CA2971413A1 - Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors - Google Patents

Info

Publication number

CA2971413A1

CA2971413A1 CA2971413A CA2971413A CA2971413A1 CA 2971413 A1 CA2971413 A1 CA 2971413A1 CA 2971413 A CA2971413 A CA 2971413A CA 2971413 A CA2971413 A CA 2971413A CA 2971413 A1 CA2971413 A1 CA 2971413A1

Authority

CA

Canada

Prior art keywords

carboxamide

thiophene

benzo

azaspiro

bicyclo

Prior art date

2014-12-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• -1 quinuclidine amide compounds Chemical class 0.000 title claims abstract description 528
• 239000000556 agonist Substances 0.000 title abstract description 8
• 102000047725 alpha7 Nicotinic Acetylcholine Receptor Human genes 0.000 title 1
• 108700006085 alpha7 Nicotinic Acetylcholine Receptor Proteins 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 344
• 238000000034 method Methods 0.000 claims abstract description 121
• 239000008194 pharmaceutical composition Chemical class 0.000 claims abstract description 48
• 230000001149 cognitive effect Effects 0.000 claims abstract description 3
• GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims description 452
• TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims description 212
• 125000004122 cyclic group Chemical group 0.000 claims description 137
• 150000003839 salts Chemical class 0.000 claims description 131
• 208000010877 cognitive disease Diseases 0.000 claims description 109
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 83
• 150000003254 radicals Chemical group 0.000 claims description 77
• 208000024827 Alzheimer disease Diseases 0.000 claims description 70
• 125000000217 alkyl group Chemical group 0.000 claims description 67
• 150000005840 aryl radicals Chemical class 0.000 claims description 62
• 208000028698 Cognitive impairment Diseases 0.000 claims description 58
• 229910052757 nitrogen Inorganic materials 0.000 claims description 58
• 208000024891 symptom Diseases 0.000 claims description 51
• 201000000980 schizophrenia Diseases 0.000 claims description 48
• 125000005605 benzo group Chemical group 0.000 claims description 44
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 43
• 239000003085 diluting agent Substances 0.000 claims description 40
• 239000003937 drug carrier Substances 0.000 claims description 40
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 38
• 206010012289 Dementia Diseases 0.000 claims description 35
• 229910052717 sulfur Inorganic materials 0.000 claims description 33
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 31
• 125000006413 ring segment Chemical group 0.000 claims description 28
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 26
• 239000011593 sulfur Substances 0.000 claims description 26
• 125000006528 (C2-C6) alkyl group Chemical group 0.000 claims description 24
• 208000027061 mild cognitive impairment Diseases 0.000 claims description 23
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 22
• ZSOLVRRGFFRUNE-UHFFFAOYSA-N 1-benzofuran-5-carboxamide Chemical compound NC(=O)C1=CC=C2OC=CC2=C1 ZSOLVRRGFFRUNE-UHFFFAOYSA-N 0.000 claims description 21
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 21
• IDCLTMRSSAXUNY-UHFFFAOYSA-N 5-hydroxylansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC(O)=CC=C2N1 IDCLTMRSSAXUNY-UHFFFAOYSA-N 0.000 claims description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 17
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 17
• IPEGSDNDXHMCNH-UHFFFAOYSA-N 1-benzothiophene-6-carboxamide Chemical compound NC(=O)C1=CC=C2C=CSC2=C1 IPEGSDNDXHMCNH-UHFFFAOYSA-N 0.000 claims description 16
• XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical compound [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 claims description 15
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 15
• 230000019771 cognition Effects 0.000 claims description 14
• 229910052760 oxygen Inorganic materials 0.000 claims description 14
• 208000028017 Psychotic disease Diseases 0.000 claims description 13
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
• 229910052799 carbon Inorganic materials 0.000 claims description 10
• 150000002367 halogens Chemical class 0.000 claims description 10
• 239000001301 oxygen Substances 0.000 claims description 10
• 229910052736 halogen Inorganic materials 0.000 claims description 9
• 208000002851 paranoid schizophrenia Diseases 0.000 claims description 8
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
• FEYWBDKIIJKIMT-MRXNPFEDSA-N 6-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1 FEYWBDKIIJKIMT-MRXNPFEDSA-N 0.000 claims description 6
• 208000024254 Delusional disease Diseases 0.000 claims description 6
• ZHTAJHVAQUWDAC-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=CC3=C(C=CO3)C=1)CC2)C ZHTAJHVAQUWDAC-MRXNPFEDSA-N 0.000 claims description 6
• WNUBZTJAEYKDQZ-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=CC=C3)CC2)C WNUBZTJAEYKDQZ-MRXNPFEDSA-N 0.000 claims description 6
• 208000020186 Schizophreniform disease Diseases 0.000 claims description 6
• 208000022610 schizoaffective disease Diseases 0.000 claims description 6
• XGYACMTYYDNTOA-QGZVFWFLSA-N 5-fluoro-6-methoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1OC XGYACMTYYDNTOA-QGZVFWFLSA-N 0.000 claims description 4
• NBNSLLQNGUZEIX-MRXNPFEDSA-N 6-bromo-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound BrC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 NBNSLLQNGUZEIX-MRXNPFEDSA-N 0.000 claims description 4
• FEYWBDKIIJKIMT-UHFFFAOYSA-N 6-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1 FEYWBDKIIJKIMT-UHFFFAOYSA-N 0.000 claims description 4
• QFCHNIAQEGRJIH-MRXNPFEDSA-N 6-chloro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 QFCHNIAQEGRJIH-MRXNPFEDSA-N 0.000 claims description 4
• MGTLCRSMMGOQIY-LJQANCHMSA-N 6-cyclopropyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 MGTLCRSMMGOQIY-LJQANCHMSA-N 0.000 claims description 4
• FPYVRQDPDQRCMS-QGZVFWFLSA-N 6-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 FPYVRQDPDQRCMS-QGZVFWFLSA-N 0.000 claims description 4
• YMMFEXFJXKPQGZ-LJQANCHMSA-N 7-cyclopropyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 YMMFEXFJXKPQGZ-LJQANCHMSA-N 0.000 claims description 4
• ZHTAJHVAQUWDAC-UHFFFAOYSA-N N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzofuran-5-carboxamide Chemical compound CC1(N2CCC(C1NC(=O)C=1C=CC3=C(C=CO3)C=1)CC2)C ZHTAJHVAQUWDAC-UHFFFAOYSA-N 0.000 claims description 4
• WNUBZTJAEYKDQZ-UHFFFAOYSA-N N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC(C1NC(=O)C1=CC3=C(S1)C=CC=C3)CC2)C WNUBZTJAEYKDQZ-UHFFFAOYSA-N 0.000 claims description 4
• WQQMZQQVVJLREX-OAHLLOKOSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=C3C(=CN=1)OC=C3)CC2)C WQQMZQQVVJLREX-OAHLLOKOSA-N 0.000 claims description 4
• XFXULGFHURSRNL-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1C=CC2=C(C=CO2)C=1)CC3 XFXULGFHURSRNL-MRXNPFEDSA-N 0.000 claims description 4
• SVFXJOTZHCGIKP-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=CC=C2)CC3 SVFXJOTZHCGIKP-MRXNPFEDSA-N 0.000 claims description 4
• HIFHKIVBOAYGIT-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-6-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1C=CC2=C(SC=C2)C=1)CC3 HIFHKIVBOAYGIT-MRXNPFEDSA-N 0.000 claims description 4
• CACOEYGIYDRJMG-OAHLLOKOSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1C=C2C(=CN=1)OC=C2)CC3 CACOEYGIYDRJMG-OAHLLOKOSA-N 0.000 claims description 4
• SVFXJOTZHCGIKP-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=CC=C2)CC3 SVFXJOTZHCGIKP-UHFFFAOYSA-N 0.000 claims description 4
• QFCHNIAQEGRJIH-UHFFFAOYSA-N 6-chloro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 QFCHNIAQEGRJIH-UHFFFAOYSA-N 0.000 claims description 3
• UPPODWWNEMRFTM-UHFFFAOYSA-N 6-methoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound COC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 UPPODWWNEMRFTM-UHFFFAOYSA-N 0.000 claims description 3
• FPYVRQDPDQRCMS-UHFFFAOYSA-N 6-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound CC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 FPYVRQDPDQRCMS-UHFFFAOYSA-N 0.000 claims description 3
• UCMQJTUETDQVSF-UHFFFAOYSA-N 7-fluoro-6-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound FC1=C(C=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)C UCMQJTUETDQVSF-UHFFFAOYSA-N 0.000 claims description 3
• XFXULGFHURSRNL-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzofuran-5-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C=1C=CC2=C(C=CO2)C=1)CC3 XFXULGFHURSRNL-UHFFFAOYSA-N 0.000 claims description 3
• DSIBSRXKQRYPJP-UHFFFAOYSA-N 1,2-oxazole-5-carboxamide Chemical compound NC(=O)C1=CC=NO1 DSIBSRXKQRYPJP-UHFFFAOYSA-N 0.000 claims description 2
• RFIMBBKICUOXTD-UHFFFAOYSA-N 2-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzofuran-5-carboxamide Chemical compound ClC=1OC2=C(C=1)C=C(C=C2)C(=O)NC1C(N2CCC1CC2)(C)C RFIMBBKICUOXTD-UHFFFAOYSA-N 0.000 claims description 2
• SFDQPHZPGAOTFE-UHFFFAOYSA-N 2-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-6-carboxamide Chemical compound ClC1=CC2=C(S1)C=C(C=C2)C(=O)NC1C(N2CCC1CC2)(C)C SFDQPHZPGAOTFE-UHFFFAOYSA-N 0.000 claims description 2
• RFIMBBKICUOXTD-MRXNPFEDSA-N 2-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamide Chemical compound ClC=1OC2=C(C=1)C=C(C=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C RFIMBBKICUOXTD-MRXNPFEDSA-N 0.000 claims description 2
• SFDQPHZPGAOTFE-MRXNPFEDSA-N 2-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-6-carboxamide Chemical compound ClC1=CC2=C(S1)C=C(C=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C SFDQPHZPGAOTFE-MRXNPFEDSA-N 0.000 claims description 2
• RFIMBBKICUOXTD-INIZCTEOSA-N 2-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC=C3OC(Cl)=CC3=C2)C2CCN1CC2 RFIMBBKICUOXTD-INIZCTEOSA-N 0.000 claims description 2
• SFDQPHZPGAOTFE-INIZCTEOSA-N 2-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-6-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC=C3C=C(Cl)SC3=C2)C2CCN1CC2 SFDQPHZPGAOTFE-INIZCTEOSA-N 0.000 claims description 2
• HGMIVFDOVXEAJG-UHFFFAOYSA-N 2-cyclopropyl-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzofuran-5-carboxamide Chemical compound C1(CC1)C=1OC2=C(C=1)C=C(C=C2)C(=O)NC1C(N2CCC1CC2)(C)C HGMIVFDOVXEAJG-UHFFFAOYSA-N 0.000 claims description 2
• HGMIVFDOVXEAJG-LJQANCHMSA-N 2-cyclopropyl-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1(CC1)C=1OC2=C(C=1)C=C(C=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C HGMIVFDOVXEAJG-LJQANCHMSA-N 0.000 claims description 2
• HGMIVFDOVXEAJG-IBGZPJMESA-N 2-cyclopropyl-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC=C3OC(=CC3=C2)C2CC2)C2CCN1CC2 HGMIVFDOVXEAJG-IBGZPJMESA-N 0.000 claims description 2
• ZISVGYWFTVKJKU-UHFFFAOYSA-N 2-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1,3-benzothiazole-5-carboxamide Chemical compound CC=1SC2=C(N=1)C=C(C=C2)C(=O)NC1C2(N3CCC1CC3)CC2 ZISVGYWFTVKJKU-UHFFFAOYSA-N 0.000 claims description 2
• VHDUVFWGINZNHG-UHFFFAOYSA-N 2-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1,3-benzothiazole-6-carboxamide Chemical compound CC=1SC2=C(N=1)C=CC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 VHDUVFWGINZNHG-UHFFFAOYSA-N 0.000 claims description 2
• PBOIBUHVDALCPO-UHFFFAOYSA-N 2-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1,3-benzoxazole-5-carboxamide Chemical compound CC=1OC2=C(N=1)C=C(C=C2)C(=O)NC1C2(N3CCC1CC3)CC2 PBOIBUHVDALCPO-UHFFFAOYSA-N 0.000 claims description 2
• CBRYHEIAHGBQPT-UHFFFAOYSA-N 2-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1,3-benzoxazole-6-carboxamide Chemical compound CC=1OC2=C(N=1)C=CC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 CBRYHEIAHGBQPT-UHFFFAOYSA-N 0.000 claims description 2
• HRVPONIKRAPPDV-UHFFFAOYSA-N 2-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzofuran-5-carboxamide Chemical compound CC=1OC2=C(C=1)C=C(C=C2)C(=O)NC1C2(N3CCC1CC3)CC2 HRVPONIKRAPPDV-UHFFFAOYSA-N 0.000 claims description 2
• JXUILQPPZCOLFJ-UHFFFAOYSA-N 3,4-dichloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)benzamide Chemical compound ClC=1C=C(C(=O)NC2C(N3CCC2CC3)(C)C)C=CC=1Cl JXUILQPPZCOLFJ-UHFFFAOYSA-N 0.000 claims description 2
• JXUILQPPZCOLFJ-CQSZACIVSA-N 3,4-dichloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]benzamide Chemical compound ClC=1C=C(C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=CC=1Cl JXUILQPPZCOLFJ-CQSZACIVSA-N 0.000 claims description 2
• JXUILQPPZCOLFJ-AWEZNQCLSA-N 3,4-dichloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]benzamide Chemical compound ClC=1C=C(C(=O)N[C@@H]2C(N3CCC2CC3)(C)C)C=CC=1Cl JXUILQPPZCOLFJ-AWEZNQCLSA-N 0.000 claims description 2
• IJMIELOVEDNHLF-UHFFFAOYSA-N 3-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzofuran-5-carboxamide Chemical compound ClC1=COC2=C1C=C(C=C2)C(=O)NC1C(N2CCC1CC2)(C)C IJMIELOVEDNHLF-UHFFFAOYSA-N 0.000 claims description 2
• IJMIELOVEDNHLF-MRXNPFEDSA-N 3-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamide Chemical compound ClC1=COC2=C1C=C(C=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C IJMIELOVEDNHLF-MRXNPFEDSA-N 0.000 claims description 2
• QSFWGRZPSJEIDG-MRXNPFEDSA-N 3-chloro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound ClC1=COC2=C1C=C(C=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 QSFWGRZPSJEIDG-MRXNPFEDSA-N 0.000 claims description 2
• IJMIELOVEDNHLF-INIZCTEOSA-N 3-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamide Chemical compound ClC1=COC2=C1C=C(C=C2)C(=O)N[C@@H]1C(N2CCC1CC2)(C)C IJMIELOVEDNHLF-INIZCTEOSA-N 0.000 claims description 2
• DFPVYCZMZZRMKO-QGZVFWFLSA-N 3-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-5-carboxamide Chemical compound CC=1C2=C(SC=1)C=CC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 DFPVYCZMZZRMKO-QGZVFWFLSA-N 0.000 claims description 2
• TZALNOADHNFNPG-QGZVFWFLSA-N 3-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-6-carboxamide Chemical compound CC=1C2=C(SC=1)C=C(C=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 TZALNOADHNFNPG-QGZVFWFLSA-N 0.000 claims description 2
• DFPVYCZMZZRMKO-KRWDZBQOSA-N 3-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-5-carboxamide Chemical compound CC=1C2=C(SC=1)C=CC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 DFPVYCZMZZRMKO-KRWDZBQOSA-N 0.000 claims description 2
• TZALNOADHNFNPG-KRWDZBQOSA-N 3-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-6-carboxamide Chemical compound CC=1C2=C(SC=1)C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 TZALNOADHNFNPG-KRWDZBQOSA-N 0.000 claims description 2
• DFPVYCZMZZRMKO-UHFFFAOYSA-N 3-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-5-carboxamide Chemical compound CC=1C2=C(SC=1)C=CC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 DFPVYCZMZZRMKO-UHFFFAOYSA-N 0.000 claims description 2
