CA3050151C - Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof - Google Patents

Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof Download PDF

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Publication number
CA3050151C
CA3050151C CA3050151A CA3050151A CA3050151C CA 3050151 C CA3050151 C CA 3050151C CA 3050151 A CA3050151 A CA 3050151A CA 3050151 A CA3050151 A CA 3050151A CA 3050151 C CA3050151 C CA 3050151C
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CA
Canada
Prior art keywords
snp
allele
nucleic acid
snps
seq
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Expired - Lifetime
Application number
CA3050151A
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English (en)
French (fr)
Other versions
CA3050151A1 (en
Inventor
Michele Cargill
Olga Iakoubova
James J. Devlin
Zenta Tsuchihashi
Peter Shaw
Lynn Marie Ploughman
Kim E. Zerba
Ranade Koustubh
Todd Kirchgessner
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Bristol Myers Squibb Co
Celera Corp
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Bristol Myers Squibb Co
Celera Corp
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Publication of CA3050151A1 publication Critical patent/CA3050151A1/en
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Publication of CA3050151C publication Critical patent/CA3050151C/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Vascular Medicine (AREA)
CA3050151A 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof Expired - Lifetime CA3050151C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US52488203P 2003-11-26 2003-11-26
US60/524,882 2003-11-26
US56821904P 2004-05-06 2004-05-06
US60/568,219 2004-05-06
CA2991249A CA2991249C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2991249A Division CA2991249C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof

Publications (2)

Publication Number Publication Date
CA3050151A1 CA3050151A1 (en) 2005-06-23
CA3050151C true CA3050151C (en) 2023-03-07

Family

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Family Applications (7)

Application Number Title Priority Date Filing Date
CA2860272A Expired - Lifetime CA2860272C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA2832293A Expired - Lifetime CA2832293C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA3048093A Withdrawn CA3048093A1 (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA2547072A Expired - Lifetime CA2547072C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA3050151A Expired - Lifetime CA3050151C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA2991249A Expired - Lifetime CA2991249C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA2921196A Expired - Lifetime CA2921196C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof

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Application Number Title Priority Date Filing Date
CA2860272A Expired - Lifetime CA2860272C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA2832293A Expired - Lifetime CA2832293C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA3048093A Withdrawn CA3048093A1 (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA2547072A Expired - Lifetime CA2547072C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof

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CA2991249A Expired - Lifetime CA2991249C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
CA2921196A Expired - Lifetime CA2921196C (en) 2003-11-26 2004-11-24 Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof

Country Status (5)

