CA2991532C - Signal amplification in solution-based plasmonic specific-binding partner assays - Google Patents

Signal amplification in solution-based plasmonic specific-binding partner assays Download PDF

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Publication number
CA2991532C
CA2991532C CA2991532A CA2991532A CA2991532C CA 2991532 C CA2991532 C CA 2991532C CA 2991532 A CA2991532 A CA 2991532A CA 2991532 A CA2991532 A CA 2991532A CA 2991532 C CA2991532 C CA 2991532C
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detection
sample
analyte
detection conjugate
target analyte
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French (fr)
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CA2991532A1 (en
Inventor
Jessica FRISZ
Rajesh K. Mehra
Kenneth P. Aron
Vincent Chiang
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Zoetis Services LLC
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Zoetis Services LLC
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Peptides Or Proteins (AREA)
  • Chemical Kinetics & Catalysis (AREA)
CA2991532A 2015-08-04 2016-08-04 Signal amplification in solution-based plasmonic specific-binding partner assays Active CA2991532C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3227799A CA3227799A1 (en) 2015-08-04 2016-08-04 Signal amplification in solution-based plasmonic specific-binding partner assays

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562201051P 2015-08-04 2015-08-04
US62/201,051 2015-08-04
PCT/US2016/045606 WO2017024163A1 (en) 2015-08-04 2016-08-04 Signal amplification in solution-based plasmonic specific-binding partner assays

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Publications (2)

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CA2991532A1 CA2991532A1 (en) 2017-02-09
CA2991532C true CA2991532C (en) 2024-03-05

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CA2991532A Active CA2991532C (en) 2015-08-04 2016-08-04 Signal amplification in solution-based plasmonic specific-binding partner assays

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US (5) US9835622B2 (enExample)
EP (2) EP3331818B1 (enExample)
JP (4) JP6944438B2 (enExample)
CN (2) CN107864670A (enExample)
AU (2) AU2016301375B2 (enExample)
CA (2) CA3227799A1 (enExample)
DK (1) DK3331818T3 (enExample)
ES (1) ES2989755T3 (enExample)
FI (1) FI3331818T3 (enExample)
HU (1) HUE067974T2 (enExample)
PL (1) PL3331818T3 (enExample)
PT (1) PT3331818T (enExample)
WO (1) WO2017024163A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2783216B1 (en) 2011-11-21 2018-09-26 Abaxis, Inc. Signal amplification immunoassays
TWI691716B (zh) 2014-08-13 2020-04-21 美商艾巴希斯公司 電漿特異性結合搭配物檢定中之信號放大
CA3227799A1 (en) 2015-08-04 2017-02-09 Zoetis Services Llc Signal amplification in solution-based plasmonic specific-binding partner assays
US11977072B2 (en) 2017-01-30 2024-05-07 Zoetis Services Llc Solution-based plasmonic specific-binding partner assays using metallic nanostructures
CN110865182B (zh) * 2019-11-19 2023-06-27 东莞市东阳光诊断产品有限公司 一种阻断剂及其在免疫检测中的应用
CN113376374A (zh) * 2020-04-03 2021-09-10 上海桀蒙生物技术有限公司 病毒蛋白抗原检测工具的制备和使用方法
EP4193148A4 (en) * 2020-08-07 2024-11-06 Vital Biosciences Inc. KINETIC MODULATION FOR MAGNETIC ANALYTE DETECTION
US20220163522A1 (en) * 2020-11-23 2022-05-26 Arizona Board Of Regents On Behalf Of Arizona State University Compositions and methods for rapid covid-19 detection
PL445690A1 (pl) * 2023-07-27 2025-02-03 Politechnika Gdańska Układ do wykrywania białka w próbce materiału biologicznego w postaci płynnej i sposób do wykrywania białka realizowany za pomocą tego układu

