CH159585A - Process for preparing an asymmetric arsenobenzene compound. - Google Patents

Process for preparing an asymmetric arsenobenzene compound.

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Publication number
CH159585A
CH159585A CH159585DA CH159585A CH 159585 A CH159585 A CH 159585A CH 159585D A CH159585D A CH 159585DA CH 159585 A CH159585 A CH 159585A
Authority
CH
Switzerland
Prior art keywords
compound
arsenobenzene
asymmetric
acid
preparing
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH159585A publication Critical patent/CH159585A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung einer asymmetrischen     Arsenobenzolverbindung.       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Darstellung einer asym  metrischen     Arsenobenzolverbindung,    welches  dadurch gekennzeichnet ist, dass man     3-Acetyl-          amino-4-oxybenzolarsinsäure    zusammen mit.  3 -     Aoetylami        no    - 4     -phenoxyessigsäure-1-arsin-          säure    reduziert.  



  Das neue Verfahrensprodukt ist ein in  Wasser klar und mit neutraler Reaktion lös  liches Pulver. Die Lösung hat den Vorzug,  haltbar und sowohl bei intravenöser, als auch  bei subkutaner     bezw.    intramuskulärer Injek  tion gut wirksam und sehr gut verträglich  zu sein.  



  <I>Beispiel:</I>  13,7     gr-        3-Acetylamino-4-oxybenzolarsin-          säure,    gelöst in 31 ein' 2     n.Natronlauge    und  31 cm' Wasser, werden mit einer Lösung  von 16,6     gr        3-Acetylamino-4-phenoxyessig-          säure-1-arsinsäure    in 56     em3    2 n.Natronlauge  und 56     ems    Wasser gemischt und die Mi-         schung    nach Zugabe von 500 cm' Wasser  bei     65     mit 195     gr        Hydrosulfit    reduziert.

    Die abgeschiedene     Arsenoverbindung    wird  mit 150 cm' Methylalkohol     angeteigt    und  dazu 75 cm' Wasser von 50   gegeben. Durch  Einrühren der filtrierten Lösung in 5 Vo  lumenteile Aceton scheidet man das Präparat  in fester Form ab. Es löst sich klar und  neutral in Wasser.



  Process for preparing an asymmetric arsenobenzene compound. The present invention relates to a method for preparing an asymmetrical arsenobenzene compound, which is characterized in that 3-acetylamino-4-oxybenzolaric acid is used together with. 3 - Aoetylami no - 4 -phenoxyacetic acid-1-arsic acid reduced.



  The new process product is a powder that is clear in water and has a neutral reaction. The solution has the advantage of being durable and with both intravenous and subcutaneous bezw. intramuscular injection to be effective and very well tolerated.



  <I> Example: </I> 13.7 gr- 3-acetylamino-4-oxybenzolar acid, dissolved in 31 a '2N sodium hydroxide solution and 31 cm' water, are mixed with a solution of 16.6 gr 3- Acetylamino-4-phenoxyacetic acid-1-arsic acid was mixed in 56 cubic meters of 2N sodium hydroxide solution and 56 cubic meters of water and the mixture was reduced after adding 500 cm of water at 65 with 195 g of hydrosulfite.

    The separated arsenic compound is made into a paste with 150 cm 'of methyl alcohol and 75 cm' of water of 50% is added. The preparation is deposited in solid form by stirring the filtered solution into 5 parts by volume of acetone. It dissolves clearly and neutrally in water.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung einer asymme trischen Arsenobenzolverbindung, dadurch ge kennzeichnet, dass man 3-Acetylamino-4-oxy- benzolarsinsäure zusammen mit 3 - Acetyl- amino-4-phenoxyessigsäure-l-arsinsäure redu ziert. Das neue Verfahrensprodukt ist ein in Wasser klar und mit neutraler Reaktion lös liches Pulver. Die Lösung hat den Vorzug, haltbar und sowohl bei intravenöser, als auch bei subkutaner bezw. intramuskulärer Injek- tion gut wirksam und sehr gut verträglich zu sein. PATENT CLAIM: Process for the preparation of an asymmetric arsenobenzene compound, characterized in that 3-acetylamino-4-oxybenzolaric acid is reduced together with 3-acetylamino-4-phenoxyacetic acid-1-arsic acid. The new process product is a powder that is clear in water and has a neutral reaction. The solution has the advantage of being durable and with both intravenous and subcutaneous bezw. intramuscular injection to be effective and very well tolerated. ÜNTERANSPRÜCII Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man mit Hydrosulfit reduziert. ÜNTERANSPRÜCII Method according to claim, characterized in that one reduces with hydrosulfite.
CH159585D 1930-07-22 1931-07-15 Process for preparing an asymmetric arsenobenzene compound. CH159585A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE159585X 1930-07-22
CH156268T 1932-12-10

Publications (1)

Publication Number Publication Date
CH159585A true CH159585A (en) 1933-01-15

Family

ID=25716735

Family Applications (1)

Application Number Title Priority Date Filing Date
CH159585D CH159585A (en) 1930-07-22 1931-07-15 Process for preparing an asymmetric arsenobenzene compound.

Country Status (1)

Country Link
CH (1) CH159585A (en)

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