CA3072455A1 - Pyruvate kinase modulators and use thereof - Google Patents

Pyruvate kinase modulators and use thereof Download PDF

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Publication number
CA3072455A1
CA3072455A1 CA3072455A CA3072455A CA3072455A1 CA 3072455 A1 CA3072455 A1 CA 3072455A1 CA 3072455 A CA3072455 A CA 3072455A CA 3072455 A CA3072455 A CA 3072455A CA 3072455 A1 CA3072455 A1 CA 3072455A1
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optionally substituted
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cycloalkyl
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CA3072455A
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English (en)
French (fr)
Inventor
Giovanni Cianchetta
Charles KUNG
Tao Liu
Anil Kumar PADYANA
Zhihua Sui
Zhenwei CAI
Dawei Cui
Jingjing Ji
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Agios Pharmaceuticals Inc
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Agios Pharmaceuticals Inc
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Publication of CA3072455A1 publication Critical patent/CA3072455A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3072455A 2017-08-15 2018-08-15 Pyruvate kinase modulators and use thereof Pending CA3072455A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/097496 2017-08-15
CN2017097496 2017-08-15
US201862673533P 2018-05-18 2018-05-18
US201862673526P 2018-05-18 2018-05-18
US62/673,526 2018-05-18
US62/673,533 2018-05-18
PCT/US2018/000129 WO2019035865A1 (en) 2017-08-15 2018-08-15 MODULATORS OF PYRUVATE KINASE AND THEIR USE

Publications (1)

Publication Number Publication Date
CA3072455A1 true CA3072455A1 (en) 2019-02-21

Family

ID=63524352

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3072455A Pending CA3072455A1 (en) 2017-08-15 2018-08-15 Pyruvate kinase modulators and use thereof

Country Status (34)

