CA2967662A1 - Sublingual formulation of riluzole - Google Patents

Sublingual formulation of riluzole Download PDF

Info

Publication number
CA2967662A1
CA2967662A1 CA2967662A CA2967662A CA2967662A1 CA 2967662 A1 CA2967662 A1 CA 2967662A1 CA 2967662 A CA2967662 A CA 2967662A CA 2967662 A CA2967662 A CA 2967662A CA 2967662 A1 CA2967662 A1 CA 2967662A1
Authority
CA
Canada
Prior art keywords
disorder
riluzole
disorders
sublingual formulation
sublingual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2967662A
Other languages
English (en)
French (fr)
Inventor
Vladimir Coric
Robert M. Berman
Ronald Samuel Vladyka
Amgad SALEH
Danny Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biohaven Pharmaceutical Holding Co Ltd
Original Assignee
Biohaven Pharmaceutical Holding Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohaven Pharmaceutical Holding Co Ltd filed Critical Biohaven Pharmaceutical Holding Co Ltd
Publication of CA2967662A1 publication Critical patent/CA2967662A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2967662A 2014-11-21 2015-11-17 Sublingual formulation of riluzole Pending CA2967662A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462083094P 2014-11-21 2014-11-21
US62/083,094 2014-11-21
PCT/US2015/061114 WO2016081472A1 (en) 2014-11-21 2015-11-17 Sublingual formulation of riluzole

Publications (1)

Publication Number Publication Date
CA2967662A1 true CA2967662A1 (en) 2016-05-26

Family

ID=55085882

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2967662A Pending CA2967662A1 (en) 2014-11-21 2015-11-17 Sublingual formulation of riluzole

Country Status (24)

Country Link
US (3) US11660267B2 (enExample)
EP (3) EP3220891B1 (enExample)
JP (3) JP6753860B2 (enExample)
KR (2) KR102580378B1 (enExample)
CN (1) CN107249567B (enExample)
AU (2) AU2015350148B2 (enExample)
BR (1) BR112017010423B1 (enExample)
CA (1) CA2967662A1 (enExample)
CY (1) CY1122469T1 (enExample)
DK (1) DK3220891T3 (enExample)
EA (1) EA038518B1 (enExample)
ES (2) ES2751300T3 (enExample)
HR (1) HRP20191892T8 (enExample)
HU (1) HUE046869T2 (enExample)
IL (2) IL278188B2 (enExample)
LT (1) LT3220891T (enExample)
MX (1) MX368838B (enExample)
PH (1) PH12017500934B1 (enExample)
PL (1) PL3220891T3 (enExample)
PT (1) PT3220891T (enExample)
RS (1) RS59490B1 (enExample)
SG (1) SG11201703896QA (enExample)
SI (1) SI3220891T1 (enExample)
WO (1) WO2016081472A1 (enExample)

Families Citing this family (12)

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KR20210024475A (ko) * 2018-05-27 2021-03-05 바이오하벤 파마슈티컬 홀딩 컴퍼니 엘티디. 질환 치료를 위한 릴루졸 경구 붕해 정제의 용도
CA3109769A1 (en) * 2018-08-16 2020-02-20 Biohaven Therapeutics Ltd. Use of riluzole oral disintigrating tablets for treating diseases
KR20220087482A (ko) * 2019-10-22 2022-06-24 아비나스 오퍼레이션스, 인코포레이티드 전립선암 치료 방법
TW202208345A (zh) 2020-05-09 2022-03-01 美商亞文納營運公司 雙官能性化合物的製造方法、該雙官能性化合物的超純形式、及含彼之劑型
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KR102625977B1 (ko) 2021-11-24 2024-01-17 부산대학교 산학협력단 리루졸을 유효성분으로 포함하는 염증성 장질환 예방 또는 치료용 조성물
US12496301B2 (en) 2023-12-08 2025-12-16 Arvinas Operations, Inc. Use of androgen receptor degrader for the treatment of spinal and bulbar muscular atrophy

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Also Published As

Publication number Publication date
PT3220891T (pt) 2019-10-31
PL3220891T3 (pl) 2020-08-24
US20250114301A1 (en) 2025-04-10
PH12017500934A1 (en) 2017-11-20
DK3220891T3 (da) 2019-11-04
IL278188A (en) 2020-11-30
MX368838B (es) 2019-10-18
KR102580378B1 (ko) 2023-09-19
EA201790958A1 (ru) 2018-01-31
US11660267B2 (en) 2023-05-30
JP6753860B2 (ja) 2020-09-09
JP2017535613A (ja) 2017-11-30
RS59490B1 (sr) 2019-12-31
CN107249567B (zh) 2021-08-03
KR102811263B1 (ko) 2025-05-23
BR112017010423A2 (pt) 2017-12-26
IL278188B1 (en) 2024-11-01
US20180153794A1 (en) 2018-06-07
KR20230135183A (ko) 2023-09-22
SI3220891T1 (sl) 2020-02-28
ES2751300T3 (es) 2020-03-31
WO2016081472A1 (en) 2016-05-26
US12121609B2 (en) 2024-10-22
CY1122469T1 (el) 2021-01-27
EP4039247B1 (en) 2025-11-05
AU2021201034B2 (en) 2023-07-06
HUE046869T2 (hu) 2020-04-28
EP3616686B1 (en) 2021-05-19
PH12017500934B1 (en) 2024-06-28
LT3220891T (lt) 2019-11-11
EP3220891B1 (en) 2019-07-24
CN107249567A (zh) 2017-10-13
AU2015350148A1 (en) 2017-06-15
EP4039247C0 (en) 2025-11-05
SG11201703896QA (en) 2017-06-29
AU2015350148B2 (en) 2020-11-26
ES2882783T3 (es) 2021-12-02
IL278188B2 (en) 2025-03-01
EA038518B1 (ru) 2021-09-09
EP3220891A1 (en) 2017-09-27
BR112017010423B1 (pt) 2023-09-26
MX2017006446A (es) 2018-02-12
KR20170137032A (ko) 2017-12-12
JP2023065398A (ja) 2023-05-12
AU2021201034A1 (en) 2021-03-11
EP3616686B8 (en) 2021-06-23
IL252285B (en) 2020-10-29
IL252285A0 (en) 2017-07-31
EP4039247A3 (en) 2022-11-16
HRP20191892T1 (hr) 2020-01-10
JP2021001173A (ja) 2021-01-07
EP4039247A2 (en) 2022-08-10
HRP20191892T8 (hr) 2020-09-18
EP3616686A1 (en) 2020-03-04
US20210038499A1 (en) 2021-02-11

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