CH151177A - Process for the preparation of p-glycolylaminobenzenic acid. - Google Patents
Process for the preparation of p-glycolylaminobenzenic acid.Info
- Publication number
- CH151177A CH151177A CH151177DA CH151177A CH 151177 A CH151177 A CH 151177A CH 151177D A CH151177D A CH 151177DA CH 151177 A CH151177 A CH 151177A
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- preparation
- glycolylaminobenzenic
- glycolylaminobenzolaric
- acetic acid
- Prior art date
Links
Description
Verfahren zur Darstellung von p-Glykolylaminobenzolarsinsäure. In dem Hauptpatent ist die Darstellung der p - Glykolylaminobenzolarsinsäure durch Erwärmen von Monohalogenacetylarsanilsäure mit Alkalien beschrieben.
Es wurde nun gefunden, dass die p-Gly- kolylaminobenzolarsinsäure auch erhalten wer den kann, indem man die nach dem im Schweizer-Patent Nr. 149253 angeführten Verfahren erhältlichen Ester der Ogyacyl- aminoarylarsenverbindungen vom Typ As O3 H2 . Ar . NH . CO . (CH2) n . 0 . CO . H einer partiellen Verseifung unterwirft.
Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Darstellung von p-Gly- kolylaminobenzolarsinsäure, welches dadurch gekennzeichnet ist, dass man den p-Glykolyl- aminobenzolarsinsäure - essigsäureester durch Erwärmen mit ',verdünnten Alkalien partiell verseift.
Die entstandene Säure ist schwer löslich in Alkohol und Eisessig, unlöslich in Aceton und Benzol. Sie zeichnet sich durch geringe Giftigkeit und hohen Heilwert aus. <I>Beispiel:</I> 31,7 gr des Essigsäureesters der p - Gly- kolylaminobenzolarsinsäure (Darstellung siehe Schweizer - Patent Nr. 149253) werden in 109 eins Wasser und 8,3 cm3 Natronlauge (40<B>(1</B> B6) gelöst und zur Lösung weitere 8,3 cm3 Natronlauge gegeben. Die Lösung wird nach einstündigem Kochen filtriert und gekühlt.
Aus dem Filtrat kristallisiert das Natronsalz der p - Glykolylaminobenzolarsin- säure aus. Die freie Säure kristallisiert aus der mit Salzsäure angesäuerten wässerigen Lösung des Natronsalzes. Ausbeute 18 gr.
Process for the preparation of p-glycolylaminobenzenic acid. The main patent describes the preparation of p-glycolylaminobenzolaric acid by heating monohaloacetylarsanilic acid with alkalis.
It has now been found that p-glycolylaminobenzolaric acid can also be obtained by converting the esters of ogyacylaminoaryl arsenic compounds of the As O3 H2 type, which can be obtained according to the process listed in Swiss Patent No. 149253. Ar. NH. CO. (CH2) n. 0. CO. H subjected to partial saponification.
The present invention relates to a process for the preparation of p-glycolylaminobenzolaric acid, which is characterized in that the p-glycolylaminobenzolaric acid ester is partially saponified by heating with dilute alkalis.
The resulting acid is sparingly soluble in alcohol and glacial acetic acid, and insoluble in acetone and benzene. It is characterized by low toxicity and high healing value. <I> Example: </I> 31.7 g of the acetic acid ester of p-glycolylaminobenzolaric acid (see Swiss patent no. 149253 for a description) are dissolved in 109 liters of water and 8.3 cm3 of sodium hydroxide solution (40 <B> (1 < / B> B6) and a further 8.3 cm3 of sodium hydroxide solution is added to the solution.
The sodium salt of p-glycolylaminobenzolaric acid crystallizes out of the filtrate. The free acid crystallizes from the aqueous solution of the sodium salt acidified with hydrochloric acid. Yield 18 gr.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE151177X | 1929-09-13 | ||
| CH144988T | 1930-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH151177A true CH151177A (en) | 1931-11-30 |
Family
ID=25714574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH151177D CH151177A (en) | 1929-09-13 | 1930-08-13 | Process for the preparation of p-glycolylaminobenzenic acid. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH151177A (en) |
-
1930
- 1930-08-13 CH CH151177D patent/CH151177A/en unknown
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