CA3071537A1 - Combinations of pd-1 antagonists and benzo[b]thiophene sting agonists for cancer treatment - Google Patents

Combinations of pd-1 antagonists and benzo[b]thiophene sting agonists for cancer treatment Download PDF

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Publication number
CA3071537A1
CA3071537A1 CA3071537A CA3071537A CA3071537A1 CA 3071537 A1 CA3071537 A1 CA 3071537A1 CA 3071537 A CA3071537 A CA 3071537A CA 3071537 A CA3071537 A CA 3071537A CA 3071537 A1 CA3071537 A1 CA 3071537A1
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Canada
Prior art keywords
group
alkyl
benzo
cell
cancer
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Pending
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CA3071537A
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English (en)
French (fr)
Inventor
Saso CEMERSKI
Jared N. Cumming
Johnny E. Kopinja
Samanthi A. Perera
Benjamin Wesley TROTTER
Archie Ngai-Chiu TSE
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of CA3071537A1 publication Critical patent/CA3071537A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3071537A 2017-08-04 2018-07-30 Combinations of pd-1 antagonists and benzo[b]thiophene sting agonists for cancer treatment Pending CA3071537A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541180P 2017-08-04 2017-08-04
US62/541,180 2017-08-04
PCT/US2018/044275 WO2019027857A1 (en) 2017-08-04 2018-07-30 COMBINATIONS OF PD-1 ANTAGONISTS AND STING BENZO [B] THIOPHENIC AGONISTS FOR THE TREATMENT OF CANCER

Publications (1)

Publication Number Publication Date
CA3071537A1 true CA3071537A1 (en) 2019-02-07

Family

ID=65234179

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3071537A Pending CA3071537A1 (en) 2017-08-04 2018-07-30 Combinations of pd-1 antagonists and benzo[b]thiophene sting agonists for cancer treatment

Country Status (8)

Country Link
US (1) US11312772B2 (https=)
EP (1) EP3661499A4 (https=)
JP (1) JP2020529421A (https=)
AU (1) AU2018311965A1 (https=)
CA (1) CA3071537A1 (https=)
MA (1) MA49773A (https=)
RU (1) RU2020109328A (https=)
WO (1) WO2019027857A1 (https=)

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Also Published As

Publication number Publication date
AU2018311965A1 (en) 2020-02-13
US11312772B2 (en) 2022-04-26
EP3661499A1 (en) 2020-06-10
EP3661499A4 (en) 2021-04-21
RU2020109328A (ru) 2021-09-06
JP2020529421A (ja) 2020-10-08
US20210130466A1 (en) 2021-05-06
RU2020109328A3 (https=) 2021-11-09
MA49773A (fr) 2021-04-21
WO2019027857A1 (en) 2019-02-07

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