• TZALNOADHNFNPG-UHFFFAOYSA-N 3-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-6-carboxamide Chemical compound CC=1C2=C(SC=1)C=C(C=C2)C(=O)NC1C2(N3CCC1CC3)CC2 TZALNOADHNFNPG-UHFFFAOYSA-N 0.000 claims description 2
• ONHTWFNWVYBAHO-UHFFFAOYSA-N 4-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)benzamide Chemical compound ClC1=CC=C(C(=O)NC2C(N3CCC2CC3)(C)C)C=C1 ONHTWFNWVYBAHO-UHFFFAOYSA-N 0.000 claims description 2
• ONHTWFNWVYBAHO-CQSZACIVSA-N 4-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]benzamide Chemical compound ClC1=CC=C(C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=C1 ONHTWFNWVYBAHO-CQSZACIVSA-N 0.000 claims description 2
• JJWKBOAZWIGOJK-CQSZACIVSA-N 4-chloro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]benzamide Chemical compound ClC1=CC=C(C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1 JJWKBOAZWIGOJK-CQSZACIVSA-N 0.000 claims description 2
• ONHTWFNWVYBAHO-AWEZNQCLSA-N 4-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]benzamide Chemical compound ClC1=CC=C(C(=O)N[C@@H]2C(N3CCC2CC3)(C)C)C=C1 ONHTWFNWVYBAHO-AWEZNQCLSA-N 0.000 claims description 2
• JJWKBOAZWIGOJK-AWEZNQCLSA-N 4-chloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]benzamide Chemical compound ClC1=CC=C(C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1 JJWKBOAZWIGOJK-AWEZNQCLSA-N 0.000 claims description 2
• JJWKBOAZWIGOJK-UHFFFAOYSA-N 4-chloro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylbenzamide Chemical compound ClC1=CC=C(C(=O)NC2C3(N4CCC2CC4)CC3)C=C1 JJWKBOAZWIGOJK-UHFFFAOYSA-N 0.000 claims description 2
• PNWLQXUVGMLQHT-UHFFFAOYSA-N 5,6-dichloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound ClC1=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=C1Cl PNWLQXUVGMLQHT-UHFFFAOYSA-N 0.000 claims description 2
• PNWLQXUVGMLQHT-MRXNPFEDSA-N 5,6-dichloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=C1Cl PNWLQXUVGMLQHT-MRXNPFEDSA-N 0.000 claims description 2
• BSPLTZHZTMTIRF-MRXNPFEDSA-N 5,6-dichloro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1Cl BSPLTZHZTMTIRF-MRXNPFEDSA-N 0.000 claims description 2
• BSPLTZHZTMTIRF-INIZCTEOSA-N 5,6-dichloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1Cl BSPLTZHZTMTIRF-INIZCTEOSA-N 0.000 claims description 2
• IISBHZIXRXYDJG-MRXNPFEDSA-N 5-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=C1 IISBHZIXRXYDJG-MRXNPFEDSA-N 0.000 claims description 2
• UPTZZCICVRFTET-MRXNPFEDSA-N 5-chloro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1 UPTZZCICVRFTET-MRXNPFEDSA-N 0.000 claims description 2
• UPTZZCICVRFTET-INIZCTEOSA-N 5-chloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1 UPTZZCICVRFTET-INIZCTEOSA-N 0.000 claims description 2
• UPTZZCICVRFTET-UHFFFAOYSA-N 5-chloro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC1=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=C1 UPTZZCICVRFTET-UHFFFAOYSA-N 0.000 claims description 2
• UASDFPUUOQDRHL-UHFFFAOYSA-N 5-cyclopropyl-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=C1 UASDFPUUOQDRHL-UHFFFAOYSA-N 0.000 claims description 2
• UASDFPUUOQDRHL-LJQANCHMSA-N 5-cyclopropyl-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=C1 UASDFPUUOQDRHL-LJQANCHMSA-N 0.000 claims description 2
• HSHMTJUSHPNJCP-LJQANCHMSA-N 5-cyclopropyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1 HSHMTJUSHPNJCP-LJQANCHMSA-N 0.000 claims description 2
• HSHMTJUSHPNJCP-IBGZPJMESA-N 5-cyclopropyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1 HSHMTJUSHPNJCP-IBGZPJMESA-N 0.000 claims description 2
• AJUQPEHETMTGCL-MRXNPFEDSA-N 5-fluoro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1 AJUQPEHETMTGCL-MRXNPFEDSA-N 0.000 claims description 2
• XWZJYNBAWRRVGJ-UHFFFAOYSA-N 5-methoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound COC1=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=C1 XWZJYNBAWRRVGJ-UHFFFAOYSA-N 0.000 claims description 2
• BSDZLEHBJFWGPA-QGZVFWFLSA-N 5-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1 BSDZLEHBJFWGPA-QGZVFWFLSA-N 0.000 claims description 2
• BSDZLEHBJFWGPA-KRWDZBQOSA-N 5-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1 BSDZLEHBJFWGPA-KRWDZBQOSA-N 0.000 claims description 2
• BSDZLEHBJFWGPA-UHFFFAOYSA-N 5-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound CC1=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=C1 BSDZLEHBJFWGPA-UHFFFAOYSA-N 0.000 claims description 2
• IUVYMTPQUPNXNZ-UHFFFAOYSA-N 6,7-dichloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1Cl IUVYMTPQUPNXNZ-UHFFFAOYSA-N 0.000 claims description 2
• IUVYMTPQUPNXNZ-MRXNPFEDSA-N 6,7-dichloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1Cl IUVYMTPQUPNXNZ-MRXNPFEDSA-N 0.000 claims description 2
• IUVYMTPQUPNXNZ-INIZCTEOSA-N 6,7-dichloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(Cl)C(Cl)=C3S2)C2CCN1CC2 IUVYMTPQUPNXNZ-INIZCTEOSA-N 0.000 claims description 2
• BKNHJKJACRCMQM-UHFFFAOYSA-N 6-(dimethylamino)-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound CN(C=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1)C BKNHJKJACRCMQM-UHFFFAOYSA-N 0.000 claims description 2
• BKNHJKJACRCMQM-GOSISDBHSA-N 6-(dimethylamino)-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CN(C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1)C BKNHJKJACRCMQM-GOSISDBHSA-N 0.000 claims description 2
• BKNHJKJACRCMQM-SFHVURJKSA-N 6-(dimethylamino)-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CN(C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C(N3CCC2CC3)(C)C)C=1)C BKNHJKJACRCMQM-SFHVURJKSA-N 0.000 claims description 2
• KKMCDJHADPKIIF-UHFFFAOYSA-N 6-amino-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound NC=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1 KKMCDJHADPKIIF-UHFFFAOYSA-N 0.000 claims description 2
• KKMCDJHADPKIIF-MRXNPFEDSA-N 6-amino-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound NC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1 KKMCDJHADPKIIF-MRXNPFEDSA-N 0.000 claims description 2
• XPLSPRMXTURUFG-MRXNPFEDSA-N 6-amino-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound NC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 XPLSPRMXTURUFG-MRXNPFEDSA-N 0.000 claims description 2
• KKMCDJHADPKIIF-INIZCTEOSA-N 6-amino-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(N)C=C3S2)C2CCN1CC2 KKMCDJHADPKIIF-INIZCTEOSA-N 0.000 claims description 2
• XPLSPRMXTURUFG-INIZCTEOSA-N 6-amino-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound NC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 XPLSPRMXTURUFG-INIZCTEOSA-N 0.000 claims description 2
• HMYRYMMIDWCZMY-UHFFFAOYSA-N 6-bromo-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound BrC=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1 HMYRYMMIDWCZMY-UHFFFAOYSA-N 0.000 claims description 2
• HMYRYMMIDWCZMY-MRXNPFEDSA-N 6-bromo-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound BrC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1 HMYRYMMIDWCZMY-MRXNPFEDSA-N 0.000 claims description 2
• HMYRYMMIDWCZMY-INIZCTEOSA-N 6-bromo-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(Br)C=C3S2)C2CCN1CC2 HMYRYMMIDWCZMY-INIZCTEOSA-N 0.000 claims description 2
• KWZIWKSYYWBVSO-UHFFFAOYSA-N 6-chloro-7-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1C KWZIWKSYYWBVSO-UHFFFAOYSA-N 0.000 claims description 2
• RYBPPFBGMGOOGO-UHFFFAOYSA-N 6-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzofuran-2-carboxamide Chemical compound ClC1=CC2=C(C=C(O2)C(=O)NC2C(N3CCC2CC3)(C)C)C=C1 RYBPPFBGMGOOGO-UHFFFAOYSA-N 0.000 claims description 2
• RYBPPFBGMGOOGO-MRXNPFEDSA-N 6-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Chemical compound ClC1=CC2=C(C=C(O2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=C1 RYBPPFBGMGOOGO-MRXNPFEDSA-N 0.000 claims description 2
• RYBPPFBGMGOOGO-INIZCTEOSA-N 6-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Chemical compound ClC1=CC2=C(C=C(O2)C(=O)N[C@@H]2C(N3CCC2CC3)(C)C)C=C1 RYBPPFBGMGOOGO-INIZCTEOSA-N 0.000 claims description 2
• QFCHNIAQEGRJIH-INIZCTEOSA-N 6-chloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 QFCHNIAQEGRJIH-INIZCTEOSA-N 0.000 claims description 2
• AXHWMAQKZXTKTI-UHFFFAOYSA-N 6-cyano-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound C(#N)C=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1 AXHWMAQKZXTKTI-UHFFFAOYSA-N 0.000 claims description 2
• AXHWMAQKZXTKTI-QGZVFWFLSA-N 6-cyano-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(#N)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1 AXHWMAQKZXTKTI-QGZVFWFLSA-N 0.000 claims description 2
• UTRYVMAQHPPWQX-UHFFFAOYSA-N 6-cyclopropyl-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1 UTRYVMAQHPPWQX-UHFFFAOYSA-N 0.000 claims description 2
• UTRYVMAQHPPWQX-LJQANCHMSA-N 6-cyclopropyl-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1 UTRYVMAQHPPWQX-LJQANCHMSA-N 0.000 claims description 2
• MGTLCRSMMGOQIY-IBGZPJMESA-N 6-cyclopropyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 MGTLCRSMMGOQIY-IBGZPJMESA-N 0.000 claims description 2
• QINVXFUYMLGRCJ-UHFFFAOYSA-N 6-cyclopropyloxy-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)OC=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1 QINVXFUYMLGRCJ-UHFFFAOYSA-N 0.000 claims description 2
• QINVXFUYMLGRCJ-LJQANCHMSA-N 6-cyclopropyloxy-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)OC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1 QINVXFUYMLGRCJ-LJQANCHMSA-N 0.000 claims description 2
• RKLAVCVKEGHMQO-MRXNPFEDSA-N 6-fluoro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 RKLAVCVKEGHMQO-MRXNPFEDSA-N 0.000 claims description 2
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• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
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• HSXQCQGZFJPNFL-INIZCTEOSA-N 1-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]indazole-3-carboxamide Chemical compound CN1N=C(C2=CC=CC=C12)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 HSXQCQGZFJPNFL-INIZCTEOSA-N 0.000 claims 1
• JOCBLJWAPPLLTF-KRWDZBQOSA-N 1-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]indole-2-carboxamide Chemical compound CN1C(=CC2=CC=CC=C12)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 JOCBLJWAPPLLTF-KRWDZBQOSA-N 0.000 claims 1
• TZYRHULELPEQKB-KRWDZBQOSA-N 1-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]indole-5-carboxamide Chemical compound CN1C=CC2=CC(=CC=C12)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 TZYRHULELPEQKB-KRWDZBQOSA-N 0.000 claims 1
• PPYHTFVIOPZQTG-KRWDZBQOSA-N 1-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]indole-6-carboxamide Chemical compound CN1C=CC2=CC=C(C=C12)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 PPYHTFVIOPZQTG-KRWDZBQOSA-N 0.000 claims 1
• JJPTZGACQJXEHJ-UHFFFAOYSA-N 1-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylbenzimidazole-2-carboxamide Chemical compound CN1C(=NC2=C1C=CC=C2)C(=O)NC1C2(N3CCC1CC3)CC2 JJPTZGACQJXEHJ-UHFFFAOYSA-N 0.000 claims 1
• VLEBINAYAVFSID-UHFFFAOYSA-N 1-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylbenzimidazole-5-carboxamide Chemical compound CN1C=NC2=C1C=CC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 VLEBINAYAVFSID-UHFFFAOYSA-N 0.000 claims 1
• HSXQCQGZFJPNFL-UHFFFAOYSA-N 1-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylindazole-3-carboxamide Chemical compound CN1N=C(C2=CC=CC=C12)C(=O)NC1C2(N3CCC1CC3)CC2 HSXQCQGZFJPNFL-UHFFFAOYSA-N 0.000 claims 1
• JOCBLJWAPPLLTF-UHFFFAOYSA-N 1-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylindole-2-carboxamide Chemical compound CN1C(=CC2=CC=CC=C12)C(=O)NC1C2(N3CCC1CC3)CC2 JOCBLJWAPPLLTF-UHFFFAOYSA-N 0.000 claims 1
• TZYRHULELPEQKB-UHFFFAOYSA-N 1-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylindole-5-carboxamide Chemical compound CN1C=CC2=CC(=CC=C12)C(=O)NC1C2(N3CCC1CC3)CC2 TZYRHULELPEQKB-UHFFFAOYSA-N 0.000 claims 1
• PPYHTFVIOPZQTG-UHFFFAOYSA-N 1-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylindole-6-carboxamide Chemical compound CN1C=CC2=CC=C(C=C12)C(=O)NC1C2(N3CCC1CC3)CC2 PPYHTFVIOPZQTG-UHFFFAOYSA-N 0.000 claims 1
• WMBVHGWYJNIOQH-CQSZACIVSA-N 2,2-difluoro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzodioxole-5-carboxamide Chemical compound FC1(OC2=C(O1)C=CC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2)F WMBVHGWYJNIOQH-CQSZACIVSA-N 0.000 claims 1
• WMBVHGWYJNIOQH-AWEZNQCLSA-N 2,2-difluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzodioxole-5-carboxamide Chemical compound FC1(OC2=C(O1)C=CC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)F WMBVHGWYJNIOQH-AWEZNQCLSA-N 0.000 claims 1
• WMBVHGWYJNIOQH-UHFFFAOYSA-N 2,2-difluoro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1,3-benzodioxole-5-carboxamide Chemical compound FC1(OC2=C(O1)C=CC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)F WMBVHGWYJNIOQH-UHFFFAOYSA-N 0.000 claims 1
• YKZWPQPBOKGKQK-UHFFFAOYSA-N 2-amino-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)thieno[2,3-d]pyrimidine-6-carboxamide Chemical compound NC=1N=CC2=C(N=1)SC(=C2)C(=O)NC1C(N2CCC1CC2)(C)C YKZWPQPBOKGKQK-UHFFFAOYSA-N 0.000 claims 1
• YKZWPQPBOKGKQK-GFCCVEGCSA-N 2-amino-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]thieno[2,3-d]pyrimidine-6-carboxamide Chemical compound NC=1N=CC2=C(N=1)SC(=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C YKZWPQPBOKGKQK-GFCCVEGCSA-N 0.000 claims 1
• YKZWPQPBOKGKQK-LBPRGKRZSA-N 2-amino-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]thieno[2,3-d]pyrimidine-6-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CN=C(N)N=C3S2)C2CCN1CC2 YKZWPQPBOKGKQK-LBPRGKRZSA-N 0.000 claims 1
• MVAZHCUJJALKTC-UHFFFAOYSA-N 2-amino-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylthieno[2,3-d]pyrimidine-6-carboxamide Chemical compound NC=1N=CC2=C(N=1)SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 MVAZHCUJJALKTC-UHFFFAOYSA-N 0.000 claims 1
• HJYOZGHCTZXIKO-INIZCTEOSA-N 2-chloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound ClC=1OC2=C(C=1)C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 HJYOZGHCTZXIKO-INIZCTEOSA-N 0.000 claims 1
• YASZZRCLGZCBSW-INIZCTEOSA-N 2-chloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-6-carboxamide Chemical compound ClC1=CC2=C(S1)C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 YASZZRCLGZCBSW-INIZCTEOSA-N 0.000 claims 1
• CBRLXLQSRGTIJP-LJQANCHMSA-N 2-cyclopropyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1(CC1)C=1OC2=C(C=1)C=C(C=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 CBRLXLQSRGTIJP-LJQANCHMSA-N 0.000 claims 1
• CBRLXLQSRGTIJP-IBGZPJMESA-N 2-cyclopropyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1(CC1)C=1OC2=C(C=1)C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 CBRLXLQSRGTIJP-IBGZPJMESA-N 0.000 claims 1
