CA3021935A1 - Stabilized glycopeptide antibiotic formulations - Google Patents
Stabilized glycopeptide antibiotic formulations Download PDFInfo
- Publication number
- CA3021935A1 CA3021935A1 CA3021935A CA3021935A CA3021935A1 CA 3021935 A1 CA3021935 A1 CA 3021935A1 CA 3021935 A CA3021935 A CA 3021935A CA 3021935 A CA3021935 A CA 3021935A CA 3021935 A1 CA3021935 A1 CA 3021935A1
- Authority
- CA
- Canada
- Prior art keywords
- vancomycin
- solution
- glycopeptide antibiotic
- sulfobutylether
- alanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201662333357P | 2016-05-09 | 2016-05-09 | |
US62/333,357 | 2016-05-09 | ||
PCT/EP2017/060653 WO2017194385A1 (en) | 2016-05-09 | 2017-05-04 | Stabilized glycopeptide antibiotic formulations |
Publications (1)
Publication Number | Publication Date |
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CA3021935A1 true CA3021935A1 (en) | 2017-11-16 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA3021935A Pending CA3021935A1 (en) | 2016-05-09 | 2017-05-04 | Stabilized glycopeptide antibiotic formulations |
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US (1) | US10729708B2 (zh) |
EP (1) | EP3454883A1 (zh) |
JP (1) | JP6946343B2 (zh) |
KR (1) | KR20190005940A (zh) |
CN (1) | CN109069580A (zh) |
AR (1) | AR109454A1 (zh) |
AU (1) | AU2017262943B2 (zh) |
BR (1) | BR112018072948A2 (zh) |
CA (1) | CA3021935A1 (zh) |
CL (1) | CL2018003147A1 (zh) |
CO (1) | CO2018011701A2 (zh) |
EA (1) | EA201892413A1 (zh) |
IL (1) | IL262796A (zh) |
JO (2) | JOP20170111B1 (zh) |
MX (1) | MX2018013584A (zh) |
SA (1) | SA518400392B1 (zh) |
SG (1) | SG11201809908TA (zh) |
TW (2) | TWI772296B (zh) |
UY (1) | UY37233A (zh) |
WO (1) | WO2017194385A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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KR102603756B1 (ko) | 2014-11-06 | 2023-11-16 | 셀리아 파마슈티칼즈 에이피에스 | 글리코펩티드 조성물 |
WO2021231361A1 (en) * | 2020-05-11 | 2021-11-18 | Anovent Pharmaceutical (U.S.), Llc | Pharmaceutical formulation containing active metabolites of remdesivir for inhalation |
EP4014965A1 (en) | 2020-12-16 | 2022-06-22 | EVER Valinject GmbH | Aqueous solution |
EP4014969A1 (en) | 2020-12-16 | 2022-06-22 | EVER Valinject GmbH | Aqueous solution |
CN115804832A (zh) * | 2021-09-14 | 2023-03-17 | 海南普利制药股份有限公司 | 一种万古霉素水溶液组合物 |
WO2023171588A1 (ja) * | 2022-03-08 | 2023-09-14 | 国立大学法人大阪大学 | 抗菌薬を含有するplga製剤 |
WO2023211501A1 (en) * | 2022-04-26 | 2023-11-02 | Hikma Pharmaceuticals Usa Inc. | Stable, ready-to-administer aqueous formulations of dalbavancin |
GB202207344D0 (en) | 2022-05-19 | 2022-07-06 | Arecor Ltd | Novel composition |
GB202207345D0 (en) | 2022-05-19 | 2022-07-06 | Arecor Ltd | Novel composition |
CN117618338A (zh) * | 2022-08-16 | 2024-03-01 | 海南普利制药股份有限公司 | 一种稳定的奥利万星药物水溶液及其制备方法 |
US20240139282A1 (en) * | 2022-10-12 | 2024-05-02 | Xellia Pharmaceuticals Aps | Liquid dalbavancin compositions |
WO2024079224A1 (en) * | 2022-10-12 | 2024-04-18 | Xellia Pharmaceuticals Aps | Liquid dalbavancin composition |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
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US1278549A (en) * | 1916-12-16 | 1918-09-10 | J E Simmons | Nut and bolt lock. |
US4670258A (en) | 1984-02-10 | 1987-06-02 | Vanderbilt University | Storable prepackaged aqueous solutions of vancomycin |
US4885275A (en) | 1987-10-15 | 1989-12-05 | Eli Lilly And Company | Vancomycin-HCL solutions and the lyophilization thereof |
AU1407197A (en) | 1995-12-01 | 1997-06-19 | Eli Lilly And Company | Stable vancomycin hydrochloride solutions |
JPH1180021A (ja) | 1997-09-02 | 1999-03-23 | Kayaku:Kk | バンコマイシン注射剤 |
CN1223378C (zh) * | 2000-05-02 | 2005-10-19 | 施万制药 | 含有糖肽抗生素和环糊精的药物组合物 |
US6770621B2 (en) * | 2000-05-02 | 2004-08-03 | Theravance, Inc. | Polyacid glycopeptide derivatives |
CN100532392C (zh) * | 2000-05-02 | 2009-08-26 | 施万制药 | 还原性烷基化方法 |
BR0112393A (pt) * | 2000-06-21 | 2003-07-08 | Internat Health Man Associates | Composições e processos para aperfeiçoamento de absorção oral de agentes antimicrobiais |
UA75083C2 (uk) * | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Похідні глікопептидфосфонатів |
