CH307559A - Process for the preparation of a diammonium compound. - Google Patents

Process for the preparation of a diammonium compound.

Info

Publication number
CH307559A
CH307559A CH307559DA CH307559A CH 307559 A CH307559 A CH 307559A CH 307559D A CH307559D A CH 307559DA CH 307559 A CH307559 A CH 307559A
Authority
CH
Switzerland
Prior art keywords
preparation
diammonium compound
ethoxy
bis
octane
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH307559A publication Critical patent/CH307559A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  <B>verfahren</B>     zur   <B>Herstellung einer</B>     Diammoniumverhindung.       Gegenstand des vorliegenden Patentes ist  ein Verfahren zur     Herstellung    einer     Diammo-          niumverbindung.    Das Verfahren ist dadurch  gekennzeichnet,     da.ss    man auf 1     Mol        1,8-Bis-          (ss-dimethylamino-äthoxy)-oktan    2     Mol        Ben-          zylehlorid    einwirken lässt.  



  Die erhaltene neue Verbindung, das     1,8-          Bis-        [ss-        (benzyl-dimethyl-ammonium)    -     äthoxy    ]     -          oktan-dichlorid,        sehmilzt    bei 135 . Sie soll als  Arzneimittel und als Zwischenprodukt für  Arzneimittel Verwendung finden.  



  <I>Beispiel:</I>  2,88 Teile     1.,8-Bis-(ss-dimethylamino-äth-          oxy)-oktan    und 3 Teile     Benzylchlorid    werden  in 20 Teilen     Butanon    etwa 14 Stunden unter       Rüekfluss    gekocht.

       Nach    Kühlen wird das ab-    geschiedene rohe     quartäre    Salz abgetrennt und  aus     Butanon    unter Zugabe von wenig     Isopro-          panol    oder Methanol     umkristallisiert.    Hierauf  trocknet man bei 50-60  im     Hochvakuum.     Das     1,8-Bis-[ss-(benzyl-dimethyl-ammonium)-          äthoxy]-oktan-diehlorid        sehmilzt    bei 135 .



  <B> Process </B> for <B> producing </B> a diammonium compound. The present patent is a process for the production of a diammonium compound. The process is characterized in that 2 moles of benzyl chloride are allowed to act on 1 mole of 1,8-bis (ss-dimethylamino-ethoxy) octane.



  The new compound obtained, 1,8-bis- [ss- (benzyl-dimethyl-ammonium) -ethoxy] -octane dichloride, sehmelt at 135. It should be used as a medicinal product and as an intermediate product for medicinal products.



  <I> Example: </I> 2.88 parts of 1., 8-bis (ss-dimethylamino-ethoxy) octane and 3 parts of benzyl chloride are refluxed in 20 parts of butanone for about 14 hours.

       After cooling, the precipitated crude quaternary salt is separated off and recrystallized from butanone with the addition of a little isopropanol or methanol. It is then dried at 50-60 in a high vacuum. The 1,8-bis- [ss- (benzyl-dimethyl-ammonium) -ethoxy] -octane-dichloride melts at 135.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer Diammo- niumv erbindung, dadurch gekennzeichnet, dass man auf 1 Mol 1,8-Bis-(ss-dimethylamino-äth- oxy)-oktan 2 Mol Benzylchlorid einwirken lässt. Die erhaltene neue Verbindung, das 1,8- Bis- [ss- (benzyl-dimethyl-ammonium) - äthoxy] - oktan-dichlorid, schmilzt bei 135 . PATENT CLAIM: Process for the production of a diammonium compound, characterized in that 2 moles of benzyl chloride are allowed to act on 1 mole of 1,8-bis- (ss-dimethylamino-ethoxy) octane. The new compound obtained, 1,8-bis- [ss- (benzyl-dimethyl-ammonium) -ethoxy] -octane dichloride, melts at 135.
CH307559D 1952-04-21 1952-04-21 Process for the preparation of a diammonium compound. CH307559A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH305890T 1952-04-21
CH307559T 1952-04-21

Publications (1)

Publication Number Publication Date
CH307559A true CH307559A (en) 1955-05-31

Family

ID=25735024

Family Applications (1)

Application Number Title Priority Date Filing Date
CH307559D CH307559A (en) 1952-04-21 1952-04-21 Process for the preparation of a diammonium compound.

Country Status (1)

Country Link
CH (1) CH307559A (en)

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