CA3202054A1 - Pharmaceutical compounds - Google Patents

Pharmaceutical compounds

Info

Publication number
CA3202054A1
CA3202054A1 CA3202054A CA3202054A CA3202054A1 CA 3202054 A1 CA3202054 A1 CA 3202054A1 CA 3202054 A CA3202054 A CA 3202054A CA 3202054 A CA3202054 A CA 3202054A CA 3202054 A1 CA3202054 A1 CA 3202054A1
Authority
CA
Canada
Prior art keywords
compound
compounds
treatment
formula
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3202054A
Other languages
English (en)
French (fr)
Inventor
Charlotte Fieldhouse
Miles Stuart Congreve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nxera Pharma UK Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3202054A1 publication Critical patent/CA3202054A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3202054A 2020-12-18 2021-12-20 Pharmaceutical compounds Pending CA3202054A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2020191.9 2020-12-18
GBGB2020191.9A GB202020191D0 (en) 2020-12-18 2020-12-18 Pharmaceutical compounds
PCT/GB2021/053372 WO2022129951A1 (en) 2020-12-18 2021-12-20 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
CA3202054A1 true CA3202054A1 (en) 2022-06-23

Family

ID=74221349

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3202054A Pending CA3202054A1 (en) 2020-12-18 2021-12-20 Pharmaceutical compounds

Country Status (19)

Country Link
US (1) US11999745B2 (enExample)
EP (1) EP4263536A1 (enExample)
JP (1) JP7730369B2 (enExample)
KR (1) KR20230121830A (enExample)
CN (1) CN116848109B (enExample)
AU (1) AU2021404194A1 (enExample)
CA (1) CA3202054A1 (enExample)
CL (1) CL2023001755A1 (enExample)
CO (1) CO2023007838A2 (enExample)
CR (1) CR20230256A (enExample)
DO (1) DOP2023000125A (enExample)
EC (1) ECSP23044370A (enExample)
GB (1) GB202020191D0 (enExample)
IL (1) IL303484A (enExample)
JO (1) JOP20230128A1 (enExample)
MX (1) MX2023007140A (enExample)
PE (1) PE20240646A1 (enExample)
UA (1) UA130897C2 (enExample)
WO (1) WO2022129951A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

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Also Published As

Publication number Publication date
US11999745B2 (en) 2024-06-04
CR20230256A (es) 2023-09-29
IL303484A (en) 2023-08-01
DOP2023000125A (es) 2023-08-31
ECSP23044370A (es) 2023-08-31
CN116848109B (zh) 2026-02-10
UA130897C2 (uk) 2026-06-10
JP7730369B2 (ja) 2025-08-27
MX2023007140A (es) 2023-08-25
GB202020191D0 (en) 2021-02-03
JP2024504252A (ja) 2024-01-31
CN116848109A (zh) 2023-10-03
JOP20230128A1 (ar) 2023-06-06
WO2022129951A1 (en) 2022-06-23
AU2021404194A1 (en) 2023-08-03
CO2023007838A2 (es) 2023-10-30
EP4263536A1 (en) 2023-10-25
AU2021404194A9 (en) 2024-10-17
CL2023001755A1 (es) 2024-01-05
PE20240646A1 (es) 2024-04-04
KR20230121830A (ko) 2023-08-21
US20220380379A1 (en) 2022-12-01

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