• ZISVGYWFTVKJKU-MRXNPFEDSA-N 2-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzothiazole-5-carboxamide Chemical compound CC=1SC2=C(N=1)C=C(C=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 ZISVGYWFTVKJKU-MRXNPFEDSA-N 0.000 claims 1
• VHDUVFWGINZNHG-MRXNPFEDSA-N 2-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzothiazole-6-carboxamide Chemical compound CC=1SC2=C(N=1)C=CC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 VHDUVFWGINZNHG-MRXNPFEDSA-N 0.000 claims 1
• PBOIBUHVDALCPO-MRXNPFEDSA-N 2-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzoxazole-5-carboxamide Chemical compound CC=1OC2=C(N=1)C=C(C=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 PBOIBUHVDALCPO-MRXNPFEDSA-N 0.000 claims 1
• CBRYHEIAHGBQPT-MRXNPFEDSA-N 2-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzoxazole-6-carboxamide Chemical compound CC=1OC2=C(N=1)C=CC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 CBRYHEIAHGBQPT-MRXNPFEDSA-N 0.000 claims 1
• HRVPONIKRAPPDV-QGZVFWFLSA-N 2-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound CC=1OC2=C(C=1)C=C(C=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 HRVPONIKRAPPDV-QGZVFWFLSA-N 0.000 claims 1
• VOCFPFPMGLTSHF-QGZVFWFLSA-N 2-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-6-carboxamide Chemical compound CC1=CC2=C(S1)C=C(C=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 VOCFPFPMGLTSHF-QGZVFWFLSA-N 0.000 claims 1
• ZISVGYWFTVKJKU-INIZCTEOSA-N 2-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzothiazole-5-carboxamide Chemical compound CC=1SC2=C(N=1)C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 ZISVGYWFTVKJKU-INIZCTEOSA-N 0.000 claims 1
• VHDUVFWGINZNHG-INIZCTEOSA-N 2-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzothiazole-6-carboxamide Chemical compound CC=1SC2=C(N=1)C=CC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 VHDUVFWGINZNHG-INIZCTEOSA-N 0.000 claims 1
• PBOIBUHVDALCPO-INIZCTEOSA-N 2-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzoxazole-5-carboxamide Chemical compound CC=1OC2=C(N=1)C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 PBOIBUHVDALCPO-INIZCTEOSA-N 0.000 claims 1
• CBRYHEIAHGBQPT-INIZCTEOSA-N 2-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzoxazole-6-carboxamide Chemical compound CC=1OC2=C(N=1)C=CC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 CBRYHEIAHGBQPT-INIZCTEOSA-N 0.000 claims 1
• HRVPONIKRAPPDV-KRWDZBQOSA-N 2-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound CC=1OC2=C(C=1)C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 HRVPONIKRAPPDV-KRWDZBQOSA-N 0.000 claims 1
• VOCFPFPMGLTSHF-KRWDZBQOSA-N 2-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-6-carboxamide Chemical compound CC1=CC2=C(S1)C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 VOCFPFPMGLTSHF-KRWDZBQOSA-N 0.000 claims 1
• VOCFPFPMGLTSHF-UHFFFAOYSA-N 2-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-6-carboxamide Chemical compound CC1=CC2=C(S1)C=C(C=C2)C(=O)NC1C2(N3CCC1CC3)CC2 VOCFPFPMGLTSHF-UHFFFAOYSA-N 0.000 claims 1
• WFGHFZYYZYQFLI-CQSZACIVSA-N 3,4-dichloro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]benzamide Chemical compound ClC=1C=C(C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=CC=1Cl WFGHFZYYZYQFLI-CQSZACIVSA-N 0.000 claims 1
• WFGHFZYYZYQFLI-AWEZNQCLSA-N 3,4-dichloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]benzamide Chemical compound ClC=1C=C(C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=CC=1Cl WFGHFZYYZYQFLI-AWEZNQCLSA-N 0.000 claims 1
• WFGHFZYYZYQFLI-UHFFFAOYSA-N 3,4-dichloro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylbenzamide Chemical compound ClC=1C=C(C(=O)NC2C3(N4CCC2CC4)CC3)C=CC=1Cl WFGHFZYYZYQFLI-UHFFFAOYSA-N 0.000 claims 1
• QSFWGRZPSJEIDG-INIZCTEOSA-N 3-chloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound ClC1=COC2=C1C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 QSFWGRZPSJEIDG-INIZCTEOSA-N 0.000 claims 1
• QSFWGRZPSJEIDG-UHFFFAOYSA-N 3-chloro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzofuran-5-carboxamide Chemical compound ClC1=COC2=C1C=C(C=C2)C(=O)NC1C2(N3CCC1CC3)CC2 QSFWGRZPSJEIDG-UHFFFAOYSA-N 0.000 claims 1
• YLAJXKVCCZCMAX-QGZVFWFLSA-N 3-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound CC1=COC2=C1C=C(C=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 YLAJXKVCCZCMAX-QGZVFWFLSA-N 0.000 claims 1
• KLPCLCRIRGDXNV-MRXNPFEDSA-N 3-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]benzimidazole-5-carboxamide Chemical compound CN1C=NC2=C1C=C(C=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 KLPCLCRIRGDXNV-MRXNPFEDSA-N 0.000 claims 1
• YLAJXKVCCZCMAX-KRWDZBQOSA-N 3-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-5-carboxamide Chemical compound CC1=COC2=C1C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 YLAJXKVCCZCMAX-KRWDZBQOSA-N 0.000 claims 1
• KLPCLCRIRGDXNV-INIZCTEOSA-N 3-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]benzimidazole-5-carboxamide Chemical compound CN1C=NC2=C1C=C(C=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 KLPCLCRIRGDXNV-INIZCTEOSA-N 0.000 claims 1
• YLAJXKVCCZCMAX-UHFFFAOYSA-N 3-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzofuran-5-carboxamide Chemical compound CC1=COC2=C1C=C(C=C2)C(=O)NC1C2(N3CCC1CC3)CC2 YLAJXKVCCZCMAX-UHFFFAOYSA-N 0.000 claims 1
• KLPCLCRIRGDXNV-UHFFFAOYSA-N 3-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylbenzimidazole-5-carboxamide Chemical compound CN1C=NC2=C1C=C(C=C2)C(=O)NC1C2(N3CCC1CC3)CC2 KLPCLCRIRGDXNV-UHFFFAOYSA-N 0.000 claims 1
• VQQANIYXBYYPHP-MRXNPFEDSA-N 4-methoxy-3-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]benzamide Chemical compound COC1=C(C=C(C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1)C VQQANIYXBYYPHP-MRXNPFEDSA-N 0.000 claims 1
• VQQANIYXBYYPHP-INIZCTEOSA-N 4-methoxy-3-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]benzamide Chemical compound COC1=C(C=C(C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1)C VQQANIYXBYYPHP-INIZCTEOSA-N 0.000 claims 1
• VQQANIYXBYYPHP-UHFFFAOYSA-N 4-methoxy-3-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-ylbenzamide Chemical compound COC1=C(C=C(C(=O)NC2C3(N4CCC2CC4)CC3)C=C1)C VQQANIYXBYYPHP-UHFFFAOYSA-N 0.000 claims 1
• GQYWELCNOAUKFA-MRXNPFEDSA-N 5,6-difluoro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1F GQYWELCNOAUKFA-MRXNPFEDSA-N 0.000 claims 1
• GQYWELCNOAUKFA-INIZCTEOSA-N 5,6-difluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1F GQYWELCNOAUKFA-INIZCTEOSA-N 0.000 claims 1
• IISBHZIXRXYDJG-UHFFFAOYSA-N 5-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound ClC1=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=C1 IISBHZIXRXYDJG-UHFFFAOYSA-N 0.000 claims 1
• HSHMTJUSHPNJCP-UHFFFAOYSA-N 5-cyclopropyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=C1 HSHMTJUSHPNJCP-UHFFFAOYSA-N 0.000 claims 1
• XGYACMTYYDNTOA-KRWDZBQOSA-N 5-fluoro-6-methoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1OC XGYACMTYYDNTOA-KRWDZBQOSA-N 0.000 claims 1
• AJUQPEHETMTGCL-INIZCTEOSA-N 5-fluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1 AJUQPEHETMTGCL-INIZCTEOSA-N 0.000 claims 1
• AJUQPEHETMTGCL-UHFFFAOYSA-N 5-fluoro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound FC1=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=C1 AJUQPEHETMTGCL-UHFFFAOYSA-N 0.000 claims 1
• XWZJYNBAWRRVGJ-QGZVFWFLSA-N 5-methoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COC1=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1 XWZJYNBAWRRVGJ-QGZVFWFLSA-N 0.000 claims 1
• XWZJYNBAWRRVGJ-KRWDZBQOSA-N 5-methoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COC1=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1 XWZJYNBAWRRVGJ-KRWDZBQOSA-N 0.000 claims 1
• JWXGWICTSWEUMC-INIZCTEOSA-N 6,7-dichloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1Cl JWXGWICTSWEUMC-INIZCTEOSA-N 0.000 claims 1
• JWXGWICTSWEUMC-UHFFFAOYSA-N 6,7-dichloro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1Cl JWXGWICTSWEUMC-UHFFFAOYSA-N 0.000 claims 1
• JLPOONDZPFQOJG-MRXNPFEDSA-N 6,7-difluoro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1F JLPOONDZPFQOJG-MRXNPFEDSA-N 0.000 claims 1
• JLPOONDZPFQOJG-INIZCTEOSA-N 6,7-difluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1F JLPOONDZPFQOJG-INIZCTEOSA-N 0.000 claims 1
• JLPOONDZPFQOJG-UHFFFAOYSA-N 6,7-difluoro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1F JLPOONDZPFQOJG-UHFFFAOYSA-N 0.000 claims 1
• ATCINKBHCMYTOG-UHFFFAOYSA-N 6-(4,4-difluoropiperidin-1-yl)-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound FC1(CCN(CC1)C=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1)F ATCINKBHCMYTOG-UHFFFAOYSA-N 0.000 claims 1
• ATCINKBHCMYTOG-HXUWFJFHSA-N 6-(4,4-difluoropiperidin-1-yl)-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1(CCN(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1)F ATCINKBHCMYTOG-HXUWFJFHSA-N 0.000 claims 1
• LUANMTYVEBHREM-HXUWFJFHSA-N 6-(4,4-difluoropiperidin-1-yl)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1(CCN(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1)F LUANMTYVEBHREM-HXUWFJFHSA-N 0.000 claims 1
• ATCINKBHCMYTOG-FQEVSTJZSA-N 6-(4,4-difluoropiperidin-1-yl)-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1(CCN(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C(N3CCC2CC3)(C)C)C=1)F ATCINKBHCMYTOG-FQEVSTJZSA-N 0.000 claims 1
• LUANMTYVEBHREM-FQEVSTJZSA-N 6-(4,4-difluoropiperidin-1-yl)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1(CCN(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1)F LUANMTYVEBHREM-FQEVSTJZSA-N 0.000 claims 1
• LUANMTYVEBHREM-UHFFFAOYSA-N 6-(4,4-difluoropiperidin-1-yl)-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound FC1(CCN(CC1)C=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1)F LUANMTYVEBHREM-UHFFFAOYSA-N 0.000 claims 1
• APPVLPYVCCRTNB-GOSISDBHSA-N 6-(dimethylamino)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CN(C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1)C APPVLPYVCCRTNB-GOSISDBHSA-N 0.000 claims 1
• APPVLPYVCCRTNB-SFHVURJKSA-N 6-(dimethylamino)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CN(C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1)C APPVLPYVCCRTNB-SFHVURJKSA-N 0.000 claims 1
• APPVLPYVCCRTNB-UHFFFAOYSA-N 6-(dimethylamino)-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound CN(C=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1)C APPVLPYVCCRTNB-UHFFFAOYSA-N 0.000 claims 1
• XWGWKXRSKQLBQM-GOSISDBHSA-N 6-(methoxymethyl)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COCC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 XWGWKXRSKQLBQM-GOSISDBHSA-N 0.000 claims 1
• XWGWKXRSKQLBQM-SFHVURJKSA-N 6-(methoxymethyl)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COCC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 XWGWKXRSKQLBQM-SFHVURJKSA-N 0.000 claims 1
• XWGWKXRSKQLBQM-UHFFFAOYSA-N 6-(methoxymethyl)-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound COCC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 XWGWKXRSKQLBQM-UHFFFAOYSA-N 0.000 claims 1
• OGJUFVQWFQIAEW-OAQYLSRUSA-N 6-(oxan-4-yl)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)C1CCOCC1)CC3 OGJUFVQWFQIAEW-OAQYLSRUSA-N 0.000 claims 1
• OGJUFVQWFQIAEW-NRFANRHFSA-N 6-(oxan-4-yl)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)C1CCOCC1)CC3 OGJUFVQWFQIAEW-NRFANRHFSA-N 0.000 claims 1
• OGJUFVQWFQIAEW-UHFFFAOYSA-N 6-(oxan-4-yl)-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)C1CCOCC1)CC3 OGJUFVQWFQIAEW-UHFFFAOYSA-N 0.000 claims 1
• CXBAOYSOOXAHCT-LJQANCHMSA-N 6-(oxetan-3-yl)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound O1CC(C1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 CXBAOYSOOXAHCT-LJQANCHMSA-N 0.000 claims 1
• CXBAOYSOOXAHCT-IBGZPJMESA-N 6-(oxetan-3-yl)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound O1CC(C1)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 CXBAOYSOOXAHCT-IBGZPJMESA-N 0.000 claims 1
• CXBAOYSOOXAHCT-UHFFFAOYSA-N 6-(oxetan-3-yl)-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound O1CC(C1)C=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 CXBAOYSOOXAHCT-UHFFFAOYSA-N 0.000 claims 1
• XPLSPRMXTURUFG-UHFFFAOYSA-N 6-amino-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound NC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 XPLSPRMXTURUFG-UHFFFAOYSA-N 0.000 claims 1
• NBNSLLQNGUZEIX-INIZCTEOSA-N 6-bromo-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound BrC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 NBNSLLQNGUZEIX-INIZCTEOSA-N 0.000 claims 1
• LHPMSCFCQPFSIJ-MRXNPFEDSA-N 6-chloro-5,7-difluoro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C(=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1F)F LHPMSCFCQPFSIJ-MRXNPFEDSA-N 0.000 claims 1
• LHPMSCFCQPFSIJ-INIZCTEOSA-N 6-chloro-5,7-difluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C(=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1F)F LHPMSCFCQPFSIJ-INIZCTEOSA-N 0.000 claims 1
• LHPMSCFCQPFSIJ-UHFFFAOYSA-N 6-chloro-5,7-difluoro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC=1C(=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1F)F LHPMSCFCQPFSIJ-UHFFFAOYSA-N 0.000 claims 1
• QPELUKUXWFAAFV-MRXNPFEDSA-N 6-chloro-5-fluoro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C(=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1)F QPELUKUXWFAAFV-MRXNPFEDSA-N 0.000 claims 1
• QPELUKUXWFAAFV-INIZCTEOSA-N 6-chloro-5-fluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C(=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1)F QPELUKUXWFAAFV-INIZCTEOSA-N 0.000 claims 1
• XELCSMJCGVUADY-INIZCTEOSA-N 6-chloro-7-fluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1F XELCSMJCGVUADY-INIZCTEOSA-N 0.000 claims 1
• DFYXADFMALVYHJ-QGZVFWFLSA-N 6-chloro-7-methoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1OC DFYXADFMALVYHJ-QGZVFWFLSA-N 0.000 claims 1
• DFYXADFMALVYHJ-KRWDZBQOSA-N 6-chloro-7-methoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1OC DFYXADFMALVYHJ-KRWDZBQOSA-N 0.000 claims 1
• DFYXADFMALVYHJ-UHFFFAOYSA-N 6-chloro-7-methoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1OC DFYXADFMALVYHJ-UHFFFAOYSA-N 0.000 claims 1
• KWZIWKSYYWBVSO-QGZVFWFLSA-N 6-chloro-7-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1C KWZIWKSYYWBVSO-QGZVFWFLSA-N 0.000 claims 1
• KWZIWKSYYWBVSO-KRWDZBQOSA-N 6-chloro-7-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1C KWZIWKSYYWBVSO-KRWDZBQOSA-N 0.000 claims 1
• PXKCBSJCGOKNBT-UHFFFAOYSA-N 6-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-5,7-difluoro-1-benzothiophene-2-carboxamide Chemical compound ClC=1C(=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1F)F PXKCBSJCGOKNBT-UHFFFAOYSA-N 0.000 claims 1
• OGVQXUMKWBZCML-UHFFFAOYSA-N 6-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-5-fluoro-1-benzothiophene-2-carboxamide Chemical compound ClC=1C(=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1)F OGVQXUMKWBZCML-UHFFFAOYSA-N 0.000 claims 1
