CA3073866A1 - Composition comprising suplatast tosilate - Google Patents
Composition comprising suplatast tosilate Download PDFInfo
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- CA3073866A1 CA3073866A1 CA3073866A CA3073866A CA3073866A1 CA 3073866 A1 CA3073866 A1 CA 3073866A1 CA 3073866 A CA3073866 A CA 3073866A CA 3073866 A CA3073866 A CA 3073866A CA 3073866 A1 CA3073866 A1 CA 3073866A1
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- tablet
- release component
- composition
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- 229950011082 suplatast tosilate Drugs 0.000 title claims abstract description 195
- RYVJQEZJUFRANT-UHFFFAOYSA-N [3-[4-(3-ethoxy-2-hydroxypropoxy)anilino]-3-oxopropyl]-dimethylsulfanium;4-methylbenzenesulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.CCOCC(O)COC1=CC=C(NC(=O)CC[S+](C)C)C=C1 RYVJQEZJUFRANT-UHFFFAOYSA-N 0.000 title claims abstract description 193
- 239000000203 mixture Substances 0.000 title claims description 134
- 150000001875 compounds Chemical class 0.000 claims abstract description 56
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 34
- 239000003826 tablet Substances 0.000 claims description 181
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 111
- 239000008185 minitablet Substances 0.000 claims description 82
- 238000013265 extended release Methods 0.000 claims description 78
- 239000008187 granular material Substances 0.000 claims description 48
- 239000002775 capsule Substances 0.000 claims description 36
- 238000000576 coating method Methods 0.000 claims description 31
- 239000011248 coating agent Substances 0.000 claims description 30
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 28
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 19
- 239000002552 dosage form Substances 0.000 claims description 19
- 239000008188 pellet Substances 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 238000009501 film coating Methods 0.000 claims description 13
- 239000007888 film coating Substances 0.000 claims description 13
- 230000001154 acute effect Effects 0.000 claims description 11
- -1 sphere Substances 0.000 claims description 10
- 208000024891 symptom Diseases 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 8
- 239000007909 solid dosage form Substances 0.000 claims description 6
- 239000007942 layered tablet Substances 0.000 claims description 5
- 239000006186 oral dosage form Substances 0.000 claims description 3
- 239000007931 coated granule Substances 0.000 claims description 2
- 239000008184 oral solid dosage form Substances 0.000 claims 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 83
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 69
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 69
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 68
- 229960003943 hypromellose Drugs 0.000 description 60
- 235000019359 magnesium stearate Nutrition 0.000 description 43
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 39
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 39
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 39
- 239000008108 microcrystalline cellulose Substances 0.000 description 39
- 229940016286 microcrystalline cellulose Drugs 0.000 description 39
- 238000013268 sustained release Methods 0.000 description 37
- 239000012730 sustained-release form Substances 0.000 description 37
- 239000001856 Ethyl cellulose Substances 0.000 description 35
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 35
- 235000019325 ethyl cellulose Nutrition 0.000 description 35
- 229920001249 ethyl cellulose Polymers 0.000 description 35
- 239000000243 solution Substances 0.000 description 29
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 26
- DYZJXZOQQRXDLE-UHFFFAOYSA-O Suplatast tosilate Chemical compound CCOCC(O)COC1=CC=C(NC(=O)CC[S+](C)C)C=C1 DYZJXZOQQRXDLE-UHFFFAOYSA-O 0.000 description 26
- 229950001956 suplatast Drugs 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
- 239000002585 base Substances 0.000 description 20
- 229920002785 Croscarmellose sodium Polymers 0.000 description 19
- 238000004090 dissolution Methods 0.000 description 18
- 239000003814 drug Substances 0.000 description 18
- 239000008213 purified water Substances 0.000 description 18
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 17
- 229960005168 croscarmellose Drugs 0.000 description 17
