CA3104237A1 - 4-substituted phenyl-1,3,5-triazine derivatives as modulators of trk receptors - Google Patents
4-substituted phenyl-1,3,5-triazine derivatives as modulators of trk receptors Download PDFInfo
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- CA3104237A1 CA3104237A1 CA3104237A CA3104237A CA3104237A1 CA 3104237 A1 CA3104237 A1 CA 3104237A1 CA 3104237 A CA3104237 A CA 3104237A CA 3104237 A CA3104237 A CA 3104237A CA 3104237 A1 CA3104237 A1 CA 3104237A1
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Classifications
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
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- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1810668.2 | 2018-06-28 | ||
| GBGB1810668.2A GB201810668D0 (en) | 2018-06-28 | 2018-06-28 | New compounds |
| PCT/GB2019/051853 WO2020002950A1 (en) | 2018-06-28 | 2019-06-28 | 4-substituted phenyl-1,3,5-triazine derivatives as modulators of trk receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3104237A1 true CA3104237A1 (en) | 2020-01-02 |
Family
ID=63143731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3104237A Pending CA3104237A1 (en) | 2018-06-28 | 2019-06-28 | 4-substituted phenyl-1,3,5-triazine derivatives as modulators of trk receptors |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11840524B2 (enExample) |
| EP (1) | EP3814335B1 (enExample) |
| JP (1) | JP7510358B2 (enExample) |
| KR (1) | KR20210024531A (enExample) |
| CN (1) | CN112513032B (enExample) |
| BR (1) | BR112020026619A2 (enExample) |
| CA (1) | CA3104237A1 (enExample) |
| ES (1) | ES2935183T3 (enExample) |
| GB (1) | GB201810668D0 (enExample) |
| WO (1) | WO2020002950A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020017341A2 (pt) | 2018-02-26 | 2020-12-15 | AlzeCure Pharma AB | Derivados de triazina para o tratamento de doenças relacionadas a neurotrofinas |
| GB201912404D0 (en) * | 2019-08-29 | 2019-10-16 | AlzeCure Pharma AB | New compounds |
| WO2021247634A1 (en) * | 2020-06-03 | 2021-12-09 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcriptional enhanced associate domain (tead) and uses thereof |
| WO2025232990A1 (en) | 2024-05-09 | 2025-11-13 | AlzeCure Pharma AB | Triazinone derivatives for use in the treatment of inflammation |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2246109A1 (de) | 1972-09-20 | 1974-03-28 | Bayer Ag | 1-(4-phenoxy-phenyl)-1,3,5-triazinderivate, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2313721A1 (de) | 1973-03-20 | 1974-10-03 | Bayer Ag | Neue 1-phenylsubstituierte 1,3,5triazine, verfahren zu ihrer herstellung, sowie ihre verwendung als arzneimittel |
| DE2413722C3 (de) | 1974-03-21 | 1982-04-08 | Bayer Ag, 5090 Leverkusen | Neue 1-(4-Phenoxy-phenyl)-1,3,5-triazin-Derivate, ein Verfahren zu ihrer Herstellung sowie ihre Anwendung als Arzneimittel |
| DE2718799A1 (de) | 1977-04-27 | 1978-11-09 | Bayer Ag | 1-(4-phenoxy-phenyl)-1,3,5-triazin- derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel und wachstumsfoerderer |
| EP0081142B1 (de) | 1981-12-03 | 1986-06-25 | BASF Aktiengesellschaft | 1,3,5-Triazinone, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung unerwünschten Pflanzenwuchses |
