CA3124422A1 - Inhibitors of cyclin-dependent kinase 7 and uses thereof - Google Patents

Inhibitors of cyclin-dependent kinase 7 and uses thereof Download PDF

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Publication number
CA3124422A1
CA3124422A1 CA3124422A CA3124422A CA3124422A1 CA 3124422 A1 CA3124422 A1 CA 3124422A1 CA 3124422 A CA3124422 A CA 3124422A CA 3124422 A CA3124422 A CA 3124422A CA 3124422 A1 CA3124422 A1 CA 3124422A1
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CA
Canada
Prior art keywords
substituted
unsubstituted
compound
certain embodiments
tautomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3124422A
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English (en)
French (fr)
Inventor
Nathanael S. Gray
Tinghu Zhang
Nicholas Paul Kwiatkowski
Jie Jiang
Mingfeng HAO
Zhixiang HE
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of CA3124422A1 publication Critical patent/CA3124422A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3124422A 2018-12-28 2019-12-27 Inhibitors of cyclin-dependent kinase 7 and uses thereof Pending CA3124422A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862786328P 2018-12-28 2018-12-28
US62/786,328 2018-12-28
PCT/US2019/068835 WO2020140098A1 (en) 2018-12-28 2019-12-27 Inhibitors of cyclin-dependent kinase 7 and uses thereof

Publications (1)

Publication Number Publication Date
CA3124422A1 true CA3124422A1 (en) 2020-07-02

Family

ID=71129897

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3124422A Pending CA3124422A1 (en) 2018-12-28 2019-12-27 Inhibitors of cyclin-dependent kinase 7 and uses thereof

Country Status (7)

Country Link
US (1) US12281126B2 (https=)
EP (1) EP3902542A4 (https=)
JP (1) JP7660063B2 (https=)
CN (1) CN113557017B (https=)
AU (1) AU2019413694B2 (https=)
CA (1) CA3124422A1 (https=)
WO (1) WO2020140098A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011090738A2 (en) 2009-12-29 2011-07-28 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
JP6854762B2 (ja) 2014-12-23 2021-04-07 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
USRE50776E1 (en) 2015-03-27 2026-02-03 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
AU2017363307B2 (en) 2016-11-22 2021-07-29 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 12 (CDK12) and uses thereof
EP3810132A4 (en) 2018-06-25 2022-06-22 Dana-Farber Cancer Institute, Inc. TAIRE FAMILY KINASE INHIBITORS AND RELATED USES
US12281126B2 (en) 2018-12-28 2025-04-22 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 and uses thereof
WO2021133601A1 (en) * 2019-12-24 2021-07-01 Dana-Farber Cancer Institute, Inc. The combination of cyclin dependent kinase 7 inhibitor and immunotherapy for treatment of cancer
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
CN114452391B (zh) * 2022-01-28 2023-08-25 深圳市泰尔康生物医药科技有限公司 Cdk16作为靶标在制备用于治疗三阴性乳腺癌的药物中的应用
WO2023246371A1 (zh) * 2022-06-24 2023-12-28 中国科学院基础医学与肿瘤研究所(筹) 具有嘧啶并噻吩结构的小分子化合物及其应用

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