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704366A (en) 1984-06-22 1987-11-03 Bio-Rad Laboratories, Inc. Process for binding IgG to protein A
US5061381A (en) 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids
US5122284A (en) 1990-06-04 1992-06-16 Abaxis, Inc. Apparatus and method for optically analyzing biological fluids
US5186844A (en) 1991-04-01 1993-02-16 Abaxis, Inc. Apparatus and method for continuous centrifugal blood cell separation
US5413732A (en) * 1991-08-19 1995-05-09 Abaxis, Inc. Reagent compositions for analytical testing
US5304348A (en) 1992-02-11 1994-04-19 Abaxis, Inc. Reagent container for analytical rotor
AU4047493A (en) 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
JP3706214B2 (ja) 1996-10-28 2005-10-12 株式会社三菱化学ヤトロン 免疫学的分析方法
US5939021A (en) 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
JP4209471B2 (ja) * 1997-02-20 2009-01-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プラズモン共鳴粒子、方法、および装置
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US7144627B2 (en) 1997-03-12 2006-12-05 William Marsh Rice University Multi-layer nanoshells comprising a metallic or conducting shell
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
JP3841559B2 (ja) 1998-07-07 2006-11-01 日東電工株式会社 免疫学的検査方法および免疫学的検査キット
JP2000028612A (ja) 1998-07-07 2000-01-28 Nitto Denko Corp 免疫学的検査方法および免疫学的検査キット
JP3298836B2 (ja) 1998-11-12 2002-07-08 アークレイ株式会社 検体分析用具
US6579726B1 (en) 1999-07-30 2003-06-17 Surromed, Inc. Instruments, methods and reagents for surface plasmon resonance
EP1236034A4 (en) * 1999-11-12 2006-05-03 Surromed Inc PLASMON RESONANCE SURFACE BIODETECTION
US6660381B2 (en) 2000-11-03 2003-12-09 William Marsh Rice University Partial coverage metal nanoshells and method of making same
US6861263B2 (en) 2001-01-26 2005-03-01 Surromed, Inc. Surface-enhanced spectroscopy-active sandwich nanoparticles
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
EP1428028A2 (de) * 2001-09-14 2004-06-16 Reinhard Zeidler Identifizierung von antigenen durch xenogene, allogene oder autologe antikörper-vermittelte präzipitation
US7135054B2 (en) 2001-09-26 2006-11-14 Northwestern University Nanoprisms and method of making them
CN1417586A (zh) 2001-11-05 2003-05-14 福州市迈新生物技术开发公司 一种免疫检测信号放大系统和它的制备方法及其应用
US6970239B2 (en) 2002-06-12 2005-11-29 Intel Corporation Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) substrate
US7212692B2 (en) 2002-11-08 2007-05-01 Ming Yan Multiple array surface plasmon resonance biosensor
JP4787938B2 (ja) 2003-03-28 2011-10-05 ザ・プロウボウスト・フェロウズ・ファウンデーション・スカラーズ・アンド・ザ・アザー・メンバーズ・オブ・ボード・オブ・ザ・カレッジ・オブ・ザ・ホリー・アンド・アンデバイデッド・トリニティ・オブ・クイーン 銀ナノ粒子を用いた検体検出用センサ
KR100531760B1 (ko) 2003-04-28 2005-11-29 대한민국(관리부서 : 농림부 국립수의과학검역원) 구제역 바이러스의 감염여부를 진단하는 방법 및 이를구현하기 위한 진단키트
US20060240573A1 (en) 2003-07-29 2006-10-26 Lamdagen, Llc Optical system including nanostructures for biological or chemical sensing
GB0321937D0 (en) 2003-09-19 2003-10-22 Univ Liverpool Nanoparticle conjugates and method of production thereof
US7573946B2 (en) * 2003-12-31 2009-08-11 Intel Corporation Apparatus and associated methods to perform space-frequency interleaving in a multicarrier wireless communication channel
JP4109205B2 (ja) 2004-01-07 2008-07-02 富士フイルム株式会社 被検体検出方法
US20080227219A1 (en) 2004-11-17 2008-09-18 Frank Gamez Electrochemiluminescent assay
CN1296492C (zh) 2004-11-18 2007-01-24 博奥生物有限公司 一种基于生物芯片检测能结合特异序列的核酸结合蛋白的方法
US7405054B1 (en) 2004-12-13 2008-07-29 University Of Washington Uw Tech Transfer - Invention Licensing Signal amplification method for surface plasmon resonance-based chemical detection
US7485471B1 (en) 2004-12-17 2009-02-03 Intel Corporation Detection of enhanced multiplex signals by surface enhanced Raman spectroscopy
CN101133328A (zh) 2004-12-31 2008-02-27 健泰科生物技术公司 检测非人血清中的人抗体
