CA3121405A1 - Sels cristallins de corydalmine - Google Patents
Sels cristallins de corydalmine Download PDFInfo
- Publication number
- CA3121405A1 CA3121405A1 CA3121405A CA3121405A CA3121405A1 CA 3121405 A1 CA3121405 A1 CA 3121405A1 CA 3121405 A CA3121405 A CA 3121405A CA 3121405 A CA3121405 A CA 3121405A CA 3121405 A1 CA3121405 A1 CA 3121405A1
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- salt form
- crystalline salt
- approximately
- tlz
- crystalline
- Prior art date
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- DIHXHTWYVOYYDC-INIZCTEOSA-N (13as)-2,3,9-trimethoxy-6,8,13,13a-tetrahydro-5h-isoquinolino[2,1-b]isoquinolin-10-ol Chemical class C1CN2CC(C(=C(O)C=C3)OC)=C3C[C@H]2C2=C1C=C(OC)C(OC)=C2 DIHXHTWYVOYYDC-INIZCTEOSA-N 0.000 title abstract description 5
- DIHXHTWYVOYYDC-UHFFFAOYSA-N tetrahydropalmatin Natural products C1CN2CC(C(=C(O)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 DIHXHTWYVOYYDC-UHFFFAOYSA-N 0.000 title abstract description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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Abstract
La présente invention concerne des formes de sel cristallin du composé suivant (1), également appelé l-corydalmine ou l-CDL, et des procédés pour leur préparation, et leur utilisation dans des méthodes pour le traitement de la douleur chronique, de l'anxiété, de l'insomnie, de l'hyperlipidémie, de l'hypercholestérolémie, de l'hypertriglycéridémie, de la stéatose hépatique et du syndrome métabolique, et al. (I)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2018/118203 WO2020107335A1 (fr) | 2018-11-29 | 2018-11-29 | Sels cristallins de corydalmine |
| CNPCT/CN2018/118203 | 2018-11-29 | ||
| PCT/CN2019/118903 WO2020108330A1 (fr) | 2018-11-29 | 2019-11-15 | Sels cristallins de corydalmine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3121405A1 true CA3121405A1 (fr) | 2020-06-04 |
| CA3121405C CA3121405C (fr) | 2024-01-02 |
Family
ID=70851885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3121405A Active CA3121405C (fr) | 2018-11-29 | 2019-11-15 | Sels cristallins de corydalmine |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11236081B2 (fr) |
| EP (1) | EP3887367A4 (fr) |
| JP (1) | JP7194828B2 (fr) |
| CN (1) | CN111788201B (fr) |
| AU (1) | AU2019385971B2 (fr) |
| CA (1) | CA3121405C (fr) |
| SG (1) | SG11202105355XA (fr) |
| WO (2) | WO2020107335A1 (fr) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280827A (zh) * | 1999-01-04 | 2001-01-24 | 中国科学院成都生物研究所 | 含一类生物碱的σ受体作用药 |
| CN1164759C (zh) * | 2002-09-29 | 2004-09-01 | 中国药科大学 | 紫堇达明的生物转化制备方法及其在制备镇痛药中的应用 |
| CN1726990A (zh) * | 2005-07-26 | 2006-02-01 | 中国人民解放军军事医学科学院基础医学研究所 | 含有效生物碱的天然中草药在戒毒药中的应用及提取工艺 |
| WO2009002873A1 (fr) | 2007-06-22 | 2008-12-31 | Cvi Pharmaceuticals Limited | Composés, compositions et procédés pour réduire des niveaux de lipide |
| CN103214477A (zh) * | 2013-05-08 | 2013-07-24 | 中国药科大学 | 一种利用碱化硅胶分离紫堇达明生物碱的工艺 |
| CN105566316A (zh) * | 2014-10-17 | 2016-05-11 | 刘力 | 二苯并喹嗪类化合物实体及其用途 |
| CN106176740B (zh) * | 2016-07-01 | 2019-02-26 | 北京泰舟利泽医药科技有限公司 | 紫堇达明抗成瘾的医药用途 |
| CN106237333A (zh) | 2016-07-08 | 2016-12-21 | 杨征 | 紫堇达明的医药用途 |
| CN107260738A (zh) | 2017-07-11 | 2017-10-20 | 上海华堇生物技术有限责任公司 | 紫堇达明碱的药物用途 |
-
2018
- 2018-11-29 US US16/612,379 patent/US11236081B2/en active Active
- 2018-11-29 WO PCT/CN2018/118203 patent/WO2020107335A1/fr active Application Filing
-
2019
- 2019-11-15 EP EP19888289.6A patent/EP3887367A4/fr active Pending
- 2019-11-15 WO PCT/CN2019/118903 patent/WO2020108330A1/fr unknown
- 2019-11-15 CN CN201980016180.3A patent/CN111788201B/zh active Active
- 2019-11-15 CA CA3121405A patent/CA3121405C/fr active Active
- 2019-11-15 JP JP2021531365A patent/JP7194828B2/ja active Active
- 2019-11-15 SG SG11202105355XA patent/SG11202105355XA/en unknown
- 2019-11-15 AU AU2019385971A patent/AU2019385971B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020107335A1 (fr) | 2020-06-04 |
| EP3887367A1 (fr) | 2021-10-06 |
| AU2019385971A1 (en) | 2021-06-10 |
| JP7194828B2 (ja) | 2022-12-22 |
| AU2019385971B2 (en) | 2022-11-03 |
| EP3887367A4 (fr) | 2022-12-28 |
| SG11202105355XA (en) | 2021-06-29 |
| WO2020108330A1 (fr) | 2020-06-04 |
| CN111788201B (zh) | 2021-12-28 |
| JP2022509701A (ja) | 2022-01-21 |
| CA3121405C (fr) | 2024-01-02 |
| CN111788201A (zh) | 2020-10-16 |
| US20210347770A1 (en) | 2021-11-11 |
| US11236081B2 (en) | 2022-02-01 |
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