• BITYXYWHGJEUOH-UHFFFAOYSA-N 6-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1C(F)(F)F BITYXYWHGJEUOH-UHFFFAOYSA-N 0.000 claims 1
• UANFXKMJOLYPHE-UHFFFAOYSA-N 6-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-7-fluoro-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1F UANFXKMJOLYPHE-UHFFFAOYSA-N 0.000 claims 1
• BZQSIRCNBRCQEX-UHFFFAOYSA-N 6-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1OC BZQSIRCNBRCQEX-UHFFFAOYSA-N 0.000 claims 1
• VWQHJDJSFBFAOU-UHFFFAOYSA-N 6-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-7-methyl-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1C VWQHJDJSFBFAOU-UHFFFAOYSA-N 0.000 claims 1
• PXKCBSJCGOKNBT-MRXNPFEDSA-N 6-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5,7-difluoro-1-benzothiophene-2-carboxamide Chemical compound ClC=1C(=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1F)F PXKCBSJCGOKNBT-MRXNPFEDSA-N 0.000 claims 1
• OGVQXUMKWBZCML-MRXNPFEDSA-N 6-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5-fluoro-1-benzothiophene-2-carboxamide Chemical compound ClC=1C(=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1)F OGVQXUMKWBZCML-MRXNPFEDSA-N 0.000 claims 1
• BITYXYWHGJEUOH-MRXNPFEDSA-N 6-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1C(F)(F)F BITYXYWHGJEUOH-MRXNPFEDSA-N 0.000 claims 1
• UANFXKMJOLYPHE-MRXNPFEDSA-N 6-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-fluoro-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1F UANFXKMJOLYPHE-MRXNPFEDSA-N 0.000 claims 1
• BZQSIRCNBRCQEX-QGZVFWFLSA-N 6-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1OC BZQSIRCNBRCQEX-QGZVFWFLSA-N 0.000 claims 1
• VWQHJDJSFBFAOU-QGZVFWFLSA-N 6-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methyl-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1C VWQHJDJSFBFAOU-QGZVFWFLSA-N 0.000 claims 1
• PZFBSKDXJDLGIS-MRXNPFEDSA-N 6-chloro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-2-carboxamide Chemical compound ClC1=CC2=C(C=C(O2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=C1 PZFBSKDXJDLGIS-MRXNPFEDSA-N 0.000 claims 1
• JESUMPJEQAFIJD-MRXNPFEDSA-N 6-chloro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1C(F)(F)F JESUMPJEQAFIJD-MRXNPFEDSA-N 0.000 claims 1
• PXKCBSJCGOKNBT-INIZCTEOSA-N 6-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5,7-difluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC(F)=C(Cl)C(F)=C3S2)C2CCN1CC2 PXKCBSJCGOKNBT-INIZCTEOSA-N 0.000 claims 1
• OGVQXUMKWBZCML-INIZCTEOSA-N 6-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5-fluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC(F)=C(Cl)C=C3S2)C2CCN1CC2 OGVQXUMKWBZCML-INIZCTEOSA-N 0.000 claims 1
• BITYXYWHGJEUOH-INIZCTEOSA-N 6-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(Cl)C(=C3S2)C(F)(F)F)C2CCN1CC2 BITYXYWHGJEUOH-INIZCTEOSA-N 0.000 claims 1
• UANFXKMJOLYPHE-INIZCTEOSA-N 6-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-fluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(Cl)C(F)=C3S2)C2CCN1CC2 UANFXKMJOLYPHE-INIZCTEOSA-N 0.000 claims 1
• BZQSIRCNBRCQEX-KRWDZBQOSA-N 6-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound COC1=C2SC(=CC2=CC=C1Cl)C(=O)N[C@H]1C2CCN(CC2)C1(C)C BZQSIRCNBRCQEX-KRWDZBQOSA-N 0.000 claims 1
• VWQHJDJSFBFAOU-KRWDZBQOSA-N 6-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1=C2SC(=CC2=CC=C1Cl)C(=O)N[C@H]1C2CCN(CC2)C1(C)C VWQHJDJSFBFAOU-KRWDZBQOSA-N 0.000 claims 1
• PZFBSKDXJDLGIS-INIZCTEOSA-N 6-chloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-2-carboxamide Chemical compound ClC1=CC2=C(C=C(O2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=C1 PZFBSKDXJDLGIS-INIZCTEOSA-N 0.000 claims 1
• JESUMPJEQAFIJD-INIZCTEOSA-N 6-chloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1C(F)(F)F JESUMPJEQAFIJD-INIZCTEOSA-N 0.000 claims 1
• PZFBSKDXJDLGIS-UHFFFAOYSA-N 6-chloro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzofuran-2-carboxamide Chemical compound ClC1=CC2=C(C=C(O2)C(=O)NC2C3(N4CCC2CC4)CC3)C=C1 PZFBSKDXJDLGIS-UHFFFAOYSA-N 0.000 claims 1
• JESUMPJEQAFIJD-UHFFFAOYSA-N 6-chloro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound ClC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1C(F)(F)F JESUMPJEQAFIJD-UHFFFAOYSA-N 0.000 claims 1
• MMMJPSZMFJGTNL-QGZVFWFLSA-N 6-cyano-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(#N)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 MMMJPSZMFJGTNL-QGZVFWFLSA-N 0.000 claims 1
• MMMJPSZMFJGTNL-KRWDZBQOSA-N 6-cyano-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(#N)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 MMMJPSZMFJGTNL-KRWDZBQOSA-N 0.000 claims 1
• MMMJPSZMFJGTNL-UHFFFAOYSA-N 6-cyano-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C(#N)C=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 MMMJPSZMFJGTNL-UHFFFAOYSA-N 0.000 claims 1
• RUHNOMQWYPPDPG-LJQANCHMSA-N 6-cyclopropyl-7-fluoro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1F RUHNOMQWYPPDPG-LJQANCHMSA-N 0.000 claims 1
• RUHNOMQWYPPDPG-IBGZPJMESA-N 6-cyclopropyl-7-fluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1F RUHNOMQWYPPDPG-IBGZPJMESA-N 0.000 claims 1
• RUHNOMQWYPPDPG-UHFFFAOYSA-N 6-cyclopropyl-7-fluoro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1F RUHNOMQWYPPDPG-UHFFFAOYSA-N 0.000 claims 1
• YGSGGHQUXJWEFB-HXUWFJFHSA-N 6-cyclopropyl-7-methoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1OC YGSGGHQUXJWEFB-HXUWFJFHSA-N 0.000 claims 1
• YGSGGHQUXJWEFB-FQEVSTJZSA-N 6-cyclopropyl-7-methoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1OC YGSGGHQUXJWEFB-FQEVSTJZSA-N 0.000 claims 1
• YGSGGHQUXJWEFB-UHFFFAOYSA-N 6-cyclopropyl-7-methoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1OC YGSGGHQUXJWEFB-UHFFFAOYSA-N 0.000 claims 1
• SJVQBLOUGCOGOE-UHFFFAOYSA-N 6-cyclopropyl-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-7-fluoro-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1F SJVQBLOUGCOGOE-UHFFFAOYSA-N 0.000 claims 1
• BINYNOYOTZABHM-UHFFFAOYSA-N 6-cyclopropyl-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)NC2C(N3CCC2CC3)(C)C)C=1OC BINYNOYOTZABHM-UHFFFAOYSA-N 0.000 claims 1
• SJVQBLOUGCOGOE-LJQANCHMSA-N 6-cyclopropyl-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-fluoro-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1F SJVQBLOUGCOGOE-LJQANCHMSA-N 0.000 claims 1
• BINYNOYOTZABHM-HXUWFJFHSA-N 6-cyclopropyl-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C(N3CCC2CC3)(C)C)C=1OC BINYNOYOTZABHM-HXUWFJFHSA-N 0.000 claims 1
• SJVQBLOUGCOGOE-IBGZPJMESA-N 6-cyclopropyl-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-fluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(C4CC4)C(F)=C3S2)C2CCN1CC2 SJVQBLOUGCOGOE-IBGZPJMESA-N 0.000 claims 1
• BINYNOYOTZABHM-FQEVSTJZSA-N 6-cyclopropyl-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound COC1=C2SC(=CC2=CC=C1C1CC1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C BINYNOYOTZABHM-FQEVSTJZSA-N 0.000 claims 1
• XDPBOFOGNGPEPW-LJQANCHMSA-N 6-cyclopropyloxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)OC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 XDPBOFOGNGPEPW-LJQANCHMSA-N 0.000 claims 1
• QINVXFUYMLGRCJ-IBGZPJMESA-N 6-cyclopropyloxy-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(OC4CC4)C=C3S2)C2CCN1CC2 QINVXFUYMLGRCJ-IBGZPJMESA-N 0.000 claims 1
• XDPBOFOGNGPEPW-IBGZPJMESA-N 6-cyclopropyloxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)OC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 XDPBOFOGNGPEPW-IBGZPJMESA-N 0.000 claims 1
• XDPBOFOGNGPEPW-UHFFFAOYSA-N 6-cyclopropyloxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)OC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 XDPBOFOGNGPEPW-UHFFFAOYSA-N 0.000 claims 1
• SGGYPOVXSOCSST-GOSISDBHSA-N 6-ethoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)OC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 SGGYPOVXSOCSST-GOSISDBHSA-N 0.000 claims 1
• SGGYPOVXSOCSST-SFHVURJKSA-N 6-ethoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)OC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 SGGYPOVXSOCSST-SFHVURJKSA-N 0.000 claims 1
• SGGYPOVXSOCSST-UHFFFAOYSA-N 6-ethoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C(C)OC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 SGGYPOVXSOCSST-UHFFFAOYSA-N 0.000 claims 1
• SIMQAOAIMIMRPB-QGZVFWFLSA-N 6-fluoro-7-methoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1OC SIMQAOAIMIMRPB-QGZVFWFLSA-N 0.000 claims 1
• SIMQAOAIMIMRPB-KRWDZBQOSA-N 6-fluoro-7-methoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1OC SIMQAOAIMIMRPB-KRWDZBQOSA-N 0.000 claims 1
• SIMQAOAIMIMRPB-UHFFFAOYSA-N 6-fluoro-7-methoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1OC SIMQAOAIMIMRPB-UHFFFAOYSA-N 0.000 claims 1
• YHAOAZSNIFZPEA-MRXNPFEDSA-N 6-fluoro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1C(F)(F)F YHAOAZSNIFZPEA-MRXNPFEDSA-N 0.000 claims 1
• YHAOAZSNIFZPEA-INIZCTEOSA-N 6-fluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1C(F)(F)F YHAOAZSNIFZPEA-INIZCTEOSA-N 0.000 claims 1
• YHAOAZSNIFZPEA-UHFFFAOYSA-N 6-fluoro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound FC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1C(F)(F)F YHAOAZSNIFZPEA-UHFFFAOYSA-N 0.000 claims 1
• JSDXBBNGJXKUHM-QGZVFWFLSA-N 6-methoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound COC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1C(F)(F)F JSDXBBNGJXKUHM-QGZVFWFLSA-N 0.000 claims 1
• UPPODWWNEMRFTM-KRWDZBQOSA-N 6-methoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 UPPODWWNEMRFTM-KRWDZBQOSA-N 0.000 claims 1
• JSDXBBNGJXKUHM-KRWDZBQOSA-N 6-methoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound COC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1C(F)(F)F JSDXBBNGJXKUHM-KRWDZBQOSA-N 0.000 claims 1
• JSDXBBNGJXKUHM-UHFFFAOYSA-N 6-methoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound COC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1C(F)(F)F JSDXBBNGJXKUHM-UHFFFAOYSA-N 0.000 claims 1
• RUBWCRZODGBWIN-QGZVFWFLSA-N 6-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1C(F)(F)F RUBWCRZODGBWIN-QGZVFWFLSA-N 0.000 claims 1
• RUBWCRZODGBWIN-KRWDZBQOSA-N 6-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1C(F)(F)F RUBWCRZODGBWIN-KRWDZBQOSA-N 0.000 claims 1
• RUBWCRZODGBWIN-UHFFFAOYSA-N 6-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1C(F)(F)F RUBWCRZODGBWIN-UHFFFAOYSA-N 0.000 claims 1
• YBYLVZXZOMEYEZ-KRWDZBQOSA-N 6-methylsulfonyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CS(=O)(=O)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 YBYLVZXZOMEYEZ-KRWDZBQOSA-N 0.000 claims 1
• YBYLVZXZOMEYEZ-UHFFFAOYSA-N 6-methylsulfonyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound CS(=O)(=O)C=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 YBYLVZXZOMEYEZ-UHFFFAOYSA-N 0.000 claims 1
• VEKINUODNRVIOG-HXUWFJFHSA-N 6-morpholin-4-yl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound O1CCN(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 VEKINUODNRVIOG-HXUWFJFHSA-N 0.000 claims 1
• VEKINUODNRVIOG-FQEVSTJZSA-N 6-morpholin-4-yl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound O1CCN(CC1)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 VEKINUODNRVIOG-FQEVSTJZSA-N 0.000 claims 1
• VEKINUODNRVIOG-UHFFFAOYSA-N 6-morpholin-4-yl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound O1CCN(CC1)C=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 VEKINUODNRVIOG-UHFFFAOYSA-N 0.000 claims 1
• XGHQTIJOGVWJRS-LJQANCHMSA-N 6-propan-2-yloxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)OC=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 XGHQTIJOGVWJRS-LJQANCHMSA-N 0.000 claims 1
• XGHQTIJOGVWJRS-IBGZPJMESA-N 6-propan-2-yloxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)OC=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 XGHQTIJOGVWJRS-IBGZPJMESA-N 0.000 claims 1
• XGHQTIJOGVWJRS-UHFFFAOYSA-N 6-propan-2-yloxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)OC=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 XGHQTIJOGVWJRS-UHFFFAOYSA-N 0.000 claims 1
• GHNPBMHBFMHFFO-LJQANCHMSA-N 6-tert-butyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)(C)C=1C=CC2=C(SC(=C2)C(=O)N[C@H]2C3(N4CCC2CC4)CC3)C=1 GHNPBMHBFMHFFO-LJQANCHMSA-N 0.000 claims 1
• GHNPBMHBFMHFFO-IBGZPJMESA-N 6-tert-butyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)(C)C=1C=CC2=C(SC(=C2)C(=O)N[C@@H]2C3(N4CCC2CC4)CC3)C=1 GHNPBMHBFMHFFO-IBGZPJMESA-N 0.000 claims 1
• GHNPBMHBFMHFFO-UHFFFAOYSA-N 6-tert-butyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)(C)C=1C=CC2=C(SC(=C2)C(=O)NC2C3(N4CCC2CC4)CC3)C=1 GHNPBMHBFMHFFO-UHFFFAOYSA-N 0.000 claims 1
• OKBKFPZFYXEZPA-LJQANCHMSA-N 7-(1-methylcyclopropyl)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1(CC1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 OKBKFPZFYXEZPA-LJQANCHMSA-N 0.000 claims 1
• OKBKFPZFYXEZPA-IBGZPJMESA-N 7-(1-methylcyclopropyl)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1(CC1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 OKBKFPZFYXEZPA-IBGZPJMESA-N 0.000 claims 1
• OKBKFPZFYXEZPA-UHFFFAOYSA-N 7-(1-methylcyclopropyl)-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound CC1(CC1)C1=CC=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 OKBKFPZFYXEZPA-UHFFFAOYSA-N 0.000 claims 1
• GVOVZBBGIRWQNO-GOSISDBHSA-N 7-(2-hydroxypropan-2-yl)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound OC(C)(C)C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 GVOVZBBGIRWQNO-GOSISDBHSA-N 0.000 claims 1
• GVOVZBBGIRWQNO-SFHVURJKSA-N 7-(2-hydroxypropan-2-yl)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound OC(C)(C)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 GVOVZBBGIRWQNO-SFHVURJKSA-N 0.000 claims 1
• RZBUCINSAXOVJU-GOSISDBHSA-N 7-(dimethylamino)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CN(C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2)C RZBUCINSAXOVJU-GOSISDBHSA-N 0.000 claims 1
• RZBUCINSAXOVJU-SFHVURJKSA-N 7-(dimethylamino)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CN(C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)C RZBUCINSAXOVJU-SFHVURJKSA-N 0.000 claims 1
• UKSIPAJWYFDSNE-GOSISDBHSA-N 7-(methoxymethyl)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COCC1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 UKSIPAJWYFDSNE-GOSISDBHSA-N 0.000 claims 1
• UKSIPAJWYFDSNE-SFHVURJKSA-N 7-(methoxymethyl)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COCC1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 UKSIPAJWYFDSNE-SFHVURJKSA-N 0.000 claims 1
• UKSIPAJWYFDSNE-UHFFFAOYSA-N 7-(methoxymethyl)-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound COCC1=CC=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 UKSIPAJWYFDSNE-UHFFFAOYSA-N 0.000 claims 1
• ZQKZEBMAAWLVFI-OAQYLSRUSA-N 7-(oxan-4-yl)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C1CCOCC1)CC3 ZQKZEBMAAWLVFI-OAQYLSRUSA-N 0.000 claims 1