US8628727B2 (en) 2005-04-08 2014-01-14 Northwestern University Compositions, devices and methods for SERS and LSPR
US20060246513A1 (en) * 2005-05-02 2006-11-02 Bohannon Robert C Method and device to detect the presence of analytes in a sample
EP1915610A4 (en) 2005-06-15 2010-05-19 Univ Maryland Biotech Inst BIOASSAYS WITH PLASMONIC SPREADING OF PRECIOUS METAL NANOSTRUCTURES
US20070092978A1 (en) 2005-10-20 2007-04-26 Ronald Mink Target ligand detection
JP5442179B2 (ja) * 2005-10-21 2014-03-12 アルフレッサファーマ株式会社 反応性物質が結合した微小粒子の沈降抑制方法および該微小粒子含有試薬
AU2006347951B2 (en) * 2005-10-25 2011-12-22 Louisiana Tech University Research Foundation Multilayer films, coatings and microcapsules comprising polypeptides
CN101360997B (zh) 2005-11-18 2013-05-01 美国政府健康及人类服务部，疾病控制和预防中心 改性心磷脂及其应用
WO2007103802A2 (en) 2006-03-03 2007-09-13 William Marsh Rice University Nanorice particles: hybrid plasmonic nanostructures
JP4810304B2 (ja) 2006-05-12 2011-11-09 キヤノン株式会社 化学センサ素子及びその製造方法
US8426152B2 (en) 2007-01-03 2013-04-23 Lamdagen Corporation Enzymatic assay for LSPR
AU2008228813C1 (en) 2007-03-20 2015-01-22 Becton, Dickinson And Company Assays using surface-enhanced raman spectroscopy (SERS)-active particles
JP2009150708A (ja) 2007-12-19 2009-07-09 Canon Inc 標的物質の検出方法及び検査キット
WO2009081386A2 (en) 2007-12-21 2009-07-02 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin A process for preparing nanoparticles
US20100279272A1 (en) * 2008-02-13 2010-11-04 Michael Craig Burrell Multiplexed analysis methods using sers-active nanoparticles
US8137920B2 (en) 2008-03-20 2012-03-20 Abaxis, Inc. Multi-wavelength analyses of sol-particle specific binding assays
WO2010006201A2 (en) 2008-07-10 2010-01-14 Abaxis, Inc. Methods of reducing non-specific interaction in metal nanoparticle assays
CA2742678C (en) 2008-12-03 2020-03-31 Abaxis, Inc. Lateral flow strip assay with immobilized conjugate
US8313915B2 (en) 2009-01-21 2012-11-20 Gundersen Lutheran Medical Foundation, Inc. Early detection of canine lyme disease by specific peptides and antibodies
WO2010091293A1 (en) * 2009-02-06 2010-08-12 The Regents Of The University Of California Plasmonic system for detecting binding of biological molecules
US9029092B2 (en) 2009-02-27 2015-05-12 Beckman Coulter, Inc. Solution phase homogeneous assays
US20120101007A1 (en) 2009-04-08 2012-04-26 Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizebeth Nea Silver nanoplates
JP5563789B2 (ja) 2009-06-11 2014-07-30 富士フイルム株式会社 検出方法
CN102687015A (zh) 2009-10-30 2012-09-19 协和梅迪克斯株式会社 用于分析样本中的待分析成分的方法和分析试剂盒
CN102791727A (zh) 2009-11-17 2012-11-21 爱贝斯股份有限公司 用于检测莱姆病抗体的肽和方法
JP6161291B2 (ja) 2009-11-20 2017-07-12 アバクシス， インコーポレイテッド エールリッヒア抗体の検出のためのペプチド、装置、および方法
KR101256628B1 (ko) 2009-11-24 2013-04-19 한국생명공학연구원 나노입자를 이용한 미생물의 고속 검출방법
US9308582B2 (en) 2009-12-24 2016-04-12 Yi Sun Solution stable and chemically reactive metallic nanoparticles
EP2354792A1 (en) 2010-02-08 2011-08-10 Biomonitor A/S Method for detecting anti-drug antibodies
WO2011139792A2 (en) 2010-04-27 2011-11-10 Ventana Medical Systems, Inc. Antibody-nanoparticle conjugates and methods for making and using such conjugates
JP5728006B2 (ja) 2010-05-28 2015-06-03 国立大学法人東京工業大学 金属微粒子複合体及びその製造方法
JP5822239B2 (ja) * 2010-12-08 2015-11-24 公立大学法人大阪府立大学 金属ナノ粒子集積構造体を利用した被検出物質の検出装置および方法
JP5614278B2 (ja) 2010-12-24 2014-10-29 セイコーエプソン株式会社 センサーチップ、センサーチップの製造方法、検出装置
CN102103145B (zh) 2011-02-24 2013-01-16 南京基蛋生物科技有限公司 一种双放大系统的胶体金试纸条及其制备方法
US8697129B2 (en) 2011-03-02 2014-04-15 Imra America, Inc. Stable colloidal gold nanoparticles with controllable surface modification and functionalization
WO2012125693A2 (en) 2011-03-15 2012-09-20 Northwestern University Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same
