/ES444730A1/es not_active Expired
- 1976-01-29 ES ES444732A patent/ES444732A1/es not_active Expired
-
1977
- 1977-12-09 CH CH1516877A patent/CH616667A5/de not_active IP Right Cessation
- 1977-12-09 CH CH1517177A patent/CH616670A5/de not_active IP Right Cessation
- 1977-12-09 CH CH1516777A patent/CH616673A5/de not_active IP Right Cessation
- 1977-12-09 CH CH1516977A patent/CH616668A5/de not_active IP Right Cessation
- 1977-12-09 CH CH1517377A patent/CH616675A5/de not_active IP Right Cessation
- 1977-12-09 CH CH1517077A patent/CH616669A5/de not_active IP Right Cessation
- 1977-12-09 CH CH1517277A patent/CH616674A5/de not_active IP Right Cessation
- 1977-12-09 CH CH1517577A patent/CH616677A5/de not_active IP Right Cessation
- 1977-12-09 CH CH1517477A patent/CH616676A5/de not_active IP Right Cessation
-
1983
- 1983-07-15 JP JP58129263A patent/JPS5976074A/ja active Pending
- 1983-07-15 JP JP58129261A patent/JPS5976070A/ja active Pending
- 1983-07-15 JP JP58129262A patent/JPS5976067A/ja active Pending
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |