CA2993377C - A pharmaceutical composition comprising electrohydrodynamically obtained fibres, the composition having improved residence time on the application site - Google Patents
A pharmaceutical composition comprising electrohydrodynamically obtained fibres, the composition having improved residence time on the application site Download PDFInfo
- Publication number
- CA2993377C CA2993377C CA2993377A CA2993377A CA2993377C CA 2993377 C CA2993377 C CA 2993377C CA 2993377 A CA2993377 A CA 2993377A CA 2993377 A CA2993377 A CA 2993377A CA 2993377 C CA2993377 C CA 2993377C
- Authority
- CA
- Canada
- Prior art keywords
- electrospun
- electrospun fibres
- fibres
- substance
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nonwoven Fabrics (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201570745 | 2015-11-19 | ||
| DKPA201570745 | 2015-11-19 | ||
| PCT/EP2016/078151 WO2017085264A1 (en) | 2015-11-19 | 2016-11-18 | A pharmaceutical composition comprising electrohydrodynamically obtained fibres, the composition having improved residence time on the application site |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2993377A1 CA2993377A1 (en) | 2017-05-26 |
| CA2993377C true CA2993377C (en) | 2019-11-12 |
Family
ID=58718438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2993377A Active CA2993377C (en) | 2015-11-19 | 2016-11-18 | A pharmaceutical composition comprising electrohydrodynamically obtained fibres, the composition having improved residence time on the application site |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20180221295A1 (https=) |
| EP (1) | EP3334412B1 (https=) |
| JP (2) | JP6606279B2 (https=) |
| KR (3) | KR20190067280A (https=) |
| CN (1) | CN108135833B (https=) |
| AU (2) | AU2016358266B2 (https=) |
| BR (1) | BR112018001978A2 (https=) |
| CA (1) | CA2993377C (https=) |
| DK (1) | DK3334412T3 (https=) |
| ES (1) | ES2900741T3 (https=) |
| IL (1) | IL258093B (https=) |
| MX (1) | MX391778B (https=) |
| MY (1) | MY167777A (https=) |
| NZ (1) | NZ740615A (https=) |
| RU (2) | RU2701513C2 (https=) |
| SG (1) | SG10201913222XA (https=) |
| WO (1) | WO2017085264A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102592782B1 (ko) | 2017-01-23 | 2023-10-20 | 에이에프와이엑스 테라퓨틱스 에스에이 | 전기방사 섬유에 기반한 2층 제품의 제조 방법 |
| IL268185B2 (en) | 2017-01-23 | 2024-01-01 | Afyx Therapeutics As | Method for preparing electrospun fibers with a high content of a bioadhesive substance |
| WO2021050532A1 (en) * | 2019-09-09 | 2021-03-18 | Afyx Therapeutics A/S | Compositions for treating fungal infections |
| EP4041190A1 (en) | 2019-10-08 | 2022-08-17 | Afyx Therapeutics A/S | Compositions for the delivery of proteins |
| CA3171147A1 (en) * | 2020-03-17 | 2021-09-23 | Nannaji Saka | Expandable, multi-excipient structured dosage form for prolonged drug release |
| CN116887866A (zh) | 2020-12-03 | 2023-10-13 | 巴特尔纪念研究院 | 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法 |
| WO2022216977A1 (en) | 2021-04-07 | 2022-10-13 | Batelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
| EP4108231A1 (en) * | 2021-06-25 | 2022-12-28 | Johann-Wolfgang-Goethe-Universität Frankfurt am Main | In-situ dissolving electrospun polymer fibers for ocular drug delivery |
| ES2962999T3 (es) * | 2021-07-30 | 2024-03-22 | Cannamedical Pharma Gmbh | Parche transmucoso que comprende un cannabinoide y/o un opiáceo |
| AU2022395509A1 (en) | 2021-11-23 | 2024-06-13 | Afyx Development A/S | Mucosal patches and methods of use thereof |
| WO2024160792A1 (en) * | 2023-01-30 | 2024-08-08 | Cannamedical Pharma Gmbh | Improved transmucosal patch comprising a cannabinoid and/or an opioid |
| CN121843694A (zh) | 2023-09-06 | 2026-04-10 | 阿费克斯发展有限公司 | 用于治疗及预防口腔癌的组合物与方法 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| US12441996B2 (en) | 2023-12-08 | 2025-10-14 | Battelle Memorial Institute | Use of DNA origami nanostructures for molecular information based data storage systems |