JP5703098B2 (ja) * 2011-03-31 2015-04-15 富士フイルム株式会社 生体分子検出装置および生体分子検出方法
US20130230717A1 (en) 2011-09-02 2013-09-05 Washington University In St. Louis Copper nanostructures and methods for their preparation
US8758772B2 (en) 2011-11-04 2014-06-24 Abaxis, Inc. Peptides and methods for the detection of lyme disease antibodies
CH705758B1 (fr) * 2011-11-15 2016-03-31 Metalor Technologies Int Nanoparticules cœur-coquille métal-silice, procédé de fabrication et dispositif de test par immunochromatographie comprenant de telles nanoparticules.
EP2783216B1 (en) 2011-11-21 2018-09-26 Abaxis, Inc. Signal amplification immunoassays
US9823246B2 (en) 2011-12-28 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon
DE112013000636T5 (de) 2012-01-20 2014-10-09 Imra America, Inc. Stabile Kolloidale Suspensionen aus Goldnanokonjugaten und das Verfahren zur Zubereitung derselben
WO2013116513A2 (en) 2012-01-31 2013-08-08 American University Of Cairo (Auc) Direct detection of disease biomarkers in clinical specimens using cationic nanoparticle-based assays & versatile and green methods forsynthesis of anisotropic silver nanostructures
EP2625966A1 (en) * 2012-02-13 2013-08-14 Bionanoplus, S.L. Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof
TWI435843B (zh) 2012-04-27 2014-05-01 Univ Nat Taiwan 奈米顆粒的製造方法
TW201408690A (zh) 2012-05-05 2014-03-01 Academia Sinica 二氨基苯甲酸或鄰苯二胺共軛的胜肽作為功能性的醣類標幟劑
WO2014020293A1 (en) 2012-07-31 2014-02-06 Imperial Innovations Limited Assay
DK2906286T3 (en) 2012-10-11 2017-07-17 Nanocomposix Inc SILVER CHARACTER COMPOSITIONS AND PROCEDURES
ES2668863T3 (es) 2012-10-11 2018-05-22 Abaxis, Inc. Péptidos, dispositivos y métodos para la detección de anticuerpos de Ehrlichia
US9441301B2 (en) * 2012-12-06 2016-09-13 Nanyang Technological University Method for forming a bimetallic core-shell nanostructure
CN105209616A (zh) 2013-03-14 2015-12-30 雅培制药有限公司 用于改进的抗体检测的hcv ns3重组抗原及其突变体
US9194873B2 (en) 2013-03-14 2015-11-24 Abbott Laboratories HCV antigen-antibody combination assay and methods and compositions for use therein
FR3003353B1 (fr) 2013-03-14 2015-03-06 Horiba Abx Sas Nouvelle methode de dosage en flux d'un objet d'interet
JP2014228385A (ja) 2013-05-22 2014-12-08 キヤノン株式会社 免疫試験方法および免疫試験キット
EP3003190A4 (en) 2013-06-05 2016-04-13 Purdue Research Foundation PLASMONIC TITANIUM RIDNANOPARTICLES FOR CLINICAL THERAPEUTIC APPLICATIONS
CN103335984B (zh) 2013-06-09 2015-10-28 清华大学 一种基于lspr的无实体壁微阵列芯片及其应用
WO2015017285A2 (en) * 2013-07-30 2015-02-05 Bio-Rad Laboratories, Inc. Multiplex blocker beads for immunoassays
JP2015102337A (ja) 2013-11-21 2015-06-04 凸版印刷株式会社 粒子の単分散状態維持方法及び分析対象物の検出方法
EP3111214B1 (en) 2014-02-26 2020-09-30 Lamdagen Corporation Digital lspr for enhanced assay sensitivity
US10024800B2 (en) 2014-04-15 2018-07-17 Rutgers, The State University Of New Jersey Gold nanostar substrates for SERS sensing in the femtomolar regime
US10518331B2 (en) 2014-07-11 2019-12-31 Northwestern University Synthesis of uniform anisotropic nanoparticles
JP5867890B1 (ja) 2014-08-01 2016-02-24 株式会社ビークル 免疫学的測定法に用いられるウイルス様粒子、それに用いられるブロッキング剤、及びこれらを含むキット
TWI691716B (zh) 2014-08-13 2020-04-21 美商艾巴希斯公司 電漿特異性結合搭配物檢定中之信號放大
AU2016219897C1 (en) 2015-02-19 2022-04-21 Ionica Sciences Reagents and methods for detecting infectious diseases
WO2016170183A1 (en) 2015-04-24 2016-10-27 Pharmadiagnostics Nv Improved method of measuring an interaction between molecules
CA3227799A1 (en) 2015-08-04 2017-02-09 Zoetis Services Llc Signal amplification in solution-based plasmonic specific-binding partner assays
US11977072B2 (en) 2017-01-30 2024-05-07 Zoetis Services Llc Solution-based plasmonic specific-binding partner assays using metallic nanostructures

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