| DE3314739A1 (de) | 1983-04-23 | 1984-10-25 | Bayer Ag, 5090 Leverkusen | 1-(4-(4-(fluoralkylmethylthio- oder -sulfinyl- oder -sulfonyl-)phenoxy) phenyl)-1,3,5-triazin-2,4,6(1h,3h,5h)-trione, verfahren zu ihrer herstellung und ihre verwendung als coccidiosemittel |
| DE3408768A1 (de) | 1984-03-09 | 1985-09-12 | Bayer Ag, 5090 Leverkusen | Immunstimulierende mittel |
| DE3516631A1 (de) | 1985-05-09 | 1986-11-13 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 3-methyl-1,3,5-triazintrionen |
| DE3516632A1 (de) | 1985-05-09 | 1986-11-13 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 1,3,5-triazintrionen |
| DE3703105A1 (de) | 1987-02-03 | 1988-08-11 | Bayer Ag | Mittel gegen protozoen bei insekten |
| DE3810080A1 (de) | 1988-03-25 | 1989-10-05 | Bayer Ag | Trisubstituierte 1,3,5-triazin-2,4,6-trione |
| DE3814323A1 (de) | 1988-04-28 | 1989-11-09 | Hoechst Ag | Wasserloesliche zubereitungen von coccidiostatica |
| US4933341A (en) | 1988-10-08 | 1990-06-12 | Bayer Aktiengesellschaft | Substituted 1,3,5-triazinetriones, for use against parasitic protozoa |
| DE4000624A1 (de) | 1990-01-11 | 1991-07-18 | Bayer Ag | Fungizide verwendung von trisubstituierten 1,3,5-triazin-2,4,6-trionen, neue trisubstituierte 1,3,5-triazin-2,4,6-trione und verfahren zu ihrer herstellung |
| DE4329096A1 (de) | 1993-08-30 | 1995-03-02 | Bayer Ag | Heterocyclylbenzoheterocyclen |
| CZ146296A3 (en) | 1995-06-02 | 1997-04-16 | American Cyanamid Co | 3-(3-aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotriones, process of their preparation and herbicidal agents |
| US5519133A (en) | 1995-06-02 | 1996-05-21 | American Cyanamid Co. | 3-(3-aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents |
| US5604180A (en) | 1995-06-02 | 1997-02-18 | Crews, Jr.; Alvin D. | 3-(3-aryloxyphenyl)-1 (substituted methyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents |
| US5726126A (en) | 1995-06-02 | 1998-03-10 | American Cyanamid Company | 1-(3-heterocyclyphenyl)-S-triazine-2,6,6-oxo or thiotrione herbicidal agents |
| US5679791A (en) | 1996-07-25 | 1997-10-21 | American Cyanamid Company | 1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents |
| CN1189175C (zh) | 1998-10-08 | 2005-02-16 | 高新研究公司 | 用于预防和治疗原虫病的组合物和方法 |
| BR9916417A (pt) | 1998-12-22 | 2001-11-06 | Bayer Ag | Compostos triazinaona para tratamento de doenças devidas à sarcosystis, neospora e toxoplasma |
| DE19937500A1 (de) | 1999-08-09 | 2001-02-15 | Bayer Ag | Substituierte Heterocyclylbenzofurane |
| DE19958388A1 (de) | 1999-12-03 | 2001-06-07 | Bayer Ag | Triazinonverbindungen zur Behandlung von durch den Befall mit parasitischen Protozoen bedingten Krankheiten |
| US6444615B1 (en) | 2000-04-18 | 2002-09-03 | Dow Agrosciences Llc | Herbicidal imidazolidinetrione and thioxo-imidazolidinediones |
| DE10034800A1 (de) | 2000-07-18 | 2002-01-31 | Bayer Ag | Substituierte Benzostickstoffheterocyclen |
| DE10040110A1 (de) | 2000-08-17 | 2002-02-28 | Bayer Ag | Verwendung von Triazintrion-Sulfoxiden zur Bekämpfung von Coccidiosen |
| DE10040174A1 (de) | 2000-08-17 | 2002-02-28 | Bayer Ag | Verwendung von Triazintrion-Sulfonen zur Bekämpfung von Coccidiosen |