| WO2025258992A1 (ko) * | 2024-06-11 | 2025-12-18 | 주식회사 아이메디텍 | 중재시술용 지혈 의료용 나노섬유 제조방법 및 이에 의한 의료용 나노섬유 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61280423A (ja) | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
| US6753454B1 (en) * | 1999-10-08 | 2004-06-22 | The University Of Akron | Electrospun fibers and an apparatus therefor |
| WO2001054667A1 (en) * | 2000-01-28 | 2001-08-02 | Smithkline Beecham Corporation | Electrospun pharmaceutical compositions |
| US7309498B2 (en) * | 2001-10-10 | 2007-12-18 | Belenkaya Bronislava G | Biodegradable absorbents and methods of preparation |
| US20030017208A1 (en) * | 2002-07-19 | 2003-01-23 | Francis Ignatious | Electrospun pharmaceutical compositions |
| TW200410714A (en) * | 2002-08-07 | 2004-07-01 | Smithkline Beecham Corp | Electrospun amorphous pharmaceutical compositions |
| AU2003265446A1 (en) * | 2002-08-13 | 2004-02-25 | Medtronic, Inc. | Active agent delivery system including a hydrophilic polymer, medical device, and method |
| CA2719637C (en) * | 2008-03-27 | 2014-10-28 | Agigma, Inc. | Methods and compositions for the delivery of agents |
| WO2013165604A1 (en) * | 2012-05-02 | 2013-11-07 | Massachusetts Institute Of Technology | Electroprocessing of active pharmaceutical ingredients |
| CN102670483B (zh) * | 2012-05-09 | 2014-04-02 | 上海交通大学 | 一种用于高血脂症治疗的静电纺丝纤维膜制剂及其制备方法 |
| WO2014066297A1 (en) * | 2012-10-22 | 2014-05-01 | North Carolina State University | Nonwoven fiber materials |
| EP2810645B1 (en) * | 2013-06-06 | 2017-05-24 | A. Sezai Sarac | New Drug Delivery System |
| NZ746573A (en) | 2014-06-10 | 2023-07-28 | Afyx Therapeutics As | Compositions comprising electrohydrodynamically obtained fibres for administration of specific dosages of an active substance to skin or mucosa |
-
2016
- 2016-11-18 RU RU2018109496A patent/RU2701513C2/ru active
- 2016-11-18 MX MX2018005206A patent/MX391778B/es unknown
- 2016-11-18 SG SG10201913222XA patent/SG10201913222XA/en unknown
- 2016-11-18 KR KR1020197016484A patent/KR20190067280A/ko not_active Withdrawn
- 2016-11-18 DK DK16797943.4T patent/DK3334412T3/da active
- 2016-11-18 WO PCT/EP2016/078151 patent/WO2017085264A1/en not_active Ceased
- 2016-11-18 RU RU2019129082A patent/RU2019129082A/ru unknown
- 2016-11-18 KR KR1020197004754A patent/KR102435996B1/ko active Active
- 2016-11-18 ES ES16797943T patent/ES2900741T3/es active Active
- 2016-11-18 CN CN201680046647.5A patent/CN108135833B/zh active Active
- 2016-11-18 BR BR112018001978A patent/BR112018001978A2/pt not_active Application Discontinuation
- 2016-11-18 EP EP16797943.4A patent/EP3334412B1/en active Active
- 2016-11-18 KR KR1020187008505A patent/KR102001163B1/ko not_active Expired - Fee Related
- 2016-11-18 AU AU2016358266A patent/AU2016358266B2/en not_active Ceased
- 2016-11-18 NZ NZ740615A patent/NZ740615A/en not_active IP Right Cessation
- 2016-11-18 CA CA2993377A patent/CA2993377C/en active Active
- 2016-11-18 MY MYPI2018700176A patent/MY167777A/en unknown
- 2016-11-18 JP JP2018516015A patent/JP6606279B2/ja active Active
-
2018
- 2018-01-29 US US15/882,637 patent/US20180221295A1/en not_active Abandoned
- 2018-03-13 IL IL258093A patent/IL258093B/en unknown
- 2018-08-21 AU AU2018220020A patent/AU2018220020C1/en not_active Ceased
-
2019
- 2019-04-24 US US16/393,597 patent/US20190254985A1/en not_active Abandoned
- 2019-10-16 JP JP2019189500A patent/JP6929916B2/ja active Active
-
2023
- 2023-05-17 US US18/198,582 patent/US20230285313A1/en not_active Abandoned
-
2024
- 2024-01-05 US US18/406,022 patent/US20240139117A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180123 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20250922 |
|
| H13 | Ip right lapsed |
Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE Effective date: 20260105 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260204 |