CA3133736A1 - Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies - Google Patents

Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies Download PDF

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Publication number
CA3133736A1
CA3133736A1 CA3133736A CA3133736A CA3133736A1 CA 3133736 A1 CA3133736 A1 CA 3133736A1 CA 3133736 A CA3133736 A CA 3133736A CA 3133736 A CA3133736 A CA 3133736A CA 3133736 A1 CA3133736 A1 CA 3133736A1
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Prior art keywords
cells
lymphocytes
receptor
mutein
native
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CA3133736A
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English (en)
French (fr)
Inventor
Kalet Leon Monzon
Galia Magela MONTALVO BEREAU
George Coukos
Melita IRVING
Elisabetta CRIBIOLI
Yaquelin Ortiz Miranda
Angel De Jesus Corria Osorio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Lausanne
Ludwig Institute for Cancer Research Ltd
Centre Hospitalier Universitaire Vaudois CHUV
Centro de Immunologia Molecular
Original Assignee
Universite de Lausanne
Ludwig Institute for Cancer Research Ltd
Centre Hospitalier Universitaire Vaudois CHUV
Centro de Immunologia Molecular
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Application filed by Universite de Lausanne, Ludwig Institute for Cancer Research Ltd, Centre Hospitalier Universitaire Vaudois CHUV, Centro de Immunologia Molecular filed Critical Universite de Lausanne
Publication of CA3133736A1 publication Critical patent/CA3133736A1/en
Pending legal-status Critical Current

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/2315—Interleukin-15 (IL-15)
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    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2317—Interleukin-17 (IL-17)
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    • C12N2501/20—Cytokines; Chemokines
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CA3133736A 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies Pending CA3133736A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CU2019000021A CU24712B1 (es) 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
CU2019-0021 2019-03-15
PCT/CU2020/050002 WO2020187340A2 (es) 2019-03-15 2020-03-09 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

Publications (1)

Publication Number Publication Date
CA3133736A1 true CA3133736A1 (en) 2020-09-24

Family

ID=72087852

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Application Number Title Priority Date Filing Date
CA3133736A Pending CA3133736A1 (en) 2019-03-15 2020-03-09 Method for the expansion and differentiation of t lymphocytes and nk cells in adoptive transfer therapies

Country Status (18)

Country Link
US (1) US20220152107A1 (https=)
EP (1) EP3940063A2 (https=)
JP (1) JP7572371B2 (https=)
KR (1) KR20220012224A (https=)
CN (1) CN113785048B (https=)
AR (1) AR118369A1 (https=)
AU (1) AU2020242520B2 (https=)
BR (1) BR112021018100A2 (https=)
CA (1) CA3133736A1 (https=)
CO (1) CO2021013127A2 (https=)
CU (1) CU24712B1 (https=)
EA (1) EA202192447A1 (https=)
MX (1) MX2021011120A (https=)
MY (1) MY206651A (https=)
SG (1) SG11202109574QA (https=)
TW (1) TW202102667A (https=)
WO (1) WO2020187340A2 (https=)
ZA (1) ZA202107758B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL276365B2 (en) 2018-02-01 2023-10-01 Nkmax Co Ltd A method for the production of natural killer cells and a preparation for cancer treatment
US12473336B2 (en) 2018-02-21 2025-11-18 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses thereof
CA3158133A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
TW202406932A (zh) 2020-10-22 2024-02-16 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
WO2023004004A1 (en) * 2021-07-23 2023-01-26 Merck Sharp & Dohme Llc Il-2 muteins for treating cancer or infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1956080E (pt) * 2005-08-08 2011-12-30 San Raffaele Centro Fond Uso de il-7 e il-15 para a modificação genética de linfócitos t da memória
EP2207875A1 (en) * 2007-10-24 2010-07-21 Anne Letsch Antigen-specific t-cell preparations from bone marrow
CU23923B1 (es) * 2010-11-12 2013-07-31 Ct De Inmunología Molecular Polipéptidos derivados de la il-2 con actividad agonista
JP2015524255A (ja) * 2012-07-13 2015-08-24 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 二重特異性抗体を共導入することによってｃａｒｔ細胞の活性を強化する方法
AU2017213659B2 (en) 2016-02-05 2024-04-18 Washington University Compositions and methods for targeted cytokine delivery

Also Published As

Publication number Publication date
MX2021011120A (es) 2022-01-18
JP7572371B2 (ja) 2024-10-23
MY206651A (en) 2024-12-30
JP2022524882A (ja) 2022-05-10
CN113785048B (zh) 2024-09-24
AR118369A1 (es) 2021-09-29
EP3940063A2 (en) 2022-01-19
ZA202107758B (en) 2022-12-21
CO2021013127A2 (es) 2022-03-18
CU20190021A7 (es) 2020-10-20
EA202192447A1 (ru) 2021-12-07
TW202102667A (zh) 2021-01-16
KR20220012224A (ko) 2022-02-03
CN113785048A (zh) 2021-12-10
AU2020242520A1 (en) 2021-11-11
AU2020242520B2 (en) 2024-04-04
CU24712B1 (es) 2024-07-10
WO2020187340A2 (es) 2020-09-24
BR112021018100A2 (pt) 2022-02-08
US20220152107A1 (en) 2022-05-19
WO2020187340A3 (es) 2021-04-15
SG11202109574QA (en) 2021-10-28

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