• ZQKZEBMAAWLVFI-NRFANRHFSA-N 7-(oxan-4-yl)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C1CCOCC1)CC3 ZQKZEBMAAWLVFI-NRFANRHFSA-N 0.000 claims 1
• ZQKZEBMAAWLVFI-UHFFFAOYSA-N 7-(oxan-4-yl)-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C1CCOCC1)CC3 ZQKZEBMAAWLVFI-UHFFFAOYSA-N 0.000 claims 1
• UZFONKSCDRAKNF-LJQANCHMSA-N 7-(oxetan-3-yl)-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound O1CC(C1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 UZFONKSCDRAKNF-LJQANCHMSA-N 0.000 claims 1
• UZFONKSCDRAKNF-IBGZPJMESA-N 7-(oxetan-3-yl)-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound O1CC(C1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 UZFONKSCDRAKNF-IBGZPJMESA-N 0.000 claims 1
• UZFONKSCDRAKNF-UHFFFAOYSA-N 7-(oxetan-3-yl)-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound O1CC(C1)C1=CC=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 UZFONKSCDRAKNF-UHFFFAOYSA-N 0.000 claims 1
• MEDJOSOYZQSXLG-LJQANCHMSA-N 7-chloro-6-cyclopropyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2)C1CC1 MEDJOSOYZQSXLG-LJQANCHMSA-N 0.000 claims 1
• MEDJOSOYZQSXLG-IBGZPJMESA-N 7-chloro-6-cyclopropyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)C1CC1 MEDJOSOYZQSXLG-IBGZPJMESA-N 0.000 claims 1
• MEDJOSOYZQSXLG-UHFFFAOYSA-N 7-chloro-6-cyclopropyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)C1CC1 MEDJOSOYZQSXLG-UHFFFAOYSA-N 0.000 claims 1
• RKFZJZNWZIIGFB-INIZCTEOSA-N 7-chloro-6-fluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)F RKFZJZNWZIIGFB-INIZCTEOSA-N 0.000 claims 1
• RKFZJZNWZIIGFB-UHFFFAOYSA-N 7-chloro-6-fluoro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)F RKFZJZNWZIIGFB-UHFFFAOYSA-N 0.000 claims 1
• ZELCRGZWVGWPDD-QGZVFWFLSA-N 7-chloro-6-methoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2)OC ZELCRGZWVGWPDD-QGZVFWFLSA-N 0.000 claims 1
• ZELCRGZWVGWPDD-KRWDZBQOSA-N 7-chloro-6-methoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)OC ZELCRGZWVGWPDD-KRWDZBQOSA-N 0.000 claims 1
• ZELCRGZWVGWPDD-UHFFFAOYSA-N 7-chloro-6-methoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)OC ZELCRGZWVGWPDD-UHFFFAOYSA-N 0.000 claims 1
• CDBWVULDFPANMP-QGZVFWFLSA-N 7-chloro-6-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2)C CDBWVULDFPANMP-QGZVFWFLSA-N 0.000 claims 1
• CDBWVULDFPANMP-KRWDZBQOSA-N 7-chloro-6-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)C CDBWVULDFPANMP-KRWDZBQOSA-N 0.000 claims 1
• CDBWVULDFPANMP-UHFFFAOYSA-N 7-chloro-6-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)C CDBWVULDFPANMP-UHFFFAOYSA-N 0.000 claims 1
• WSKZCTVUXTXPQV-UHFFFAOYSA-N 7-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-6-fluoro-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)NC1C(N2CCC1CC2)(C)C)F WSKZCTVUXTXPQV-UHFFFAOYSA-N 0.000 claims 1
• MSSQCBLHXGHXMK-UHFFFAOYSA-N 7-chloro-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-6-methoxy-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)NC1C(N2CCC1CC2)(C)C)OC MSSQCBLHXGHXMK-UHFFFAOYSA-N 0.000 claims 1
• WSKZCTVUXTXPQV-MRXNPFEDSA-N 7-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-fluoro-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C)F WSKZCTVUXTXPQV-MRXNPFEDSA-N 0.000 claims 1
• MSSQCBLHXGHXMK-QGZVFWFLSA-N 7-chloro-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methoxy-1-benzothiophene-2-carboxamide Chemical compound ClC1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C)OC MSSQCBLHXGHXMK-QGZVFWFLSA-N 0.000 claims 1
• FVRASWWVGDEDOT-MRXNPFEDSA-N 7-chloro-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-2-carboxamide Chemical compound ClC1=CC=CC=2C=C(OC=21)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 FVRASWWVGDEDOT-MRXNPFEDSA-N 0.000 claims 1
• WSKZCTVUXTXPQV-INIZCTEOSA-N 7-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-fluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(F)C(Cl)=C3S2)C2CCN1CC2 WSKZCTVUXTXPQV-INIZCTEOSA-N 0.000 claims 1
• MSSQCBLHXGHXMK-KRWDZBQOSA-N 7-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methoxy-1-benzothiophene-2-carboxamide Chemical compound COC1=CC=C2C=C(SC2=C1Cl)C(=O)N[C@H]1C2CCN(CC2)C1(C)C MSSQCBLHXGHXMK-KRWDZBQOSA-N 0.000 claims 1
• IEXWVCPGJPZNIH-KRWDZBQOSA-N 7-chloro-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1=CC=C2C=C(SC2=C1Cl)C(=O)N[C@H]1C2CCN(CC2)C1(C)C IEXWVCPGJPZNIH-KRWDZBQOSA-N 0.000 claims 1
• FVRASWWVGDEDOT-INIZCTEOSA-N 7-chloro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzofuran-2-carboxamide Chemical compound ClC1=CC=CC=2C=C(OC=21)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 FVRASWWVGDEDOT-INIZCTEOSA-N 0.000 claims 1
• FVRASWWVGDEDOT-UHFFFAOYSA-N 7-chloro-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzofuran-2-carboxamide Chemical compound ClC1=CC=CC=2C=C(OC=21)C(=O)NC1C2(N3CCC1CC3)CC2 FVRASWWVGDEDOT-UHFFFAOYSA-N 0.000 claims 1
• QDWIHGKVRKTTLI-GOSISDBHSA-N 7-cyano-6-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(#N)C1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2)C QDWIHGKVRKTTLI-GOSISDBHSA-N 0.000 claims 1
• QDWIHGKVRKTTLI-SFHVURJKSA-N 7-cyano-6-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(#N)C1=C(C=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)C QDWIHGKVRKTTLI-SFHVURJKSA-N 0.000 claims 1
• QDWIHGKVRKTTLI-UHFFFAOYSA-N 7-cyano-6-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C(#N)C1=C(C=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)C QDWIHGKVRKTTLI-UHFFFAOYSA-N 0.000 claims 1
• LCOOIOXKFCSOGZ-UHFFFAOYSA-N 7-cyano-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-6-methyl-1-benzothiophene-2-carboxamide Chemical compound C(#N)C1=C(C=CC2=C1SC(=C2)C(=O)NC1C(N2CCC1CC2)(C)C)C LCOOIOXKFCSOGZ-UHFFFAOYSA-N 0.000 claims 1
• LCOOIOXKFCSOGZ-GOSISDBHSA-N 7-cyano-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methyl-1-benzothiophene-2-carboxamide Chemical compound C(#N)C1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C)C LCOOIOXKFCSOGZ-GOSISDBHSA-N 0.000 claims 1
• LCOOIOXKFCSOGZ-SFHVURJKSA-N 7-cyano-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1=CC=C2C=C(SC2=C1C#N)C(=O)N[C@H]1C2CCN(CC2)C1(C)C LCOOIOXKFCSOGZ-SFHVURJKSA-N 0.000 claims 1
• CCGSTBSDYHGTEC-KRWDZBQOSA-N 7-cyano-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(#N)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 CCGSTBSDYHGTEC-KRWDZBQOSA-N 0.000 claims 1
• IPZJPIUIHUHJMB-HXUWFJFHSA-N 7-cyclopropyl-6-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2)C IPZJPIUIHUHJMB-HXUWFJFHSA-N 0.000 claims 1
• IPZJPIUIHUHJMB-FQEVSTJZSA-N 7-cyclopropyl-6-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=C(C=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)C IPZJPIUIHUHJMB-FQEVSTJZSA-N 0.000 claims 1
• IPZJPIUIHUHJMB-UHFFFAOYSA-N 7-cyclopropyl-6-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=C(C=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)C IPZJPIUIHUHJMB-UHFFFAOYSA-N 0.000 claims 1
• UCKWNMCMLSHBTJ-UHFFFAOYSA-N 7-cyclopropyl-N-(2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl)-6-methyl-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=C(C=CC2=C1SC(=C2)C(=O)NC1C(N2CCC1CC2)(C)C)C UCKWNMCMLSHBTJ-UHFFFAOYSA-N 0.000 claims 1
• DMGKTIDNNWALJM-LJQANCHMSA-N 7-cyclopropyl-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C DMGKTIDNNWALJM-LJQANCHMSA-N 0.000 claims 1
• UCKWNMCMLSHBTJ-HXUWFJFHSA-N 7-cyclopropyl-N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methyl-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C(N2CCC1CC2)(C)C)C UCKWNMCMLSHBTJ-HXUWFJFHSA-N 0.000 claims 1
• UCKWNMCMLSHBTJ-FQEVSTJZSA-N 7-cyclopropyl-N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1=CC=C2C=C(SC2=C1C1CC1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C UCKWNMCMLSHBTJ-FQEVSTJZSA-N 0.000 claims 1
• YMMFEXFJXKPQGZ-IBGZPJMESA-N 7-cyclopropyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(CC1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 YMMFEXFJXKPQGZ-IBGZPJMESA-N 0.000 claims 1
• VFIFSUHWHJHYJR-SFHVURJKSA-N 7-ethoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)OC1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 VFIFSUHWHJHYJR-SFHVURJKSA-N 0.000 claims 1
• WIHCHZXZKLIHFS-QGZVFWFLSA-N 7-fluoro-6-methoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2)OC WIHCHZXZKLIHFS-QGZVFWFLSA-N 0.000 claims 1
• WIHCHZXZKLIHFS-UHFFFAOYSA-N 7-fluoro-6-methoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound FC1=C(C=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)OC WIHCHZXZKLIHFS-UHFFFAOYSA-N 0.000 claims 1
• UCMQJTUETDQVSF-KRWDZBQOSA-N 7-fluoro-6-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1=C(C=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)C UCMQJTUETDQVSF-KRWDZBQOSA-N 0.000 claims 1
• BOJVRMCXKCSTBM-INIZCTEOSA-N 7-fluoro-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound FC1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 BOJVRMCXKCSTBM-INIZCTEOSA-N 0.000 claims 1
• PAWYNNCHLHOSEY-GOSISDBHSA-N 7-methoxy-6-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COC1=C(C=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2)C PAWYNNCHLHOSEY-GOSISDBHSA-N 0.000 claims 1
• PAWYNNCHLHOSEY-SFHVURJKSA-N 7-methoxy-6-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COC1=C(C=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2)C PAWYNNCHLHOSEY-SFHVURJKSA-N 0.000 claims 1
• PAWYNNCHLHOSEY-UHFFFAOYSA-N 7-methoxy-6-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound COC1=C(C=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2)C PAWYNNCHLHOSEY-UHFFFAOYSA-N 0.000 claims 1
• HDVMGKGTLCDZNU-QGZVFWFLSA-N 7-methoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COC1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 HDVMGKGTLCDZNU-QGZVFWFLSA-N 0.000 claims 1
• HDVMGKGTLCDZNU-KRWDZBQOSA-N 7-methoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound COC1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 HDVMGKGTLCDZNU-KRWDZBQOSA-N 0.000 claims 1
• HDVMGKGTLCDZNU-UHFFFAOYSA-N 7-methoxy-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound COC1=CC=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 HDVMGKGTLCDZNU-UHFFFAOYSA-N 0.000 claims 1
• FBDSJUSEZSFHOW-QGZVFWFLSA-N 7-methyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 FBDSJUSEZSFHOW-QGZVFWFLSA-N 0.000 claims 1
• FBDSJUSEZSFHOW-KRWDZBQOSA-N 7-methyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CC1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 FBDSJUSEZSFHOW-KRWDZBQOSA-N 0.000 claims 1
• FBDSJUSEZSFHOW-UHFFFAOYSA-N 7-methyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound CC1=CC=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 FBDSJUSEZSFHOW-UHFFFAOYSA-N 0.000 claims 1
• RYBMWKRIVHVOOR-QGZVFWFLSA-N 7-methylsulfonyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CS(=O)(=O)C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 RYBMWKRIVHVOOR-QGZVFWFLSA-N 0.000 claims 1
• RYBMWKRIVHVOOR-KRWDZBQOSA-N 7-methylsulfonyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound CS(=O)(=O)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 RYBMWKRIVHVOOR-KRWDZBQOSA-N 0.000 claims 1
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• DVCMHABPDJTSFE-FQEVSTJZSA-N 7-morpholin-4-yl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound O1CCN(CC1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 DVCMHABPDJTSFE-FQEVSTJZSA-N 0.000 claims 1
• YYXITPMMGBMZSU-JOCHJYFZSA-N 7-phenyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(=CC=CC=C1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 YYXITPMMGBMZSU-JOCHJYFZSA-N 0.000 claims 1
• YYXITPMMGBMZSU-QFIPXVFZSA-N 7-phenyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C1(=CC=CC=C1)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 YYXITPMMGBMZSU-QFIPXVFZSA-N 0.000 claims 1
• YYXITPMMGBMZSU-UHFFFAOYSA-N 7-phenyl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C1(=CC=CC=C1)C1=CC=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 YYXITPMMGBMZSU-UHFFFAOYSA-N 0.000 claims 1
• UFXJIPGDVROFEN-LJQANCHMSA-N 7-propan-2-yl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 UFXJIPGDVROFEN-LJQANCHMSA-N 0.000 claims 1
• UFXJIPGDVROFEN-IBGZPJMESA-N 7-propan-2-yl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 UFXJIPGDVROFEN-IBGZPJMESA-N 0.000 claims 1
• UFXJIPGDVROFEN-UHFFFAOYSA-N 7-propan-2-yl-N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)C1=CC=CC2=C1SC(=C2)C(=O)NC1C2(N3CCC1CC3)CC2 UFXJIPGDVROFEN-UHFFFAOYSA-N 0.000 claims 1
• AVIUIQJBENUKLG-LJQANCHMSA-N 7-propoxy-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(CC)OC1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 AVIUIQJBENUKLG-LJQANCHMSA-N 0.000 claims 1
• AVIUIQJBENUKLG-IBGZPJMESA-N 7-propoxy-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(CC)OC1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 AVIUIQJBENUKLG-IBGZPJMESA-N 0.000 claims 1
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• FRVUAAGRCGXHSZ-LJQANCHMSA-N 7-tert-butyl-N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)(C)C1=CC=CC2=C1SC(=C2)C(=O)N[C@H]1C2(N3CCC1CC3)CC2 FRVUAAGRCGXHSZ-LJQANCHMSA-N 0.000 claims 1
• FRVUAAGRCGXHSZ-IBGZPJMESA-N 7-tert-butyl-N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1-benzothiophene-2-carboxamide Chemical compound C(C)(C)(C)C1=CC=CC2=C1SC(=C2)C(=O)N[C@@H]1C2(N3CCC1CC3)CC2 FRVUAAGRCGXHSZ-IBGZPJMESA-N 0.000 claims 1
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• XWYOQYQNPLKZRO-CQSZACIVSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2,2-difluoro-1,3-benzodioxole-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(OC(O3)(F)F)C=C1)CC2)C XWYOQYQNPLKZRO-CQSZACIVSA-N 0.000 claims 1
• SFVFLRZVYKMVFF-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(OCCO3)C=C1)CC2)C SFVFLRZVYKMVFF-MRXNPFEDSA-N 0.000 claims 1
• RLEKURPXTNSMAP-OAHLLOKOSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(C=N1)OCCO3)CC2)C RLEKURPXTNSMAP-OAHLLOKOSA-N 0.000 claims 1
• ZNVOYBAHHGMZCP-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1,3-benzothiazole-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=CC3=C(N=C(S3)C)C=1)CC2)C ZNVOYBAHHGMZCP-MRXNPFEDSA-N 0.000 claims 1
• LJBUEWQLSNKFDQ-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1,3-benzothiazole-6-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(N=C(S3)C)C=C1)CC2)C LJBUEWQLSNKFDQ-MRXNPFEDSA-N 0.000 claims 1
• VASZGKPHOHCVOF-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1,3-benzoxazole-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=CC3=C(N=C(O3)C)C=1)CC2)C VASZGKPHOHCVOF-MRXNPFEDSA-N 0.000 claims 1
• KUGIAUFJAJYVHR-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1,3-benzoxazole-6-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(N=C(O3)C)C=C1)CC2)C KUGIAUFJAJYVHR-MRXNPFEDSA-N 0.000 claims 1
• UFNNKSBYQVQKSN-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1-benzofuran-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=CC3=C(C=C(O3)C)C=1)CC2)C UFNNKSBYQVQKSN-QGZVFWFLSA-N 0.000 claims 1
