CA3021349A1 - Nlrp3 modulators - Google Patents
Nlrp3 modulators Download PDFInfo
- Publication number
- CA3021349A1 CA3021349A1 CA3021349A CA3021349A CA3021349A1 CA 3021349 A1 CA3021349 A1 CA 3021349A1 CA 3021349 A CA3021349 A CA 3021349A CA 3021349 A CA3021349 A CA 3021349A CA 3021349 A1 CA3021349 A1 CA 3021349A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- alkyl
- independently selected
- optionally substituted
- ring atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 101150061038 NLRP3 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 279
- 238000000034 method Methods 0.000 claims abstract description 69
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- 150000003839 salts Chemical class 0.000 claims abstract description 35
- 230000000694 effects Effects 0.000 claims abstract description 16
- 125000006413 ring segment Chemical group 0.000 claims description 302
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- 125000002947 alkylene group Chemical group 0.000 claims description 208
- 125000001072 heteroaryl group Chemical group 0.000 claims description 143
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 112
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 106
- -1 -OH Chemical group 0.000 claims description 96
- 229910052760 oxygen Inorganic materials 0.000 claims description 84
- 229910052739 hydrogen Inorganic materials 0.000 claims description 80
- 239000001257 hydrogen Substances 0.000 claims description 79
- 229910052717 sulfur Inorganic materials 0.000 claims description 72
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 68
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 65
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 53
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 46
- 125000005843 halogen group Chemical group 0.000 claims description 42
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 25
- 150000002431 hydrogen Chemical group 0.000 claims description 23
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 19
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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-
2017
- 2017-04-19 AU AU2017252640A patent/AU2017252640A1/en not_active Abandoned
- 2017-04-19 CN CN201780024285.4A patent/CN109071535B/zh active Active
- 2017-04-19 BR BR112018071347A patent/BR112018071347A2/pt not_active Application Discontinuation
- 2017-04-19 SG SG11201809082WA patent/SG11201809082WA/en unknown
- 2017-04-19 MX MX2018012249A patent/MX2018012249A/es unknown
- 2017-04-19 WO PCT/US2017/028384 patent/WO2017184746A1/en not_active Ceased
- 2017-04-19 EP EP17722231.2A patent/EP3445761A1/en not_active Withdrawn
- 2017-04-19 CA CA3021349A patent/CA3021349A1/en not_active Abandoned
- 2017-04-19 KR KR1020187032949A patent/KR20180134395A/ko not_active Ceased
- 2017-04-19 JP JP2018554782A patent/JP7104633B6/ja active Active
- 2017-04-19 US US16/093,990 patent/US10556903B2/en active Active
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2018
- 2018-10-11 IL IL262303A patent/IL262303A/en unknown
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2019
- 2019-12-05 US US16/703,974 patent/US11072612B2/en active Active
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|---|---|
| BR112018071347A2 (pt) | 2019-02-05 |
| US10556903B2 (en) | 2020-02-11 |
| IL262303A (en) | 2018-12-31 |
| SG11201809082WA (en) | 2018-11-29 |
| JP7104633B6 (ja) | 2023-12-22 |
| MX2018012249A (es) | 2019-02-07 |
| CN109071535A (zh) | 2018-12-21 |
| US11072612B2 (en) | 2021-07-27 |
| US20190127367A1 (en) | 2019-05-02 |
| CN109071535B (zh) | 2021-10-08 |
| AU2017252640A1 (en) | 2018-12-06 |
| US20200157097A1 (en) | 2020-05-21 |
| WO2017184746A1 (en) | 2017-10-26 |
| EP3445761A1 (en) | 2019-02-27 |
| KR20180134395A (ko) | 2018-12-18 |
| JP7104633B2 (ja) | 2022-07-21 |
| JP2019513809A (ja) | 2019-05-30 |
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