CA954858A - Pyridyl oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same - Google Patents

Pyridyl oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same

Info

Publication number
CA954858A
CA954858A CA049,755A CA49755A CA954858A CA 954858 A CA954858 A CA 954858A CA 49755 A CA49755 A CA 49755A CA 954858 A CA954858 A CA 954858A
Authority
CA
Canada
Prior art keywords
pyridyl
preparation
pharmaceutical compositions
compositions containing
containing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA049,755A
Other languages
English (en)
Inventor
Csaba Gonczi
Gyorgy Leszkovszky
Erzsebet Bako
Kalman Takacs
Kalman Harsanyi
Dezso Korbonits
Csaba Vertesy
Jozsef Reiter
Laszlo Tardos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Application granted granted Critical
Publication of CA954858A publication Critical patent/CA954858A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA049,755A 1968-04-26 1969-04-25 Pyridyl oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same Expired CA954858A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI000796 1968-04-26

Publications (1)

Publication Number Publication Date
CA954858A true CA954858A (en) 1974-09-17

Family

ID=10994349

Family Applications (1)

Application Number Title Priority Date Filing Date
CA049,755A Expired CA954858A (en) 1968-04-26 1969-04-25 Pyridyl oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same

Country Status (15)

Country Link
US (1) US3647809A (cs)
JP (1) JPS4824394B1 (cs)
AT (2) AT292728B (cs)
BE (1) BE732131A (cs)
BR (1) BR6908381D0 (cs)
CA (1) CA954858A (cs)
CH (2) CH542232A (cs)
DE (1) DE1920037A1 (cs)
FR (1) FR2007529B1 (cs)
GB (1) GB1271302A (cs)
IL (1) IL31990A (cs)
NL (1) NL6906401A (cs)
NO (1) NO124253B (cs)
PL (1) PL79435B1 (cs)
SE (1) SE368576B (cs)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853893A (en) * 1973-04-02 1974-12-10 Squibb & Sons Inc Anthelmintic 5-(pyridyl)-3-(isothiocyanophenyl) oxadiazoles
HU177086B (en) * 1975-06-09 1981-07-28 Eszakmagyar Vegyimuevek Herbicide and fungicide preparation containing substituted 1,2,4-oxadiazolidin-3-one derivatives
JPS58150576A (ja) * 1982-03-03 1983-09-07 Sumitomo Chem Co Ltd 新規な１，２，４−オキサジアゾ−ル誘導体
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
BR0013427A (pt) * 1999-08-19 2002-07-30 Nps Pharma Inc Compostos heteropolicìclicos e seus usos como antagonistas no receptor de glutamato metabotrópico
EP1582519A3 (en) * 1999-08-19 2005-12-21 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
DE60222872T2 (de) * 2001-02-21 2008-07-24 Astrazeneca Ab Heteropolycyclische verbindungen und deren verwendung als metabotrope glutamatrezeptorantagonisten
MXPA05001590A (es) 2002-08-09 2005-05-23 Astrazeneca Ab Compuestos que tienen actividad en los receptores metabotropicos de glutamato.
US8178570B2 (en) * 2003-04-09 2012-05-15 Exelixis, Inc. Tie-2 modulators and methods of use
US20060252741A1 (en) * 2003-05-15 2006-11-09 Colandrea Vincent J 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists
US20060189661A1 (en) * 2003-11-03 2006-08-24 Wagenen Bradford V Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005060961A2 (en) * 2003-12-18 2005-07-07 Astrazeneca Ab Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd)
NZ547965A (en) * 2003-12-24 2009-12-24 Prosidion Ltd 1,2,4-Oxadiazole derivatives as GPCR receptor agonists
WO2005077368A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
US8017631B2 (en) * 2005-04-26 2011-09-13 Neurosearch A/S Oxadiazole derivatives and their medical use