• URANTZBCBDFUGT-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1-benzothiophene-6-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=CC3=C(SC(=C3)C)C=1)CC2)C URANTZBCBDFUGT-QGZVFWFLSA-N 0.000 claims 1
• VZTMYZNDLUMQDR-LJQANCHMSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3,4-dihydro-2H-thieno[3,2-h]chromene-8-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=CC=C4CCCOC4=C3S1)CC2)C VZTMYZNDLUMQDR-LJQANCHMSA-N 0.000 claims 1
• CENCTXUWKNTBRN-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3-methyl-1-benzofuran-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=CC3=C(C(=CO3)C)C=1)CC2)C CENCTXUWKNTBRN-QGZVFWFLSA-N 0.000 claims 1
• VCRQCJNTJKPEPM-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3-methyl-1-benzothiophene-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(SC=C3C)C=C1)CC2)C VCRQCJNTJKPEPM-QGZVFWFLSA-N 0.000 claims 1
• QZDIKDWMNXAYII-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3-methyl-1-benzothiophene-6-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=CC3=C(SC=C3C)C=1)CC2)C QZDIKDWMNXAYII-QGZVFWFLSA-N 0.000 claims 1
• SMVWGTNLCBICOQ-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3-methylbenzimidazole-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=CC3=C(N(C=N3)C)C=1)CC2)C SMVWGTNLCBICOQ-MRXNPFEDSA-N 0.000 claims 1
• ZXVCCEGHCZHOBM-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)CCCC3)CC2)C ZXVCCEGHCZHOBM-MRXNPFEDSA-N 0.000 claims 1
• AWTLESVEQFKCHA-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-4-methoxy-3-methylbenzamide Chemical compound CC1(N2CCC([C@H]1NC(C1=CC(=C(C=C1)OC)C)=O)CC2)C AWTLESVEQFKCHA-MRXNPFEDSA-N 0.000 claims 1
• VZUBXIBZZZHLAO-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5,6-difluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C(=C3)F)F)CC2)C VZUBXIBZZZHLAO-MRXNPFEDSA-N 0.000 claims 1
• NKPXTHDTWVNLTH-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=CC(=C3)C(F)(F)F)CC2)C NKPXTHDTWVNLTH-MRXNPFEDSA-N 0.000 claims 1
• TYBUZZXUZCWTRI-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5-fluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=CC(=C3)F)CC2)C TYBUZZXUZCWTRI-MRXNPFEDSA-N 0.000 claims 1
• QWDUZIMOASFOHK-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5-fluoro-6-methoxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C(=C3)F)OC)CC2)C QWDUZIMOASFOHK-QGZVFWFLSA-N 0.000 claims 1
• HZPPYFBBNOWURB-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5-methoxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=CC(=C3)OC)CC2)C HZPPYFBBNOWURB-QGZVFWFLSA-N 0.000 claims 1
• OUNHDPNECXHQHX-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=CC(=C3)C)CC2)C OUNHDPNECXHQHX-QGZVFWFLSA-N 0.000 claims 1
• WIIMCDDFIJDYQN-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6,7-difluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=C(C=C3)F)F)CC2)C WIIMCDDFIJDYQN-MRXNPFEDSA-N 0.000 claims 1
• NPZQEKLWJLDAKB-GOSISDBHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(methoxymethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)COC)CC2)C NPZQEKLWJLDAKB-GOSISDBHSA-N 0.000 claims 1
• FZNRPCZZNKXXIH-OAQYLSRUSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(oxan-4-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)C1CCOCC1)CC2)C FZNRPCZZNKXXIH-OAQYLSRUSA-N 0.000 claims 1
• GYNMFNLSFDUUME-LJQANCHMSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(oxetan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)C1COC1)CC2)C GYNMFNLSFDUUME-LJQANCHMSA-N 0.000 claims 1
• MXKYRCYSOBASNV-GOSISDBHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(triazol-1-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)N1N=NC=C1)CC2)C MXKYRCYSOBASNV-GOSISDBHSA-N 0.000 claims 1
• XHAFAMPYUQBHSY-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(trifluoromethoxy)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)OC(F)(F)F)CC2)C XHAFAMPYUQBHSY-MRXNPFEDSA-N 0.000 claims 1
• ZUSCOURGNSURMW-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)C(F)(F)F)CC2)C ZUSCOURGNSURMW-MRXNPFEDSA-N 0.000 claims 1
• GCTBNBYQHDYHLA-GOSISDBHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-ethoxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)OCC)CC2)C GCTBNBYQHDYHLA-GOSISDBHSA-N 0.000 claims 1
• PASBKGUGKCRDLE-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-fluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)F)CC2)C PASBKGUGKCRDLE-MRXNPFEDSA-N 0.000 claims 1
• CUWSLYZNUHADJB-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-fluoro-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=C(C=C3)F)C(F)(F)F)CC2)C CUWSLYZNUHADJB-MRXNPFEDSA-N 0.000 claims 1
• SUQMOTBKAQMVQR-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-fluoro-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=C(C=C3)F)OC)CC2)C SUQMOTBKAQMVQR-QGZVFWFLSA-N 0.000 claims 1
• JPESBDCCYOYWCL-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methoxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)OC)CC2)C JPESBDCCYOYWCL-QGZVFWFLSA-N 0.000 claims 1
• XCHKXABISGXPGA-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methoxy-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=C(C=C3)OC)C(F)(F)F)CC2)C XCHKXABISGXPGA-QGZVFWFLSA-N 0.000 claims 1
• KZCGOUOENDLVHO-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)C)CC2)C KZCGOUOENDLVHO-QGZVFWFLSA-N 0.000 claims 1
• UXRMHGPPXAZPPO-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methyl-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=C(C=C3)C)C(F)(F)F)CC2)C UXRMHGPPXAZPPO-QGZVFWFLSA-N 0.000 claims 1
• PBTNSQGXLDZFQW-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methylsulfonyl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)S(=O)(=O)C)CC2)C PBTNSQGXLDZFQW-QGZVFWFLSA-N 0.000 claims 1
• LAGRKMMSLLAGJO-HXUWFJFHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-morpholin-4-yl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)N1CCOCC1)CC2)C LAGRKMMSLLAGJO-HXUWFJFHSA-N 0.000 claims 1
• GYWPCUCLAALISP-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-nitro-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)[N+](=O)[O-])CC2)C GYWPCUCLAALISP-MRXNPFEDSA-N 0.000 claims 1
• BUODJIIDKGWENO-LJQANCHMSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-propan-2-yloxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)OC(C)C)CC2)C BUODJIIDKGWENO-LJQANCHMSA-N 0.000 claims 1
• OFHWWCZOJZHPFZ-GOSISDBHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(1,3-thiazol-2-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C=1SC=CN=1)CC2)C OFHWWCZOJZHPFZ-GOSISDBHSA-N 0.000 claims 1
• YIXOIUGHHCCEMQ-LJQANCHMSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(1-methylcyclopropyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C1(CC1)C)CC2)C YIXOIUGHHCCEMQ-LJQANCHMSA-N 0.000 claims 1
• ABQBCLMQPXYHDS-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(2,2,2-trifluoroethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)CC(F)(F)F)CC2)C ABQBCLMQPXYHDS-QGZVFWFLSA-N 0.000 claims 1
• HGJDECQKYPDUPB-GOSISDBHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(2-hydroxypropan-2-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C(C)(C)O)CC2)C HGJDECQKYPDUPB-GOSISDBHSA-N 0.000 claims 1
• VZNBEHZTGROPAO-GOSISDBHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(methoxymethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)COC)CC2)C VZNBEHZTGROPAO-GOSISDBHSA-N 0.000 claims 1
• RLSLRQAXDNZKBJ-OAQYLSRUSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(oxan-4-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C1CCOCC1)CC2)C RLSLRQAXDNZKBJ-OAQYLSRUSA-N 0.000 claims 1
• VCTFJQBMILZLCF-LJQANCHMSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(oxetan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C1COC1)CC2)C VCTFJQBMILZLCF-LJQANCHMSA-N 0.000 claims 1
• NTULSDKUMHDDNC-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(trifluoromethoxy)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)OC(F)(F)F)CC2)C NTULSDKUMHDDNC-MRXNPFEDSA-N 0.000 claims 1
• MFFSPCBAGBPAPG-MRXNPFEDSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C(F)(F)F)CC2)C MFFSPCBAGBPAPG-MRXNPFEDSA-N 0.000 claims 1
• SWSUITUEHRVFNP-GOSISDBHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-[1-(trifluoromethyl)cyclopropyl]-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C1(CC1)C(F)(F)F)CC2)C SWSUITUEHRVFNP-GOSISDBHSA-N 0.000 claims 1
• UYILTHJFGFVZGG-GOSISDBHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-ethoxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)OCC)CC2)C UYILTHJFGFVZGG-GOSISDBHSA-N 0.000 claims 1
• VPQPWXJRJQWJIZ-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-fluoro-6-methoxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=C(C=C3)OC)F)CC2)C VPQPWXJRJQWJIZ-QGZVFWFLSA-N 0.000 claims 1
• YQBFPVBTXMITDN-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)OC)CC2)C YQBFPVBTXMITDN-QGZVFWFLSA-N 0.000 claims 1
• VZCXMFMRAXLJEP-GOSISDBHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methoxy-6-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=C(C=C3)C)OC)CC2)C VZCXMFMRAXLJEP-GOSISDBHSA-N 0.000 claims 1
• DIBHIFSZXTZWAW-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C)CC2)C DIBHIFSZXTZWAW-QGZVFWFLSA-N 0.000 claims 1
• RPFXERBVCZWJPV-QGZVFWFLSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methylsulfonyl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)S(=O)(=O)C)CC2)C RPFXERBVCZWJPV-QGZVFWFLSA-N 0.000 claims 1
• XOXPYLOWCBYQEN-HXUWFJFHSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-morpholin-4-yl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)N1CCOCC1)CC2)C XOXPYLOWCBYQEN-HXUWFJFHSA-N 0.000 claims 1
• YLVNDFYGPNTLDN-JOCHJYFZSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-phenyl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C1=CC=CC=C1)CC2)C YLVNDFYGPNTLDN-JOCHJYFZSA-N 0.000 claims 1
• BJFGJRVXHSURTO-LJQANCHMSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-propan-2-yl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)C(C)C)CC2)C BJFGJRVXHSURTO-LJQANCHMSA-N 0.000 claims 1
• HLWQUUCDCUTGPL-LJQANCHMSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-propoxy-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)OCCC)CC2)C HLWQUUCDCUTGPL-LJQANCHMSA-N 0.000 claims 1
• CMTGXQICPFCMHM-CQSZACIVSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-b]pyridine-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=C3C(=NC=1)OC=C3)CC2)C CMTGXQICPFCMHM-CQSZACIVSA-N 0.000 claims 1
• YXTBOECDUDRBMJ-OAHLLOKOSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]furo[3,2-b]pyridine-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC=C3C(=N1)C=CO3)CC2)C YXTBOECDUDRBMJ-OAHLLOKOSA-N 0.000 claims 1
• RRMAYDAZJQJECJ-CQSZACIVSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]imidazo[1,2-a]pyrazine-6-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1N=CC=3N(C=1)C=CN=3)CC2)C RRMAYDAZJQJECJ-CQSZACIVSA-N 0.000 claims 1
• GBEQPICPVWHHNJ-CQSZACIVSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]pyrazolo[1,5-b]pyridazine-3-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=NN3N=CC=CC3=1)CC2)C GBEQPICPVWHHNJ-CQSZACIVSA-N 0.000 claims 1
• HVMMETCXGUDIHG-OAHLLOKOSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]thieno[2,3-c]pyridine-2-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C1=CC=3C(=CN=CC=3)S1)CC2)C HVMMETCXGUDIHG-OAHLLOKOSA-N 0.000 claims 1
• QGEUGISCXKLYQY-OAHLLOKOSA-N N-[(3R)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound CC1(N2CCC([C@H]1NC(=O)C=1C=C3C(=CN=1)SC=C3)CC2)C QGEUGISCXKLYQY-OAHLLOKOSA-N 0.000 claims 1
• VVSXKTKQYUMUDX-OAHLLOKOSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,2-benzoxazole-3-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=NOC2=C1C=CC=C2)CC3 VVSXKTKQYUMUDX-OAHLLOKOSA-N 0.000 claims 1
• NPMYRVKBNXJJIS-OAHLLOKOSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,2-benzoxazole-6-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(C=NO2)C=C1)CC3 NPMYRVKBNXJJIS-OAHLLOKOSA-N 0.000 claims 1
• QFWDSWIBWBRTEP-CQSZACIVSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzoxazole-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1OC2=C(N=1)C=CC=C2)CC3 QFWDSWIBWBRTEP-CQSZACIVSA-N 0.000 claims 1
• VQGJKSNSSKXCIP-CQSZACIVSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1H-benzimidazole-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=NC2=C(N1)C=CC=C2)CC3 VQGJKSNSSKXCIP-CQSZACIVSA-N 0.000 claims 1
• QBSLBAVTMNFTOR-OAHLLOKOSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1H-indazole-3-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=NNC2=CC=CC=C12)CC3 QBSLBAVTMNFTOR-OAHLLOKOSA-N 0.000 claims 1
• UPQDSOGWDXPNJO-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1H-indole-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1NC2=CC=CC=C2C=1)CC3 UPQDSOGWDXPNJO-MRXNPFEDSA-N 0.000 claims 1
• ZMRKSLKJKKMTPN-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1H-indole-5-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1C=C2C=CNC2=CC=1)CC3 ZMRKSLKJKKMTPN-MRXNPFEDSA-N 0.000 claims 1
• ZYQPPCOBTAPUIP-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(OCCO2)C=C1)CC3 ZYQPPCOBTAPUIP-MRXNPFEDSA-N 0.000 claims 1
• AYCQKAVXHQOQGV-OAHLLOKOSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(C=N1)OCCO2)CC3 AYCQKAVXHQOQGV-OAHLLOKOSA-N 0.000 claims 1
• JWOFQVIMEVGWEI-LJQANCHMSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-3,4-dihydro-2H-thieno[3,2-h]chromene-8-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=CC=C4CCCOC4=C2S1)CC3 JWOFQVIMEVGWEI-LJQANCHMSA-N 0.000 claims 1
• AJXQJMIKKVOPIQ-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)CCCC2)CC3 AJXQJMIKKVOPIQ-MRXNPFEDSA-N 0.000 claims 1
• HCNCQIGGZMPFHE-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-5-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=CC(=C2)C(F)(F)F)CC3 HCNCQIGGZMPFHE-MRXNPFEDSA-N 0.000 claims 1
• VXNCYNRVQZCZJQ-GOSISDBHSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-6-(triazol-1-yl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)N1N=NC=C1)CC3 VXNCYNRVQZCZJQ-GOSISDBHSA-N 0.000 claims 1
• MYTAEGUODWRXDE-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-6-(trifluoromethoxy)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)OC(F)(F)F)CC3 MYTAEGUODWRXDE-MRXNPFEDSA-N 0.000 claims 1
• SLBXYLHAFJDOQG-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-6-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)C(F)(F)F)CC3 SLBXYLHAFJDOQG-MRXNPFEDSA-N 0.000 claims 1
• CAIDHVXIMVKUTP-GOSISDBHSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(1,3-thiazol-2-yl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C=1SC=CN=1)CC3 CAIDHVXIMVKUTP-GOSISDBHSA-N 0.000 claims 1
• JKXJYPUQCHXWQU-QGZVFWFLSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(2,2,2-trifluoroethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)CC(F)(F)F)CC3 JKXJYPUQCHXWQU-QGZVFWFLSA-N 0.000 claims 1