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US (6) US20050272054A1 (enExample)
EP (7) EP2386656B1 (enExample)
JP (9) JP5649263B2 (enExample)
CA (7) CA2860272C (enExample)
WO (1) WO2005056837A2 (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318517B1 (it) * 2000-05-12 2003-08-27 Ist Naz Stud Cura Dei Tumori Polinucleotidi codificanti per forme polimorfiche della proteinapthrp, le proteine codificate, e loro applicazioni terapeutiche.
WO2002038794A2 (en) 2000-11-09 2002-05-16 The Brigham And Women's Hospital, Inc. Cardiovascular disease diagnostic and therapeutic targets
DK1402073T3 (da) * 2001-06-05 2007-06-11 Auckland Uniservices Ltd Fremgangsmåder og præparater til vurdering af lungefunktion og -lidelser
CN102533972B (zh) 2002-05-09 2014-07-02 布赖汉姆妇女医院 作为心血管病的标志和治疗靶的1l1rl-1
US8178294B2 (en) * 2002-06-14 2012-05-15 Cedars-Sinai Medical Center Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
US7306562B1 (en) * 2004-04-23 2007-12-11 Medical Software, Llc Medical risk assessment method and program product
BRPI0510079A (pt) * 2004-04-23 2007-10-16 Amgen Inc anticorpo isolado ou região de ligação de antìgeno do mesmo, célula de hibridoma, célula de transfectoma, anticorpo monoclonal ou região de ligação de antìgeno do mesmo, animal não humano transgênico, método para produzir um anticorpo ou região de ligação de antìgeno do mesmo, composição farmacêutica, uso do anticorpo ou região de ligação de antìgeno, polipeptìdeo isolado, imunoensaio, e, método para identificar um composto
US7947436B2 (en) * 2004-12-13 2011-05-24 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
WO2006116622A2 (en) * 2005-04-27 2006-11-02 Emiliem Novel methods and devices for evaluating poisons
US20060269946A1 (en) * 2005-05-10 2006-11-30 Young Robert P Methods and compositions for assessment of pulmonary function and disorders
MX2007014220A (es) * 2005-05-19 2009-02-16 Synergenz Bioscience Ltd Metodos para la valoracion del riesgo de desarrollar cancer de pulmon usando un analisis de polimorfismos geneticos.
WO2006123954A1 (en) * 2005-05-19 2006-11-23 Synergenz Bioscience Limited Methods and compositions for assessment of pulmonary function and disorders
US7933722B2 (en) * 2005-05-20 2011-04-26 Synergenz Bioscience Limited Methods of analysis of polymorphisms and uses thereof
US20070099239A1 (en) * 2005-06-24 2007-05-03 Raymond Tabibiazar Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease
WO2007023148A2 (en) * 2005-08-22 2007-03-01 Innogenetics N.V. Nucleic acid variants in the lbp gene associated with altered innate immunity
WO2007028147A2 (en) * 2005-09-01 2007-03-08 Philadelphia Health & Education Corporation D.B.A. Drexel University College Of Medicin Identification of a prostatic intraepithelial neoplasia (pin)-specific gene and protein (pin-1) useful as a diagnostic treatment for prostate cancer
US7799530B2 (en) * 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
EP1795609A1 (en) * 2005-12-06 2007-06-13 Sanofi-Aventis Deutschland GmbH Method for the diagnosis and treatment of cardiovascular diseases
AU2007244927B2 (en) 2006-04-24 2012-01-12 Critical Care Diagnostics, Inc. Predicting mortality and detecting severe disease
ATE517341T1 (de) * 2006-04-27 2011-08-15 Critical Care Diagnostics Inc Interleukin-33 (il-33) zur diagnose und vorhersage von herz-gefäss-erkrankungen
HUE028594T2 (en) * 2006-05-01 2016-12-28 Critical Care Diagnostics Inc Diagnosis of cardiovascular disease
US20100055683A1 (en) * 2006-05-02 2010-03-04 Critical Care Diagnostics, Inc. Diagnosis of pulmonary and/or cardiovascular disease
JP4884180B2 (ja) * 2006-11-21 2012-02-29 東京エレクトロン株式会社 基板処理装置および基板処理方法
US20080131887A1 (en) * 2006-11-30 2008-06-05 Stephan Dietrich A Genetic Analysis Systems and Methods
MX2009008878A (es) * 2007-02-21 2009-08-28 Decode Genetics Ehf Variantes de susceptibilidad genetica asociada con la enfermedad cardiovascular.
US7695916B2 (en) 2007-03-22 2010-04-13 Celera Corporation Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof
US9012143B2 (en) * 2007-04-30 2015-04-21 The Ohio State University Research Foundation Polymorphisms in genes affecting ace-related disorders and uses thereof
EP2150627B1 (en) * 2007-05-09 2013-09-11 The Brigham and Women's Hospital, Inc. Polymorphism in the apo (a) gene predict responsiveness to acetylsalicylic acid treatment
JP5491400B2 (ja) * 2007-09-26 2014-05-14 ナビジェニクス インコーポレイティド 祖先データを用いるゲノム解析の方法及びシステム
