CA3105953A1 - Fusosome compositions and uses thereof - Google Patents
Fusosome compositions and uses thereof Download PDFInfo
- Publication number
- CA3105953A1 CA3105953A1 CA3105953A CA3105953A CA3105953A1 CA 3105953 A1 CA3105953 A1 CA 3105953A1 CA 3105953 A CA3105953 A CA 3105953A CA 3105953 A CA3105953 A CA 3105953A CA 3105953 A1 CA3105953 A1 CA 3105953A1
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- CA
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- Prior art keywords
- fusosome
- cell
- protein
- liver
- fold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18211—Henipavirus, e.g. hendra virus
- C12N2760/18222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18811—Sendai virus
- C12N2760/18822—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862695650P | 2018-07-09 | 2018-07-09 | |
| US201862695537P | 2018-07-09 | 2018-07-09 | |
| US62/695,650 | 2018-07-09 | ||
| US62/695,537 | 2018-07-09 | ||
| US201862767241P | 2018-11-14 | 2018-11-14 | |
| US201862767261P | 2018-11-14 | 2018-11-14 | |
| US62/767,241 | 2018-11-14 | ||
| US62/767,261 | 2018-11-14 | ||
| US201962848284P | 2019-05-15 | 2019-05-15 | |
| US201962848305P | 2019-05-15 | 2019-05-15 | |
| US62/848,284 | 2019-05-15 | ||
| US62/848,305 | 2019-05-15 | ||
| PCT/US2019/040978 WO2020014209A1 (en) | 2018-07-09 | 2019-07-09 | Fusosome compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3105953A1 true CA3105953A1 (en) | 2020-01-16 |
Family
ID=67659932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3105953A Pending CA3105953A1 (en) | 2018-07-09 | 2019-07-09 | Fusosome compositions and uses thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12378578B2 (https=) |
| EP (1) | EP3820509A1 (https=) |
| JP (1) | JP7588578B2 (https=) |
| KR (1) | KR20210043574A (https=) |
| CN (1) | CN112955174A (https=) |
| AU (1) | AU2019301053A1 (https=) |
| BR (1) | BR112021000145A2 (https=) |
| CA (1) | CA3105953A1 (https=) |
| IL (1) | IL279897A (https=) |
| MX (1) | MX2021000308A (https=) |
| SG (1) | SG11202100071YA (https=) |
| WO (1) | WO2020014209A1 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
| US12590321B2 (en) | 2016-03-19 | 2026-03-31 | Exuma Biotech Corp. | Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| EP3820509A1 (en) | 2018-07-09 | 2021-05-19 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| US12496274B2 (en) | 2018-11-14 | 2025-12-16 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート,インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| WO2021016075A1 (en) | 2019-07-19 | 2021-01-28 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| AU2020341454A1 (en) | 2019-09-03 | 2022-03-10 | Sana Biotechnology, Inc. | CD24-associated particles and related methods and uses thereof |
| IL296024A (en) | 2020-03-04 | 2022-10-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for modulating a genome |
| JP2023521663A (ja) * | 2020-03-31 | 2023-05-25 | サナ バイオテクノロジー,インコーポレイテッド | 標的化脂質粒子及び組成物ならびにその使用 |
| EP3913060A1 (en) * | 2020-05-22 | 2021-11-24 | Genethon | Vectors encoding a glucose-6-phosphatase (g6pase-a) for gene therapy |
| US20230210959A1 (en) * | 2020-06-16 | 2023-07-06 | Novel Pharma Inc. | Composition for treatment of glutaric aciduria and administration method therefor |
| EP4185600A4 (en) | 2020-07-24 | 2024-12-04 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| CN114058689B (zh) * | 2020-07-30 | 2024-08-20 | 南京市妇幼保健院 | 一种基因突变检测试剂盒及其应用 |
| EP4274901A1 (en) * | 2021-01-11 | 2023-11-15 | Sana Biotechnology, Inc. | Use of cd8-targeted viral vectors |
| IL307544A (en) | 2021-04-08 | 2023-12-01 | Sana Biotechnology Inc | Cd8-specific antibody constructs and compositions thereof |