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 17
- 229940079593 drug Drugs 0.000 description 17
- 230000037396 body weight Effects 0.000 description 15
- 238000004519 manufacturing process Methods 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 14
- 238000005507 spraying Methods 0.000 description 14
- 101000939517 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Proteins 0.000 description 13
- 239000002202 Polyethylene glycol Substances 0.000 description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 13
- 102100029643 Ubiquitin carboxyl-terminal hydrolase 2 Human genes 0.000 description 13
- 230000004888 barrier function Effects 0.000 description 13
- 238000007922 dissolution test Methods 0.000 description 13
- 235000019441 ethanol Nutrition 0.000 description 13
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 13
- 229920001223 polyethylene glycol Polymers 0.000 description 13
- 239000000377 silicon dioxide Substances 0.000 description 13
- 239000007941 film coated tablet Substances 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 12
- 235000012239 silicon dioxide Nutrition 0.000 description 12
- 230000004584 weight gain Effects 0.000 description 12
- 235000019786 weight gain Nutrition 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 10
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 10
- 229920000881 Modified starch Polymers 0.000 description 10
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- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 9
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 9
- 229950004288 tosilate Drugs 0.000 description 9
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 8
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- 239000001768 carboxy methyl cellulose Substances 0.000 description 8
- 229960002303 citric acid monohydrate Drugs 0.000 description 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 8
- 239000000314 lubricant Substances 0.000 description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 8
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- 229940079832 sodium starch glycolate Drugs 0.000 description 8
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000000945 filler Substances 0.000 description 7
- 229920000159 gelatin Polymers 0.000 description 7
- 235000019322 gelatine Nutrition 0.000 description 7
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 6
- 235000010443 alginic acid Nutrition 0.000 description 6
- 229920000615 alginic acid Polymers 0.000 description 6
- 235000010980 cellulose Nutrition 0.000 description 6
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- 239000001913 cellulose Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
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- 229920000609 methyl cellulose Polymers 0.000 description 6
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 6
- 235000010413 sodium alginate Nutrition 0.000 description 6
- 239000000661 sodium alginate Substances 0.000 description 6
- 229940005550 sodium alginate Drugs 0.000 description 6
- 206010012438 Dermatitis atopic Diseases 0.000 description 5
- 229920002907 Guar gum Polymers 0.000 description 5
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- 239000002253 acid Substances 0.000 description 5
- 201000008937 atopic dermatitis Diseases 0.000 description 5
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- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 5
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 229920002774 Maltodextrin Polymers 0.000 description 4
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Classifications
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17188229.3 | 2017-08-29 | ||
| EP17188229 | 2017-08-29 | ||
| PCT/EP2018/073123 WO2019042995A1 (en) | 2017-08-29 | 2018-08-28 | COMPOSITION COMPRISING SUPLATAST TOSILATE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3073866A1 true CA3073866A1 (en) | 2019-03-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3073866A Pending CA3073866A1 (en) | 2017-08-29 | 2018-08-28 | Composition comprising suplatast tosilate |
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| Country | Link |
|---|---|
| US (1) | US11819482B2 (enExample) |
| EP (1) | EP3675831A1 (enExample) |
| JP (1) | JP7330948B2 (enExample) |
| KR (1) | KR20200045496A (enExample) |