CN101230392B (zh) * 2007-12-06 2010-11-24 卫生部北京医院 一种预测2型糖尿病易感性的方法及试剂
WO2009079456A2 (en) 2007-12-14 2009-06-25 Minitube Of America, Inc. Gender-specific separation of sperm cells and embryos
US20090221620A1 (en) * 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
CN102016073A (zh) * 2008-02-29 2011-04-13 Isis创新有限公司 诊断方法
US20090234202A1 (en) * 2008-03-05 2009-09-17 Goix Philippe J Method and compositions for highly sensitive detection of molecules
JP5409658B2 (ja) 2008-03-13 2014-02-05 セレラ コーポレーション 静脈血栓症に関連した遺伝子多型、その検出方法および使用
WO2009129454A2 (en) 2008-04-18 2009-10-22 Critical Care Diagnostics, Inc. Predicting risk of major adverse cardiac events
DK2282764T3 (da) * 2008-04-22 2019-10-14 Vib Vzw Leverspecifikke nukleinsyreregulerende elementer samt fremgangsmåder og anvendelser heraf
US20100098775A1 (en) * 2008-05-02 2010-04-22 Interleukin Genetics, Inc. Detecting genetic predisposition to osteoarthritis associated conditions
US9817001B2 (en) 2008-05-27 2017-11-14 Boston Heart Diagnostics Corporation Methods for determining LDL cholesterol treatment
US8216786B2 (en) * 2008-07-09 2012-07-10 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
GB2477868A (en) * 2008-09-12 2011-08-17 Navigenics Inc Methods and systems for incorporating multiple environmental and genetic risk factors
US8470541B1 (en) 2008-09-27 2013-06-25 Boston Heart Diagnostics Corporation Methods for separation and immuno-detection of biomolecules, and apparatus related thereto
CN102341498B (zh) 2008-12-04 2017-12-19 库尔纳公司 通过抑制血管内皮生长因子(vegf)的天然反义转录子治疗vegf相关的疾病
WO2010129477A1 (en) * 2009-05-04 2010-11-11 Duke University Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
US20110269735A1 (en) * 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
WO2011140484A1 (en) 2010-05-06 2011-11-10 Singulex, Inc Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis
US20120108651A1 (en) * 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
US20140044668A1 (en) * 2011-02-15 2014-02-13 The Ohio State University Methods for Predicting Cardiovascular Risks and Responsiveness to Statin Therapy Using SNPs
JP6215713B2 (ja) 2011-03-17 2017-10-18 クリティカル ケア ダイアグノスティクス インコーポレイテッド 有害臨床転帰のリスクを予測する方法
WO2013056087A2 (en) * 2011-10-13 2013-04-18 Boston Heart Diagnostics Compositions and methods for treating and preventing coronary heart disease
MX2014008299A (es) * 2012-01-04 2014-08-21 Mofa Group Llc Identificacion de genero especifico de celulas espermaticas y embriones utilizando acidos nucleicos bloqueados.
HK1212057A1 (en) 2012-08-21 2016-06-03 重症监护诊断股份有限公司 Multimarker risk stratification
US9938576B1 (en) 2012-09-21 2018-04-10 Ohio State Innovation Foundation Materials and methods for determining metabolizer status in humans
US9828624B2 (en) 2013-07-24 2017-11-28 Boston Heart Diagnostics Corporation Driving patient compliance with therapy
EP3220810A4 (en) 2014-11-17 2018-05-16 Boston Heart Diagnostic Corporation Cardiovascular disease risk assessment
CA2984267A1 (en) * 2016-11-01 2018-05-01 Medarchon, Inc. Patient handoff device, system and predictive method
MY202410A (en) 2017-09-01 2024-04-27 Venn Biosciences Corp Identification and use of glycopeptides as biomarkers for diagnosis and treatment monitoring
WO2020002602A1 (fr) * 2018-06-29 2020-01-02 bioMérieux Procédé pour déterminer in vitro ou ex vivo le statut immunitaire d'un individu
JP2020060975A (ja) * 2018-10-10 2020-04-16 トヨタ自動車株式会社 信用評価装置、信用評価方法およびプログラム
CA3128973A1 (en) 2019-03-04 2020-09-10 Bhaskar Bhattacharyya Data compression and communication using machine learning
MX2022010600A (es) * 2020-02-28 2022-09-09 Simplot Co J R Vectores de transformacion de la papa.
CN112410440B (zh) * 2020-12-15 2022-08-02 吉林省农业科学院 一种检测绵羊肌肉脂肪含量的试剂、引物、试剂盒和应用
US12406413B2 (en) * 2021-05-10 2025-09-02 Optum Services (Ireland) Limited Predictive data analysis using image representations of genomic data
CN113549688B (zh) * 2021-08-27 2023-08-04 河北医科大学第二医院 一组诊断冠状动脉疾病的分子标志物
AU2023230867A1 (en) * 2022-01-07 2024-06-06 Regents Of The University Of Minnesota Hemostatic composition containing recombinant human clotting factors, and method of producing
JP7331325B1 (ja) * 2022-08-30 2023-08-23 株式会社seeDNA ２種以上の検査を実施可能な遺伝学的解析方法
CN116949180A (zh) * 2023-08-03 2023-10-27 中山大学孙逸仙纪念医院 用于胰腺导管腺癌的诊断、治疗和预后预测的产品及其应用
CN118557734B (zh) * 2024-07-24 2024-11-22 中山大学中山眼科中心 Serpinb2抑制剂在制备用于治疗湿性年龄相关性黄斑变性药物中的应用
CN118949044B (zh) * 2024-10-15 2025-03-28 北京大学第一医院(北京大学第一临床医学院) Lrp3在缺血性心脏病治疗中的应用