| AU2022280957A1 (en) | 2021-05-28 | 2023-11-30 | Sana Biotechnology, Inc. | Lipid particles containing a truncated baboon endogenous retrovirus (baev) envelope glycoprotein and related methods and uses |
| WO2023015217A1 (en) | 2021-08-04 | 2023-02-09 | Sana Biotechnology, Inc. | Use of cd4-targeted viral vectors |
| WO2023023467A1 (en) * | 2021-08-17 | 2023-02-23 | Interius Biotherapeutics, Inc. | Nucleic acid molecules and methods of using the same |
| CN113960317A (zh) * | 2021-08-19 | 2022-01-21 | 深圳市辅酶医科技有限公司 | 一种测量生物样品中nad+浓度的生物传感器及方法 |
| CN113694072A (zh) * | 2021-08-27 | 2021-11-26 | 南京大学 | Ggpp结合并变构激活人源fbp1在制备抗肝细胞癌药物中的应用 |
| JP2024533311A (ja) | 2021-09-08 | 2024-09-12 | フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー | ゲノムを調節するための方法及び組成物 |
| US20240342314A1 (en) * | 2021-09-30 | 2024-10-17 | The Board Of Regents Of The University Of Texas System | Slc13a5 gene therapy vectors and uses thereof |
| CN114032239B (zh) * | 2021-10-28 | 2024-06-21 | 北京美康基免生物科技有限公司 | 一种组织特异启动子及其应用 |
| EP4426331A1 (en) | 2021-11-02 | 2024-09-11 | University of Rochester | Tcf7l2 mediated remyelination in the brain |
| CN113969264B (zh) * | 2021-11-29 | 2023-12-08 | 中南大学 | Cog5基因敲除的人胚胎干细胞系、构建方法及应用 |
| EP4448775A1 (en) | 2021-12-17 | 2024-10-23 | Sana Biotechnology, Inc. | Modified paramyxoviridae attachment glycoproteins |
| US20250059239A1 (en) | 2021-12-17 | 2025-02-20 | Sana Biotechnology, Inc. | Modified paramyxoviridae fusion glycoproteins |
| CN114292319B (zh) * | 2021-12-31 | 2023-11-14 | 中国科学院遗传与发育生物学研究所 | 水稻ETFβ基因在调控植物育性中的应用 |
| EP4472646A1 (en) | 2022-02-01 | 2024-12-11 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
| US20250144235A1 (en) | 2022-02-02 | 2025-05-08 | Sana Biotechnology, Inc. | Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023158487A1 (en) * | 2022-02-15 | 2023-08-24 | The Broad Institute, Inc. | Cell-type specific membrane fusion proteins |
| US20250222027A1 (en) | 2022-04-01 | 2025-07-10 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| CN114875087B (zh) * | 2022-04-27 | 2023-08-04 | 河北维达康生物科技有限公司 | 以β-吲哚基丙氨酸为底物合成5-羟基β-吲哚基丙氨酸的方法及其应用 |
| CN119213133B (zh) | 2022-05-16 | 2026-01-06 | 上海天泽云泰生物医药有限公司 | 用于治疗i型戊二酸尿症的重组aav载体 |
| EP4641202A3 (en) | 2022-05-25 | 2026-01-21 | Flagship Pioneering Innovations VII, LLC | Compositions and methods for modulation of immune responses |
| US20250319115A1 (en) | 2022-05-25 | 2025-10-16 | Flagship Pioneering Innovations Vii, Llc | Compositions and Methods for Modulating Cytokines |
| JP2025517969A (ja) | 2022-05-25 | 2025-06-12 | フラッグシップ パイオニアリング イノベーションズ セブン,エルエルシー | 腫瘍抑制因子及び癌遺伝子の調節のための組成物及び方法 |
| CA3253328A1 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vii, Llc | Compositions and Modulation Methods of Genetic Drivers |
| US20250320254A1 (en) | 2022-05-25 | 2025-10-16 | Flagship Pioneering Innovations Vii, Llc | Compositions and Methods for Modulating Circulating Factors |
| US20260055146A1 (en) | 2022-08-24 | 2026-02-26 | Sana Biotechnology, Inc. | Delivery of heterologous proteins |
| CN115851632B (zh) * | 2022-08-25 | 2024-04-26 | 华中农业大学 | 一种漆酶突变体及其应用 |
| US20260098062A1 (en) | 2022-09-21 | 2026-04-09 | Sana Biotechnology, Inc. | Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof |
| WO2024081820A1 (en) | 2022-10-13 | 2024-04-18 | Sana Biotechnology, Inc. | Viral particles targeting hematopoietic stem cells |
| WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
| WO2024163747A2 (en) | 2023-02-02 | 2024-08-08 | University Of Rochester | Competitive replacement of glial cells |
| WO2024186695A2 (en) * | 2023-03-03 | 2024-09-12 | Trustees Of Boston University | Immune cell fusion (icf) and uses thereof |
