KR20220118500A - 치환 직쇄 스피로 유도체 - Google Patents

치환 직쇄 스피로 유도체 Download PDF

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Publication number
KR20220118500A
KR20220118500A KR1020227024649A KR20227024649A KR20220118500A KR 20220118500 A KR20220118500 A KR 20220118500A KR 1020227024649 A KR1020227024649 A KR 1020227024649A KR 20227024649 A KR20227024649 A KR 20227024649A KR 20220118500 A KR20220118500 A KR 20220118500A
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alkyl
group
independently selected
leukemia
hydrogen
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Korean (ko)
Inventor
웨이 카이
슈에동 다이
올리비에 알렉시스 조지스 퀘롤
요하네스 빌헬무스 욘 에프. 튜링겐
잉타오 리우
리안주 리우
얀핑 슈
리퀴앙 푸
밍 리
리차오 팡
시앙준 덩
치우 자오
캉잉 리
알리시아 티 푸에이 엔쥐
니콜라스 프레디 제이 다빌
에드워드 클리터
그레고르 토마스 어바니에츠
윌리엄 마크 메이튼
비네트 판데
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얀센 파마슈티카 엔.브이.
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Publication of KR20220118500A publication Critical patent/KR20220118500A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020227024649A 2019-12-19 2020-12-17 치환 직쇄 스피로 유도체 Pending KR20220118500A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN2019126760 2019-12-19
CNPCT/CN2019/126760 2019-12-19
US202062961775P 2020-01-16 2020-01-16
US62/961,775 2020-01-16
CN2020126595 2020-11-04
CNPCT/CN2020/126595 2020-11-04
PCT/CN2020/137266 WO2021121327A1 (en) 2019-12-19 2020-12-17 Substituted straight chain spiro derivatives

Publications (1)

Publication Number Publication Date
KR20220118500A true KR20220118500A (ko) 2022-08-25

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EP (1) EP4077312A4 (enExample)
JP (3) JP7554829B2 (enExample)
KR (1) KR20220118500A (enExample)
CN (4) CN118255773A (enExample)
AU (1) AU2020404305B2 (enExample)
CA (1) CA3161045A1 (enExample)
CL (3) CL2022001583A1 (enExample)
CO (1) CO2022009085A2 (enExample)
CR (1) CR20220346A (enExample)
DO (1) DOP2022000125A (enExample)
EC (1) ECSP22054700A (enExample)
IL (1) IL293965A (enExample)
JO (1) JOP20220154A1 (enExample)
MX (1) MX2022007652A (enExample)
PE (1) PE20230162A1 (enExample)
PH (1) PH12022551502A1 (enExample)
TW (2) TW202525813A (enExample)
UA (1) UA129208C2 (enExample)
UY (1) UY38988A (enExample)
WO (1) WO2021121327A1 (enExample)

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