|
DE2856393C2
(de)
*
|
1978-12-27 |
1983-04-28 |
Merz + Co GmbH & Co, 6000 Frankfurt |
Arzneimittel zur Behandlung von Morbus Parkinson
|
|
US5334618A
(en)
*
|
1991-04-04 |
1994-08-02 |
The Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
|
US5506231A
(en)
*
|
1989-03-31 |
1996-04-09 |
The Children's Medical Center Corporation |
Treatment of aids dementia, myelopathy and blindness
|
|
US5455279A
(en)
*
|
1991-04-19 |
1995-10-03 |
The Children's Medical Center Corporation |
Regimen method of mediating neuronal damage using nitroglycerine
|
|
WO1992017168A1
(en)
*
|
1991-04-04 |
1992-10-15 |
The Children's Medical Center Corporation |
Method of preventing nmda receptor-mediated neuronal damage
|
|
US5614560A
(en)
*
|
1991-04-04 |
1997-03-25 |
Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
|
DE4225730C2
(de)
*
|
1992-08-04 |
2003-04-30 |
Merz Pharma Gmbh & Co Kgaa |
Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung
|
|
US6057373A
(en)
*
|
1997-05-22 |
2000-05-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists
|
|
US5866585A
(en)
*
|
1997-05-22 |
1999-02-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia using NMDA receptor antagonists
|
|
US5952389A
(en)
*
|
1998-01-13 |
1999-09-14 |
Synchroneuron |
Methods of treating tardive dyskinesia and other movement disorders
|
|
US6294583B1
(en)
|
1998-01-13 |
2001-09-25 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders
|
|
US6444702B1
(en)
|
2000-02-22 |
2002-09-03 |
Neuromolecular, Inc. |
Aminoadamantane derivatives as therapeutic agents
|
|
US7250394B2
(en)
*
|
2001-08-20 |
2007-07-31 |
Maiken Nedergaard |
Treatment of glial tumors with glutamate antagonists
|
|
EP1298581A1
(fr)
*
|
2001-09-27 |
2003-04-02 |
C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa |
Procédé et dispositif pour calculer les valeurs des neurones d'un réseau neuronal
|
|
AU2003274353B2
(en)
|
2002-10-24 |
2007-04-05 |
Merz Pharma Gmbh & Co. Kgaa |
Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors
|
|
RU2246482C2
(ru)
*
|
2002-12-25 |
2005-02-20 |
ООО "Циклан" |
Способ получения гидрохлорида 1-амино-3,5-диметиладамантана
|
|
MXPA05012493A
(es)
*
|
2003-05-27 |
2006-05-25 |
Forest Laboratories |
Combinacion de un antagonista del receptor de nmda y un inhibidor selectivo de reabsorcion de serotonina para el tratamiento de depresion y otros trastornos de estado de animo.
|
|
CN1240668C
(zh)
*
|
2003-09-10 |
2006-02-08 |
上海医药工业研究院 |
一种新的盐酸美金刚制备方法
|
|
US20050113458A1
(en)
*
|
2003-10-22 |
2005-05-26 |
Forest Laboratories, Inc. |
Use of 1-aminocyclohexane derivatives to modify deposition of fibrillogenic a-beta peptides in amyloidopathies
|
|
AR046314A1
(es)
|
2003-11-05 |
2005-11-30 |
Merz Pharma Gmbh & Co Kgaa |
Composiciones que comprenden ciclohexilaminas y aminoadamantanos
|
|
WO2005069742A2
(en)
*
|
2003-12-10 |
2005-08-04 |
Sun Pharmaceutical Industries Limited |
Crystal form ii of memantine hydrochloride
|
|
AU2005204358B2
(en)
*
|
2004-01-05 |
2008-09-04 |
Merz Pharma Gmbh & Co. Kgaa |
Memantine for the treatment of mild and mild-to-moderate Alzheimer's disease
|
|
CN100363329C
(zh)
*
|
2004-01-09 |
2008-01-23 |
南京大学 |
合成美金刚胺盐酸盐的方法
|
|
US7456224B2
(en)
*
|
2004-04-05 |
2008-11-25 |
Forest Laboratories Holdings, Ltd. |
Method for treating autism
|
|
ES2483126T3
(es)
|
2004-06-17 |
2014-08-05 |
Merz Pharma Gmbh & Co. Kgaa |
Formulaciones de formas de dosificación de neramexano
|
|
JP2008503475A
(ja)
*
|
2004-06-17 |
2008-02-07 |
フォーレスト ラボラトリーズ， インコーポレイテッド |
メマンチンの放出が改変された製剤
|
|
US20060002999A1
(en)
*
|
2004-06-17 |
2006-01-05 |
Forest Laboratories, Inc. |
Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
|
|
TW200616608A
(en)
*
|
2004-07-09 |
2006-06-01 |
Forest Laboratories |
Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
|
|
CA2578953A1
(en)
*
|
2004-09-23 |