| EP4698665A1 (en) | 2023-04-18 | 2026-02-25 | Sana Biotechnology, Inc. | Engineered protein g fusogens and related lipid particles and methods thereof |
| EP4698666A1 (en) | 2023-04-18 | 2026-02-25 | Sana Biotechnology, Inc. | Universal protein g fusogens and adapter systems thereof and related lipid particles and uses |
| KR20240154736A (ko) * | 2023-04-18 | 2024-10-28 | 가톨릭대학교 산학협력단 | 면역관문 억제제의 표적화된 전달을 위한 세포외소포체의 용도 |
| KR20260016952A (ko) | 2023-05-23 | 2026-02-04 | 사나 바이오테크놀로지, 인크. | 탠덤 퓨소젠 및 관련 지질 입자 |
| CN116970650B (zh) * | 2023-09-22 | 2023-12-08 | 深圳华大生命科学研究院 | 一种包膜蛋白组合、含其的靶向病毒载体及制备方法 |
| WO2025072667A2 (en) * | 2023-09-29 | 2025-04-03 | University Of Utah Research Foundation | Compositions and methods for treating phosphomannomutase 2 (pmm2) deficiency |
| WO2025184529A1 (en) | 2024-03-01 | 2025-09-04 | Sana Biotechnology, Inc. | Viral particles with fusogen display and related compositions and methods |
| WO2025194138A1 (en) | 2024-03-14 | 2025-09-18 | Tessera Therapeutics, Inc. | St1cas9 compositions and methods for modulating a genome |
| WO2025256433A1 (zh) * | 2024-06-14 | 2025-12-18 | 四川大学华西医院 | 一种转铁蛋白受体1靶向性糖苷水解酶复合体的制备方法及应用 |
| CN120160961B (zh) * | 2025-03-25 | 2026-02-03 | 北京大学第三医院(北京大学第三临床医学院) | 一种全光谱流式检测细胞代谢的新探针组合及其应用 |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US274651A (en) | 1883-03-27 | Advertising-windmill | ||
| US4623620A (en) | 1983-08-02 | 1986-11-18 | Stichting Vrienden Van De Stichting Dr. Karl Landsteiner | Enucleated granulocytes, their preparation and use |
| IL78703A (en) | 1985-05-10 | 1993-02-21 | Benzon Alfred | Method of producing extracellular enzymes, the enzymes produced thereby and compositions containing them; a hybrid plasmid and a dna fragment comprising dna encoding the enzymes; a microorganism harbouring the plasmid; and a method for removing nucleic acids from biological materials |
| CA2096222C (en) | 1990-11-13 | 1998-12-29 | Stephen D. Lupton | Bifunctional selectable fusion genes |
| ATE245703T1 (de) | 1992-09-22 | 2003-08-15 | Biofocus Discovery Ltd | Rekombinante viren, die an ihrer äusseren oberfläche ein nichtvirales polypeptid präsentieren |
| US6534051B1 (en) | 1992-11-20 | 2003-03-18 | University Of Medicine And Dentistry Of New Jersey | Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins |
| WO1994028143A1 (en) | 1993-05-21 | 1994-12-08 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| JPH10501403A (ja) | 1994-03-04 | 1998-02-10 | ユニバーシティ オブ メディシン アンド デンティストリー オブ ニュージャージー | 抗体−エンベロープ融合タンパク質および野生型エンベロープ融合タンパク質を含むレトロウィルスベクターを用いる細胞型特異的遺伝子移入 |
| AU2589095A (en) | 1994-05-16 | 1995-12-05 | Washington University | Cell membrane fusion composition and method |
| WO1997004748A2 (en) | 1995-08-01 | 1997-02-13 | Advanced Therapies, Inc. | Enhanced artificial viral envelopes for cellular delivery of therapeutic substances |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| PL332875A1 (en) | 1996-10-17 | 1999-10-25 | Oxford Biomedica Ltd | Retroviral vectors |
| JPH10313865A (ja) | 1997-05-15 | 1998-12-02 | Deinabetsuku Kenkyusho:Kk | ヒト補体制御因子が呈示されたベクター |
| WO1999013905A1 (en) | 1997-09-18 | 1999-03-25 | The Trustees Of The University Of Pennsylvania | Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery |
| GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| ES2373406T3 (es) | 1997-12-22 | 2012-02-03 | Oxford Biomedica (Uk) Limited | Vectores basados en el virus de la anemia infecciosa equina (vaie). |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| FR2777909B1 (fr) | 1998-04-24 | 2002-08-02 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
