EA202192447A1 - Способ размножения и дифференцировки т-лимфоцитов и nk-клеток в методах лечения с адоптивным переносом - Google Patents

Способ размножения и дифференцировки т-лимфоцитов и nk-клеток в методах лечения с адоптивным переносом

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Publication number
EA202192447A1
EA202192447A1 EA202192447A EA202192447A EA202192447A1 EA 202192447 A1 EA202192447 A1 EA 202192447A1 EA 202192447 A EA202192447 A EA 202192447A EA 202192447 A EA202192447 A EA 202192447A EA 202192447 A1 EA202192447 A1 EA 202192447A1
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Eurasian Patent Office
Prior art keywords
lymphocytes
cells
adoptional
differentiation
reproduction
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EA202192447A
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English (en)
Inventor
Калет Леон Монзон
Галиа Магела Монталво Береау
Георге Каукос
Мелита Ирвинг
Элизабетта Крибиоли
Якелин Ортис Миранда
Ангел де Жезус Коррия Осорио
Original Assignee
Центро Де Инмунология Молекулар
Лудвиг Институте Фор Кансер Ресеарч Лтд
Центре Хоспиталиер Университаире Ваудоис
Университи Оф Лаусанне
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Application filed by Центро Де Инмунология Молекулар, Лудвиг Институте Фор Кансер Ресеарч Лтд, Центре Хоспиталиер Университаире Ваудоис, Университи Оф Лаусанне filed Critical Центро Де Инмунология Молекулар
Publication of EA202192447A1 publication Critical patent/EA202192447A1/ru

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Abstract

Изобретение описывает способ получения лимфоцитов с желаемым фенотипом для методов лечения с адоптивным переносом, пригодных для лечения рака. В частности, настоящее изобретение относится к стратегиям для индуцирования предпочтительного сигналинга через рецептор IL-2 с промежуточной аффинностью для размножения клеток с желаемым фенотипом центральной памяти. Способ настоящего изобретения пригоден для получения инфильтрующих опухоль лимфоцитов, TCR или химерного антигенного рецептора полученных методами инженерии Т-клеток для лечения рака.
EA202192447A 2019-03-15 2020-03-09 Способ размножения и дифференцировки т-лимфоцитов и nk-клеток в методах лечения с адоптивным переносом EA202192447A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU2019000021A CU20190021A7 (es) 2019-03-15 2019-03-15 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva
PCT/CU2020/050002 WO2020187340A2 (es) 2019-03-15 2020-03-09 Método para la expansión y diferenciación de linfocitos t y células nk en terapias de transferencia adoptiva

Publications (1)

Publication Number Publication Date
EA202192447A1 true EA202192447A1 (ru) 2021-12-07

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EA202192447A EA202192447A1 (ru) 2019-03-15 2020-03-09 Способ размножения и дифференцировки т-лимфоцитов и nk-клеток в методах лечения с адоптивным переносом

Country Status (17)

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US (1) US20220152107A1 (ru)
EP (1) EP3940063A2 (ru)
JP (1) JP2022524882A (ru)
KR (1) KR20220012224A (ru)
CN (1) CN113785048A (ru)
AR (1) AR118369A1 (ru)
AU (1) AU2020242520B2 (ru)
BR (1) BR112021018100A2 (ru)
CA (1) CA3133736A1 (ru)
CO (1) CO2021013127A2 (ru)
CU (1) CU20190021A7 (ru)
EA (1) EA202192447A1 (ru)
MX (1) MX2021011120A (ru)
SG (1) SG11202109574QA (ru)
TW (1) TW202102667A (ru)
WO (1) WO2020187340A2 (ru)
ZA (1) ZA202107758B (ru)

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
NZ766453A (en) 2018-02-01 2022-02-25 Nkmax Co Ltd Method of producing natural killer cells and composition for treating cancer
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
WO2023004004A1 (en) * 2021-07-23 2023-01-26 Merck Sharp & Dohme Llc Il-2 muteins for treating cancer or infection

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PT1956080E (pt) * 2005-08-08 2011-12-30 San Raffaele Centro Fond Uso de il-7 e il-15 para a modificação genética de linfócitos t da memória
WO2009053109A1 (en) * 2007-10-24 2009-04-30 Anne Letsch Antigen-specific t-cell preparations from bone marrow
CU23923B1 (es) 2010-11-12 2013-07-31 Ct De Inmunología Molecular Polipéptidos derivados de la il-2 con actividad agonista
US11053293B2 (en) * 2016-02-05 2021-07-06 Washington University Compositions and methods for targeted cytokine delivery

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AU2020242520A1 (en) 2021-11-11
TW202102667A (zh) 2021-01-16
CO2021013127A2 (es) 2022-03-18
ZA202107758B (en) 2022-12-21
WO2020187340A2 (es) 2020-09-24
AU2020242520B2 (en) 2024-04-04
CA3133736A1 (en) 2020-09-24
US20220152107A1 (en) 2022-05-19
CN113785048A (zh) 2021-12-10
KR20220012224A (ko) 2022-02-03
EP3940063A2 (en) 2022-01-19
BR112021018100A2 (pt) 2022-02-08
CU20190021A7 (es) 2020-10-20
MX2021011120A (es) 2022-01-18
JP2022524882A (ja) 2022-05-10
SG11202109574QA (en) 2021-10-28
WO2020187340A3 (es) 2021-04-15
AR118369A1 (es) 2021-09-29

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