IL169855A (en) * 2005-07-25 2014-05-28 Elta Systems Ltd A system and method for locating a receiver location
CN102816157B (zh) 2005-07-26 2016-05-18 比艾尔-坡特拉有限公司 作为comt抑制剂的硝基儿茶酚衍生物
EP1845097A1 (en) 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
BRPI0716171B8 (pt) * 2006-09-07 2021-05-25 Actelion Pharmaceuticals Ltd composto, composição farmacêutica e uso de um composto
SI2069335T1 (sl) * 2006-09-08 2013-04-30 Actelion Pharmaceuticals Ltd. Derivati piridin-3-ila kot imunomodulacijska sredstva
CN101631548B (zh) 2007-01-31 2014-08-27 比艾尔-坡特拉有限公司 Comt抑制剂的单次药物剂量单元和药物组合物
EP2125797B1 (en) * 2007-03-16 2014-01-15 Actelion Pharmaceuticals Ltd. Amino- pyridine derivatives as s1p1 /edg1 receptor agonists
NZ583957A (en) * 2007-08-17 2011-09-30 Actelion Pharmaceuticals Ltd Pyridine derivatives as s1p1/edg1 receptor modulators
WO2009108077A2 (en) * 2008-02-28 2009-09-03 Bial - Portela & Ca., S.A. Pharmaceutical composition for poorly soluble drugs
WO2009109906A1 (en) * 2008-03-06 2009-09-11 Actelion Pharmaceuticals Ltd Pyridine compounds
RU2494099C2 (ru) * 2008-03-07 2013-09-27 Актелион Фармасьютиклз Лтд Пиридин-2-ильные производные в качестве иммуномодулирующих агентов
RU2010139315A (ru) 2008-03-17 2012-04-27 Биал - Портела Энд Ка., С.А. (Pt) Кристаллические формы 5-[3-(2,5-дихлор-4,6-диметил-1-окси-пиридин-3-ил)[1,2,4]оксадиазол-5-ил]-3-нитробензол-1,2-диола
FI2291080T5 (fi) * 2008-05-14 2023-11-06 The Scripps Research Institute Uusia sfingosiinifosfaattireseptorimodulaattoreita
EP2396321B1 (en) 2009-02-10 2015-05-06 Monsanto Technology LLC Compositions and methods for controlling nematodes
PL2413913T3 (pl) * 2009-04-01 2022-09-26 Bial-Portela & Ca, S.A. Formulacje farmaceutyczne zawierające pochodne nitrokatecholu oraz sposoby ich wytwarzania
PT2413912T (pt) 2009-04-01 2019-06-11 Bial Portela & Ca Sa Formulações farmacêuticas compreendendo derivados de nitrocatecol e métodos para as produzir
CA2767585C (en) 2009-07-16 2017-09-26 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives
HUE026012T2 (en) 2011-01-19 2016-05-30 Actelion Pharmaceuticals Ltd 2-methoxy-pyridin-4-yl derivatives
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
CA2858025C (en) 2011-12-13 2020-09-22 Bial-Portela & Ca., S.A. 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene as an intermediate to prepare a catechol-o-methyltransferase inhibitor
WO2014127195A1 (en) 2013-02-15 2014-08-21 Monsanto Technology Llc 3,5-disubstituted-4,5-dihydro-1,2,4-oxadiazoles for controlling nematode pests
RU2017120184A (ru) 2014-11-28 2018-12-28 БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. Лекарства для замедления течения болезни паркинсона
PH12017502097B1 (en) 2015-05-20 2023-05-05 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL256329A (cs) * 1959-09-29
US3227725A (en) * 1962-04-17 1966-01-04 Union Carbide Corp Certain 3,5-disubstituted 1,2,4-oxadiazole compounds

Also Published As

Publication number Publication date
FR2007529A1 (cs) 1970-01-09
AT292727B (de) 1971-09-10
BR6908381D0 (pt) 1973-02-08
IL31990A0 (en) 1969-06-25
AT292728B (de) 1971-09-10
JPS4824394B1 (cs) 1973-07-20
PL79435B1 (en) 1975-06-30
SE368576B (cs) 1974-07-08
BE732131A (cs) 1969-10-01
DE1920037A1 (de) 1970-11-12
IL31990A (en) 1974-05-16
NO124253B (cs) 1972-03-27
NL6906401A (cs) 1969-10-28
CH540925A (de) 1973-08-31
US3647809A (en) 1972-03-07
CH542232A (de) 1973-11-15
FR2007529B1 (cs) 1973-03-16
GB1271302A (en) 1972-04-19

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