| NZ509978A (en) | 1998-09-23 | 2002-12-20 | Austrian Nordic Biotherapeutic | Removed particles protected against complement mediated destruction |
| US6896881B1 (en) | 1999-09-24 | 2005-05-24 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
| DE60132436T2 (de) | 2000-03-30 | 2008-04-17 | Oxford Biomedica (Uk) Ltd. | Retinolsäure-rezeptor beta-2 und gentherapievektoren für die behandlung von neurologischen erkrankungen |
| WO2001074861A2 (en) | 2000-03-31 | 2001-10-11 | Mayo Foundation For Medical Education And Research | Compositions and methods for tissue specific gene regulation therapy |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| WO2002002765A2 (en) | 2000-07-05 | 2002-01-10 | Transgene S.A. | Chimeric promoters for controlling expression in smooth muscle cells |
| US6276394B1 (en) | 2000-07-11 | 2001-08-21 | General Valve, Inc. | Compact stem set with load-balanced rollers for non-lubricated double block and bleed plug valves |
| CA2325088A1 (en) | 2000-12-01 | 2002-06-01 | Fusogenix Inc. | Novel membrane fusion proteins derived from poikilothermic reovirus |
| ATE452972T1 (de) | 2001-05-01 | 2010-01-15 | Ca Nat Research Council | Induzierbares expressionssystem in eukaryotischen zellen |
| CA2464887A1 (en) | 2001-10-30 | 2003-05-08 | Biogen, Inc. | Methods and compositions for treating parkinson's disease |
| US20040028687A1 (en) | 2002-01-15 | 2004-02-12 | Waelti Ernst Rudolf | Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues |
| AU2003258060B2 (en) | 2002-03-27 | 2007-07-12 | Baylor College Of Medicine | Potent oncolytic herpes simplex virus for cancer therapy |
| ES2627445T3 (es) | 2002-05-01 | 2017-07-28 | Miltenyi Biotec Technology, Inc. | Partículas de vector de lentivirus resistentes a la inactivación por el complemento |
| DE60335672D1 (de) | 2002-05-14 | 2011-02-17 | Merck Sharp & Dohme | Verfahren zur reinigung von adenovirus |
| CA2503317A1 (en) | 2002-10-24 | 2004-05-06 | Dnavec Research Inc. | Method of transferring gene into t cells |
| PL377161A1 (pl) | 2002-11-21 | 2006-01-23 | Pevion Biotech Ltd. | Wysoce efektywne pęcherzyki fuzogenne, sposób ich wytwarzania oraz kompozycje farmaceutyczne zawierające te pęcherzyki |
| US7842673B2 (en) | 2003-12-17 | 2010-11-30 | The Trustees Of Columbia University In The City Of New York | Delivery of DNA or RNA via gap junctions from host cells to target cells and a cell-based delivery system for antisense or siRNA |
| US20060045910A1 (en) | 2004-09-02 | 2006-03-02 | Ehringer William D | Preserved fusogenic vesicles |
| WO2006027202A1 (en) | 2004-09-06 | 2006-03-16 | Unite De Recherche En Biotherapie Et Oncologie (Rubio) | Generation of multiparent cell hybrids |
| JP2008518630A (ja) | 2004-11-08 | 2008-06-05 | イェール ユニバーシティ | リボスイッチ、リボスイッチによる、構造を基礎とする化合物設計、ならびにリボスイッチの使用方法およびリボスイッチを伴う組成物 |
| GB0426641D0 (en) | 2004-12-03 | 2005-01-05 | Bioactive Protein Delivery The | Protein delivery system |
| US8034331B2 (en) | 2005-01-20 | 2011-10-11 | Agency For Science, Technology And Research | Method of delivery of nucleic acids to peripheral neurons |
| PT1881845E (pt) | 2005-04-25 | 2010-05-31 | Merial Ltd | Vacinas de vírus nipah |
| PL2002003T3 (pl) | 2005-05-27 | 2016-06-30 | Ospedale San Raffaele Srl | Wektor genetyczny zawierający mi-RNA |
| WO2007005244A1 (en) | 2005-07-05 | 2007-01-11 | The Regents Of The University Of California | Henipavirus receptor and uses thereof |
| WO2007099387A1 (en) | 2006-03-03 | 2007-09-07 | Mymetics Corporation | Virosome-like vesicles comprising gp41-derived antigens |
| EP2062246A4 (en) | 2006-08-18 | 2010-09-29 | Univ North Carolina | VACCINES AGAINST CHIMARICAL VIRUSES |