2006-03-30 |
Merz Pharma Gmbh & Co. Kgaa |
Memantine for the treatment of childhood behavioral disorders
|
|
US20060205822A1
(en)
*
|
2004-12-22 |
2006-09-14 |
Forest Laboratories, Inc. |
1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
|
|
US20060173215A1
(en)
*
|
2005-01-11 |
2006-08-03 |
Valeriano Merli |
Process for the preparation of 1-amino-3,5-dimethyladamantane hydrochloride
|
|
ITMI20050833A1
(it)
*
|
2005-05-10 |
2006-11-11 |
A M S A S P A Anonima Materie Sintetiche Affini |
Nuovo procedimento per la sintesi di aminoadamantani
|
|
EA013474B1
(ru)
*
|
2005-06-16 |
2010-04-30 |
Форест Лэборэтериз, Инк. |
Композиция в виде гранул с модифицированным и немедленным высвобождением мемантина
|
|
AU2006275870B2
(en)
|
2005-07-27 |
2013-01-10 |
Otsuka America Pharmaceutical, Inc. |
Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
|
|
US20070099947A1
(en)
*
|
2005-11-03 |
2007-05-03 |
Alkermes, Inc. |
Methods and compositions for the treatment of brain reward system disorders by combination therapy
|
|
ES2379181T3
(es)
*
|
2006-02-21 |
2012-04-23 |
Hexal Ag |
Procedimiento para la preparación de adamantanaminas
|
|
MX2007014913A
(es)
*
|
2006-03-27 |
2008-10-24 |
Teva Pharma |
Proceso para perparar clorhidrato de memantina sustancialmente libre de impurezas.
|
|
US7985753B2
(en)
|
2006-08-04 |
2011-07-26 |
Merz Pharma Gmbh & Co. Kgaa |
Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators
|
|
EP1908748A1
(en)
*
|
2006-10-05 |
2008-04-09 |
Krka |
Process for the preparation of memantine and its hydrochloric acid salt form
|
|
US20080108643A1
(en)
*
|
2006-11-03 |
2008-05-08 |
Forest Laboratories Holdings Limited |
Method for treating autism
|
|
JP2010513569A
(ja)
|
2006-12-19 |
2010-04-30 |
ユニバーシティ オブ バージニア パテント ファウンデーション |
アルコール摂取に対するトピラメートおよびオンダンセトロンの併用効果
|
|
AU2008220104B2
(en)
|
2007-02-28 |
2012-09-27 |
Asahi Kasei Pharma Corporation |
Sulfonamide derivative
|
|
EP2167083B1
(en)
|
2007-06-06 |
2015-10-28 |
Euthymics Bioscience, Inc. |
1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
|
US9133159B2
(en)
|
2007-06-06 |
2015-09-15 |
Neurovance, Inc. |
1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
|
GB0713930D0
(en)
|
2007-07-18 |
2007-08-29 |
Generics Uk Ltd |
Novel assay methods
|
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
|
EP2090576A1
(en)
|
2008-02-01 |
2009-08-19 |
Merz Pharma GmbH & Co.KGaA |
6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
|
|
US20090247644A1
(en)
*
|
2008-03-28 |
2009-10-01 |
Forest Laboratories Holdings Limited |
Memantine formulations
|
|
US20110034565A1
(en)
|
2008-04-18 |
2011-02-10 |
University College Dublin, National University Of Ireland, Dublin |
Psycho-pharmaceuticals
|
|
EP2111858A1
(en)
|
2008-04-25 |
2009-10-28 |
EPFL Ecole Polytechnique Fédérale de Lausanne |
Novel treatment for alzheimer's disease
|
|
US20090275597A1
(en)
*
|
2008-05-02 |
2009-11-05 |
Forest Laboratories Holdings Limited |
Methods of treating cns disorders
|
|
EP2138173A1
(en)
|
2008-06-26 |
2009-12-30 |
Merz Pharma GmbH & Co.KGaA |
Pharmaceutical compositions comprising aminoadamantane derivatives
|
|
JP5195256B2
(ja)
*
|
2008-10-10 |
2013-05-08 |
東ソー株式会社 |
アミノアダマンタン誘導体の製造方法
|
|
HRP20090186A2
(hr)
|
2009-03-31 |
2010-10-31 |
Institut Ruđer Bošković |
Adamantanski bisureidni derivati, metoda priprave i primjena u detekciji aniona
|
|
WO2010112221A1
(en)
|
2009-04-03 |
2010-10-07 |
Synthon B.V. |
Pharmaceutical compositions comprising memantine
|
|
CN102070463A
(zh)
*
|
2009-06-11 |
2011-05-25 |
辽宁利锋科技开发有限公司 |
具有金刚烷结构药物美金刚胺及其衍生物和类似物抗肿瘤新适应症的应用
|
|
TW201116532A
(en)
|
2009-08-05 |
2011-05-16 |
Merz Pharma Gmbh & Co Kgaa |
Metabotropic glutamate receptor modulators
|
|
AU2010325960C1
(en)
|
2009-12-02 |
2015-08-06 |
Adamas Pharma, Llc |
Amantadine compositions and methods of use
