CH312534A - Process for making a pyridazone. - Google Patents

Process for making a pyridazone.

Info

Publication number
CH312534A
CH312534A CH312534DA CH312534A CH 312534 A CH312534 A CH 312534A CH 312534D A CH312534D A CH 312534DA CH 312534 A CH312534 A CH 312534A
Authority
CH
Switzerland
Prior art keywords
phenyl
pyridazon
pyridazone
methylamine
making
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Ciba
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of CH312534A publication Critical patent/CH312534A/en

Links

Description

  

  <B>verfahren zur Herstellung eines</B>     Pyridazons.       Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung von     6-Methyl-          amino-2-nhenvl-nvridazon-(3)    der Formel  
EMI0001.0004     
    Die neue Verbindung wird erhalten, wenn  man     2-Phenyl-pyridazon-(3),    das in     6-Stel-          lung    einen austauschfähigen     Substituenten          aufweist,    mit     Methylamin    umsetzt.

   Ein aus  tauschfähiger     Substituent    ist zum Beispiel ein  Halogen-, insbesondere ein Chloratom, oder  auch eine substituierte     Oxy-,    wie     Phenosy-,     oder     Mercapto-,    wie     Methylmereaptogruppe.     



  Die Reaktion kann in An- oder Abwesen  heit von Verdünnungsmitteln     und/oder    Kon  densationsmitteln     und/oder    Katalysatoren im  offenen oder geschlossenen Gefäss unter  Druck durchgeführt werden.  



  Das     Verfahrensprodukt.,    das     6-Methyl-          amino-2-phenyl-pyridazon-(3)    vom F. = 145  bis 147 , ist neu. Es zeigt eine     antipyretische     und     analgetische        Wirkung    und soll als Heil  mittel Verwendung finden.  



  Die Erfindung wird im nachfolgenden Bei  spiel näher beschrieben. Zwischen Gewichts  teil und     Volumteil    besteht die gleiche Bezie  hung wie zwischen Gramm und     Kubikzenti-          matPr       <I>Beispiel:</I>  20,6     Gewichtsteile        2-Phenyl-6-chlör-pyrid          azon-(3)    werden mit 60     Volumteilen        25 /oiger          äthy        lalkoholischer        Methylaminlösung    im ge  schlossenen Gefäss 6 Stunden auf 150-155   erhitzt.

   Hierauf verdampft man den     Äthyl-          alkohol    im Vakuum und kristallisiert den er  haltenen Rückstand mehrmals aus     Benzol    un  ter Verwendung von     Tierkohle    um. Man er  hält so das 6     -1VIethylamino    - 2 -     phenyl    -     pyrid-          azon-    (3) ; F. = 145-147 .



  <B> Method for producing </B> a pyridazone. The present patent is a process for the preparation of 6-methyl-amino-2-nhenvl-nvridazon- (3) of the formula
EMI0001.0004
    The new compound is obtained when 2-phenyl-pyridazon- (3), which has an exchangeable substituent in the 6-position, is reacted with methylamine.

   An exchangeable substituent is, for example, a halogen, in particular a chlorine atom, or a substituted oxy, such as phenosy, or mercapto, such as methylmereapto group.



  The reaction can be carried out in the presence or absence of diluents and / or condensation agents and / or catalysts in an open or closed vessel under pressure.



  The product of the process, the 6-methylamino-2-phenyl-pyridazon- (3) with a melting point of 145 to 147, is new. It has an antipyretic and analgesic effect and is said to be used as a medicinal product.



  The invention is described in more detail in the following example. The relationship between part by weight and part by volume is the same as that between the gram and the cubic centimeter. oiger ethyl alcoholic methylamine solution in a closed vessel heated to 150-155 for 6 hours.

   The ethyl alcohol is then evaporated in vacuo and the residue obtained is recrystallized several times from benzene using animal charcoal. So he keeps the 6 -1VIethylamino - 2 - phenyl - pyrid- azon- (3); F. = 145-147.

Claims (1)

PATENTANTSPRUCH Verfahren zur Herstellung eines Pyrid- azons, dadurch gekennzeichnet, dass man 2- Phenyl-pyridazon-(3), das in 6-Stellung einen austauschfähigen Substituenten aufweist, mit Methylamin iunsetzt. Das Verfahrensprodukt, das 6-hIethyl- amino-2-phenyl-pyridazon-(3) vom F. = 145 bis 147 , ist neu. Es soll als Heilmittel Ver wendung finden. UNTERANSPRÜCHE: 1. PATENT CLAIM Process for the production of a pyridazone, characterized in that 2-phenyl-pyridazon- (3), which has an exchangeable substituent in the 6-position, is exposed to methylamine. The product of the process, 6-ethylamino-2-phenyl-pyridazon- (3) with a melting point of 145 to 147, is new. It is said to be used as a remedy. SUBCLAIMS: 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man 2-Phenyl-6- halogen-pyridazon- (3) mit Methylamin um setzt. 2. Verfahren nach Patentanspruch und Unteranspruch 1, dadurch gekennzeichnet, dass man 2-Phenyl-6-chlor-pyridazon-(3) mit Methylamin umsetzt. Process according to patent claim, characterized in that 2-phenyl-6-halo-pyridazon- (3) is reacted with methylamine. 2. The method according to claim and dependent claim 1, characterized in that 2-phenyl-6-chloro-pyridazon- (3) is reacted with methylamine.
CH312534D 1952-06-20 1952-06-20 Process for making a pyridazone. CH312534A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH310245T 1952-06-20
CH312534T 1952-06-20

Publications (1)

Publication Number Publication Date
CH312534A true CH312534A (en) 1955-12-31

Family

ID=25735642

Family Applications (1)

Application Number Title Priority Date Filing Date
CH312534D CH312534A (en) 1952-06-20 1952-06-20 Process for making a pyridazone.

Country Status (1)

Country Link
CH (1) CH312534A (en)

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