CA3132444C - Neuroprotective liposome compositions and methods for treatment of stroke - Google Patents

Neuroprotective liposome compositions and methods for treatment of stroke Download PDF

Info

Publication number
CA3132444C
CA3132444C CA3132444A CA3132444A CA3132444C CA 3132444 C CA3132444 C CA 3132444C CA 3132444 A CA3132444 A CA 3132444A CA 3132444 A CA3132444 A CA 3132444A CA 3132444 C CA3132444 C CA 3132444C
Authority
CA
Canada
Prior art keywords
composition
liposomes
stroke
elip
xenon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3132444A
Other languages
English (en)
French (fr)
Other versions
CA3132444A1 (en
Inventor
Shao-ling HUANG
Melvin E. Klegerman
Yong-Jian Geng
Hyunggun KIM
David D. Mcpherson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of CA3132444A1 publication Critical patent/CA3132444A1/en
Application granted granted Critical
Publication of CA3132444C publication Critical patent/CA3132444C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3132444A 2012-08-10 2013-08-09 Neuroprotective liposome compositions and methods for treatment of stroke Active CA3132444C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682130P 2012-08-10 2012-08-10
US61/682,130 2012-08-10
CN201210356929.9A CN103565745A (zh) 2012-08-10 2012-09-21 用于治疗中风的神经保护性脂质体组合物和方法
CN201210356929.9 2012-09-21
CA2881096A CA2881096C (en) 2012-08-10 2013-08-09 Neuroprotective liposome compositions and methods for treatment of stroke

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2881096A Division CA2881096C (en) 2012-08-10 2013-08-09 Neuroprotective liposome compositions and methods for treatment of stroke

Publications (2)

Publication Number Publication Date
CA3132444A1 CA3132444A1 (en) 2014-02-13
CA3132444C true CA3132444C (en) 2023-11-07

Family

ID=50039028

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3132444A Active CA3132444C (en) 2012-08-10 2013-08-09 Neuroprotective liposome compositions and methods for treatment of stroke
CA2881096A Active CA2881096C (en) 2012-08-10 2013-08-09 Neuroprotective liposome compositions and methods for treatment of stroke

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2881096A Active CA2881096C (en) 2012-08-10 2013-08-09 Neuroprotective liposome compositions and methods for treatment of stroke

Country Status (7)

Country Link
US (4) US10369103B2 (OSRAM)
EP (2) EP2882422B1 (OSRAM)
JP (1) JP6297040B2 (OSRAM)
CN (2) CN103565745A (OSRAM)
AU (1) AU2013299453B2 (OSRAM)
CA (2) CA3132444C (OSRAM)
WO (1) WO2014026117A2 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103565745A (zh) 2012-08-10 2014-02-12 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法
EP4082552B1 (en) 2013-03-15 2026-05-06 The Board of Regents of the University of Texas System Liquids rich in noble gas and methods of their preparation and use
US10456483B2 (en) 2014-12-03 2019-10-29 University Of Cincinnati Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease
US10500227B2 (en) * 2014-12-03 2019-12-10 University Of Cincinnati Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease
JP6622822B2 (ja) * 2015-06-23 2019-12-18 ノビリス セラピューティクス インコーポレイテッド 希ガス組成物を用いた治療的な免疫調節
EP3158992A1 (en) * 2015-10-21 2017-04-26 Universität Heidelberg Liposomes containing cell penetrating peptides and tetraetherlipids for the oral delivery of macromolecules
CZ307851B6 (cs) * 2017-02-14 2019-06-26 Ústav experimentální medicíny AV ČR, v. v. i. Léčebný přípravek k prevenci a léčení zánětlivých a degenerativních onemocnění
JP2020033304A (ja) * 2018-08-30 2020-03-05 医療法人ふじいやさか 薬剤又はサプリメント、組成物、及び水素供給器の使用
EP3628309A1 (en) 2018-09-28 2020-04-01 Universität Heidelberg Method of making oral dosage forms
JP7716076B2 (ja) * 2021-02-04 2025-07-31 学校法人産業医科大学 血管内穿孔によるくも膜下出血モデルの血腫を可視化する方法
JP2022144013A (ja) * 2021-03-18 2022-10-03 橋本電子工業株式会社 抗血栓リポソーム