US7034013B2 (en) | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
US7119061B2 (en) * | 2002-11-18 | 2006-10-10 | Vicuron Pharmaceuticals, Inc. | Dalbavancin compositions for treatment of bacterial infections |
KR20060096490A (ko) * | 2003-10-31 | 2006-09-11 | 더 유니버시티 오브 캔사스 | 술포알킬 에테르-알킬 에테르 시클로덱스트린 유도체 |
AU2006213441B2 (en) | 2005-02-14 | 2011-12-01 | Venus Remedies Limited | Parenteral combination therpy for infective conditions with drug resistant bacterium |
CN1857716A (zh) * | 2006-03-14 | 2006-11-08 | 浙江大学 | 注射用盐酸万古霉素及其制备方法 |
JP2008201778A (ja) | 2007-01-25 | 2008-09-04 | Mochida Pharmaceut Co Ltd | バンコマイシン液状製剤 |
JP5591112B2 (ja) | 2007-09-12 | 2014-09-17 | ターガンタ セラピューティクス コーポレイション | オリタバンシンの投与によってクロストリジウム・ディフィシレを抑制する方法 |
US7635773B2 (en) * | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
CN102755629A (zh) * | 2012-08-02 | 2012-10-31 | 上海瑞创医药科技有限公司 | 与万古霉素形成抗菌增效包合物的组分和制备方法及其应用 |
RU2018135921A (ru) | 2012-11-29 | 2019-02-05 | Инсмед Инкорпорейтед | Стабилизированные составы ванкомицина |
CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
WO2014194296A1 (en) | 2013-05-30 | 2014-12-04 | Scidose, Llc | Formulations of vancomycin |
KR102603756B1 (ko) * | 2014-11-06 | 2023-11-16 | 셀리아 파마슈티칼즈 에이피에스 | 글리코펩티드 조성물 |
WO2017118994A1 (en) | 2016-01-08 | 2017-07-13 | Gufic Biosciences Limited | A freeze dried parenteral composition of tigecycline and process for preparation thereof |
AU2017221435A1 (en) * | 2016-02-18 | 2018-09-06 | Melinta Therapeutics, Inc. | Oritavancin formulations |
-
2017
- 2017-05-04 CN CN201780027315.7A patent/CN109069580A/zh active Pending
- 2017-05-04 BR BR112018072948-5A patent/BR112018072948A2/pt not_active IP Right Cessation
- 2017-05-04 JP JP2018558750A patent/JP6946343B2/ja active Active
- 2017-05-04 EA EA201892413A patent/EA201892413A1/ru unknown
- 2017-05-04 EP EP17724773.1A patent/EP3454883A1/en not_active Withdrawn
- 2017-05-04 AU AU2017262943A patent/AU2017262943B2/en not_active Ceased
- 2017-05-04 MX MX2018013584A patent/MX2018013584A/es unknown
- 2017-05-04 KR KR1020187035449A patent/KR20190005940A/ko not_active Application Discontinuation
- 2017-05-04 US US16/300,137 patent/US10729708B2/en active Active
- 2017-05-04 SG SG11201809908TA patent/SG11201809908TA/en unknown
- 2017-05-04 CA CA3021935A patent/CA3021935A1/en active Pending
- 2017-05-04 WO PCT/EP2017/060653 patent/WO2017194385A1/en unknown
- 2017-05-07 JO JOP/2017/0111A patent/JOP20170111B1/ar active
- 2017-05-08 UY UY0001037233A patent/UY37233A/es active IP Right Grant
- 2017-05-08 AR ARP170101197A patent/AR109454A1/es unknown
- 2017-05-09 TW TW106115255A patent/TWI772296B/zh active
- 2017-05-09 TW TW110104598A patent/TWI769694B/zh active
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2018
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- 2018-11-05 IL IL262796A patent/IL262796A/en unknown
- 2018-11-06 CL CL2018003147A patent/CL2018003147A1/es unknown
- 2018-11-07 SA SA518400392A patent/SA518400392B1/ar unknown
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2022
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Also Published As
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MX2018013584A (es) | 2019-04-01 |
JOP20170111B1 (ar) | 2022-03-14 |
BR112018072948A2 (pt) | 2019-02-19 |
EA201892413A1 (ru) | 2019-05-31 |
TW202133875A (zh) | 2021-09-16 |
WO2017194385A1 (en) | 2017-11-16 |
TW201740955A (zh) | 2017-12-01 |
EP3454883A1 (en) | 2019-03-20 |
SA518400392B1 (ar) | 2022-05-09 |
AU2017262943A1 (en) | 2018-11-22 |
AR109454A1 (es) | 2018-12-12 |
US10729708B2 (en) | 2020-08-04 |
TWI772296B (zh) | 2022-08-01 |
CN109069580A (zh) | 2018-12-21 |
US20190175632A1 (en) | 2019-06-13 |
UY37233A (es) | 2018-01-02 |
CL2018003147A1 (es) | 2018-12-28 |
JOP20220039A1 (ar) | 2023-01-30 |
TWI769694B (zh) | 2022-07-01 |
CO2018011701A2 (es) | 2019-02-08 |
KR20190005940A (ko) | 2019-01-16 |
JP2019518733A (ja) | 2019-07-04 |
AU2017262943B2 (en) | 2020-05-14 |
IL262796A (en) | 2018-12-31 |
SG11201809908TA (en) | 2018-12-28 |
JP6946343B2 (ja) | 2021-10-06 |
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