Country Link
US (8) US11464775B2 (https=)
EP (4) EP3668881B1 (https=)
JP (5) JP7301040B2 (https=)
KR (3) KR102642408B1 (https=)
CN (3) CN111032045B (https=)
AU (4) AU2018316588B2 (https=)
BR (1) BR112020003254A2 (https=)
CA (1) CA3072455A1 (https=)
CL (1) CL2020000375A1 (https=)
CO (2) CO2020002959A2 (https=)
CR (1) CR20200123A (https=)
CY (1) CY1124953T1 (https=)
DK (2) DK3668513T3 (https=)
EC (1) ECSP20018487A (https=)
ES (3) ES2905100T3 (https=)
FI (1) FI3668512T3 (https=)
HR (2) HRP20220039T1 (https=)
HU (2) HUE061910T2 (https=)
IL (3) IL272599B (https=)
LT (2) LT3668513T (https=)
MD (1) MD3668513T2 (https=)
MX (2) MX2020001833A (https=)
MY (1) MY204421A (https=)
PE (1) PE20200724A1 (https=)
PH (1) PH12020500343B1 (https=)
PL (2) PL3668513T3 (https=)
PT (2) PT3668513T (https=)
RS (2) RS62871B1 (https=)
SG (2) SG11202001262QA (https=)
SI (2) SI3668512T1 (https=)
SM (2) SMT202200023T1 (https=)
TW (3) TWI796353B (https=)
UA (1) UA126292C2 (https=)
WO (3) WO2019035864A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3483164T (lt) 2017-03-20 2020-05-11 Forma Therapeutics, Inc. Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai
TWI796353B (zh) * 2017-08-15 2023-03-21 美商阿吉歐斯製藥公司 丙酮酸激酶調節劑及其用途
EP3697354A4 (en) 2017-10-20 2021-06-30 The Regents of The University of Michigan EYE DISEASE COMPOSITIONS AND METHODS
EP3852791B1 (en) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Activating pyruvate kinase r
EP3853206B1 (en) 2018-09-19 2024-04-10 Novo Nordisk Health Care AG Treating sickle cell disease with a pyruvate kinase r activating compound
BR112021015996A2 (pt) * 2019-02-13 2021-11-09 Agios Pharmaceuticals Inc Derivados de tieno[3,2-b]pirrol[3,2-d]piridazinona e seu uso como derivados de pkm2 para o tratamento de câncer, obesidade e distúrbios relacionados a diabetes
WO2020262419A1 (ja) * 2019-06-26 2020-12-30 日産化学株式会社 電荷輸送性ワニス
HRP20251148T1 (hr) 2019-09-19 2025-11-21 Novo Nordisk Health Care Ag Pripravci koji aktiviraju piruvat-kinazu r (pkr)
EP4185293A4 (en) * 2020-07-21 2025-01-15 The Regents of The University of Michigan COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE
CN112490502B (zh) * 2020-12-04 2022-01-21 广州天赐高新材料股份有限公司 一种电解液及锂二次电池
US11566030B2 (en) 2021-02-08 2023-01-31 Global Blood Therapeutics, Inc. Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
WO2023052783A1 (en) * 2021-09-30 2023-04-06 Sitryx Therapeutics Limited Novel compounds
IL312679A (en) * 2021-11-16 2024-07-01 Agios Pharmaceuticals Inc Compounds for the treatment of anemia associated with MDS and other conditions
CN116159061A (zh) * 2023-03-09 2023-05-26 上海市第十人民医院 丙酮酸激酶m2激活剂在制备预防或治疗心力衰竭的药物中的应用
EP4671102A1 (en) 2023-03-28 2025-12-31 Honda Motor Co., Ltd. METHOD FOR PROVIDING INFORMATION, PROGRAM FOR PROVIDING INFORMATION, STORAGE MEDIA AND INFORMATION PROCESSING APPARATUS
TW202509043A (zh) 2023-05-15 2025-03-01 美商阿吉歐斯製藥公司 ２－（（１ｈ－吡唑－３－基）甲基）－６－（（６－胺基吡啶－２－基）甲基）－４－甲基－４，６－二氫－５ｈ－噻唑基［５＇，４＇：４，５］吡咯并［２，３－ｄ］嗒𠯤－５－酮之結晶形式
KR20260035223A (ko) * 2023-07-05 2026-03-12 아지오스 파마슈티컬스 아이엔씨. 피루브산 키나아제 활성화제의 합성
TW202539675A (zh) 2024-03-27 2025-10-16 美商阿吉歐斯製藥公司 Ｐｋ活化劑在治療鐮狀細胞疾病中之用途
WO2026076363A1 (en) 2024-10-04 2026-04-09 Agios Pharmaceuticals, Inc. Compounds for treating mds-associated anemias and other conditions

