AU2016304387B2 - Muscarinic agonists - Google Patents

Muscarinic agonists Download PDF

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Publication number
AU2016304387B2
AU2016304387B2 AU2016304387A AU2016304387A AU2016304387B2 AU 2016304387 B2 AU2016304387 B2 AU 2016304387B2 AU 2016304387 A AU2016304387 A AU 2016304387A AU 2016304387 A AU2016304387 A AU 2016304387A AU 2016304387 B2 AU2016304387 B2 AU 2016304387B2
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AU
Australia
Prior art keywords
compound according
hydrocarbon group
hydrogen
fluorine
ethyl
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AU2016304387A
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English (en)
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AU2016304387A1 (en
Inventor
Giles Albert Brown
Julie CANSFIELD
Mark PICKWORTH
Benjamin Gerald TEHAN
Barry John Teobald
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Nxera Pharma UK Ltd
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Nxera Pharma UK Ltd
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Assigned to NXERA PHARMA UK LIMITED reassignment NXERA PHARMA UK LIMITED Request to Amend Deed and Register Assignors: HEPTARES THERAPEUTICS LIMITED
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2016304387A 2015-08-03 2016-08-03 Muscarinic agonists Active AU2016304387B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1513743.3A GB201513743D0 (en) 2015-08-03 2015-08-03 Muscarinic agonists
GB1513743.3 2015-08-03
PCT/GB2016/052385 WO2017021729A1 (en) 2015-08-03 2016-08-03 Muscarinic agonists

Publications (2)

Publication Number Publication Date
AU2016304387A1 AU2016304387A1 (en) 2018-02-22
AU2016304387B2 true AU2016304387B2 (en) 2020-10-22

Family

ID=54063149

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016304387A Active AU2016304387B2 (en) 2015-08-03 2016-08-03 Muscarinic agonists

Country Status (10)

Country Link
US (3) US10738029B2 (enExample)
EP (1) EP3331529B1 (enExample)
JP (1) JP6843114B2 (enExample)
CN (1) CN108025004B (enExample)
AU (1) AU2016304387B2 (enExample)
CA (1) CA2994203C (enExample)
DK (1) DK3331529T3 (enExample)
ES (1) ES2894637T3 (enExample)
GB (1) GB201513743D0 (enExample)
WO (1) WO2017021729A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE033114T2 (en) 2011-11-18 2017-11-28 Heptares Therapeutics Ltd Muscarin M1 receptor agonists
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) * 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201513740D0 (en) * 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonist
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201709652D0 (en) * 2017-06-16 2017-08-02 Heptares Therapeutics Ltd Pharmaceutical compounds
EP3697781B1 (en) * 2017-10-17 2023-06-07 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
TWI801540B (zh) 2018-03-23 2023-05-11 美商輝瑞大藥廠 哌嗪氮雜螺衍生物
GB201810245D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
CR20220153A (es) * 2019-10-09 2022-05-03 Novartis Ag Derivados de 2–azaespiro [3.4] octano como agonistas de m4
UY38906A (es) 2019-10-09 2021-05-31 Novartis Ag Compuestos 2- derivados de azaspiro[3,4]octano como agonistas de m4 y composiciones de los mismos

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015118342A1 (en) * 2014-02-06 2015-08-13 Heptares Therapeutics Limited Bicyclic aza compounds as muscarinic m1 receptor agonists.

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GB201513742D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
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Also Published As

Publication number Publication date
US12024499B2 (en) 2024-07-02
US20200354339A1 (en) 2020-11-12
US11254656B2 (en) 2022-02-22
CA2994203C (en) 2023-11-28
EP3331529A1 (en) 2018-06-13
JP2018522033A (ja) 2018-08-09
WO2017021729A1 (en) 2017-02-09
CN108025004A (zh) 2018-05-11
US20180222885A1 (en) 2018-08-09
AU2016304387A1 (en) 2018-02-22
CA2994203A1 (en) 2017-02-09
CN108025004B (zh) 2021-07-09
EP3331529B1 (en) 2021-09-29
HK1250138A1 (en) 2018-11-30
ES2894637T3 (es) 2022-02-15
US10738029B2 (en) 2020-08-11
DK3331529T3 (da) 2021-10-18
GB201513743D0 (en) 2015-09-16
US20230002354A1 (en) 2023-01-05
JP6843114B2 (ja) 2021-03-17

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