CA3115082A1 - B7h3 single domain antibodies and therapeutic compositions thereof - Google Patents
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
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| US201862744640P | 2018-10-11 | 2018-10-11 | |
| US62/744,640 | 2018-10-11 | ||
| US201962832274P | 2019-04-10 | 2019-04-10 | |
| US62/832,274 | 2019-04-10 | ||
| US201962877812P | 2019-07-23 | 2019-07-23 | |
| US62/877,812 | 2019-07-23 | ||
| PCT/US2019/055427 WO2020076970A1 (en) | 2018-10-11 | 2019-10-09 | B7h3 single domain antibodies and therapeutic compositions thereof |
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| CA3115082A1 true CA3115082A1 (en) | 2020-04-16 |
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| CA3115082A Pending CA3115082A1 (en) | 2018-10-11 | 2019-10-09 | B7h3 single domain antibodies and therapeutic compositions thereof |
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| EP (1) | EP3864044A1 (enExample) |
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| CA (1) | CA3115082A1 (enExample) |
| TW (1) | TW202028246A (enExample) |
| WO (1) | WO2020076970A1 (enExample) |
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| KR20210006913A (ko) | 2018-04-11 | 2021-01-19 | 인히브릭스, 인크. | 제한된 ｃｄ3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도 |
| TW202035451A (zh) | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| CA3115089A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
| MX2022009306A (es) * | 2020-01-29 | 2022-09-26 | Inhibrx Inc | Loseta de nucleo de espuma densificada (dfc) con linea de anticuerpos de dominio individual de cd28 y constructos multivalentes y multiespecíficas de los mismos. |
| CN112961242B (zh) * | 2020-06-30 | 2022-01-04 | 广州百暨基因科技有限公司 | 抗b7h3抗体及其应用 |
| EP4154910A4 (en) * | 2020-06-30 | 2024-09-11 | Harbour Biomed (Shanghai) Co., Ltd | Binding protein having h2l2 and hcab structures |
| WO2022040482A1 (en) | 2020-08-19 | 2022-02-24 | Xencor, Inc. | Anti-cd28 and/or anti-b7h3 compositions |
| WO2022200525A1 (en) | 2021-03-26 | 2022-09-29 | Innate Pharma | Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging |
| WO2022258691A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a |
| WO2022258678A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a |
| CN117616050A (zh) | 2021-06-09 | 2024-02-27 | 先天制药公司 | 与nkp46、细胞因子受体、肿瘤抗原和cd16a结合的多特异性蛋白质 |
| MX2023015153A (es) * | 2021-07-01 | 2024-04-16 | Ningbo T Maximum Biopharmaceuticals Co Ltd | Polipéptido de unión a antígeno que se dirige a b7h3 y aplicación del mismo. |
| US20240417469A1 (en) * | 2021-10-12 | 2024-12-19 | Concept To Medicine Biotech Co., Ltd. | Cd3-targeting t-cell engagers with improved therapeutic index |
| CN113980143B (zh) * | 2021-11-02 | 2023-04-25 | 深圳先进技术研究院 | 靶向cd276的嵌合抗原受体、嵌合抗原受体t细胞及制备方法和制药应用 |
| US20250019460A1 (en) * | 2021-12-01 | 2025-01-16 | Epsilon Molecular Engineering Inc. | Peptide having framework sequence for random region placement and peptide library composed of said peptide |
| MX2024010339A (es) | 2022-02-23 | 2024-09-30 | Xencor Inc | Anticuerpos anti-cd28 x anti-psma. |
| CN120077067A (zh) * | 2022-08-08 | 2025-05-30 | 提克瓦阿洛塞尔私人有限公司 | B7-h3抗原结合分子 |
| EP4590712A1 (en) * | 2022-09-22 | 2025-07-30 | Shanghai Henlius Biotech, Inc. | Anti-b7h3 antibodies and methods of use |
| WO2024061297A1 (en) * | 2022-09-22 | 2024-03-28 | Shanghai Henlius Biotech , Inc. | Anti-b7h3 antibodies, multispecific antibodies and methods of use |
| TW202428608A (zh) * | 2022-12-29 | 2024-07-16 | 英屬開曼群島商百濟神州有限公司 | 抗b7h3抗體以及其使用方法 |
| CN120530135A (zh) * | 2022-12-29 | 2025-08-22 | 广州百济神州生物制药有限公司 | 抗b7h3抗体和使用方法 |
| WO2024208818A1 (en) | 2023-04-04 | 2024-10-10 | Innate Pharma | Modular chimeric antigen receptor |
| WO2025112030A1 (zh) * | 2023-12-01 | 2025-06-05 | 苏州智核生物医药科技有限公司 | B7h3结合多肽及其用途 |
| WO2025146081A1 (zh) * | 2024-01-03 | 2025-07-10 | 北京泰德制药股份有限公司 | B7-h3结合蛋白 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| WO2025157244A1 (zh) * | 2024-01-25 | 2025-07-31 | 山东先声生物制药有限公司 | 抗b7h3抗体及其应用 |
| CN118702816B (zh) * | 2024-06-03 | 2025-03-28 | 内蒙古正德缘生物科技有限责任公司 | 一种nk细胞及其在抗肿瘤治疗中的应用 |
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2019
- 2019-10-09 CA CA3115082A patent/CA3115082A1/en active Pending
- 2019-10-09 TW TW108136773A patent/TW202028246A/zh unknown
- 2019-10-09 JP JP2021520197A patent/JP2022512684A/ja not_active Ceased
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- 2019-10-09 WO PCT/US2019/055427 patent/WO2020076970A1/en not_active Ceased
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| EP3864044A1 (en) | 2021-08-18 |
| JP2024167342A (ja) | 2024-12-03 |
| TW202028246A (zh) | 2020-08-01 |
| CN113166261A (zh) | 2021-07-23 |
| JP2022512684A (ja) | 2022-02-07 |
| US20230124851A1 (en) | 2023-04-20 |
| WO2020076970A1 (en) | 2020-04-16 |
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