• KAJKLJPCBJPNMB-MRXNPFEDSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C(F)(F)F)CC3 KAJKLJPCBJPNMB-MRXNPFEDSA-N 0.000 claims 1
• KIXXMASWNIXGIV-GOSISDBHSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-[1-(trifluoromethyl)cyclopropyl]-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C1(CC1)C(F)(F)F)CC3 KIXXMASWNIXGIV-GOSISDBHSA-N 0.000 claims 1
• XNOWZDFQIHCNEH-LJQANCHMSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-8,9-dihydro-7H-thieno[2,3-f]chromene-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC=2C(=C4CCCOC4=CC=2)S1)CC3 XNOWZDFQIHCNEH-LJQANCHMSA-N 0.000 claims 1
• XGEQCPYPFGSLGY-CQSZACIVSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]furo[2,3-b]pyridine-5-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1C=C2C(=NC=1)OC=C2)CC3 XGEQCPYPFGSLGY-CQSZACIVSA-N 0.000 claims 1
• ZEGCHNKGLSVFOU-OAHLLOKOSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]furo[3,2-b]pyridine-5-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC=C2C(=N1)C=CO2)CC3 ZEGCHNKGLSVFOU-OAHLLOKOSA-N 0.000 claims 1
• XPMORJDPKGRNJM-CQSZACIVSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]imidazo[1,2-a]pyrazine-6-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1N=CC=2N(C=1)C=CN=2)CC3 XPMORJDPKGRNJM-CQSZACIVSA-N 0.000 claims 1
• DFAQJJXSNLGXGY-QGZVFWFLSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]isoquinoline-3-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1N=CC2=CC=CC=C2C=1)CC3 DFAQJJXSNLGXGY-QGZVFWFLSA-N 0.000 claims 1
• KETCQCXSGLPUOT-CQSZACIVSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]pyrazolo[1,5-b]pyridazine-3-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1C=NN2N=CC=CC2=1)CC3 KETCQCXSGLPUOT-CQSZACIVSA-N 0.000 claims 1
• WHWLKNUFSHFPMA-QGZVFWFLSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]quinoline-3-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1C=NC2=CC=CC=C2C=1)CC3 WHWLKNUFSHFPMA-QGZVFWFLSA-N 0.000 claims 1
• OCCJNRAYRZTZJL-QGZVFWFLSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]quinoline-6-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1C=C2C=CC=NC2=CC=1)CC3 OCCJNRAYRZTZJL-QGZVFWFLSA-N 0.000 claims 1
• HGARNYPMTBMCJM-QGZVFWFLSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]quinoline-7-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC=C2C=CC=NC2=C1)CC3 HGARNYPMTBMCJM-QGZVFWFLSA-N 0.000 claims 1
• QGHXMYPQSBYWFY-CQSZACIVSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]thieno[2,3-b]pyridine-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC=2C(=NC=CC=2)S1)CC3 QGHXMYPQSBYWFY-CQSZACIVSA-N 0.000 claims 1
• SJPKSGGBYXYNNW-OAHLLOKOSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]thieno[2,3-c]pyridine-2-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C1=CC=2C(=CN=CC=2)S1)CC3 SJPKSGGBYXYNNW-OAHLLOKOSA-N 0.000 claims 1
• KSGSFRSZNPFDNI-OAHLLOKOSA-N N-[(3R)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N12C3([C@@H](C(CC1)CC2)NC(=O)C=1C=C2C(=CN=1)SC=C2)CC3 KSGSFRSZNPFDNI-OAHLLOKOSA-N 0.000 claims 1
• PMNWRFOUQAIHBQ-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1,2-benzoxazole-3-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=NOC3=CC=CC=C23)C2CCN1CC2 PMNWRFOUQAIHBQ-HNNXBMFYSA-N 0.000 claims 1
• NKFLRTZBFAYVEZ-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1,2-benzoxazole-5-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC=C3ON=CC3=C2)C2CCN1CC2 NKFLRTZBFAYVEZ-HNNXBMFYSA-N 0.000 claims 1
• QQNROKNNSVGPAU-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1,2-benzoxazole-6-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC=C3C=NOC3=C2)C2CCN1CC2 QQNROKNNSVGPAU-HNNXBMFYSA-N 0.000 claims 1
• VOEWLOQZLNHFHQ-AWEZNQCLSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1,3-benzothiazole-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=NC3=CC=CC=C3S2)C2CCN1CC2 VOEWLOQZLNHFHQ-AWEZNQCLSA-N 0.000 claims 1
• RZQRSNIAOISPDD-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-methylbenzimidazole-2-carboxamide Chemical compound CN1C(=NC2=CC=CC=C12)C(=O)N[C@H]1C2CCN(CC2)C1(C)C RZQRSNIAOISPDD-HNNXBMFYSA-N 0.000 claims 1
• HZEXHBNHERKXEK-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-methylbenzimidazole-5-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(N(C=N3)C)C=C1)CC2)C HZEXHBNHERKXEK-INIZCTEOSA-N 0.000 claims 1
• JFQWYTUORZXRTK-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-methylindazole-3-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=NN(C3=CC=CC=C13)C)CC2)C JFQWYTUORZXRTK-INIZCTEOSA-N 0.000 claims 1
• WOAWXZGLLOOQQC-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-methylindole-2-carboxamide Chemical compound CN1C(=CC2=CC=CC=C12)C(=O)N[C@H]1C2CCN(CC2)C1(C)C WOAWXZGLLOOQQC-KRWDZBQOSA-N 0.000 claims 1
• UINHDHGLTKZQAM-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-methylindole-5-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C=1C=C3C=CN(C3=CC=1)C)CC2)C UINHDHGLTKZQAM-KRWDZBQOSA-N 0.000 claims 1
• XEALUSNAYRWXDZ-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1-methylindole-6-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC=C3C=CN(C3=C1)C)CC2)C XEALUSNAYRWXDZ-KRWDZBQOSA-N 0.000 claims 1
• DGSJCQWYHVNROY-AWEZNQCLSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1H-benzimidazole-2-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=NC3=C(N1)C=CC=C3)CC2)C DGSJCQWYHVNROY-AWEZNQCLSA-N 0.000 claims 1
• CXUNCKKYFPPFGF-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1H-indazole-3-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=NNC3=CC=CC=C13)CC2)C CXUNCKKYFPPFGF-HNNXBMFYSA-N 0.000 claims 1
• SUZVFHLFLRUZGO-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1H-indole-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=CC=C3N2)C2CCN1CC2 SUZVFHLFLRUZGO-INIZCTEOSA-N 0.000 claims 1
• ZJATVEJTWDEVFC-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1H-indole-5-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C=1C=C3C=CNC3=CC=1)CC2)C ZJATVEJTWDEVFC-INIZCTEOSA-N 0.000 claims 1
• ABRVROQCPRIUDB-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-1H-indole-6-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC=C3C=CNC3=C2)C2CCN1CC2 ABRVROQCPRIUDB-INIZCTEOSA-N 0.000 claims 1
• XWYOQYQNPLKZRO-AWEZNQCLSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2,2-difluoro-1,3-benzodioxole-5-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(OC(O3)(F)F)C=C1)CC2)C XWYOQYQNPLKZRO-AWEZNQCLSA-N 0.000 claims 1
• SFVFLRZVYKMVFF-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(OCCO3)C=C1)CC2)C SFVFLRZVYKMVFF-INIZCTEOSA-N 0.000 claims 1
• RLEKURPXTNSMAP-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(C=N1)OCCO3)CC2)C RLEKURPXTNSMAP-HNNXBMFYSA-N 0.000 claims 1
• ZNVOYBAHHGMZCP-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1,3-benzothiazole-5-carboxamide Chemical compound CC1=NC2=CC(=CC=C2S1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C ZNVOYBAHHGMZCP-INIZCTEOSA-N 0.000 claims 1
• LJBUEWQLSNKFDQ-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1,3-benzothiazole-6-carboxamide Chemical compound CC1=NC2=CC=C(C=C2S1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C LJBUEWQLSNKFDQ-INIZCTEOSA-N 0.000 claims 1
• VASZGKPHOHCVOF-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1,3-benzoxazole-5-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C=1C=CC3=C(N=C(O3)C)C=1)CC2)C VASZGKPHOHCVOF-INIZCTEOSA-N 0.000 claims 1
• KUGIAUFJAJYVHR-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1,3-benzoxazole-6-carboxamide Chemical compound CC1=NC2=CC=C(C=C2O1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C KUGIAUFJAJYVHR-INIZCTEOSA-N 0.000 claims 1
• UFNNKSBYQVQKSN-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1-benzofuran-5-carboxamide Chemical compound CC1=CC2=CC(=CC=C2O1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C UFNNKSBYQVQKSN-KRWDZBQOSA-N 0.000 claims 1
• URANTZBCBDFUGT-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-2-methyl-1-benzothiophene-6-carboxamide Chemical compound CC1=CC2=CC=C(C=C2S1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C URANTZBCBDFUGT-KRWDZBQOSA-N 0.000 claims 1
• VZTMYZNDLUMQDR-IBGZPJMESA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3,4-dihydro-2H-thieno[3,2-h]chromene-8-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=CC=C4CCCOC4=C3S1)CC2)C VZTMYZNDLUMQDR-IBGZPJMESA-N 0.000 claims 1
• CENCTXUWKNTBRN-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3-methyl-1-benzofuran-5-carboxamide Chemical compound CC1=COC2=CC=C(C=C12)C(=O)N[C@H]1C2CCN(CC2)C1(C)C CENCTXUWKNTBRN-KRWDZBQOSA-N 0.000 claims 1
• VCRQCJNTJKPEPM-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3-methyl-1-benzothiophene-5-carboxamide Chemical compound CC1=CSC2=CC=C(C=C12)C(=O)N[C@H]1C2CCN(CC2)C1(C)C VCRQCJNTJKPEPM-KRWDZBQOSA-N 0.000 claims 1
• QZDIKDWMNXAYII-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3-methyl-1-benzothiophene-6-carboxamide Chemical compound CC1=CSC2=CC(=CC=C12)C(=O)N[C@H]1C2CCN(CC2)C1(C)C QZDIKDWMNXAYII-KRWDZBQOSA-N 0.000 claims 1
• SMVWGTNLCBICOQ-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-3-methylbenzimidazole-5-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C=1C=CC3=C(N(C=N3)C)C=1)CC2)C SMVWGTNLCBICOQ-INIZCTEOSA-N 0.000 claims 1
• ZXVCCEGHCZHOBM-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=C(CCCC3)S2)C2CCN1CC2 ZXVCCEGHCZHOBM-INIZCTEOSA-N 0.000 claims 1
• AWTLESVEQFKCHA-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-4-methoxy-3-methylbenzamide Chemical compound CC1(N2CCC([C@@H]1NC(C1=CC(=C(C=C1)OC)C)=O)CC2)C AWTLESVEQFKCHA-INIZCTEOSA-N 0.000 claims 1
• VZUBXIBZZZHLAO-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5,6-difluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC(F)=C(F)C=C3S2)C2CCN1CC2 VZUBXIBZZZHLAO-INIZCTEOSA-N 0.000 claims 1
• QWDUZIMOASFOHK-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-5-fluoro-6-methoxy-1-benzothiophene-2-carboxamide Chemical compound COC1=C(F)C=C2C=C(SC2=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C QWDUZIMOASFOHK-KRWDZBQOSA-N 0.000 claims 1
• WIIMCDDFIJDYQN-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6,7-difluoro-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(F)C(F)=C3S2)C2CCN1CC2 WIIMCDDFIJDYQN-INIZCTEOSA-N 0.000 claims 1
• NPZQEKLWJLDAKB-SFHVURJKSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(methoxymethyl)-1-benzothiophene-2-carboxamide Chemical compound COCC1=CC=C2C=C(SC2=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C NPZQEKLWJLDAKB-SFHVURJKSA-N 0.000 claims 1
• FZNRPCZZNKXXIH-NRFANRHFSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(oxan-4-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(C=C3S2)C2CCOCC2)C2CCN1CC2 FZNRPCZZNKXXIH-NRFANRHFSA-N 0.000 claims 1
• GYNMFNLSFDUUME-IBGZPJMESA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(oxetan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(C=C3S2)C2COC2)C2CCN1CC2 GYNMFNLSFDUUME-IBGZPJMESA-N 0.000 claims 1
• MXKYRCYSOBASNV-SFHVURJKSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(triazol-1-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)N1N=NC=C1)CC2)C MXKYRCYSOBASNV-SFHVURJKSA-N 0.000 claims 1
• XHAFAMPYUQBHSY-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-(trifluoromethoxy)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)OC(F)(F)F)CC2)C XHAFAMPYUQBHSY-INIZCTEOSA-N 0.000 claims 1
• GCTBNBYQHDYHLA-SFHVURJKSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-ethoxy-1-benzothiophene-2-carboxamide Chemical compound CCOC1=CC=C2C=C(SC2=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C GCTBNBYQHDYHLA-SFHVURJKSA-N 0.000 claims 1
• CUWSLYZNUHADJB-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-fluoro-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(F)C(=C3S2)C(F)(F)F)C2CCN1CC2 CUWSLYZNUHADJB-INIZCTEOSA-N 0.000 claims 1
• SUQMOTBKAQMVQR-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-fluoro-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound COC1=C2SC(=CC2=CC=C1F)C(=O)N[C@H]1C2CCN(CC2)C1(C)C SUQMOTBKAQMVQR-KRWDZBQOSA-N 0.000 claims 1
• XCHKXABISGXPGA-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methoxy-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(S1)C(=C(C=C3)OC)C(F)(F)F)CC2)C XCHKXABISGXPGA-KRWDZBQOSA-N 0.000 claims 1
• UXRMHGPPXAZPPO-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methyl-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(S1)C(=C(C=C3)C)C(F)(F)F)CC2)C UXRMHGPPXAZPPO-KRWDZBQOSA-N 0.000 claims 1
• PBTNSQGXLDZFQW-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-methylsulfonyl-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(C=C3S2)S(C)(=O)=O)C2CCN1CC2 PBTNSQGXLDZFQW-KRWDZBQOSA-N 0.000 claims 1
• LAGRKMMSLLAGJO-FQEVSTJZSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-morpholin-4-yl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(S1)C=C(C=C3)N1CCOCC1)CC2)C LAGRKMMSLLAGJO-FQEVSTJZSA-N 0.000 claims 1
• GYWPCUCLAALISP-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-nitro-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=C(C=C3S2)[N+]([O-])=O)C2CCN1CC2 GYWPCUCLAALISP-INIZCTEOSA-N 0.000 claims 1
• BUODJIIDKGWENO-IBGZPJMESA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-6-propan-2-yloxy-1-benzothiophene-2-carboxamide Chemical compound CC(C)OC1=CC=C2C=C(SC2=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C BUODJIIDKGWENO-IBGZPJMESA-N 0.000 claims 1
• OFHWWCZOJZHPFZ-SFHVURJKSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(1,3-thiazol-2-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=CC(C4=NC=CS4)=C3S2)C2CCN1CC2 OFHWWCZOJZHPFZ-SFHVURJKSA-N 0.000 claims 1
• YIXOIUGHHCCEMQ-IBGZPJMESA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(1-methylcyclopropyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(CC1)C1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C YIXOIUGHHCCEMQ-IBGZPJMESA-N 0.000 claims 1
• ABQBCLMQPXYHDS-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(2,2,2-trifluoroethyl)-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=CC(CC(F)(F)F)=C3S2)C2CCN1CC2 ABQBCLMQPXYHDS-KRWDZBQOSA-N 0.000 claims 1
• HGJDECQKYPDUPB-SFHVURJKSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(2-hydroxypropan-2-yl)-1-benzothiophene-2-carboxamide Chemical compound CC(C)(O)C1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C HGJDECQKYPDUPB-SFHVURJKSA-N 0.000 claims 1
• VZNBEHZTGROPAO-SFHVURJKSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(methoxymethyl)-1-benzothiophene-2-carboxamide Chemical compound COCC1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C VZNBEHZTGROPAO-SFHVURJKSA-N 0.000 claims 1
• RLSLRQAXDNZKBJ-NRFANRHFSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(oxan-4-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=CC(C4CCOCC4)=C3S2)C2CCN1CC2 RLSLRQAXDNZKBJ-NRFANRHFSA-N 0.000 claims 1