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405635A (en) 1979-06-18 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Aroylimidazol-2-ones and their use as pharmaceuticals
US4883914A (en) 1987-08-17 1989-11-28 American Cyanamid Company Benzenesulfonyl carboxamide compounds useful as herbicidal agents
CA2380644A1 (en) 1999-07-30 2001-02-08 Basf Aktiengesellschaft 2-pyrazolin-5-ones
CA2381581A1 (en) 1999-09-04 2001-03-15 Astrazeneca Ab Substituted n-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity
EP1972629A1 (en) * 2007-03-23 2008-09-24 Mutabilis SA New imidazolo-heteroaryl derivatives with antibacterial properties
FR2933983B1 (fr) * 2008-07-15 2010-08-27 Servier Lab Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
MX2011000843A (es) * 2008-07-23 2011-04-11 Vertex Pharma Inhibidores de pirazolopiridin cinasa triciclicos.
EP2334673A1 (en) * 2008-08-29 2011-06-22 Amgen Inc. PYRIDO[3,2-d]PYRIDAZINE-2(1H)-ONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF
WO2010042867A2 (en) 2008-10-09 2010-04-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
CA2758071C (en) * 2009-04-06 2018-01-09 Agios Pharmaceuticals, Inc. Pyruvate kinase m2 modulators, therapeutic compositions and related methods of use
TWI598337B (zh) 2009-06-29 2017-09-11 阿吉歐斯製藥公司 治療化合物及組成物
US20130109672A1 (en) 2010-04-29 2013-05-02 The United States Of America,As Represented By The Secretary, Department Of Health And Human Service Activators of human pyruvate kinase
KR101861883B1 (ko) 2010-12-06 2018-05-28 글락소 그룹 리미티드 Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물
TWI549947B (zh) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 治療化合物及組成物
CN103608016A (zh) * 2011-05-03 2014-02-26 安吉奥斯医药品有限公司 丙酮酸激酶激活剂在治疗中的用途
US9388164B2 (en) * 2011-05-03 2016-07-12 Agios Pharmaceuticals, Inc Methods of using pyruvate kinase activators
WO2012151450A1 (en) 2011-05-03 2012-11-08 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia
SMT202400081T1 (it) * 2011-05-03 2024-03-13 Agios Pharmaceuticals Inc Attivatori della piruvato chinasi per uso in terapia
HK1198443A1 (en) * 2011-07-19 2015-04-24 无限药品股份有限公司 Heterocyclic compounds and uses thereof
WO2013056153A1 (en) * 2011-10-13 2013-04-18 Kung Charles Activators of pyruvate kinase m2 and methods of treating disease
US9921221B2 (en) 2012-07-26 2018-03-20 Joslin Diabetes Center, Inc. Predicting and treating diabetic complications
EA032007B1 (ru) 2012-11-08 2019-03-29 Аджиос Фармасьютикалз, Инк. Терапевтические соединения и композиции и их использование в качестве модуляторов пк-m2
WO2014118135A1 (en) * 2013-01-30 2014-08-07 Bayer Pharma Aktiengesellschaft Amidoimidazopyridazines as mknk-1 kinase inhibitors
EP2968323A4 (en) 2013-03-13 2016-12-14 Flatley Discovery Lab PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
WO2014139144A1 (en) 2013-03-15 2014-09-18 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
AR097543A1 (es) * 2013-09-06 2016-03-23 Lexicon Pharmaceuticals Inc COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
US11465992B2 (en) 2017-07-07 2022-10-11 Inflazome Limited Sulfonamide carboxamide compounds
MX2020001776A (es) 2017-08-15 2020-03-24 Inflazome Ltd Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3.
AR112475A1 (es) 2017-08-15 2019-10-30 Agios Pharmaceuticals Inc Moduladores de piruvato quinasas y uso de los mismos
US10676485B2 (en) 2017-08-15 2020-06-09 Abbvie Inc. Macrocyclic MCL-1 inhibitors and methods of use
TWI796353B (zh) 2017-08-15 2023-03-21 美商阿吉歐斯製藥公司 丙酮酸激酶調節劑及其用途
BR112021015996A2 (pt) * 2019-02-13 2021-11-09 Agios Pharmaceuticals Inc Derivados de tieno[3,2-b]pirrol[3,2-d]piridazinona e seu uso como derivados de pkm2 para o tratamento de câncer, obesidade e distúrbios relacionados a diabetes

