CA3167275A1 - Compounds and uses thereof - Google Patents

Compounds and uses thereof

Info

Publication number
CA3167275A1
CA3167275A1 CA3167275A CA3167275A CA3167275A1 CA 3167275 A1 CA3167275 A1 CA 3167275A1 CA 3167275 A CA3167275 A CA 3167275A CA 3167275 A CA3167275 A CA 3167275A CA 3167275 A1 CA3167275 A1 CA 3167275A1
Authority
CA
Canada
Prior art keywords
cancer
compound
subject
cell
brg1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3167275A
Other languages
English (en)
French (fr)
Inventor
Rishi G. Vaswani
David S. HUANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Foghorn Therapeutics Inc
Original Assignee
Foghorn Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Foghorn Therapeutics Inc filed Critical Foghorn Therapeutics Inc
Publication of CA3167275A1 publication Critical patent/CA3167275A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
CA3167275A 2020-01-29 2021-01-29 Compounds and uses thereof Pending CA3167275A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062967359P 2020-01-29 2020-01-29
US62/967,359 2020-01-29
PCT/US2021/015876 WO2021155262A1 (en) 2020-01-29 2021-01-29 Compounds and uses thereof

Publications (1)

Publication Number Publication Date
CA3167275A1 true CA3167275A1 (en) 2021-08-05

Family

ID=76970694

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3167275A Pending CA3167275A1 (en) 2020-01-29 2021-01-29 Compounds and uses thereof

Country Status (17)

Country Link
US (3) US11485732B2 (enExample)
EP (1) EP4096664A4 (enExample)
JP (1) JP7561195B2 (enExample)
KR (1) KR20220133258A (enExample)
CN (1) CN115023226A (enExample)
AR (1) AR121226A1 (enExample)
AU (1) AU2021213811A1 (enExample)
BR (1) BR112022015004A2 (enExample)
CA (1) CA3167275A1 (enExample)
CO (1) CO2022010547A2 (enExample)
IL (1) IL295100A (enExample)
MX (1) MX2022009309A (enExample)
PH (1) PH12022551937A1 (enExample)
TW (1) TWI859406B (enExample)
UA (1) UA129728C2 (enExample)
WO (1) WO2021155262A1 (enExample)
ZA (1) ZA202207804B (enExample)

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US12384776B2 (en) 2019-01-29 2025-08-12 Foghorn Therapeutics Inc. Compounds and uses thereof
EP3917517A4 (en) 2019-01-29 2023-01-25 Foghorn Therapeutics Inc. CONNECTIONS AND USES THEREOF
US12509453B2 (en) 2019-01-29 2025-12-30 Foghorn Therapeutics Inc. BRM/BRG1 inhibitors and uses thereof
AU2021213811A1 (en) 2020-01-29 2022-07-28 Foghorn Therapeutics Inc. Compounds and uses thereof
EP4153176A4 (en) * 2020-05-20 2024-05-29 Foghorn Therapeutics Inc. METHODS OF TREATING CANCER
US12383555B2 (en) 2020-05-20 2025-08-12 Foghorn Therapeutics Inc. Methods of treating cancers
US12606553B2 (en) 2021-03-09 2026-04-21 Foghorn Therapeutics Inc. Crystalline forms, compositions containing same, and methods of their use
CN117337179A (zh) * 2021-03-19 2024-01-02 福宏治疗公司 Brg1和brm的酶活性抑制剂的治疗方案
US20240374605A1 (en) * 2021-07-29 2024-11-14 Foghorn Therapeutics Inc. Methods of treating cancer
US20250339441A1 (en) * 2022-04-08 2025-11-06 Foghorn Therapeutics Inc. Methods of treating cancer
US20250325553A1 (en) * 2022-04-08 2025-10-23 Foghorn Therapeutics Inc. Methods of treating cancer
AR129299A1 (es) * 2022-05-11 2024-08-07 Foghorn Therapeutics Inc Compuestos para modular complejos de factores asociados a brg1 o brm (baf)
WO2024125543A1 (zh) * 2022-12-16 2024-06-20 苏州科睿思制药有限公司 达洛色替的晶型及其制备方法和用途
WO2024249769A2 (en) * 2023-06-02 2024-12-05 Foghorn Therapeutics Inc. Combination therapy for treating hematological cancers
IL326645A (en) * 2023-08-21 2026-04-01 Ideaya Biosciences Inc Pharmaceutical compounds containing a PKC inhibitor.
WO2025080769A1 (en) * 2023-10-10 2025-04-17 Foghorn Therapeutics Inc. Methods of treating cancer

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