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162282A (en) 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4310505A (en) 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4533254A (en) 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US5030453A (en) 1983-03-24 1991-07-09 The Liposome Company, Inc. Stable plurilamellar vesicles
US4728575A (en) 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
IL79559A0 (en) 1986-07-29 1986-10-31 Univ Ramot Contrast agents for nmr medical imaging
US4728578A (en) 1986-08-13 1988-03-01 The Lubrizol Corporation Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
WO1993020802A1 (en) 1992-04-09 1993-10-28 Northwestern University Acoustically reflective liposomes and methods to make and use the same
US5858399A (en) 1992-04-09 1999-01-12 Northwestern University Acoustically reflective liposomes and methods to make and use the same
JP3746293B2 (ja) 1993-02-22 2006-02-15 アメリカン バイオサイエンス、インコーポレイテッド 生物製剤のインビボ送達の方法とそのための組成物
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US6123919A (en) 1994-04-08 2000-09-26 The Trustees Of Princeton University Magnetic resonance imaging using hyperpolarized noble gases
US5545396A (en) 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5855911A (en) 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
WO1997015311A1 (fr) 1995-10-20 1997-05-01 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Composition a base de monoxyde d'azote en tant que medicament
US6770291B2 (en) 1996-08-30 2004-08-03 The United States Of America As Represented By The Department Of Health And Human Services Liposome complexes for increased systemic delivery
CA2263705C (en) 1996-08-19 2007-12-04 Nancy Smyth-Templeton Novel sandwich liposome complexes comprising a biologically active agent
US5891467A (en) 1997-01-31 1999-04-06 Depotech Corporation Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
DE19709704C2 (de) 1997-03-10 1999-11-04 Michael Georgieff Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie
US6548047B1 (en) * 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6050444A (en) 1998-07-22 2000-04-18 Sugg; James Wesley Consumable beverage dispenser with one-way valve
DE19910986C2 (de) 1999-03-11 2001-06-07 Aga Ab Verwendung von Xenon bei der Behandlung von Neurointoxikationen
GB9913677D0 (en) 1999-06-11 1999-08-11 Imperial College Formulation
DE19933704A1 (de) 1999-07-19 2001-01-25 Michael Georgieff Verwendung einer lipophile Gase enthaltenden Präparation zur Neuroprotektion und Neuroregeneration
GB9917822D0 (en) 1999-07-29 1999-09-29 Imperial College Nmda antagonist
US6653354B2 (en) 1999-07-29 2003-11-25 Protexeon Limited NMDA antagonist comprising xenon
US6680068B2 (en) 2000-07-06 2004-01-20 The General Hospital Corporation Drug delivery formulations and targeting
DE10054563A1 (de) 2000-11-03 2002-05-16 Messer Griesheim Gmbh Verfahren und Vorrichtung zur Betonherstellung
AU2002220881A1 (en) 2000-12-04 2002-06-18 Uws Ventures Limited Noble gas complexes
ES2243350T3 (es) 2001-01-31 2005-12-01 Bracco International B.V. Agente de contraste liofizable que comprende microburbujas de gas.
WO2002100435A1 (en) 2001-06-11 2002-12-19 Centre Hospitalier Universitaire De Montreal Compositions and methods for enhancing nucleic acid transfer into cells
DE60236520D1 (de) 2001-08-16 2010-07-08 Univ Pennsylvania Synthese und verwendung von reagenzien für die verbesserte dna-lipofektion und/oder prodrug- und arzneimitteltherapien mit langsamer freisetzung
US7202089B2 (en) 2001-09-14 2007-04-10 Alan Kleinfeld Early diagnosis of stroke
GB0209998D0 (en) 2002-05-01 2002-06-12 Protexeon Ltd Use
CN1668315A (zh) * 2002-06-12 2005-09-14 梅瑟·格里斯海姆有限公司 使用含氙气体进行脑保护
DE10328272A1 (de) 2002-06-22 2004-01-15 Messer Griesheim Gmbh Medikament mit Xenon und NO
EP1519714B1 (en) 2002-06-28 2010-10-20 Protiva Biotherapeutics Inc. Method and apparatus for producing liposomes
EP1521598A1 (de) 2002-07-05 2005-04-13 Air Liquide Deutschland GmbH Xenon enthaltendes adjuvans
GB0218153D0 (en) 2002-08-05 2002-09-11 Ic Innovations Ltd An analgesic agent for newborn or retal subjects
