CA2994203C - Azaspiro compounds as muscarinic agonists - Google Patents

Azaspiro compounds as muscarinic agonists Download PDF

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Publication number
CA2994203C
CA2994203C CA2994203A CA2994203A CA2994203C CA 2994203 C CA2994203 C CA 2994203C CA 2994203 A CA2994203 A CA 2994203A CA 2994203 A CA2994203 A CA 2994203A CA 2994203 C CA2994203 C CA 2994203C
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CA
Canada
Prior art keywords
compound according
treatment
compound
ethyl
carboxylate
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Active
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CA2994203A
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English (en)
French (fr)
Other versions
CA2994203A1 (en
Inventor
Giles Albert Brown
Julie CANSFIELD
Mark PICKWORTH
Benjamin Gerald TEHAN
Barry John Teobald
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Nxera Pharma UK Ltd
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Heptares Therapeutics Ltd
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Publication of CA2994203A1 publication Critical patent/CA2994203A1/en
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Publication of CA2994203C publication Critical patent/CA2994203C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2994203A 2015-08-03 2016-08-03 Azaspiro compounds as muscarinic agonists Active CA2994203C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1513743.3 2015-08-03
GBGB1513743.3A GB201513743D0 (en) 2015-08-03 2015-08-03 Muscarinic agonists
PCT/GB2016/052385 WO2017021729A1 (en) 2015-08-03 2016-08-03 Muscarinic agonists

Publications (2)

Publication Number Publication Date
CA2994203A1 CA2994203A1 (en) 2017-02-09
CA2994203C true CA2994203C (en) 2023-11-28

Family

ID=54063149

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2994203A Active CA2994203C (en) 2015-08-03 2016-08-03 Azaspiro compounds as muscarinic agonists

Country Status (10)

Country Link
US (3) US10738029B2 (enExample)
EP (1) EP3331529B1 (enExample)
JP (1) JP6843114B2 (enExample)
CN (1) CN108025004B (enExample)
AU (1) AU2016304387B2 (enExample)
CA (1) CA2994203C (enExample)
DK (1) DK3331529T3 (enExample)
ES (1) ES2894637T3 (enExample)
GB (1) GB201513743D0 (enExample)
WO (1) WO2017021729A1 (enExample)

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* Cited by examiner, † Cited by third party
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GB201709652D0 (en) * 2017-06-16 2017-08-02 Heptares Therapeutics Ltd Pharmaceutical compounds
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GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
KR102798432B1 (ko) 2019-10-09 2025-04-22 노파르티스 아게 M4 작용제로서의 5-옥사-2-아자스피로[3.4]옥탄 유도체
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Also Published As

Publication number Publication date
US11254656B2 (en) 2022-02-22
EP3331529B1 (en) 2021-09-29
JP6843114B2 (ja) 2021-03-17
CN108025004B (zh) 2021-07-09
CA2994203A1 (en) 2017-02-09
GB201513743D0 (en) 2015-09-16
US10738029B2 (en) 2020-08-11
CN108025004A (zh) 2018-05-11
US20200354339A1 (en) 2020-11-12
EP3331529A1 (en) 2018-06-13
US20230002354A1 (en) 2023-01-05
ES2894637T3 (es) 2022-02-15
AU2016304387A1 (en) 2018-02-22
US20180222885A1 (en) 2018-08-09
JP2018522033A (ja) 2018-08-09
US12024499B2 (en) 2024-07-02
DK3331529T3 (da) 2021-10-18
WO2017021729A1 (en) 2017-02-09
AU2016304387B2 (en) 2020-10-22
HK1250138A1 (en) 2018-11-30

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