CH306917A - Process for the preparation of a diammonium compound. - Google Patents

Process for the preparation of a diammonium compound.

Info

Publication number
CH306917A
CH306917A CH306917DA CH306917A CH 306917 A CH306917 A CH 306917A CH 306917D A CH306917D A CH 306917DA CH 306917 A CH306917 A CH 306917A
Authority
CH
Switzerland
Prior art keywords
preparation
diammonium compound
bis
diammonium
ethoxy
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH306917A publication Critical patent/CH306917A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B45/00—Complex metal compounds of azo dyes
    • C09B45/02—Preparation from dyes containing in o-position a hydroxy group and in o'-position hydroxy, alkoxy, carboxyl, amino or keto groups
    • C09B45/24—Disazo or polyazo compounds
    • C09B45/28—Disazo or polyazo compounds containing copper

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren     zur    Herstellung einer     Diammoniumverhindung.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung einer     Diammo-          niumverbindung.    Das Verfahren ist dadurch  gekennzeichnet, dass man auf 1     Mol        1,10-Bis-          (ss        -morpholino-äthoxy)        -dekan    2     Mol    Brom  einwirken lässt.  



  Die erhaltene neue     Verbindung,    das     1,1.0-          Bis-        [(1-        (carbohexyloxymethyl    -     morpholinium)        -          ät.hoxy]-dekan-dibromid,    schmilzt bei 199 . Sie  soll als Arzneimittel     und    als Zwischenprodukt  für Arzneimittel Verwendung finden.

           Beispiel:     4,0 Teile     1,10-Bis-(ss-morpholino-ätlioxy)-          dekan,    20     Volumteile    Aceton und 4,9 Teile       Bromessigsäure-n-hexylester    werden etwa 14  Stunden unter     Rückfluss    gekocht.

   Das     quar-          täre    Salz wird nach Erkalten, falls ölig ab-    geschieden, zuerst durch Kühlen und     Reiben     zur Kristallisation gebracht, abgesaugt,     ge-          wünsehtenfalls    aus heissem     Butanon,    unter  Zusatz von     Hexanol        umkristallisiert    und im  Vakuum bei 50-60  getrocknet. Es schmilzt  bei 199 .



  Process for the preparation of a diammonium compound. The present patent relates to a process for the preparation of a diammonium compound. The process is characterized in that 1 mole of 1,10-bis (ss-morpholino-ethoxy) decane is allowed to act with 2 moles of bromine.



  The new compound obtained, the 1,1.0-bis- [(1- (carbohexyloxymethyl - morpholinium) - ethoxy] decane dibromide, melts at 199. It is said to be used as a drug and as an intermediate for drugs.

           Example: 4.0 parts of 1,10-bis (ss-morpholino-ätlioxy) - decane, 20 parts by volume of acetone and 4.9 parts of n-hexyl bromoacetate are refluxed for about 14 hours.

   After cooling, the quaternary salt, if it has deposited oily, is first made to crystallize by cooling and rubbing, filtered off with suction, if desired recrystallized from hot butanone with the addition of hexanol and dried in vacuo at 50-60. It melts at 199.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer Diammo- niumverbindimg, dadurch gekennzeichnet, dass man auf 111M1 1,10-Bis- (ss-morpholino-äth- oxy)-dekan 2 Mol Bromessigsäure-n-hexylester einwirken lässt. Die erhaltene neue Verbindung, das 1,10- Bis- [ss-(carbohexy loxymethyl-morpholinittm) - äthoxy]-dekan-dibromid, schmilzt bei 199 . PATENT CLAIM: A process for the production of a diammonium compound, characterized in that 2 mol of n-hexyl bromoacetate are allowed to act on 111M1 1,10-bis- (ss-morpholino-ethoxy) -decan. The new compound obtained, the 1,10-bis- [ss- (carbohexy loxymethyl-morpholinittm) -ethoxy] -dekan-dibromid, melts at 199.
CH306917D 1952-04-22 1952-04-22 Process for the preparation of a diammonium compound. CH306917A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH305263T 1952-04-22
CH306917T 1952-04-22

Publications (1)

Publication Number Publication Date
CH306917A true CH306917A (en) 1955-04-30

Family

ID=25734930

Family Applications (1)

Application Number Title Priority Date Filing Date
CH306917D CH306917A (en) 1952-04-22 1952-04-22 Process for the preparation of a diammonium compound.

Country Status (1)

Country Link
CH (1) CH306917A (en)

Similar Documents

Publication Publication Date Title
CH306917A (en) Process for the preparation of a diammonium compound.
CH307551A (en) Process for the preparation of a diammonium compound.
CH306913A (en) Process for the preparation of a diammonium compound.
CH306914A (en) Process for the preparation of a diammonium compound.
CH306911A (en) Process for the preparation of a diammonium compound.
CH306916A (en) Process for the preparation of a diammonium compound.
CH306912A (en) Process for the preparation of a diammonium compound.
CH306910A (en) Process for the preparation of a diammonium compound.
CH306908A (en) Process for the preparation of a diammonium compound.
CH306923A (en) Process for the preparation of a diammonium compound.
CH306921A (en) Process for the preparation of a diammonium compound.
CH306922A (en) Process for the preparation of a diammonium compound.
CH306919A (en) Process for the preparation of a diammonium compound.
CH306906A (en) Process for the preparation of a diammonium compound.
CH306924A (en) Process for the preparation of a diammonium compound.
CH306915A (en) Process for the preparation of a diammonium compound.
CH307564A (en) Process for the preparation of a diammonium compound.
CH306918A (en) Process for the preparation of a diammonium compound.
CH306909A (en) Process for the preparation of a diammonium compound.
CH306920A (en) Process for the preparation of a diammonium compound.
CH307558A (en) Process for the preparation of a diammonium compound.
CH306907A (en) Process for the preparation of a diammonium compound.
CH307561A (en) Process for the preparation of a diammonium compound.
CH307556A (en) Process for the preparation of a diammonium compound.
CH307562A (en) Process for the preparation of a diammonium compound.