CH159587A - Process for preparing an asymmetric arsenobenzene compound. - Google Patents

Process for preparing an asymmetric arsenobenzene compound.

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Publication number
CH159587A
CH159587A CH159587DA CH159587A CH 159587 A CH159587 A CH 159587A CH 159587D A CH159587D A CH 159587DA CH 159587 A CH159587 A CH 159587A
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CH
Switzerland
Prior art keywords
compound
arsenobenzene
asymmetric
acid
preparing
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH159587A publication Critical patent/CH159587A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung einer     asymmetrischen        Arsenobenzolverbindung.       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Herstellung einer asym  metrischen     Arsenobenzolverbindung,    welches  dadurch gekennzeichnet ist, dass man     4-Ace-          tylamino-2-phenoxyessigsäure-l-arsinsäure    zu  sammen mit     3-Acetylamino    - 4 -     oxybenzol        -1-          arsinsäure    reduziert.  



  Das neue Verfahrensprodukt ist ein in  Wasser klar und mit neutraler Reaktion  lösliches Pulver. Die Lösung hat den     Vorzug,     haltbar und sowohl bei intravenöser, als auch  bei subkutaner beziehungsweise intramusku  lärer Injektion gut wirksam und sehr gut  verträglich zu sein.    <I>Beispiel:</I>  16,6     gr        4-Acetylamino-2-phenoxyessig-          säure-l-arsinsäure    (erhalten durch Umsetzung  von     2-Oxy-4-acetylaminobenzol    -1-     arsinsäure     und     Monochloressigsäure)    werden in 56     cm3     2 n.Natronlauge und 56 cm' Wasser gelöst.

    13,7     gr    3-Acetylamirio-4-oxybenzol-l-arsin-    säure löst man in 31     cm3    2 n.Natronlauge  und 31 cm' Wasser. Die vereinigten Lösun  gen werden mit 500 cm' Wasser verdünnt  und bei     65     mit 195     gr        Hydrosulfit    reduziert.  Die abgeschiedene     Arsenoverbindung    wird  mit 75 cm' Methylalkohol     angeteigt    und  durch Zugabe von Wasser von     5011    gelöst.  Die filtrierte Lösung rührt man in 5 Volumen  teile Aceton ein und saugt das abgeschiedene  Präparat ab. Es ist klar und neutral in  Wasser löslich.



  Method for preparing an asymmetric arsenobenzene compound. The present invention relates to a process for the production of an asymmetric arsenobenzene compound, which is characterized in that 4-acetylamino-2-phenoxyacetic acid-1-arsic acid is reduced together with 3-acetylamino-4-oxybenzene-1-arsic acid.



  The new process product is a powder that is clear in water and soluble with a neutral reaction. The solution has the advantage of being durable and very effective and very well tolerated by intravenous as well as subcutaneous or intramuscular injection. <I> Example: </I> 16.6 g of 4-acetylamino-2-phenoxyacetic acid-1-arsic acid (obtained by reacting 2-oxy-4-acetylaminobenzene-1-arsic acid and monochloroacetic acid) are in 56 cm3 2 after sodium hydroxide solution and 56 cm 'of water dissolved.

    13.7 g of 3-acetylamirio-4-oxybenzene-1-arsic acid are dissolved in 31 cm3 of 2 sodium hydroxide solution and 31 cm of water. The combined solutions are diluted with 500 cm 'of water and reduced at 65 with 195 g of hydrosulfite. The separated arsenic compound is made into a paste with 75 cm 'of methyl alcohol and 5011 is dissolved by adding water. The filtered solution is stirred into 5 parts by volume of acetone and the separated preparation is filtered off with suction. It is clear and neutrally soluble in water.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung einer asym metrischen Arsenobenzolverbindung, dadurch gekennzeichnet, dass man 4-Acetylamino-2- phenoxyessigsäure-l-arsinsäure zusammen mit 3 - Acetylamino-4-oxybenzol -1-arsinsäui-e re duziert. Das neue Verfahrensprodukt ist ein in Wasser klar und mit neutraler Reaktion lösliches Pulver. Die Lösung hat den Vor- zug, haltbar und sowohl bei intravenöser, als auch bei subkutaner beziehungsweise intra muskulärer Injektion gut wirksam und sehr gut verträglich zu sein. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man mit Hydrosulfit reduziert. Claim: method for the preparation of an asymmetric arsenobenzene compound, characterized in that 4-acetylamino-2-phenoxyacetic acid-1-arsic acid is reduced together with 3-acetylamino-4-oxybenzene-1-arsinic acid. The new process product is a powder that is clear in water and soluble with a neutral reaction. The solution has the advantage of being durable and very effective and very well tolerated by intravenous as well as subcutaneous or intramuscular injection. SUBCLAIM: Process according to claim, characterized in that reduction is carried out with hydrosulfite.
CH159587D 1930-07-22 1931-07-15 Process for preparing an asymmetric arsenobenzene compound. CH159587A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE159587X 1930-07-22
CH156268T 1932-12-10

Publications (1)

Publication Number Publication Date
CH159587A true CH159587A (en) 1933-01-15

Family

ID=25716737

Family Applications (1)

Application Number Title Priority Date Filing Date
CH159587D CH159587A (en) 1930-07-22 1931-07-15 Process for preparing an asymmetric arsenobenzene compound.

Country Status (1)

Country Link
CH (1) CH159587A (en)

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