DE2856393C2
(de)
*
|
1978-12-27 |
1983-04-28 |
Merz + Co GmbH & Co, 6000 Frankfurt |
Arzneimittel zur Behandlung von Morbus Parkinson
|
US5334618A
(en)
*
|
1991-04-04 |
1994-08-02 |
The Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
US5506231A
(en)
*
|
1989-03-31 |
1996-04-09 |
The Children's Medical Center Corporation |
Treatment of aids dementia, myelopathy and blindness
|
WO1992017168A1
(en)
*
|
1991-04-04 |
1992-10-15 |
The Children's Medical Center Corporation |
Method of preventing nmda receptor-mediated neuronal damage
|
US5614560A
(en)
*
|
1991-04-04 |
1997-03-25 |
Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
US5455279A
(en)
*
|
1991-04-19 |
1995-10-03 |
The Children's Medical Center Corporation |
Regimen method of mediating neuronal damage using nitroglycerine
|
DE4225730C2
(de)
*
|
1992-08-04 |
2003-04-30 |
Merz Pharma Gmbh & Co Kgaa |
Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung
|
US6057373A
(en)
*
|
1997-05-22 |
2000-05-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists
|
US5866585A
(en)
*
|
1997-05-22 |
1999-02-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia using NMDA receptor antagonists
|
US6294583B1
(en)
|
1998-01-13 |
2001-09-25 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders
|
US5952389A
(en)
*
|
1998-01-13 |
1999-09-14 |
Synchroneuron |
Methods of treating tardive dyskinesia and other movement disorders
|
US6444702B1
(en)
|
2000-02-22 |
2002-09-03 |
Neuromolecular, Inc. |
Aminoadamantane derivatives as therapeutic agents
|
CA2457011C
(en)
*
|
2001-08-20 |
2012-04-24 |
Maiken Nedergaard |
Treatment of glial tumors with glutamate antagonists
|
EP1298581A1
(fr)
*
|
2001-09-27 |
2003-04-02 |
C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa |
Procédé et dispositif pour calculer les valeurs des neurones d'un réseau neuronal
|
CN100339070C
(zh)
|
2002-10-24 |
2007-09-26 |
莫茨药物股份两合公司 |
包含1-氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物
|
RU2246482C2
(ru)
*
|
2002-12-25 |
2005-02-20 |
ООО "Циклан" |
Способ получения гидрохлорида 1-амино-3,5-диметиладамантана
|
UA80055C2
(en)
|
2003-05-27 |
2007-08-10 |
Forest Laboratories |
Combination of nmda-receptor antagonist and selective inhibitor of serotonin reuptake for a depression and other pscihiatric disorders treatment
|
CN1240668C
(zh)
*
|
2003-09-10 |
2006-02-08 |
上海医药工业研究院 |
一种新的盐酸美金刚制备方法
|
WO2005079779A1
(en)
*
|
2003-10-22 |
2005-09-01 |
Merz Pharma Gmbh & Co. Kgaa |
THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC Aß PEPTIDES IN AMYLOIDOPATHIES
|
AR046314A1
(es)
|
2003-11-05 |
2005-11-30 |
Merz Pharma Gmbh & Co Kgaa |
Composiciones que comprenden ciclohexilaminas y aminoadamantanos
|
WO2005069742A2
(en)
*
|
2003-12-10 |
2005-08-04 |
Sun Pharmaceutical Industries Limited |
Crystal form ii of memantine hydrochloride
|
PT1703902E
(pt)
*
|
2004-01-05 |
2010-11-17 |
Merz Pharma Gmbh & Co Kgaa |
Memantina para o tratamento da doença de alzheimer ligeira e ligeira a moderada
|
CN100363329C
(zh)
*
|
2004-01-09 |
2008-01-23 |
南京大学 |
合成美金刚胺盐酸盐的方法
|
US7456224B2
(en)
*
|
2004-04-05 |
2008-11-25 |
Forest Laboratories Holdings, Ltd. |
Method for treating autism
|
JP2008503475A
(ja)
*
|
2004-06-17 |
2008-02-07 |
フォーレスト ラボラトリーズ, インコーポレイテッド |
メマンチンの放出が改変された製剤
|
ES2483126T3
(es)
|
2004-06-17 |
2014-08-05 |
Merz Pharma Gmbh & Co. Kgaa |
Formulaciones de formas de dosificación de neramexano
|
US20060002999A1
(en)
*
|
2004-06-17 |
2006-01-05 |
Forest Laboratories, Inc. |
Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
|
TW200616608A
(en)
*
|
2004-07-09 |
2006-06-01 |
Forest Laboratories |
Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
|
JP2008514620A
(ja)
*
|
2004-09-23 |
2008-05-08 |
メルツ・ファルマ・ゲゼルシヤフト・ミト・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンデイトゲゼルシヤフト・アウフ・アクティーン |