• VCTFJQBMILZLCF-IBGZPJMESA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(oxetan-3-yl)-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=CC(C4COC4)=C3S2)C2CCN1CC2 VCTFJQBMILZLCF-IBGZPJMESA-N 0.000 claims 1
• NTULSDKUMHDDNC-INIZCTEOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-(trifluoromethoxy)-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)OC(F)(F)F)CC2)C NTULSDKUMHDDNC-INIZCTEOSA-N 0.000 claims 1
• SWSUITUEHRVFNP-SFHVURJKSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-[1-(trifluoromethyl)cyclopropyl]-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=CC(=C3S2)C2(CC2)C(F)(F)F)C2CCN1CC2 SWSUITUEHRVFNP-SFHVURJKSA-N 0.000 claims 1
• UYILTHJFGFVZGG-SFHVURJKSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-ethoxy-1-benzothiophene-2-carboxamide Chemical compound CCOC1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C UYILTHJFGFVZGG-SFHVURJKSA-N 0.000 claims 1
• VPQPWXJRJQWJIZ-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-fluoro-6-methoxy-1-benzothiophene-2-carboxamide Chemical compound COC1=CC=C2C=C(SC2=C1F)C(=O)N[C@H]1C2CCN(CC2)C1(C)C VPQPWXJRJQWJIZ-KRWDZBQOSA-N 0.000 claims 1
• OYEAKXPAGKKYEL-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-fluoro-6-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1=CC=C2C=C(SC2=C1F)C(=O)N[C@H]1C2CCN(CC2)C1(C)C OYEAKXPAGKKYEL-KRWDZBQOSA-N 0.000 claims 1
• YQBFPVBTXMITDN-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methoxy-1-benzothiophene-2-carboxamide Chemical compound COC1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C YQBFPVBTXMITDN-KRWDZBQOSA-N 0.000 claims 1
• VZCXMFMRAXLJEP-SFHVURJKSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methoxy-6-methyl-1-benzothiophene-2-carboxamide Chemical compound COC1=C2SC(=CC2=CC=C1C)C(=O)N[C@H]1C2CCN(CC2)C1(C)C VZCXMFMRAXLJEP-SFHVURJKSA-N 0.000 claims 1
• DIBHIFSZXTZWAW-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methyl-1-benzothiophene-2-carboxamide Chemical compound CC1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C DIBHIFSZXTZWAW-KRWDZBQOSA-N 0.000 claims 1
• RPFXERBVCZWJPV-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-methylsulfonyl-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=CC(=C3S2)S(C)(=O)=O)C2CCN1CC2 RPFXERBVCZWJPV-KRWDZBQOSA-N 0.000 claims 1
• XOXPYLOWCBYQEN-FQEVSTJZSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-morpholin-4-yl-1-benzothiophene-2-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C1=CC3=C(S1)C(=CC=C3)N1CCOCC1)CC2)C XOXPYLOWCBYQEN-FQEVSTJZSA-N 0.000 claims 1
• YLVNDFYGPNTLDN-QFIPXVFZSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-phenyl-1-benzothiophene-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=CC(=C3S2)C2=CC=CC=C2)C2CCN1CC2 YLVNDFYGPNTLDN-QFIPXVFZSA-N 0.000 claims 1
• BJFGJRVXHSURTO-IBGZPJMESA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-propan-2-yl-1-benzothiophene-2-carboxamide Chemical compound CC(C)C1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C BJFGJRVXHSURTO-IBGZPJMESA-N 0.000 claims 1
• HLWQUUCDCUTGPL-IBGZPJMESA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]-7-propoxy-1-benzothiophene-2-carboxamide Chemical compound CCCOC1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1C2CCN(CC2)C1(C)C HLWQUUCDCUTGPL-IBGZPJMESA-N 0.000 claims 1
• CMTGXQICPFCMHM-AWEZNQCLSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-b]pyridine-5-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CN=C3OC=CC3=C2)C2CCN1CC2 CMTGXQICPFCMHM-AWEZNQCLSA-N 0.000 claims 1
• WQQMZQQVVJLREX-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound CC1(N2CCC([C@@H]1NC(=O)C=1C=C3C(=CN=1)OC=C3)CC2)C WQQMZQQVVJLREX-HNNXBMFYSA-N 0.000 claims 1
• YXTBOECDUDRBMJ-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]furo[3,2-b]pyridine-5-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC=C3OC=CC3=N2)C2CCN1CC2 YXTBOECDUDRBMJ-HNNXBMFYSA-N 0.000 claims 1
• RRMAYDAZJQJECJ-AWEZNQCLSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]imidazo[1,2-a]pyrazine-6-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CN3C=CN=C3C=N2)C2CCN1CC2 RRMAYDAZJQJECJ-AWEZNQCLSA-N 0.000 claims 1
• WJRLZBUGMJBBQR-KRWDZBQOSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]isoquinoline-3-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=CC=C3C=N2)C2CCN1CC2 WJRLZBUGMJBBQR-KRWDZBQOSA-N 0.000 claims 1
• GBEQPICPVWHHNJ-AWEZNQCLSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]pyrazolo[1,5-b]pyridazine-3-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=C3C=CC=NN3N=C2)C2CCN1CC2 GBEQPICPVWHHNJ-AWEZNQCLSA-N 0.000 claims 1
• HVMMETCXGUDIHG-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]thieno[2,3-c]pyridine-2-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=CC3=CC=NC=C3S2)C2CCN1CC2 HVMMETCXGUDIHG-HNNXBMFYSA-N 0.000 claims 1
• QGEUGISCXKLYQY-HNNXBMFYSA-N N-[(3S)-2,2-dimethyl-1-azabicyclo[2.2.2]octan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound CC1(C)[C@@H](NC(=O)C2=NC=C3SC=CC3=C2)C2CCN1CC2 QGEUGISCXKLYQY-HNNXBMFYSA-N 0.000 claims 1
• VVSXKTKQYUMUDX-HNNXBMFYSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,2-benzoxazole-3-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=NOC2=C1C=CC=C2)CC3 VVSXKTKQYUMUDX-HNNXBMFYSA-N 0.000 claims 1
• LWAIMERPYXSJOU-HNNXBMFYSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,2-benzoxazole-5-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1C=CC2=C(C=NO2)C=1)CC3 LWAIMERPYXSJOU-HNNXBMFYSA-N 0.000 claims 1
• NPMYRVKBNXJJIS-HNNXBMFYSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,2-benzoxazole-6-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(C=NO2)C=C1)CC3 NPMYRVKBNXJJIS-HNNXBMFYSA-N 0.000 claims 1
• QFWDSWIBWBRTEP-AWEZNQCLSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1,3-benzoxazole-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1OC2=C(N=1)C=CC=C2)CC3 QFWDSWIBWBRTEP-AWEZNQCLSA-N 0.000 claims 1
• VQGJKSNSSKXCIP-AWEZNQCLSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1H-benzimidazole-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=NC2=C(N1)C=CC=C2)CC3 VQGJKSNSSKXCIP-AWEZNQCLSA-N 0.000 claims 1
• QBSLBAVTMNFTOR-HNNXBMFYSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1H-indazole-3-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=NNC2=CC=CC=C12)CC3 QBSLBAVTMNFTOR-HNNXBMFYSA-N 0.000 claims 1
• UPQDSOGWDXPNJO-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1H-indole-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1NC2=CC=CC=C2C=1)CC3 UPQDSOGWDXPNJO-INIZCTEOSA-N 0.000 claims 1
• ZMRKSLKJKKMTPN-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1H-indole-5-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1C=C2C=CNC2=CC=1)CC3 ZMRKSLKJKKMTPN-INIZCTEOSA-N 0.000 claims 1
• GNIBIBLEGLWUTE-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-1H-indole-6-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC=C2C=CNC2=C1)CC3 GNIBIBLEGLWUTE-INIZCTEOSA-N 0.000 claims 1
• ZYQPPCOBTAPUIP-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(OCCO2)C=C1)CC3 ZYQPPCOBTAPUIP-INIZCTEOSA-N 0.000 claims 1
• AYCQKAVXHQOQGV-HNNXBMFYSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(C=N1)OCCO2)CC3 AYCQKAVXHQOQGV-HNNXBMFYSA-N 0.000 claims 1
• JWOFQVIMEVGWEI-IBGZPJMESA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-3,4-dihydro-2H-thieno[3,2-h]chromene-8-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=CC=C4CCCOC4=C2S1)CC3 JWOFQVIMEVGWEI-IBGZPJMESA-N 0.000 claims 1
• AJXQJMIKKVOPIQ-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)CCCC2)CC3 AJXQJMIKKVOPIQ-INIZCTEOSA-N 0.000 claims 1
• HCNCQIGGZMPFHE-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-5-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=CC(=C2)C(F)(F)F)CC3 HCNCQIGGZMPFHE-INIZCTEOSA-N 0.000 claims 1
• VXNCYNRVQZCZJQ-SFHVURJKSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-6-(triazol-1-yl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)N1N=NC=C1)CC3 VXNCYNRVQZCZJQ-SFHVURJKSA-N 0.000 claims 1
• MYTAEGUODWRXDE-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-6-(trifluoromethoxy)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)OC(F)(F)F)CC3 MYTAEGUODWRXDE-INIZCTEOSA-N 0.000 claims 1
• SLBXYLHAFJDOQG-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-6-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)C(F)(F)F)CC3 SLBXYLHAFJDOQG-INIZCTEOSA-N 0.000 claims 1
• CAIDHVXIMVKUTP-SFHVURJKSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(1,3-thiazol-2-yl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C=1SC=CN=1)CC3 CAIDHVXIMVKUTP-SFHVURJKSA-N 0.000 claims 1
• JKXJYPUQCHXWQU-KRWDZBQOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(2,2,2-trifluoroethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)CC(F)(F)F)CC3 JKXJYPUQCHXWQU-KRWDZBQOSA-N 0.000 claims 1
• TXFAZGWNVUZLNN-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethoxy)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)OC(F)(F)F)CC3 TXFAZGWNVUZLNN-INIZCTEOSA-N 0.000 claims 1
• KAJKLJPCBJPNMB-INIZCTEOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C(F)(F)F)CC3 KAJKLJPCBJPNMB-INIZCTEOSA-N 0.000 claims 1
• KIXXMASWNIXGIV-SFHVURJKSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-7-[1-(trifluoromethyl)cyclopropyl]-1-benzothiophene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C1(CC1)C(F)(F)F)CC3 KIXXMASWNIXGIV-SFHVURJKSA-N 0.000 claims 1
• XNOWZDFQIHCNEH-IBGZPJMESA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]-8,9-dihydro-7H-thieno[2,3-f]chromene-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC=2C(=C4CCCOC4=CC=2)S1)CC3 XNOWZDFQIHCNEH-IBGZPJMESA-N 0.000 claims 1
• XGEQCPYPFGSLGY-AWEZNQCLSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]furo[2,3-b]pyridine-5-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1C=C2C(=NC=1)OC=C2)CC3 XGEQCPYPFGSLGY-AWEZNQCLSA-N 0.000 claims 1
• CACOEYGIYDRJMG-HNNXBMFYSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1C=C2C(=CN=1)OC=C2)CC3 CACOEYGIYDRJMG-HNNXBMFYSA-N 0.000 claims 1
• ZEGCHNKGLSVFOU-HNNXBMFYSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]furo[3,2-b]pyridine-5-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC=C2C(=N1)C=CO2)CC3 ZEGCHNKGLSVFOU-HNNXBMFYSA-N 0.000 claims 1
• XPMORJDPKGRNJM-AWEZNQCLSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]imidazo[1,2-a]pyrazine-6-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1N=CC=2N(C=1)C=CN=2)CC3 XPMORJDPKGRNJM-AWEZNQCLSA-N 0.000 claims 1
• DFAQJJXSNLGXGY-KRWDZBQOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]isoquinoline-3-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1N=CC2=CC=CC=C2C=1)CC3 DFAQJJXSNLGXGY-KRWDZBQOSA-N 0.000 claims 1
• KETCQCXSGLPUOT-AWEZNQCLSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]pyrazolo[1,5-b]pyridazine-3-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1C=NN2N=CC=CC2=1)CC3 KETCQCXSGLPUOT-AWEZNQCLSA-N 0.000 claims 1
• WHWLKNUFSHFPMA-KRWDZBQOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]quinoline-3-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1C=NC2=CC=CC=C2C=1)CC3 WHWLKNUFSHFPMA-KRWDZBQOSA-N 0.000 claims 1
• OCCJNRAYRZTZJL-KRWDZBQOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]quinoline-6-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1C=C2C=CC=NC2=CC=1)CC3 OCCJNRAYRZTZJL-KRWDZBQOSA-N 0.000 claims 1
• HGARNYPMTBMCJM-KRWDZBQOSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]quinoline-7-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC=C2C=CC=NC2=C1)CC3 HGARNYPMTBMCJM-KRWDZBQOSA-N 0.000 claims 1
• QGHXMYPQSBYWFY-AWEZNQCLSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]thieno[2,3-b]pyridine-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC=2C(=NC=CC=2)S1)CC3 QGHXMYPQSBYWFY-AWEZNQCLSA-N 0.000 claims 1
• SJPKSGGBYXYNNW-HNNXBMFYSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]thieno[2,3-c]pyridine-2-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C1=CC=2C(=CN=CC=2)S1)CC3 SJPKSGGBYXYNNW-HNNXBMFYSA-N 0.000 claims 1
• KSGSFRSZNPFDNI-HNNXBMFYSA-N N-[(3S)-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N12C3([C@H](C(CC1)CC2)NC(=O)C=1C=C2C(=CN=1)SC=C2)CC3 KSGSFRSZNPFDNI-HNNXBMFYSA-N 0.000 claims 1
• QFWDSWIBWBRTEP-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1,3-benzoxazole-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C=1OC2=C(N=1)C=CC=C2)CC3 QFWDSWIBWBRTEP-UHFFFAOYSA-N 0.000 claims 1
• VQGJKSNSSKXCIP-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1H-benzimidazole-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=NC2=C(N1)C=CC=C2)CC3 VQGJKSNSSKXCIP-UHFFFAOYSA-N 0.000 claims 1
• QBSLBAVTMNFTOR-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1H-indazole-3-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=NNC2=CC=CC=C12)CC3 QBSLBAVTMNFTOR-UHFFFAOYSA-N 0.000 claims 1
• UPQDSOGWDXPNJO-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1H-indole-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C=1NC2=CC=CC=C2C=1)CC3 UPQDSOGWDXPNJO-UHFFFAOYSA-N 0.000 claims 1
• ZMRKSLKJKKMTPN-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-1H-indole-5-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C=1C=C2C=CNC2=CC=1)CC3 ZMRKSLKJKKMTPN-UHFFFAOYSA-N 0.000 claims 1
• ZYQPPCOBTAPUIP-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-2,3-dihydro-1,4-benzodioxine-6-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(OCCO2)C=C1)CC3 ZYQPPCOBTAPUIP-UHFFFAOYSA-N 0.000 claims 1
• AYCQKAVXHQOQGV-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(C=N1)OCCO2)CC3 AYCQKAVXHQOQGV-UHFFFAOYSA-N 0.000 claims 1
• JWOFQVIMEVGWEI-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-3,4-dihydro-2H-thieno[3,2-h]chromene-8-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=CC=C4CCCOC4=C2S1)CC3 JWOFQVIMEVGWEI-UHFFFAOYSA-N 0.000 claims 1
• AJXQJMIKKVOPIQ-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(S1)CCCC2)CC3 AJXQJMIKKVOPIQ-UHFFFAOYSA-N 0.000 claims 1
• HCNCQIGGZMPFHE-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-5-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=CC(=C2)C(F)(F)F)CC3 HCNCQIGGZMPFHE-UHFFFAOYSA-N 0.000 claims 1
• MYTAEGUODWRXDE-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-6-(trifluoromethoxy)-1-benzothiophene-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)OC(F)(F)F)CC3 MYTAEGUODWRXDE-UHFFFAOYSA-N 0.000 claims 1
• SLBXYLHAFJDOQG-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-6-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(S1)C=C(C=C2)C(F)(F)F)CC3 SLBXYLHAFJDOQG-UHFFFAOYSA-N 0.000 claims 1
• TXFAZGWNVUZLNN-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-7-(trifluoromethoxy)-1-benzothiophene-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)OC(F)(F)F)CC3 TXFAZGWNVUZLNN-UHFFFAOYSA-N 0.000 claims 1
• KAJKLJPCBJPNMB-UHFFFAOYSA-N N-spiro[1-azabicyclo[2.2.2]octane-2,1'-cyclopropane]-3-yl-7-(trifluoromethyl)-1-benzothiophene-2-carboxamide Chemical compound N12C3(C(C(CC1)CC2)NC(=O)C1=CC2=C(S1)C(=CC=C2)C(F)(F)F)CC3 KAJKLJPCBJPNMB-UHFFFAOYSA-N 0.000 claims 1
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