CA3161045A1 - Substituted straight chain spiro derivatives - Google Patents

Substituted straight chain spiro derivatives Download PDF

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Publication number
CA3161045A1
CA3161045A1 CA3161045A CA3161045A CA3161045A1 CA 3161045 A1 CA3161045 A1 CA 3161045A1 CA 3161045 A CA3161045 A CA 3161045A CA 3161045 A CA3161045 A CA 3161045A CA 3161045 A1 CA3161045 A1 CA 3161045A1
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CA
Canada
Prior art keywords
6alkyl
independently selected
group
4alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3161045A
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English (en)
French (fr)
Inventor
Wei Cai
Xuedong Dai
Olivier Alexis Georges Querolle
Johannes Wilhelmus John F. Thuring
Yingtao LIU
Lianzhu LIU
Yanping Xu
Liqiang Fu
Ming Li
Lichao FANG
Xiangjun DENG
Qiwu ZHAO
Kangying LI
Alicia Tee Fuay Ng
Nicolas Freddy J. Darville
Edward Cleator
Gregor Thomas URBANIETZ
William Marc Maton
Vineet PANDE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CA3161045A1 publication Critical patent/CA3161045A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3161045A 2019-12-19 2020-12-17 Substituted straight chain spiro derivatives Pending CA3161045A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN2019126760 2019-12-19
CNPCT/CN2019/126760 2019-12-19
US202062961775P 2020-01-16 2020-01-16
US62/961,775 2020-01-16
CN2020126595 2020-11-04
CNPCT/CN2020/126595 2020-11-04
PCT/CN2020/137266 WO2021121327A1 (en) 2019-12-19 2020-12-17 Substituted straight chain spiro derivatives

Publications (1)

Publication Number Publication Date
CA3161045A1 true CA3161045A1 (en) 2021-06-24

Family

ID=76476870

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3161045A Pending CA3161045A1 (en) 2019-12-19 2020-12-17 Substituted straight chain spiro derivatives

Country Status (21)

Country Link
US (1) US12473295B2 (enExample)
EP (1) EP4077312A4 (enExample)
JP (3) JP7554829B2 (enExample)
KR (1) KR20220118500A (enExample)
CN (4) CN118255773A (enExample)
AU (1) AU2020404305B2 (enExample)
CA (1) CA3161045A1 (enExample)
CL (3) CL2022001583A1 (enExample)
CO (1) CO2022009085A2 (enExample)
CR (1) CR20220346A (enExample)
DO (1) DOP2022000125A (enExample)
EC (1) ECSP22054700A (enExample)
IL (1) IL293965A (enExample)
JO (1) JOP20220154A1 (enExample)
MX (1) MX2022007652A (enExample)
PE (1) PE20230162A1 (enExample)
PH (1) PH12022551502A1 (enExample)
TW (2) TW202525813A (enExample)
UA (1) UA129208C2 (enExample)
UY (1) UY38988A (enExample)
WO (1) WO2021121327A1 (enExample)

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