| EP1975239A1 (en) | 2006-09-27 | 2008-10-01 | Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer | Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening |
| WO2008071959A1 (en) | 2006-12-12 | 2008-06-19 | Oxford Biomedica (Uk) Limited | Lentiviral vectors comprising micrornas |
| CN102014934B (zh) | 2008-02-22 | 2014-08-20 | 新加坡科技研究局 | 间充质干细胞颗粒 |
| EP4154903A1 (en) * | 2008-04-22 | 2023-03-29 | Vib Vzw | Liver-specific nucleic acid regulatory elements and methods and use thereof |
| US9296790B2 (en) | 2008-10-03 | 2016-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for protein delivery |
| CN102264349A (zh) | 2008-11-07 | 2011-11-30 | 儿童医院医疗中心 | 用于跨膜药物递送系统的鞘脂激活蛋白c以及相关蛋白和肽促融合性质 |
| US9050269B2 (en) | 2009-03-10 | 2015-06-09 | The Trustees Of The University Of Pennsylvania | Protection of virus particles from phagocytosis by expression of CD47 |
| JP5667180B2 (ja) | 2009-07-01 | 2015-02-12 | イオン メディックス インコーポレイテッド | 哺乳類の有核細胞に由来するマイクロベシクル及びその用途 |
| ES2455544T5 (es) | 2009-07-24 | 2017-08-16 | Immune Design Corp | Vectores de lentivirus pseudotipificados con una glucoproteína de envoltura de virus sindbis |
| ES2693167T3 (es) | 2009-11-13 | 2018-12-07 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Administración directa de proteínas con microvesículas modificadas por ingeniería |
| US20120093885A1 (en) | 2010-10-18 | 2012-04-19 | Northwestern University | Therapeutic vesicles |
| AU2012249474A1 (en) | 2011-04-28 | 2013-11-07 | Stc.Unm | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same |
| WO2012156839A2 (en) | 2011-05-19 | 2012-11-22 | Ospedale San Raffaele S.R.L. | New generation of splice-less lentiviral vectors for safer gene therapy applications |
| CN103857387B (zh) | 2011-06-02 | 2017-03-15 | 加利福尼亚大学董事会 | 膜包封的纳米颗粒及使用方法 |
| RU2014100160A (ru) | 2011-06-10 | 2015-07-20 | Блуберд Байо, Инк. | Векторы генной терапии адренолейкодистрофии и адреномиелонейропатии |
| JP2013034401A (ja) | 2011-08-04 | 2013-02-21 | Gunma Univ | アストロサイトで遺伝子を発現させるためのベクター |
| GB201121070D0 (en) | 2011-12-07 | 2012-01-18 | Isis Innovation | composition for delivery of biotherapeutics |
| EP2615176A1 (en) | 2012-01-11 | 2013-07-17 | Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe | Novel pseudotyped lentiviral particles and their use in the in vitro targeted transduction of undifferentiated pluripotent human embryonic stem cells and induced pluripotent stem cells |
| WO2013148327A1 (en) | 2012-03-26 | 2013-10-03 | The Regents Of The University Of California | Nipah virus envelope psuedotyped lentiviruses and methods of their use |
| EP2839032A4 (en) | 2012-04-16 | 2015-11-18 | Univ Texas | PROOF OF EXCELLULAR JCV MIRNA |
| ES2686129T3 (es) | 2012-11-13 | 2018-10-16 | Codiak Biosciences, Inc. | Administración de agentes terapéuticos |
| GB201313249D0 (en) | 2013-07-25 | 2013-09-11 | Isis Innovation | Method |
| EA037503B1 (ru) | 2014-01-21 | 2021-04-05 | Анджариум Байосайенсиз Аг | Способ получения гибридосомы, гибридосома, полученная при помощи способа, и способ доставки терапевтического или диагностического средства |
| US9668147B2 (en) | 2014-01-22 | 2017-05-30 | Maxlinear, Inc. | Autoconfigured backhaul transceiver |
| CA2945335A1 (en) | 2014-04-18 | 2015-10-22 | Editas Medicine, Inc. | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| GB201412494D0 (en) | 2014-07-14 | 2014-08-27 | Ospedale San Raffaele And Fond Telethon | Vector production |
| US10501733B2 (en) | 2015-02-27 | 2019-12-10 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
| US20180135012A1 (en) | 2015-05-13 | 2018-05-17 | Rubius Therapeutics, Inc. | Membrane-receiver complex therapeutics |
