CA3056777A1 - Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain - Google Patents

Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain Download PDF

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Publication number
CA3056777A1
CA3056777A1 CA3056777A CA3056777A CA3056777A1 CA 3056777 A1 CA3056777 A1 CA 3056777A1 CA 3056777 A CA3056777 A CA 3056777A CA 3056777 A CA3056777 A CA 3056777A CA 3056777 A1 CA3056777 A1 CA 3056777A1
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CA
Canada
Prior art keywords
compound
crystalline form
disease
theta
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3056777A
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English (en)
French (fr)
Inventor
Jack Lin
Marika Nespi
Jason WALTERS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Plexxikon Inc
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Plexxikon Inc
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Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of CA3056777A1 publication Critical patent/CA3056777A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3056777A 2017-03-20 2018-03-19 Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain Abandoned CA3056777A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762473903P 2017-03-20 2017-03-20
US62/473,903 2017-03-20
PCT/US2018/023127 WO2018175311A1 (en) 2017-03-20 2018-03-19 Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain

Publications (1)

Publication Number Publication Date
CA3056777A1 true CA3056777A1 (en) 2018-09-27

Family

ID=61906865

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3056777A Abandoned CA3056777A1 (en) 2017-03-20 2018-03-19 Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain

Country Status (7)

Country Link
US (1) US10577366B2 (enExample)
EP (1) EP3601281B1 (enExample)
JP (1) JP2020511467A (enExample)
AU (1) AU2018237047A1 (enExample)
CA (1) CA3056777A1 (enExample)
ES (1) ES2896502T3 (enExample)
WO (1) WO2018175311A1 (enExample)

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Also Published As

Publication number Publication date
US20180265508A1 (en) 2018-09-20
AU2018237047A2 (en) 2019-10-31
JP2020511467A (ja) 2020-04-16
EP3601281B1 (en) 2021-09-29
AU2018237047A1 (en) 2019-10-17
US10577366B2 (en) 2020-03-03
ES2896502T3 (es) 2022-02-24
EP3601281A1 (en) 2020-02-05
WO2018175311A1 (en) 2018-09-27

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Legal Events

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FZDE Discontinued

Effective date: 20230921