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US117329A (en) 1871-07-25 Improvement in parlor-skates
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
FR2540122B1 (fr) 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
NO870613L (no) 1986-03-05 1987-09-07 Molecular Diagnostics Inc Deteksjon av mikroorganismer i en prŸve inneholdende nukleinsyre.
US5004565A (en) 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5637677A (en) 1987-07-16 1997-06-10 The Trustees Of The University Of Pennsylvania Biologically active compounds and methods of constructing and using the same
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US5856522A (en) 1995-05-04 1999-01-05 Tropix, Inc. Method of using synthesis of 1,2-dioxetanes and kits therefore
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
DE68928853T2 (de) 1988-05-20 1999-08-05 Cetus Corp., Emeryville, Calif. Befestigung von sequenzspezifischen proben
US4988167A (en) 1988-08-10 1991-01-29 Fergason James L Light blocking and vision restoration apparatus with glint control
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994073A (en) 1990-08-30 1999-11-30 Tropix, Inc. Enhancement of chemiluminescent assays
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
EP0655090B1 (en) 1992-04-27 2000-12-27 The Trustees Of Dartmouth College Detection of gene sequences in biological fluids
DE69333366T2 (de) 1992-10-30 2004-09-16 The General Hospital Corp., Boston Ein neues zellzyklus kontrollprotein
DE69433811T2 (de) 1993-01-07 2005-06-23 Sequenom, Inc., San Diego Dns - sequenzierung durch massenspektronomie
US5422252A (en) 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6027923A (en) 1993-07-23 2000-02-22 Bio-Rad Laboratories, Inc. Linked linear amplification of nucleic acids
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
US5498531A (en) 1993-09-10 1996-03-12 President And Fellows Of Harvard College Intron-mediated recombinant techniques and reagents
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
AU8126694A (en) 1993-10-26 1995-05-22 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5705333A (en) 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US5773628A (en) 1994-11-14 1998-06-30 Tropix, Inc. 1,2-dioxetane compounds with haloalkoxy groups, methods preparation and use
US5591591A (en) 1995-02-09 1997-01-07 Tropix, Inc. Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
GB9517780D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517779D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US5801115A (en) 1995-09-05 1998-09-01 Kataleuna Gmbh Catalyst composition and methods for using and preparing same
US5679803A (en) 1995-10-25 1997-10-21 Tropix, Inc. 1,2 chemiluminescent dioxetanes of improved performance
EP2368897B1 (en) 1996-02-09 2016-10-19 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
JP2000508912A (ja) 1996-04-19 2000-07-18 スペクトラ バイオメディカル，インコーポレイテッド 多型形態と複数の表現型との相関付け
EP0912761A4 (en) 1996-05-29 2004-06-09 Cornell Res Foundation Inc DETERMINATION OF DIFFERENCES IN THE NUCLEIC ACID SEQUENCE BY MEANS OF A COMBINATION OF LIGASE DETERMINATION AND POLYMERASE CHAIN REACTION
US5866336A (en) 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6233205B1 (en) 1996-09-17 2001-05-15 Xilinx, Inc. Built-in self test method for measuring clock to out delays
US5800999A (en) 1996-12-16 1998-09-01 Tropix, Inc. Dioxetane-precursor-labeled probes and detection assays employing the same
JP2001518793A (ja) * 1997-04-10 2001-10-16 ジェネティックス・インスチチュート・インコーポレーテッド 分泌発現配列タグ（ｓＥＳＴｓ）
CN1105914C (zh) 1997-04-25 2003-04-16 卡钳技术有限公司 改进了通道几何结构的微型流体装置
