CH306914A - Process for the preparation of a diammonium compound. - Google Patents

Process for the preparation of a diammonium compound.

Info

Publication number
CH306914A
CH306914A CH306914DA CH306914A CH 306914 A CH306914 A CH 306914A CH 306914D A CH306914D A CH 306914DA CH 306914 A CH306914 A CH 306914A
Authority
CH
Switzerland
Prior art keywords
preparation
diammonium compound
bis
decane
diammonium
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH306914A publication Critical patent/CH306914A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B45/00—Complex metal compounds of azo dyes
    • C09B45/02—Preparation from dyes containing in o-position a hydroxy group and in o'-position hydroxy, alkoxy, carboxyl, amino or keto groups
    • C09B45/24—Disazo or polyazo compounds
    • C09B45/28—Disazo or polyazo compounds containing copper

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Description

  

  <B>Verfahren</B>     zur        Herstellung   <B>einer</B>     Diammoniumverhindung.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung einer     Diammo-          niumverbindung.    Das Verfahren ist dadurch  gekennzeichnet, dass man auf 1     Mol        1,10-Bis-          (ss-pyrrolidin.o-äthoxy)        -dekan    2     Mol        Brom-          c,ssigsäure-äthylester    einwirken lässt.  



  Die erhaltene neue Verbindung, das     1,10-          Bis    -     [(i    -     (carbäthoxymethyl    -     pyrrolidinium)-          ätlioxy        ]-dekan-dibromid,        schmilzt    bei 139 bis  142 . Sie soll als Arzneimittel und als Zwi  schenprodukt für Arzneimittel Verwendung  finden.  



  <I>Beispiel:</I>  3,68 Teile     1,10-Bis-(ss-pyrrolidino-äthoxy)-          dekan,    20     Volumteile    Aceton und 4 Teile       Bromessigsäure-äthylester    werden etwa 14  Stunden unter     Rüekfluss    gekocht. Das     quar-          täre    Salz wird nach Erkalten, falls ölig ab-    geschieden, zuerst durch     Kühlen    und Reiben  zur Kristallisation gebracht, abgesaugt,     ge-          wünschtenfalls    aus heissem     Butanon,    unter  Zusatz von Äthanol umkristallisiert     und    im  Vakuum bei 50-60  getrocknet.

   Es     schmilzt     bei     139---14211.  



  <B> Process </B> for the production of <B> a </B> diammonium compound. The present patent relates to a process for the preparation of a diammonium compound. The process is characterized in that 1 mole of 1,10-bis- (ss-pyrrolidin.o-ethoxy) decane is allowed to act with 2 moles of ethyl bromine, ethyl ester.



  The new compound obtained, the 1,10-bis - [(i - (carbäthoxymethyl - pyrrolidinium) - ätlioxy] decane dibromide, melts at 139 to 142. It is said to be used as a medicament and as an intermediate product for medicaments.



  <I> Example: </I> 3.68 parts of 1,10-bis- (ss-pyrrolidino-ethoxy) decane, 20 parts by volume of acetone and 4 parts of ethyl bromoacetate are refluxed for about 14 hours. After cooling, the quaternary salt, if it has deposited oily, is first made to crystallize by cooling and rubbing, suction filtered, if desired recrystallized from hot butanone with the addition of ethanol and dried in vacuo at 50-60.

   It melts at 139 --- 14211.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer Diammo- niumverbindung, dadurch gekennzeichnet, dass man auf 1 Mol 1,10 - Bis - (ss - pyrrolidino- äthoxy)-dekan 2 Mol Bromessigsäure-äthyl- ester einwirken lässt. PATENT CLAIM: Process for the production of a diammonium compound, characterized in that 2 mol of ethyl bromoacetate are allowed to act on 1 mol of 1,10-bis (ss-pyrrolidinoethoxy) decane. Die erhaltene neue Verbindung, das 1,10 Bis - [ss - (carbäthoxymethyl - pyrrolidinium)- äthoxy] -dekan-dibromid, schmilzt bei 139 bis 142 . The new compound obtained, the 1.10 bis - [ss - (carbäthoxymethyl - pyrrolidinium) - ethoxy] decane dibromide, melts at 139 to 142.
CH306914D 1952-04-22 1952-04-22 Process for the preparation of a diammonium compound. CH306914A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH305263T 1952-04-22
CH306914T 1952-04-22

Publications (1)

Publication Number Publication Date
CH306914A true CH306914A (en) 1955-04-30

Family

ID=25734927

Family Applications (1)

Application Number Title Priority Date Filing Date
CH306914D CH306914A (en) 1952-04-22 1952-04-22 Process for the preparation of a diammonium compound.

Country Status (1)

Country Link
CH (1) CH306914A (en)

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