CA3170247A1 - Methods of producing molindone and its salts - Google Patents
Methods of producing molindone and its salts Download PDFInfo
- Publication number
- CA3170247A1 CA3170247A1 CA3170247A CA3170247A CA3170247A1 CA 3170247 A1 CA3170247 A1 CA 3170247A1 CA 3170247 A CA3170247 A CA 3170247A CA 3170247 A CA3170247 A CA 3170247A CA 3170247 A1 CA3170247 A1 CA 3170247A1
- Authority
- CA
- Canada
- Prior art keywords
- sumo
- molindone
- reaction
- sum0
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261701007P | 2012-09-14 | 2012-09-14 | |
| US61/701,007 | 2012-09-14 | ||
| CA3111577A CA3111577C (en) | 2012-09-14 | 2013-03-15 | Methods of producing molindone and its salts |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3111577A Division CA3111577C (en) | 2012-09-14 | 2013-03-15 | Methods of producing molindone and its salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3170247A1 true CA3170247A1 (en) | 2014-03-20 |
Family
ID=48050289
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3170247A Pending CA3170247A1 (en) | 2012-09-14 | 2013-03-15 | Methods of producing molindone and its salts |
| CA3111577A Active CA3111577C (en) | 2012-09-14 | 2013-03-15 | Methods of producing molindone and its salts |
| CA2884179A Active CA2884179C (en) | 2012-09-14 | 2013-03-15 | Methods of producing molindone and its salts |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3111577A Active CA3111577C (en) | 2012-09-14 | 2013-03-15 | Methods of producing molindone and its salts |
| CA2884179A Active CA2884179C (en) | 2012-09-14 | 2013-03-15 | Methods of producing molindone and its salts |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US8957206B2 (https=) |
| EP (3) | EP2895175B1 (https=) |
| JP (4) | JP6133427B2 (https=) |
| AU (3) | AU2013316119B2 (https=) |
| CA (3) | CA3170247A1 (https=) |
| ES (1) | ES2643557T3 (https=) |
| MX (4) | MX379124B (https=) |
| WO (1) | WO2014042688A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6133427B2 (ja) * | 2012-09-14 | 2017-05-24 | スパーナス ファーマシューティカルズ インコーポレイテッド | モリンドン及びその塩の製造方法 |
| CN107011237B (zh) * | 2016-01-27 | 2020-04-21 | 合肥立方制药股份有限公司 | 一种改进的吗茚酮的合成方法 |
| US10752586B1 (en) | 2019-02-16 | 2020-08-25 | Lupin Limited | Process for preparation of molindone |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3467755A (en) * | 1966-05-11 | 1969-09-16 | Endo Lab | Compositions and methods for producing sedation and tranquilization with substituted 4,5,6,7- tetrahydro-4-oxindoles |
| US3491093A (en) * | 1967-11-29 | 1970-01-20 | Endo Lab | Derivatives of 5 aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles |
| US3646042A (en) | 1970-02-09 | 1972-02-29 | Velsicol Chemical Corp | Certain n-phenyl n-lower-alkyl-pyridine carboxamides and derivatives thereof |
| US4016281A (en) * | 1975-02-22 | 1977-04-05 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Tetralone and indanone compounds |
| US4065453A (en) | 1976-11-01 | 1977-12-27 | Endo Laboratories, Inc. | Levorotatory molindone and the use as an antidepressant |
| US4707484A (en) * | 1986-11-25 | 1987-11-17 | Hoffmann-La Roche Inc. | Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives |
| US5114936A (en) * | 1990-08-23 | 1992-05-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use |
| US5180834A (en) * | 1990-08-23 | 1993-01-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones |
| JP2804364B2 (ja) * | 1990-10-31 | 1998-09-24 | 三井化学株式会社 | オキシム類の製造方法 |
| JP4169562B2 (ja) | 2002-10-09 | 2008-10-22 | 横浜ゴム株式会社 | タイヤ成形用金型及び空気入りタイヤ |
| NZ569317A (en) * | 2005-12-29 | 2010-08-27 | Toyama Chemical Co Ltd | Novel arylamidine derivative, salt thereof and antifungal agent containing those |
| JP2007217353A (ja) * | 2006-02-17 | 2007-08-30 | Sankyo Agro Kk | １，２，３，４−テトラヒドロキノリン化合物 |
| JP6133427B2 (ja) * | 2012-09-14 | 2017-05-24 | スパーナス ファーマシューティカルズ インコーポレイテッド | モリンドン及びその塩の製造方法 |
-
2013
- 2013-03-15 JP JP2015531913A patent/JP6133427B2/ja not_active Expired - Fee Related
- 2013-03-15 CA CA3170247A patent/CA3170247A1/en active Pending
- 2013-03-15 EP EP13714783.1A patent/EP2895175B1/en active Active
- 2013-03-15 EP EP22177217.1A patent/EP4074691A1/en not_active Withdrawn
- 2013-03-15 MX MX2017015078A patent/MX379124B/es unknown
- 2013-03-15 EP EP17180165.7A patent/EP3290403A3/en not_active Withdrawn
- 2013-03-15 WO PCT/US2013/032142 patent/WO2014042688A1/en not_active Ceased
- 2013-03-15 MX MX2017015076A patent/MX382345B/es unknown
- 2013-03-15 AU AU2013316119A patent/AU2013316119B2/en active Active
- 2013-03-15 MX MX2017015070A patent/MX379125B/es unknown
- 2013-03-15 US US13/834,097 patent/US8957206B2/en active Active
- 2013-03-15 ES ES13714783.1T patent/ES2643557T3/es active Active
- 2013-03-15 CA CA3111577A patent/CA3111577C/en active Active
- 2013-03-15 CA CA2884179A patent/CA2884179C/en active Active
- 2013-03-15 MX MX2015003237A patent/MX356357B/es active IP Right Grant
-
2015
- 2015-01-29 US US14/608,262 patent/US9562011B2/en active Active
-
2016
- 2016-11-30 US US15/365,566 patent/US9802893B2/en active Active
-
2017
- 2017-03-13 JP JP2017047064A patent/JP6324567B2/ja not_active Expired - Fee Related
- 2017-07-27 AU AU2017208312A patent/AU2017208312B2/en active Active
- 2017-10-03 US US15/723,515 patent/US10081595B2/en active Active
-
2018
- 2018-02-09 JP JP2018021784A patent/JP2018090604A/ja active Pending
- 2018-08-21 US US16/107,836 patent/US10676432B2/en active Active
-
2019
- 2019-02-26 JP JP2019032306A patent/JP2019108351A/ja active Pending
- 2019-05-09 AU AU2019203270A patent/AU2019203270B2/en active Active
-
2020
- 2020-04-30 US US16/863,020 patent/US11117862B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220811 |