| CN (1) | CN111032021A (enExample) |
| AU (1) | AU2018322756B2 (enExample) |
| CA (1) | CA3073866A1 (enExample) |
| WO (1) | WO2019042995A1 (enExample) |
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| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
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| US4556737A (en) | 1983-03-11 | 1985-12-03 | Taiho Pharmaceutical Company Limited | Sulfonium compounds, processes for preparing the compounds and pharmacological composiitons containing the same |
| JPS6168455A (ja) | 1984-09-12 | 1986-04-08 | Taiho Yakuhin Kogyo Kk | アミド化合物 |
| JPH0370698A (ja) | 1989-08-11 | 1991-03-26 | Naomasa Nomura | 頭部回転式高性能飛行機 |
| WO1995003052A1 (en) | 1993-07-22 | 1995-02-02 | Warner-Lambert Company | Controlled release tacrine drug delivery systems and methods for preparing same |
| EP0886519A1 (en) | 1996-11-01 | 1998-12-30 | Ilex Oncology, Inc. | Sustained release formulation containing dfmo |
| JP2002179554A (ja) | 1997-09-05 | 2002-06-26 | Takeda Chem Ind Ltd | 医 薬 |
| FR2772615B1 (fr) * | 1997-12-23 | 2002-06-14 | Lipha | Comprime multicouche pour la liberation instantanee puis prolongee de substances actives |
| EP1107740A4 (en) | 1998-08-25 | 2002-03-06 | Platt Chris | SLOW RELEASE TABLET COMPRISING NAPROXENE AND PSEUDOEPHEDRINE |
| US6294199B1 (en) | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US7138140B2 (en) * | 2001-04-16 | 2006-11-21 | Taiho Pharmaceutical Co., Ltd. | Suplatast tosilate crystals |
| WO2002087549A1 (fr) | 2001-04-25 | 2002-11-07 | Taisho Pharmaceutical Co., Ltd. | Comprimes a liberation prolongee du type a unites multiples |
| JP4974419B2 (ja) | 2001-06-12 | 2012-07-11 | 東和薬品株式会社 | 薬物含有徐放性顆粒およびそれを含む錠剤 |
| US20050171119A1 (en) * | 2002-01-09 | 2005-08-04 | Ucb, S.A. | Pharmaceutical formulations with modified release |
| US20100092562A1 (en) | 2002-11-26 | 2010-04-15 | Hollenbeck R Gary | Sustained-release drug delivery compositions and methods |
| EP1591109B1 (en) | 2004-04-30 | 2008-07-02 | TopoTarget Germany AG | Formulation comprising histone deacetylase inhibitor exhibiting biphasic release |
| JP4498101B2 (ja) | 2004-11-04 | 2010-07-07 | 大鵬薬品工業株式会社 | 頭痛の予防及び／または治療剤 |
| WO2007001058A1 (ja) * | 2005-06-27 | 2007-01-04 | Juntendo Educational Foundation | ヘルペスウイルス由来疼痛治療剤 |
| JP2006335771A (ja) | 2006-09-22 | 2006-12-14 | Takeda Chem Ind Ltd | 徐放性製剤およびその製造方法 |
| JP5489719B2 (ja) | 2006-11-17 | 2014-05-14 | スパーナス ファーマシューティカルズ インコーポレイテッド | トピラマートの徐放性配合物 |
| WO2008119988A1 (en) * | 2007-03-30 | 2008-10-09 | Cardoz Ab | New combination for use in the treatment of inflammatory disorders |
| CN101028254B (zh) * | 2007-04-05 | 2010-05-19 | 合肥合源医药科技股份有限公司 | 一种多索茶碱缓释制剂及其制备方法 |
| CN101590022A (zh) * | 2008-05-29 | 2009-12-02 | 焦作平光制药有限责任公司 | 甘氨酸茶碱钠缓释片及其制备方法 |
| JP2011246454A (ja) | 2010-04-27 | 2011-12-08 | Daiichi Sankyo Healthcare Co Ltd | 安全な免疫抑制剤または免疫異常抑制剤組成物 |
| CN102210688B (zh) | 2011-05-24 | 2013-04-03 | 赛乐医药科技(上海)有限公司 | 复方甲氧那明的速释-缓释制剂 |
| WO2016192680A1 (en) * | 2015-06-03 | 2016-12-08 | Triastek, Inc. | Dosage forms and use thereof |
| WO2017032384A1 (en) | 2015-08-25 | 2017-03-02 | Conrig Pharma Aps | Compound and use in the treatment of cough |
| DK3393463T3 (da) * | 2015-12-23 | 2021-04-26 | Conrig Pharma Aps | Suplatast-tosilat til behandling af hoste forbundet med interstitiel lungesygdom |
-
2018
- 2018-08-28 JP JP2020512637A patent/JP7330948B2/ja active Active
- 2018-08-28 WO PCT/EP2018/073123 patent/WO2019042995A1/en not_active Ceased
- 2018-08-28 EP EP18759323.1A patent/EP3675831A1/en not_active Withdrawn
- 2018-08-28 CA CA3073866A patent/CA3073866A1/en active Pending
- 2018-08-28 US US16/641,524 patent/US11819482B2/en active Active
- 2018-08-28 CN CN201880056343.6A patent/CN111032021A/zh active Pending
- 2018-08-28 AU AU2018322756A patent/AU2018322756B2/en not_active Expired - Fee Related
- 2018-08-28 KR KR1020207006620A patent/KR20200045496A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP3675831A1 (en) | 2020-07-08 |
| WO2019042995A1 (en) | 2019-03-07 |
| AU2018322756A1 (en) | 2020-03-19 |
| JP7330948B2 (ja) | 2023-08-22 |
| JP2020532548A (ja) | 2020-11-12 |
| CN111032021A (zh) | 2020-04-17 |
| US20200230083A1 (en) | 2020-07-23 |
| KR20200045496A (ko) | 2020-05-04 |
| US11819482B2 (en) | 2023-11-21 |
| AU2018322756B2 (en) | 2023-10-19 |
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