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JP2020531443A (ja) 2020-11-05
JP2020531432A (ja) 2020-11-05
US20230226055A1 (en) 2023-07-20
BR112020003262A2 (pt) 2020-09-01
KR20200054200A (ko) 2020-05-19
US11590132B2 (en) 2023-02-28
DK3668512T3 (da) 2023-05-22
WO2019035863A1 (en) 2019-02-21
US20210077490A1 (en) 2021-03-18
JP2023052478A (ja) 2023-04-11
JP2023027276A (ja) 2023-03-01
IL272597B (en) 2022-06-01
MD3668513T2 (ro) 2022-04-30
SI3668512T1 (sl) 2023-06-30
IL292530A (en) 2022-06-01
TWI796353B (zh) 2023-03-21
KR102642408B1 (ko) 2024-02-28
LT3668512T (lt) 2023-06-12
KR20230127364A (ko) 2023-08-31
CN111032045A (zh) 2020-04-17
EP4026838A1 (en) 2022-07-13
WO2019035863A8 (en) 2019-03-28
PL3668512T3 (pl) 2023-06-19
US11364240B2 (en) 2022-06-21
US20210130371A1 (en) 2021-05-06
MX2020001833A (es) 2020-07-22
US20200206225A1 (en) 2020-07-02
US20250144093A1 (en) 2025-05-08
TW202323258A (zh) 2023-06-16
CY1124953T1 (el) 2023-01-05
US20220233541A1 (en) 2022-07-28
EP3668513B1 (en) 2021-11-10
IL272599B (en) 2022-08-01
CR20200123A (es) 2020-06-29
KR102764124B1 (ko) 2025-02-05
TW201919631A (zh) 2019-06-01
CO2020002961A2 (es) 2020-04-13
AU2018316588A1 (en) 2020-02-20
EP3668881B1 (en) 2023-10-04
HUE057178T2 (hu) 2022-04-28
RU2020110573A3 (https=) 2021-12-24
US20220395503A1 (en) 2022-12-15
PT3668513T (pt) 2022-01-21
TWI823580B (zh) 2023-11-21
WO2019035864A1 (en) 2019-02-21
US11957680B2 (en) 2024-04-16
SG11202001353PA (en) 2020-03-30
LT3668513T (lt) 2022-03-25
RS62871B1 (sr) 2022-02-28
SMT202200023T1 (it) 2022-03-21
CN111032045B (zh) 2023-08-15
IL272597A (en) 2020-03-31
WO2019035865A1 (en) 2019-02-21
SMT202300146T1 (it) 2023-07-20
CN117186119A (zh) 2023-12-08
IL272599A (en) 2020-03-31
HUE061910T2 (hu) 2023-08-28
IL292530B2 (en) 2023-06-01
SG11202001262QA (en) 2020-03-30
PT3668512T (pt) 2023-05-22
ES2905100T3 (es) 2022-04-07
JP7301040B2 (ja) 2023-06-30
EP3668513A1 (en) 2020-06-24
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AU2018316588B2 (en) 2023-02-02
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AU2023202772B2 (en) 2024-05-16
RS64221B1 (sr) 2023-06-30
PE20200724A1 (es) 2020-07-21
RU2020110573A (ru) 2021-09-16
AU2018316587B2 (en) 2023-05-11
KR20200054199A (ko) 2020-05-19
US11464775B2 (en) 2022-10-11
HRP20230452T1 (hr) 2023-07-21
ES2966825T3 (es) 2024-04-24
HRP20220039T1 (hr) 2022-04-15
KR102717594B1 (ko) 2024-10-14
CN117186119B (zh) 2026-04-28
US20200207785A1 (en) 2020-07-02
US11040036B2 (en) 2021-06-22
WO2019035865A8 (en) 2019-03-28
AU2024205818A1 (en) 2024-09-05
AU2018316587A1 (en) 2020-02-20
TWI790271B (zh) 2023-01-21
JP7530453B2 (ja) 2024-08-07
CN111032046A (zh) 2020-04-17
JP7275107B2 (ja) 2023-05-17
US11872225B2 (en) 2024-01-16
PH12020500343B1 (en) 2024-02-21
ES2944545T3 (es) 2023-06-22
DK3668513T3 (da) 2022-01-10
SI3668513T1 (sl) 2022-04-29
UA126292C2 (uk) 2022-09-14
MX2020001832A (es) 2020-07-22
BR112020003254A2 (pt) 2020-10-27
WO2019035864A8 (en) 2019-03-28
PL3668513T3 (pl) 2022-03-21
TW201920203A (zh) 2019-06-01
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