| WO2016196350A1 (en) | 2015-05-29 | 2016-12-08 | New York University | Auf1 encoding compositions for muscle cell uptake, satellite cell populations, and satellite cell mediated muscle generation |
| WO2016210170A1 (en) | 2015-06-23 | 2016-12-29 | The Children's Hospital Of Philadelphia | Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues |
| EP3322297B1 (en) | 2015-07-13 | 2024-12-04 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| US10624849B2 (en) | 2015-09-28 | 2020-04-21 | Northwestern University | Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites |
| US20170112773A1 (en) | 2015-10-23 | 2017-04-27 | Board Of Regents, The University Of Texas System | Plasma membrane vesicles comprising functional transmembrane proteins |
| WO2017151717A1 (en) | 2016-03-01 | 2017-09-08 | French Brent A | Compositions and methods for adeno-associated virus mediated gene expression in myofibroblast-like cells |
| IL261713B2 (en) | 2016-03-19 | 2023-09-01 | F1 Oncology Inc | Methods and preparations for the transfer of lymphocytes and their regulated expansion |
| WO2017173034A1 (en) | 2016-03-30 | 2017-10-05 | The University Of North Carolina At Chapel Hill | Biological agent-exosome compositions and uses thereof |
| WO2017173367A2 (en) | 2016-03-31 | 2017-10-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Extracellular vesicles, methods of making them, and methods of reducing liver uptake of extracellular vesicles |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| JP7072807B2 (ja) | 2016-06-09 | 2022-05-23 | アルマ・マテール・ストゥディオルム・ウニベルシータ・ディ・ボローニャ | 細胞内増殖のための改変糖タンパク質hを有するヘルペスウイルス |
| CN109415698A (zh) | 2016-06-16 | 2019-03-01 | 斯隆-凯特林纪念癌症中心 | 工程化Treg细胞 |
| EP3472318B1 (en) | 2016-07-08 | 2023-09-06 | Exuma Biotech Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| US20180028600A1 (en) | 2016-07-15 | 2018-02-01 | Korea Institute Of Science And Technology | Novel recombinant exosome and use thereof |
| KR20190053179A (ko) | 2016-07-26 | 2019-05-17 | 센티 바이오사이언시스, 인코포레이티드 | 유전자 지우개들 |
| JP7483373B2 (ja) | 2016-07-29 | 2024-05-15 | ジュノー セラピューティクス インコーポレイテッド | 複製可能ウイルスの存在または非存在を評価するための方法 |
| EP3540056A4 (en) | 2016-11-10 | 2020-06-03 | Kaneka Corporation | METHOD FOR PRODUCING TRANSGENIC CELLS |
| AU2018206485B2 (en) | 2017-01-09 | 2024-12-05 | Oisin Biotechnologies | Fusogenic lipid nanoparticles and methods for manufacturing and use for therapeutic protein production and for treatment |
| AU2018266111B2 (en) * | 2017-05-08 | 2024-11-07 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| US20210187018A1 (en) | 2017-12-07 | 2021-06-24 | Flagship Pioneering Innovations V, Inc. | Cytobiologics and therapeutic uses thereof |
| AU2019215063B2 (en) | 2018-02-01 | 2025-10-16 | Bioverativ Therapeutics, Inc. | Use of lentiviral vectors expressing Factor VIII |
| CA3091478A1 (en) | 2018-02-17 | 2019-08-22 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for membrane protein delivery |
| AU2019269593A1 (en) | 2018-05-15 | 2020-11-26 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
| EP3820509A1 (en) | 2018-07-09 | 2021-05-19 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
| EP3880832A1 (en) | 2018-11-14 | 2021-09-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for hematopoietic stem cell delivery |
| SG11202105079QA (en) | 2018-11-14 | 2021-06-29 | Flagship Pioneering Innovations V Inc | Fusosome compositions for cns delivery |
| US12496274B2 (en) | 2018-11-14 | 2025-12-16 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
| WO2020102503A2 (en) | 2018-11-14 | 2020-05-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for t cell delivery |
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