小児行動障害の治療用メマンチン
|
US20060205822A1
(en)
*
|
2004-12-22 |
2006-09-14 |
Forest Laboratories, Inc. |
1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
|
WO2006076562A1
(en)
*
|
2005-01-11 |
2006-07-20 |
Teva Pharmaceutical Fine Chemicals S.R.L. |
Process for the preparation of 1-amino-3,5-dimethyladamantane hydrochloride
|
ITMI20050833A1
(it)
|
2005-05-10 |
2006-11-11 |
A M S A S P A Anonima Materie Sintetiche Affini |
Nuovo procedimento per la sintesi di aminoadamantani
|
AU2006259619A1
(en)
*
|
2005-06-16 |
2006-12-28 |
Forest Laboratories, Inc. |
Modified and immediate release memantine bead formulation
|
PL2719384T3
(pl)
|
2005-07-27 |
2019-02-28 |
Otsuka America Pharmaceutical, Inc. |
Nowe 1-naftylo-3-azabicyklo[3.1.0]heksany: wytwarzanie i zastosowanie do leczenia zaburzeń neuropsychiatrycznych
|
US20070099947A1
(en)
*
|
2005-11-03 |
2007-05-03 |
Alkermes, Inc. |
Methods and compositions for the treatment of brain reward system disorders by combination therapy
|
PL1820792T3
(pl)
*
|
2006-02-21 |
2012-06-29 |
Hexal Ag |
Sposób otrzymywania adamantanoamin
|
CA2644819A1
(en)
*
|
2006-03-27 |
2007-11-08 |
Teva Pharmaceutical Fine Chemicals S.R.L. |
Process for preparing memantine hydrochloride substantially free of impurities
|
TW200823215A
(en)
|
2006-08-04 |
2008-06-01 |
Merz Pharma Gmbh & Amp Co Kgaa |
Pyrazolopyrimidines, a process for their preparation and the use as a medicine
|
EP1908748A1
(en)
*
|
2006-10-05 |
2008-04-09 |
Krka |
Process for the preparation of memantine and its hydrochloric acid salt form
|
WO2008063847A2
(en)
*
|
2006-11-03 |
2008-05-29 |
Forest Laboratories Holdings Limited |
Method for treating autism
|
JP2010513569A
(ja)
|
2006-12-19 |
2010-04-30 |
ユニバーシティ オブ バージニア パテント ファウンデーション |
アルコール摂取に対するトピラメートおよびオンダンセトロンの併用効果
|
WO2008105442A1
(ja)
|
2007-02-28 |
2008-09-04 |
Asahi Kasei Pharma Corporation |
スルホンアミド誘導体
|
US9133159B2
(en)
|
2007-06-06 |
2015-09-15 |
Neurovance, Inc. |
1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
EP2167083B1
(en)
|
2007-06-06 |
2015-10-28 |
Euthymics Bioscience, Inc. |
1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
GB0713930D0
(en)
|
2007-07-18 |
2007-08-29 |
Generics Uk Ltd |
Novel assay methods
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
EP2090576A1
(en)
|
2008-02-01 |
2009-08-19 |
Merz Pharma GmbH & Co.KGaA |
6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
|
US20090247644A1
(en)
*
|
2008-03-28 |
2009-10-01 |
Forest Laboratories Holdings Limited |
Memantine formulations
|
US20110034565A1
(en)
|
2008-04-18 |
2011-02-10 |
University College Dublin, National University Of Ireland, Dublin |
Psycho-pharmaceuticals
|
EP2111858A1
(en)
|
2008-04-25 |
2009-10-28 |
EPFL Ecole Polytechnique Fédérale de Lausanne |
Novel treatment for alzheimer's disease
|
US20090275597A1
(en)
*
|
2008-05-02 |
2009-11-05 |
Forest Laboratories Holdings Limited |
Methods of treating cns disorders
|
EP2138173A1
(en)
|
2008-06-26 |
2009-12-30 |
Merz Pharma GmbH & Co.KGaA |
Pharmaceutical compositions comprising aminoadamantane derivatives
|
JP5195256B2
(ja)
*
|
2008-10-10 |
2013-05-08 |
東ソー株式会社 |
アミノアダマンタン誘導体の製造方法
|
HRP20090186A2
(hr)
|
2009-03-31 |
2010-10-31 |
Institut Ruđer Bošković |
Adamantanski bisureidni derivati, metoda priprave i primjena u detekciji aniona
|
WO2010112221A1
(en)
|
2009-04-03 |
2010-10-07 |
Synthon B.V. |
Pharmaceutical compositions comprising memantine
|
CN102070463A
(zh)
*
|
2009-06-11 |
2011-05-25 |
辽宁利锋科技开发有限公司 |
具有金刚烷结构药物美金刚胺及其衍生物和类似物抗肿瘤新适应症的应用
|
TW201116532A
(en)
|
2009-08-05 |
2011-05-16 |
Merz Pharma Gmbh & Co Kgaa |
Metabotropic glutamate receptor modulators
|
JP5885668B2
(ja)
|
2009-12-02 |
2016-03-15 |
アダマス ファーマシューティカルズ, インコーポレイテッド |
アマンタジン組成物および使用方法
|
WO2011127235A1
(en)
|
2010-04-07 |
