CN108025004B - 毒蕈碱激动剂 - Google Patents

毒蕈碱激动剂 Download PDF

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Publication number
CN108025004B
CN108025004B CN201680045224.1A CN201680045224A CN108025004B CN 108025004 B CN108025004 B CN 108025004B CN 201680045224 A CN201680045224 A CN 201680045224A CN 108025004 B CN108025004 B CN 108025004B
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compound
acid
group
hydrogen
compound according
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Chinese (zh)
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CN108025004A (zh
Inventor
盖尔斯·艾伯特·布朗
朱莉·坎斯菲尔德
马克·皮克沃斯
本杰明·杰拉尔德·特汉
巴里·约翰·泰奥巴尔德
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Nexla Pharmaceuticals Uk Ltd
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Heptares Therapeutics Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201680045224.1A 2015-08-03 2016-08-03 毒蕈碱激动剂 Active CN108025004B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1513743.3 2015-08-03
GBGB1513743.3A GB201513743D0 (en) 2015-08-03 2015-08-03 Muscarinic agonists
PCT/GB2016/052385 WO2017021729A1 (en) 2015-08-03 2016-08-03 Muscarinic agonists

Publications (2)

Publication Number Publication Date
CN108025004A CN108025004A (zh) 2018-05-11
CN108025004B true CN108025004B (zh) 2021-07-09

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CN201680045224.1A Active CN108025004B (zh) 2015-08-03 2016-08-03 毒蕈碱激动剂

Country Status (10)

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US (3) US10738029B2 (enExample)
EP (1) EP3331529B1 (enExample)
JP (1) JP6843114B2 (enExample)
CN (1) CN108025004B (enExample)
AU (1) AU2016304387B2 (enExample)
CA (1) CA2994203C (enExample)
DK (1) DK3331529T3 (enExample)
ES (1) ES2894637T3 (enExample)
GB (1) GB201513743D0 (enExample)
WO (1) WO2017021729A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014012056B1 (pt) 2011-11-18 2021-12-14 Heptares Therapeutics Limited Compostos agonistas do receptor m1 muscarínico, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para tratar um distúrbio cognitivo ou psicótico ou para tratamento ou diminuição da severidade da dor aguda, crônica, neuropática ou inflamatória
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) * 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201513740D0 (en) * 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonist
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201709652D0 (en) * 2017-06-16 2017-08-02 Heptares Therapeutics Ltd Pharmaceutical compounds
CA3079188A1 (en) 2017-10-17 2019-04-25 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
HUE061533T2 (hu) * 2018-03-23 2023-07-28 Pfizer Piperazin azaspiro származékok
GB201810245D0 (en) * 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201810239D0 (en) * 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
PH12022550860A1 (en) 2019-10-09 2023-06-14 Novartis Ag 5-oxa-2-azaspiro[3.4]octane derivatives as m4 agonists
JOP20220082A1 (ar) 2019-10-09 2023-01-30 Novartis Ag مشتقات 2- آزا سبيرو [3.4] أوكتان كناهضات لـ m4

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2007100670A1 (en) * 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Spiro condensed piperidnes as modulators of muscarinic receptors
CN104039321A (zh) * 2011-11-18 2014-09-10 赫普泰雅治疗有限公司 药物化合物
CN104640851A (zh) * 2012-09-18 2015-05-20 赫普泰雅治疗有限公司 作为毒蕈碱的m1受体激动剂的二环氮杂化合物

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GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
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Patent Citations (3)

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CN104039321A (zh) * 2011-11-18 2014-09-10 赫普泰雅治疗有限公司 药物化合物
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Also Published As

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US10738029B2 (en) 2020-08-11
US20230002354A1 (en) 2023-01-05
AU2016304387B2 (en) 2020-10-22
JP2018522033A (ja) 2018-08-09
GB201513743D0 (en) 2015-09-16
AU2016304387A1 (en) 2018-02-22
HK1250138A1 (en) 2018-11-30
US20200354339A1 (en) 2020-11-12
WO2017021729A1 (en) 2017-02-09
US20180222885A1 (en) 2018-08-09
EP3331529B1 (en) 2021-09-29
US12024499B2 (en) 2024-07-02
US11254656B2 (en) 2022-02-22
CA2994203A1 (en) 2017-02-09
JP6843114B2 (ja) 2021-03-17
CA2994203C (en) 2023-11-28
CN108025004A (zh) 2018-05-11
DK3331529T3 (da) 2021-10-18
ES2894637T3 (es) 2022-02-15
EP3331529A1 (en) 2018-06-13

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