CH233769A - Process for the preparation of a salt of a p-amino-benzene-sulfamido-thiazole. - Google Patents

Process for the preparation of a salt of a p-amino-benzene-sulfamido-thiazole.

Info

Publication number
CH233769A
CH233769A CH233769DA CH233769A CH 233769 A CH233769 A CH 233769A CH 233769D A CH233769D A CH 233769DA CH 233769 A CH233769 A CH 233769A
Authority
CH
Switzerland
Prior art keywords
thiazole
amino
salt
preparation
sulfamido
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH233769A publication Critical patent/CH233769A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines Salzes eines     p-Amino-benzol-sulfamido-tliiazols.       Es wurde gefunden,     dass    man ein Salz  eines     p-Amino-benzolsulfamido-thiazols    her  stellen     kann,        wenn    man 2-     [p-Amino-benzol-          suJfamido]    - 4 -     methyl    -     thiazol    mit einem       Wasserstoff,dureh    Natrium ersetzenden Mit  tel umsetzt.  



  Die neue     Verbindung        ist    ein weisses Pulver       und    in     Wasser    mit schwach alkalischer       Reaktion    leicht löslich. Sie soll als Heilmittel  Verwendung, finden.  



  <I>Beispiel:</I>  269     ;g    2 -<B>[</B>p -     Amvno    -     benzolsulf        amido]    -4     -          methyl-thiazo,l    werden bei 80  unter     Rühren     in eine Lösung von 40     .g    Natrium in 1 Liter  Alkohol     (abs.)    eingetragen. Nach     1i'        .tündi-          gem#    Rühren bei     obiger    Temperatur wird auf       1-2     abgekühlt.

   Das     Natriumsalz        des        2-[p-          Amino    -     benzalsulfamida]        -4-methyl    -     thiazols     scheidet     sich        hierbei    in feiner     Form    als  weisses Pulver ab. Nach     Absaugen    und  Waschen mit wenig Alkohol und Äther und  Trocknen im Vakuum erhält man das Salz     in     guter Ausbeute.

   Es ist leicht löslich in  Wasser und Alkohol,     unläslich    in Äther und       #        and        -ern        mit        Wasser        nicht        mischbaren        Lö-          sungsmitteln.       Die     .gleiche        Verbindung    erhält man, wenn  man statt einer Lösung von Natrium in Al  kohol     Natronlauge    verwendet.



  Process for the preparation of a salt of a p-amino-benzene-sulfamido-tliiazole. It has been found that a salt of a p-aminobenzenesulfamido-thiazole can be produced if 2- [p-aminobenzene-suJfamido] -4-methyl-thiazole is reacted with a hydrogen-replacing agent.



  The new compound is a white powder and easily soluble in water with a weakly alkaline reaction. It should be used as a remedy.



  <I> Example: </I> 269; g 2 - <B> [</B> p - Amvno - benzenesulf amido] -4 - methyl-thiazo, l are poured into a solution of 40 .g sodium at 80 while stirring registered in 1 liter of alcohol (abs.). After stirring for 1.5 hours at the above temperature, the mixture is cooled to 1-2.

   The sodium salt of 2- [p-amino-benzalsulfamida] -4-methyl-thiazole is deposited in fine form as a white powder. After filtering off with suction and washing with a little alcohol and ether and drying in vacuo, the salt is obtained in good yield.

   It is easily soluble in water and alcohol, insoluble in ether and other solvents which are immiscible with water. The same compound is obtained if sodium hydroxide solution is used instead of a solution of sodium in alcohol.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines Salzes eines p-Amino-benzolsulfamidio-thiazols., da durch gekennzeichnet, dass man 2- 'p-Amino,- benzodsulfamido@]-4-methyl-thiazol mit einem Wasserstoff durch Natrium ersetzenden Mit tel umsetzt. Die neue Verbindung ist ein weisses Pulver und in #Vasser mit sehwach alkalischer Reaktion leicht löslich. PATENT CLAIM: Process for the preparation of a salt of a p-amino-benzenesulfamidio-thiazole., Characterized in that 2- 'p-amino, - benzodsulfamido @] - 4-methyl-thiazole is reacted with a hydrogen-replacing agent. The new compound is a white powder and easily soluble in water with a weakly alkaline reaction. Sie soll als Heil mittel Verwendung finden. UNTERANSPR-CCHE 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man mit einer Lösung von Natrium in Alkohol umsetzt. 2. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man mit Natron lauge umsletzt. It should be used as a remedy. SUB-CLAIM 1. The method according to claim, characterized in that it is reacted with a solution of sodium in alcohol. 2. The method according to claim, characterized in that it is reacted with caustic soda.
CH233769D 1939-10-16 1939-10-16 Process for the preparation of a salt of a p-amino-benzene-sulfamido-thiazole. CH233769A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH233769T 1939-10-16
CH227703T 1939-10-16

Publications (1)

Publication Number Publication Date
CH233769A true CH233769A (en) 1944-08-15

Family

ID=25727134

Family Applications (1)

Application Number Title Priority Date Filing Date
CH233769D CH233769A (en) 1939-10-16 1939-10-16 Process for the preparation of a salt of a p-amino-benzene-sulfamido-thiazole.

Country Status (1)

Country Link
CH (1) CH233769A (en)

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