DE10336768B4 (de) 2002-08-10 2010-09-09 Air Liquide Deutschland Gmbh Medikament zur Verbesserung der Sauerstoffutilation
DE10336778B4 (de) 2002-08-10 2010-09-16 Air Liquide Deutschland Gmbh Stabilisierung eines Patienten mit einem xenonhaltigen Gas
JP2006512906A (ja) 2002-09-28 2006-04-20 マサチューセッツ インスティチュート オブ テクノロジー インフルエンザ治療剤
WO2004047768A2 (en) 2002-11-26 2004-06-10 Seacoast Neuroscience, Inc. Buoyant polymer particles delivering therapeutic agents
WO2004064731A2 (en) 2003-01-14 2004-08-05 University Of Washington Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymlplhoid tissues
FR2849779B1 (fr) 2003-01-15 2006-07-14 Air Liquide Sante Sa Utilisation de xenon ou de n2o dans le traitement des deteriorations cellulaires cerebrales post-ischemiques
US7198179B2 (en) 2003-02-25 2007-04-03 Therox, Inc. System for storing and dispensing a gas-solubilized product
US20060019868A1 (en) 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
AU2004280118B2 (en) 2003-10-10 2009-01-15 Imperial Innovations Limited Use of xenon with hypothermia for treating neonatal asphyxia
EP1552840A1 (en) 2004-01-07 2005-07-13 Aga Ab Use of a xenon/carbon monoxide mixture for the protection of cells
GB0418540D0 (en) 2004-08-19 2004-09-22 Protexeon Ltd Use
EP1714642A1 (en) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
AU2005332157A1 (en) 2005-05-23 2006-11-30 Mebiopharm Co., Ltd., Method of producing liposomes containing gas enclosed therein
JP2009536663A (ja) 2006-05-09 2009-10-15 コルゲート・パーモリブ・カンパニー 口腔ケア措置
US7976743B2 (en) * 2006-10-16 2011-07-12 Northwestern University Gas-containing liposomes
US20080187605A1 (en) 2007-02-02 2008-08-07 Olney John W Preventing pathological nerve cell suicide (neuroapoptosis) in immature nervous systems
US9814672B2 (en) * 2007-03-09 2017-11-14 Susan T. Laing Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
EP1980260A1 (en) 2007-04-10 2008-10-15 Nicholas Peter Franks Use of hyperbaric conditions to provide neuroprotection
US8435569B2 (en) 2007-04-30 2013-05-07 Nnoxe Pharmaceutiques Inc. Pharmaceutical composition comprising at least one thrombolytic agent (A) and at least one gas (B) selected from the group consisting of nitrous oxide, argon, xenon, helium, neon
ITMI20071031A1 (it) 2007-05-22 2008-11-23 Acetilene & Deriv Ati Siad Spa Uso di xenon per la protezione di organi da danno ischemico
EP2229147A2 (en) * 2007-12-03 2010-09-22 The Johns Hopkins University Methods of synthesis and use of chemospheres
JP2011506432A (ja) 2007-12-10 2011-03-03 エピターゲット・アーエス 非ラメラ形成脂質を含む音響感受性薬物送達粒子
CL2007003772A1 (es) 2007-12-21 2008-04-25 Vulco Sa Procedimiento para la fabricacion de un mandril flexible de poliuretano, que contiene un alma metalica que comprende recubrir con goma un alma metalica, aplicar desmoldante, precalentar el conjunto, curar el poliuretano y enfriar el codo.
US8618056B2 (en) * 2007-12-22 2013-12-31 Cuthbert O. Simpkins Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
ES2758830T3 (es) 2008-11-10 2020-05-06 Moleac Pte Ltd Terapia combinada para el tratamiento de pacientes con trastornos neurológicos e infarto cerebral
EP2391341A4 (en) * 2009-01-30 2012-05-09 Cuthbert O Simpkins REVIVAL LIQUID
FR2944969B1 (fr) 2009-04-29 2011-08-26 Air Liquide Utilisation de n2o gazeux dans le traitement des douleurs chroniques
CN102625658B (zh) 2009-05-13 2015-01-28 锡德克斯药物公司 包含普拉格雷和环糊精衍生物的药物组合物及其制备和使用方法
US10130689B2 (en) * 2009-06-22 2018-11-20 Diffusion Pharmaceuticals Llc Diffusion enhancing compounds and their use alone or with thrombolytics
US8974818B2 (en) 2010-01-20 2015-03-10 Henry Wu Custom-formulated phospholipid microbubbles and methods and uses thereof
FR2956323B1 (fr) 2010-02-15 2013-12-20 Air Liquide Medicament gazeux inhalable a base d'argon contre les deficiences ou defaillances d'organes peripheriques
CN103079599B (zh) 2010-08-09 2017-05-10 博莱科瑞士股份有限公司 靶向气体填充微囊
WO2012096697A1 (en) 2011-01-14 2012-07-19 Simpkins Cuthbert O Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
US20130247924A1 (en) 2012-03-23 2013-09-26 Mark Scatterday Electronic cigarette having a flexible and soft configuration
CN103565745A (zh) 2012-08-10 2014-02-12 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法