|
|
WO2011127235A1
(en)
|
2010-04-07 |
2011-10-13 |
Eisai Inc. |
Combination therapy for the treatment of dementia
|
|
WO2012052451A1
(en)
|
2010-10-18 |
2012-04-26 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
JP5848768B2
(ja)
|
2010-10-29 |
2016-01-27 |
ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． |
インドール誘導体及びその製造方法
|
|
DK3034079T3
(en)
|
2010-11-15 |
2018-02-05 |
Agenebio Inc |
PYRIDAZINE DERIVATIVES, COMPOSITIONS AND PROCEDURES FOR TREATING COGNITIVE WEAKNESS
|
|
AR084515A1
(es)
|
2010-12-22 |
2013-05-22 |
Merz Pharma Gmbh & Co Kgaa |
Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras
|
|
WO2012085166A1
(en)
|
2010-12-22 |
2012-06-28 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
CN102241678B
(zh)
|
2011-04-26 |
2014-10-29 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
WO2012152854A1
(en)
|
2011-05-12 |
2012-11-15 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
WO2012172093A1
(en)
|
2011-06-17 |
2012-12-20 |
Merz Pharma Gmbh & Co. Kgaa |
Dihydroindolizine derivate as metabotropic glutamate receptor modulators
|
|
US20140206740A1
(en)
|
2011-07-30 |
2014-07-24 |
Neurovance, Inc. |
Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
|
|
CN103288650B
(zh)
*
|
2012-02-28 |
2015-09-30 |
广州白云山制药股份有限公司广州白云山制药总厂 |
一种盐酸1-氨基-3,5-二甲基金刚烷的制备方法
|
|
EP2650284A1
(en)
|
2012-04-10 |
2013-10-16 |
Merz Pharma GmbH & Co. KGaA |
Heterocyclic derivatives as metabotropic glutamate receptor modulators
|
|
RU2488388C1
(ru)
|
2012-05-24 |
2013-07-27 |
Ооо "Валента Интеллект" |
Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
|
|
US10154971B2
(en)
|
2013-06-17 |
2018-12-18 |
Adamas Pharma, Llc |
Methods of administering amantadine
|
|
US9566264B2
(en)
|
2013-07-01 |
2017-02-14 |
Euthymics Bioscience, Inc. |
Combinations and methods
|
|
CN112409363B
(zh)
|
2013-12-20 |
2023-11-14 |
艾吉因生物股份有限公司 |
用于治疗认知损害的苯并二氮杂䓬衍生物、组合物和方法
|
|
EP3102186B1
(en)
|
2014-02-04 |
2021-01-27 |
Forest Laboratories Holdings Limited |
Donepezil compositions and method of treating alzheimer's disease
|
|
WO2016205739A1
(en)
|
2015-06-19 |
2016-12-22 |
Belew Mekonnen |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
JP6354701B2
(ja)
*
|
2015-08-19 |
2018-07-11 |
大日本印刷株式会社 |
高純度メマンチン塩酸塩の製造法
|
|
SG11201805570WA
(en)
|
2015-12-30 |
2018-07-30 |
Corium Int Inc |
Systems and methods for long term transdermal administration
|
|
WO2017223402A1
(en)
|
2016-06-23 |
2017-12-28 |
Corium International, Inc. |
Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
|
|
AU2017301928B2
(en)
|
2016-07-27 |
2023-04-06 |
Corium, LLC. |
Donepezil transdermal delivery system
|
|
US10945968B2
(en)
|
2016-07-27 |
2021-03-16 |
Corium, Inc. |
Memantine transdermal delivery systems
|
|
CA3031944A1
(en)
|
2016-07-27 |
2018-02-01 |
Corium International, Inc. |
Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
|
|
US20180170941A1
(en)
|
2016-12-19 |
2018-06-21 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US11505555B2
(en)
|
2016-12-19 |
2022-11-22 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US10369187B2
(en)
|
2017-02-09 |
2019-08-06 |
Vanderbilt University |
Peptide regulators of JNK family kinases
|
|
JP2019094304A
(ja)
*
|
2017-11-27 |
2019-06-20 |
学校法人順天堂 |
オートファジー誘導剤
|
|
US11173132B2
(en)
|
2017-12-20 |
2021-11-16 |
Corium, Inc. |
Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
|
|
BR112020026062B1
(pt)
|
2018-06-19 |
2023-04-04 |
Agenebio, Inc |
Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson
|
|
EP3721857A1
(en)
*
|
2019-04-11 |
2020-10-14 |
Dentsply DeTrey GmbH |
Dental composition
|
|
WO2021232232A1
(zh)
*
|
2020-05-19 |
2021-11-25 |
山东泓瑞医药科技股份公司 |
一种金刚烷胺的制备方法
|
|
US20240132513A1
(en)
|
2022-08-19 |
2024-04-25 |
Agenebio, Inc. |
Benzazepine derivatives, compositions, and methods for treating cognitive impairment
|