| AU2002324586B2 (en) | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
| US6861523B2 (en) | 2002-02-08 | 2005-03-01 | Torrey Pines Institute For Molecular Studies | 1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries |
| CA2484981C (en) | 2002-05-30 | 2011-07-26 | Solvay Pharmaceuticals B.V. | 1,3,5-triazine derivatives as ligands for human adenosine-a3 receptors |
| ES2282673T3 (es) | 2002-07-15 | 2007-10-16 | Janssen Pharmaceutica N.V. | Analogos 3-furanilo de toxoflavina como inhibidores de quinasas. |
| DE102006038292A1 (de) | 2006-08-16 | 2008-02-21 | Bayer Healthcare Ag | Transdermale Anwendung von Triazinen zur Bekämpfung von Coccidien-Infektionen |
| WO2008148008A1 (en) * | 2007-05-23 | 2008-12-04 | Emory University | High throughput bioassay for identifying selective trka receptor agonists, and gambogic amide, a selective trka agonist with neuroprotective activity |
| WO2011150347A2 (en) | 2010-05-28 | 2011-12-01 | Pharmatrophix | Non-peptide bdnf neurotrophin mimetics |
| US9828330B2 (en) | 2013-03-15 | 2017-11-28 | Pharmatrophix, Inc. | Non-peptide BDNF neurotrophin mimetics |
| KR101861942B1 (ko) | 2014-01-20 | 2018-06-29 | 에프. 호프만-라 로슈 아게 | 신경 발생을 자극할 수 있는 n-페닐-락탐 유도체 및 이의 신경 장애 치료에서의 용도 |
| CA2967999C (en) | 2014-12-10 | 2024-01-02 | Mars, Incorporated | Flavor compositions and pet food products containing the same |
| EP3558320A1 (en) | 2016-12-21 | 2019-10-30 | Alzecure Pharma AB | Triazinetrione derivatives and their use as modulators of neurotrophin receptor and receptor tyrosine kinases |
| BR112020017341A2 (pt) | 2018-02-26 | 2020-12-15 | AlzeCure Pharma AB | Derivados de triazina para o tratamento de doenças relacionadas a neurotrofinas |
| GB201810669D0 (en) | 2018-06-28 | 2018-08-15 | Stiftelsen Alzecure | New compounds |
| GB201912404D0 (en) | 2019-08-29 | 2019-10-16 | AlzeCure Pharma AB | New compounds |
-
2018
- 2018-06-28 GB GBGB1810668.2A patent/GB201810668D0/en not_active Ceased
-
2019
- 2019-06-28 CN CN201980045116.8A patent/CN112513032B/zh active Active
- 2019-06-28 KR KR1020217000575A patent/KR20210024531A/ko active Pending
- 2019-06-28 JP JP2020570716A patent/JP7510358B2/ja active Active
- 2019-06-28 BR BR112020026619-1A patent/BR112020026619A2/pt not_active Application Discontinuation
- 2019-06-28 ES ES19739692T patent/ES2935183T3/es active Active
- 2019-06-28 US US17/255,642 patent/US11840524B2/en active Active
- 2019-06-28 WO PCT/GB2019/051853 patent/WO2020002950A1/en not_active Ceased
- 2019-06-28 EP EP19739692.2A patent/EP3814335B1/en active Active
- 2019-06-28 CA CA3104237A patent/CA3104237A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020026619A2 (pt) | 2021-03-30 |
| KR20210024531A (ko) | 2021-03-05 |
| GB201810668D0 (en) | 2018-08-15 |
| WO2020002950A1 (en) | 2020-01-02 |
| CN112513032B (zh) | 2024-07-02 |
| CN112513032A (zh) | 2021-03-16 |
| JP7510358B2 (ja) | 2024-07-03 |
| ES2935183T3 (es) | 2023-03-02 |
| JP2021529168A (ja) | 2021-10-28 |
| US11840524B2 (en) | 2023-12-12 |
| US20210371402A1 (en) | 2021-12-02 |
| EP3814335B1 (en) | 2022-11-09 |
| EP3814335A1 (en) | 2021-05-05 |
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