AR118369A1 - Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva - Google Patents

Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

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Publication number
AR118369A1
AR118369A1 ARP200100724A ARP200100724A AR118369A1 AR 118369 A1 AR118369 A1 AR 118369A1 AR P200100724 A ARP200100724 A AR P200100724A AR P200100724 A ARP200100724 A AR P200100724A AR 118369 A1 AR118369 A1 AR 118369A1
Authority
AR
Argentina
Prior art keywords
cells
lymphocytes
adoptive transfer
differentiation
expansion
Prior art date
Application number
ARP200100724A
Other languages
English (en)
Inventor
Osorio Ngela De Jess Corria
Miranda Yaqueln Ortiz
Elisabetta Cribioli
Melita Irving
George Coukos
Bereau Magela Montalvo
Monzn Kalet Len
Original Assignee
Ct Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Inmunologia Molecular filed Critical Ct Inmunologia Molecular
Publication of AR118369A1 publication Critical patent/AR118369A1/es

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • A61K2239/57—Skin; melanoma
    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2740/00—Reverse transcribing RNA viruses
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    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Abstract

Método para obtener linfocitos T y células NK con el fenotipo deseado en la transferencia adoptiva de células para la terapia del cáncer. Especialmente, se basa en estrategias para inducir una señalización preferencial a través del receptor de lL2 de afinidad intermedia, con lo cual se logra expandir las células con el fenotipo de memoria central deseado. El método de la presente es útil en la obtención de linfocitos infiltrantes de tumor, TCR o de receptores quiméricos ingenierizados de células T empleados en el tratamiento del cáncer.
ARP200100724A 2019-03-15 2020-03-13 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva AR118369A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU2019000021A CU20190021A7 (es) 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

Publications (1)

Publication Number Publication Date
AR118369A1 true AR118369A1 (es) 2021-09-29

Family

ID=72087852

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200100724A AR118369A1 (es) 2019-03-15 2020-03-13 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

Country Status (17)

Country Link
US (1) US20220152107A1 (es)
EP (1) EP3940063A2 (es)
JP (1) JP2022524882A (es)
KR (1) KR20220012224A (es)
CN (1) CN113785048A (es)
AR (1) AR118369A1 (es)
AU (1) AU2020242520B2 (es)
BR (1) BR112021018100A2 (es)
CA (1) CA3133736A1 (es)
CO (1) CO2021013127A2 (es)
CU (1) CU20190021A7 (es)
EA (1) EA202192447A1 (es)
MX (1) MX2021011120A (es)
SG (1) SG11202109574QA (es)
TW (1) TW202102667A (es)
WO (1) WO2020187340A2 (es)
ZA (1) ZA202107758B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ766453A (en) 2018-02-01 2022-02-25 Nkmax Co Ltd Method of producing natural killer cells and composition for treating cancer
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
WO2023004004A1 (en) * 2021-07-23 2023-01-26 Merck Sharp & Dohme Llc Il-2 muteins for treating cancer or infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1956080E (pt) * 2005-08-08 2011-12-30 San Raffaele Centro Fond Uso de il-7 e il-15 para a modificação genética de linfócitos t da memória
WO2009053109A1 (en) * 2007-10-24 2009-04-30 Anne Letsch Antigen-specific t-cell preparations from bone marrow
CU23923B1 (es) 2010-11-12 2013-07-31 Ct De Inmunología Molecular Polipéptidos derivados de la il-2 con actividad agonista
US11053293B2 (en) * 2016-02-05 2021-07-06 Washington University Compositions and methods for targeted cytokine delivery

Also Published As

Publication number Publication date
AU2020242520A1 (en) 2021-11-11
TW202102667A (zh) 2021-01-16
CO2021013127A2 (es) 2022-03-18
ZA202107758B (en) 2022-12-21
EA202192447A1 (ru) 2021-12-07
WO2020187340A2 (es) 2020-09-24
AU2020242520B2 (en) 2024-04-04
CA3133736A1 (en) 2020-09-24
US20220152107A1 (en) 2022-05-19
CN113785048A (zh) 2021-12-10
KR20220012224A (ko) 2022-02-03
EP3940063A2 (en) 2022-01-19
BR112021018100A2 (pt) 2022-02-08
CU20190021A7 (es) 2020-10-20
MX2021011120A (es) 2022-01-18
JP2022524882A (ja) 2022-05-10
SG11202109574QA (en) 2021-10-28
WO2020187340A3 (es) 2021-04-15

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