2011-10-13 |
Eisai Inc. |
Combination therapy for the treatment of dementia
|
WO2012052451A1
(en)
|
2010-10-18 |
2012-04-26 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
WO2012055945A1
(en)
|
2010-10-29 |
2012-05-03 |
Merz Pharma Gmbh & Co. Kgaa |
Indole derivatives and process for their preparation
|
CA2818025A1
(en)
|
2010-11-15 |
2012-05-24 |
Agenebio, Inc. |
Pyridazine derivatives, compositions and methods for treating cognitive impairment
|
WO2012085167A1
(en)
|
2010-12-22 |
2012-06-28 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
WO2012085166A1
(en)
|
2010-12-22 |
2012-06-28 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
CN102241678B
(zh)
|
2011-04-26 |
2014-10-29 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
WO2012152854A1
(en)
|
2011-05-12 |
2012-11-15 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
WO2012172093A1
(en)
|
2011-06-17 |
2012-12-20 |
Merz Pharma Gmbh & Co. Kgaa |
Dihydroindolizine derivate as metabotropic glutamate receptor modulators
|
US20140206740A1
(en)
|
2011-07-30 |
2014-07-24 |
Neurovance, Inc. |
Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
|
CN103288650B
(zh)
*
|
2012-02-28 |
2015-09-30 |
广州白云山制药股份有限公司广州白云山制药总厂 |
一种盐酸1-氨基-3,5-二甲基金刚烷的制备方法
|
EP2650284A1
(en)
|
2012-04-10 |
2013-10-16 |
Merz Pharma GmbH & Co. KGaA |
Heterocyclic derivatives as metabotropic glutamate receptor modulators
|
RU2488388C1
(ru)
|
2012-05-24 |
2013-07-27 |
Ооо "Валента Интеллект" |
Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
|
US10154971B2
(en)
|
2013-06-17 |
2018-12-18 |
Adamas Pharma, Llc |
Methods of administering amantadine
|
US9566264B2
(en)
|
2013-07-01 |
2017-02-14 |
Euthymics Bioscience, Inc. |
Combinations and methods
|
CA3123897C
(en)
|
2013-12-20 |
2024-02-06 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
WO2015120013A1
(en)
|
2014-02-04 |
2015-08-13 |
Forest Laboratories Holdings Limited |
Donepezil compositions and method of treating alzheimer's disease
|
AU2016279052A1
(en)
|
2015-06-19 |
2018-02-15 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
JP6354701B2
(ja)
*
|
2015-08-19 |
2018-07-11 |
大日本印刷株式会社 |
高純度メマンチン塩酸塩の製造法
|
RU2737464C2
(ru)
|
2015-12-30 |
2020-11-30 |
Кориум Интернэшнл, Инк. |
Системы и способы длительного трансдермального введения
|
WO2017223402A1
(en)
|
2016-06-23 |
2017-12-28 |
Corium International, Inc. |
Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
|
RU2764764C2
(ru)
|
2016-07-27 |
2022-01-21 |
Кориум Интернэшнл, Инк. |
Трансдермальные системы доставки мемантина
|
AU2017302306A1
(en)
|
2016-07-27 |
2019-02-14 |
Corium, LLC. |
Transdermal formulation and delivery method of low solubility or unstable unionized neutral drugs by in situ salt-to-neutral drug conversion of salt drug
|
US10016372B2
(en)
|
2016-07-27 |
2018-07-10 |
Corium International, Inc. |
Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
|
US20180170941A1
(en)
|
2016-12-19 |
2018-06-21 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
BR112019012821A2
(pt)
|
2016-12-19 |
2019-11-26 |
Agenebio Inc |
derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
|
US10369187B2
(en)
|
2017-02-09 |
2019-08-06 |
Vanderbilt University |
Peptide regulators of JNK family kinases
|
JP2019094304A
(ja)
*
|
2017-11-27 |
2019-06-20 |
学校法人順天堂 |
オートファジー誘導剤
|
CA3086163A1
(en)
|
2017-12-20 |
2019-06-27 |
Corium, Inc. |
Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
|
WO2019246300A1
(en)
|
2018-06-19 |
2019-12-26 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
EP3721857A1
(en)
*
|
2019-04-11 |
2020-10-14 |
Dentsply DeTrey GmbH |
Dental composition
|
CN111757862B
(zh)
*
|
2020-05-19 |
2021-10-08 |
山东泓瑞医药科技股份公司 |
一种金刚烷胺的制备方法
|
JP2025529834A
(ja)
|
2022-08-19 |
2025-09-09 |
エージンバイオ, インコーポレイテッド |
認知障害を処置するためのベンゾアゼピン誘導体、組成物および方法
|