Also Published As

Publication number Publication date
AU2013299453B2 (en) 2017-12-14
EP2882422A4 (en) 2016-03-16
US20200101015A1 (en) 2020-04-02
US10369103B2 (en) 2019-08-06
WO2014026117A2 (en) 2014-02-13
CN103565745A (zh) 2014-02-12
US20150216800A1 (en) 2015-08-06
CA2881096C (en) 2021-11-16
EP3932394B1 (en) 2024-08-07
JP6297040B2 (ja) 2018-03-20
EP2882422B1 (en) 2021-04-28
CA3132444A1 (en) 2014-02-13
WO2014026117A3 (en) 2014-10-23
EP3932394A1 (en) 2022-01-05
JP2015528441A (ja) 2015-09-28
CA2881096A1 (en) 2014-02-13
US20210378959A1 (en) 2021-12-09
US20240398708A1 (en) 2024-12-05
AU2013299453A1 (en) 2015-02-26
US11872312B2 (en) 2024-01-16
CN110464709A (zh) 2019-11-19
US10973764B2 (en) 2021-04-13
EP2882422A2 (en) 2015-06-17

Similar Documents

Publication Publication Date Title
US11872312B2 (en) Neuroprotective liposome compositions and methods for treatment of stroke
JP4555569B2 (ja) 増強された血中安定性を有する脂質キャリア組成物
US7976743B2 (en) Gas-containing liposomes
ES2704299T3 (es) Formulaciones de liposomas multivesiculares de ácido tranexámico
US10675245B2 (en) Sustained release formulation of a non-steroidal anti-inflammatory drug
AU2018307509A1 (en) Liposome compositions comprising weak acid drugs and uses thereof
CN107206110B (zh) 靶向的充气微囊制剂
MX2014007664A (es) Composiciones liposomicas de clorito o clorato.
JP2011506432A (ja) 非ラメラ形成脂質を含む音響感受性薬物送達粒子
JP6903318B2 (ja) 一酸化窒素内包バブルリポソーム及びその利用
Uhl et al. Reduction of skin flap necrosis by transdermal application of buflomedil bound to liposomes
HK40017554A (en) Neuroprotective liposome compositions and methods for treatment of stroke
HK1193995A (en) Neuroprotective liposome compositions and methods for treatment of stroke
CN115843246A (zh) 用于治疗血管瘤的方法和组合物
Wang Studies on temperature-sensitive liposomes for targeted delivery to the eye
HK1240506B (zh) 靶向的充气微囊制剂
HK1240506A1 (en) Targeted gas-filled microvesicles formulation

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210929

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 11TH ANNIV.) - STANDARD

Year of fee payment: 11

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240726

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20240726