CA3027124A1 - Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response - Google Patents

Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response Download PDF

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Publication number
CA3027124A1
CA3027124A1 CA3027124A CA3027124A CA3027124A1 CA 3027124 A1 CA3027124 A1 CA 3027124A1 CA 3027124 A CA3027124 A CA 3027124A CA 3027124 A CA3027124 A CA 3027124A CA 3027124 A1 CA3027124 A1 CA 3027124A1
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Prior art keywords
amino acid
cell
acid sequence
seq
sequence
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CA3027124A
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English (en)
French (fr)
Inventor
Jurgen Herbert Ernst Kuball
Anke JANSSEN
Dennis BERINGER
Paul Fisch
Jose Alberto VILLACORTA HIDALGO
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Albert Ludwigs Universitaet Freiburg
Gadeta Bv
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Albert Ludwigs Universitaet Freiburg
Gadeta Bv
UMC Utrecht Holding BV
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Publication of CA3027124A1 publication Critical patent/CA3027124A1/en
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/19Cytokines; Lymphokines; Interferons
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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CA3027124A 2016-06-10 2017-06-12 Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response Pending CA3027124A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16173970 2016-06-10
EP16173970.1 2016-06-10
EP16173986 2016-06-10
EP16173986.7 2016-06-10
PCT/EP2017/064325 WO2017212074A1 (en) 2016-06-10 2017-06-12 Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response

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Publication Number Publication Date
CA3027124A1 true CA3027124A1 (en) 2017-12-14

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA3026180A Pending CA3026180A1 (en) 2016-06-10 2017-06-12 Human leukocyte antigen restricted gamma delta t cell receptors and methods of use thereof
CA3027124A Pending CA3027124A1 (en) 2016-06-10 2017-06-12 Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response

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Application Number Title Priority Date Filing Date
CA3026180A Pending CA3026180A1 (en) 2016-06-10 2017-06-12 Human leukocyte antigen restricted gamma delta t cell receptors and methods of use thereof

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US (5) US11166984B2 (enExample)
EP (4) EP4099015A1 (enExample)
JP (1) JP2019525898A (enExample)
KR (1) KR102489954B1 (enExample)
CN (1) CN109997041B (enExample)
CA (2) CA3026180A1 (enExample)
ES (1) ES2987986T3 (enExample)
HU (1) HUE068936T2 (enExample)
PL (1) PL3469361T3 (enExample)
WO (2) WO2017212074A1 (enExample)

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PT2831109T (pt) 2012-03-28 2018-02-07 Gadeta B V Resumo
CA3026180A1 (en) 2016-06-10 2017-12-14 Gadeta B.V. Human leukocyte antigen restricted gamma delta t cell receptors and methods of use thereof
EP3624823A1 (en) 2017-05-18 2020-03-25 UMC Utrecht Holding B.V. Compositions and methods for cell targeting therapies
WO2019156566A1 (en) * 2018-02-12 2019-08-15 Umc Utrecht Holding B.V. Bispecific molecules comprising gamma-delta tcr and t-cell or nk cell binding domain
US11770910B2 (en) * 2018-04-23 2023-09-26 Commscope Technologies Llc Telecommunications enclosure with modular locking system
WO2019219979A1 (en) 2018-05-18 2019-11-21 Umc Utrecht Holding B.V. Compositions and methods for cell targeting therapies
UY38427A (es) 2018-10-26 2020-05-29 Novartis Ag Métodos y composiciones para terapia con células oculares
CN115667504A (zh) 2020-04-27 2023-01-31 诺华股份有限公司 用于眼细胞疗法的方法和组合物
EP4267604A1 (en) 2020-12-23 2023-11-01 Gadeta B.V. Chimeric, transmembrane proteins with bidirectional signalling activity
CN113046320B (zh) * 2021-02-19 2023-04-14 中国医学科学院基础医学研究所 胞外段为Vδ1(GTM)Vγ4的CAR分子及表达该分子的CAR-T细胞及其用途
EP4059955A1 (en) 2021-03-19 2022-09-21 Medizinische Hochschule Hannover Hla-dr-specific gamma delta tcr constructs and use thereof
WO2022214707A1 (en) 2021-04-09 2022-10-13 Gadeta B.V. Cellular reporter and methods of using the same
WO2022258606A1 (en) 2021-06-07 2022-12-15 Gadeta B.V. Delta T-cell or Gamma T-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response
AU2022310862A1 (en) 2021-07-14 2024-02-01 Regeneron Pharmaceuticals, Inc. Engineered t cell receptors fused to binding domains from antibodies
AU2023248532A1 (en) 2022-04-08 2024-11-21 Regeneron Pharmaceuticals, Inc. Multipartite receptor and signaling complexes
WO2023227594A1 (en) 2022-05-24 2023-11-30 Gadeta Bv Novel deltat-cell receptor chains, gammat-cell receptor chains, or parts thereof
WO2023237541A1 (en) 2022-06-07 2023-12-14 Gadeta B.V. Delta t-cell or gamma t-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response
WO2023242434A1 (en) 2022-06-17 2023-12-21 Gadeta B.V. Modified immune cells
WO2024013402A1 (en) * 2022-07-15 2024-01-18 Gadeta B.V. Novel soluble gamma t-cell (or soluble delta t-cell) receptor chains (or soluble gammadelta t-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response
US20240043496A1 (en) * 2022-07-26 2024-02-08 Gadeta B.V. Delta t-cell or gamma receptor chains or parts thereof for treating ovarian cancer
WO2025231488A1 (en) * 2024-05-03 2025-11-06 Northwestern University Gamma-delta t cell receptors for cancer therapy

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