CH307556A - Process for the preparation of a diammonium compound. - Google Patents

Process for the preparation of a diammonium compound.

Info

Publication number
CH307556A
CH307556A CH307556DA CH307556A CH 307556 A CH307556 A CH 307556A CH 307556D A CH307556D A CH 307556DA CH 307556 A CH307556 A CH 307556A
Authority
CH
Switzerland
Prior art keywords
preparation
diammonium compound
ethoxy
bis
diammonium
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH307556A publication Critical patent/CH307556A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Description

  

  Verfahren zur Herstellung einer     Diammoniumverbindung.       Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung einer     Diammo-          niumverbindung.    Das Verfahren ist dadurch  gekennzeichnet, dass man auf 1     1Vfol        1,10-Bis-          (ss-piperidino-äthoxy)-dekan    2     Mol        Benzylbro-          mid    einwirken lässt.  



  Die erhaltene neue Verbindung, das     1,10-          Bis    -     [ss-        (benzyl    -     piperdinium)    -     äthoxy    ] -     deli#an-          dibromicl,    schmilzt bei 110-112 . Sie soll als  Arzneimittel und als Zwischenprodukt für  Arzneimittel Verwendung finden.    <I>Beispiel:</I>  3,96 Teile     1,10-Bis-(ss-piperidino-äthoxy)-          dekan    und 4,1 Teile     Benzylbromid    werden in  20 Teilen     Butanon    etwa 14 Stunden unter         Riickfluss    gekocht.

   Nach Kühlen wird das ab  geschiedene rohe     quartäre        Salz    abgetrennt  und aus     Butanon    unter Zugabe von wenig       Isopropanol    oder Methanol umkristallisiert.  Hierauf trocknet man bei 50-60  im Hoch  vakuum. Das     1,10-Bis-        [ss-        (benzyl-piperidi-          nium)        -äthoxy    ]     -dekan-dibromid    schmilzt bei  110-112 .



  Process for the preparation of a diammonium compound. The present patent is a process for the production of a diammonium compound. The method is characterized in that 1 1Vfol 1,10-bis (ss-piperidino-ethoxy) decane is allowed to act with 2 mol of benzyl bromide.



  The new compound obtained, the 1,10-bis - [ss- (benzyl - piperdinium) - ethoxy] - deli # an- dibromicl, melts at 110-112. It should be used as a medicinal product and as an intermediate product for medicinal products. <I> Example: </I> 3.96 parts of 1,10-bis (ss-piperidino-ethoxy) -decane and 4.1 parts of benzyl bromide are refluxed in 20 parts of butanone for about 14 hours.

   After cooling, the separated crude quaternary salt is separated off and recrystallized from butanone with the addition of a little isopropanol or methanol. Then dry at 50-60 in a high vacuum. The 1,10-bis [ss- (benzyl-piperidinium) -ethoxy] -dekan-dibromid melts at 110-112.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer Diammo- niumverbindung, dadurch gekennzeichnet, dass man auf 1 Mol 1,10-Bis- (ss-piperidino-äthoxy)- dekan 2 Mol Benzylbromid einwirken lässt. Die erhaltene neue Verbindung, das 1,10- Bis - [ss- (benzyl - piperidinium) -äthoxy] -dekan- dibromid, schmilzt bei 110-112 . Claim: Process for the production of a diammonium compound, characterized in that 1 mole of 1,10-bis- (ss-piperidino-ethoxy) decane is allowed to act with 2 moles of benzyl bromide. The new compound obtained, the 1,10-bis- [ss- (benzyl-piperidinium) -ethoxy] -dekan- dibromide, melts at 110-112.
CH307556D 1952-04-21 1952-04-21 Process for the preparation of a diammonium compound. CH307556A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH307556T 1952-04-21
CH305890T 1952-04-21

Publications (1)

Publication Number Publication Date
CH307556A true CH307556A (en) 1955-05-31

Family

ID=25735021

Family Applications (1)

Application Number Title Priority Date Filing Date
CH307556D CH307556A (en) 1952-04-21 1952-04-21 Process for the preparation of a diammonium compound.

Country Status (1)

Country Link
CH (1) CH307556A (en)

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