WO1999001555A1 (en) * 1997-07-03 1999-01-14 The United States Of America Represented By The Secretary, Department Of Health And Human Services Genes for niemann-pick type c disease
US6119096A (en) 1997-07-31 2000-09-12 Eyeticket Corporation System and method for aircraft passenger check-in and boarding using iris recognition
GB9717766D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Methods
US20030082677A1 (en) * 1997-09-30 2003-05-01 Holtzman Douglas A. Novel EDIRF, MTR-1, LSP-1, TAP-1, and PA-I molecules and uses therefor
AU9790798A (en) * 1997-10-06 1999-04-27 Millennium Pharmaceuticals, Inc. Signal peptide containing proteins and uses therefor
AU4158799A (en) * 1998-06-06 1999-12-30 Genostic Pharma Limited Probes used for genetic filing
US6506594B1 (en) 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
DE10019058A1 (de) * 2000-04-06 2001-12-20 Epigenomics Ag Detektion von Variationen des DNA-Methylierungsprofils
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
WO2002024747A2 (en) * 2000-09-19 2002-03-28 Epidauros Biotechnologie Ag Polymorphisms in human genes of cardiovascular regulators and their use in diagnostic and therapeutic applications
WO2002031125A2 (en) * 2000-10-10 2002-04-18 Bayer Aktiengesellschaft Human phospholipase a2-like enzyme
USH2191H1 (en) * 2000-10-24 2007-06-05 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
FR2815970A1 (fr) * 2000-10-31 2002-05-03 Aventis Pharma Sa Sequences polymorphes du gene humain abca1, leurs utilisations, les methodes et kits de detection
EP1364334A2 (en) * 2000-11-30 2003-11-26 Third Wave Technologies, Inc. Systems and method for detection assay production and sale
US20030104470A1 (en) * 2001-08-14 2003-06-05 Third Wave Technologies, Inc. Electronic medical record, library of electronic medical records having polymorphism data, and computer systems and methods for use thereof
DE10061279A1 (de) * 2000-12-08 2002-07-25 Vinzenz Hombach Verfahren und Diagnose-Kit zur Bestimmung der Prädisposition für Herz-Kreislauf-Krankheiten und Arteriosklerose
US20030152924A1 (en) * 2000-12-19 2003-08-14 Ullman Edwin F. Strand displacement detection of target nucleic acid
EP1816212A2 (en) * 2000-12-27 2007-08-08 Riken Detection of genetic polymorphisms in genes associated with pharmacogenomics
AU2002255478A1 (en) * 2001-01-10 2002-09-12 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
WO2002072889A2 (en) 2001-01-12 2002-09-19 Applera Corporation Methods and compositions for microarray control
US20030036057A1 (en) * 2001-03-09 2003-02-20 Andreas Braun Genes and polymorphisms associated with cardiovascular disease and their use
AU2002305019A1 (en) * 2001-05-25 2002-12-09 University Of British Columbia Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
US20030215819A1 (en) * 2001-06-29 2003-11-20 Frudakis Tony N. Compositions and methods for inferring a response to statin
US20030124536A1 (en) * 2001-07-20 2003-07-03 Vitivity, Inc. Diagnosis and treatment of vascular disease
US7468244B2 (en) * 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
US20030207327A1 (en) * 2001-09-27 2003-11-06 Kmiec Eric B. Coisogenic eukaryotic cell collections
EP1298220A1 (en) * 2001-10-01 2003-04-02 Bayer Ag Single nucleotide polymorphisms predicting cardiovascular disease
WO2003057911A2 (en) * 2002-01-08 2003-07-17 Bayer Healthcare Ag Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy
AU2003210276A1 (en) * 2002-02-27 2003-09-09 Bayer Aktiengesellschaft Single nucleotide polymorphisms predicting adverse drug reactions and medication efficacy

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