CA2949961C - Combination therapies for the treatment of cancer - Google Patents

Combination therapies for the treatment of cancer Download PDF

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Publication number
CA2949961C
CA2949961C CA2949961A CA2949961A CA2949961C CA 2949961 C CA2949961 C CA 2949961C CA 2949961 A CA2949961 A CA 2949961A CA 2949961 A CA2949961 A CA 2949961A CA 2949961 C CA2949961 C CA 2949961C
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Prior art keywords
cancer
therapy
use according
combination
antagonist
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CA2949961A
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English (en)
French (fr)
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CA2949961A1 (en
Inventor
Xingfeng Bao
Diana ALBU
Mary WOODALL-JAPPE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Publication of CA2949961A1 publication Critical patent/CA2949961A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2949961A 2014-05-23 2015-05-21 Combination therapies for the treatment of cancer Active CA2949961C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462002366P 2014-05-23 2014-05-23
US62/002,366 2014-05-23
US201562150004P 2015-04-20 2015-04-20
US62/150,004 2015-04-20
PCT/US2015/031931 WO2015179615A1 (en) 2014-05-23 2015-05-21 Combination therapies for the treatment of cancer

Publications (2)

Publication Number Publication Date
CA2949961A1 CA2949961A1 (en) 2015-11-26
CA2949961C true CA2949961C (en) 2023-09-19

Family

ID=53277114

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2949961A Active CA2949961C (en) 2014-05-23 2015-05-21 Combination therapies for the treatment of cancer

Country Status (13)

Country Link
US (2) US20170182003A1 (cg-RX-API-DMAC7.html)
EP (2) EP4656246A2 (cg-RX-API-DMAC7.html)
JP (2) JP6787792B2 (cg-RX-API-DMAC7.html)
KR (1) KR102535283B1 (cg-RX-API-DMAC7.html)
CN (2) CN106572993B (cg-RX-API-DMAC7.html)
AU (1) AU2015264102C1 (cg-RX-API-DMAC7.html)
CA (1) CA2949961C (cg-RX-API-DMAC7.html)
IL (1) IL249065A0 (cg-RX-API-DMAC7.html)
MA (1) MA39906A (cg-RX-API-DMAC7.html)
MX (1) MX393818B (cg-RX-API-DMAC7.html)
RU (1) RU2708374C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201609770TA (cg-RX-API-DMAC7.html)
WO (1) WO2015179615A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
EP3134085B1 (en) 2025-07-02
JP2020128432A (ja) 2020-08-27
CA2949961A1 (en) 2015-11-26
US20220071959A1 (en) 2022-03-10
JP6787792B2 (ja) 2020-11-18
MX2016015363A (es) 2017-05-30
AU2015264102C1 (en) 2020-10-08
CN106572993B (zh) 2019-07-16
CN106572993A (zh) 2017-04-19
JP7562296B2 (ja) 2024-10-07
JP2017516775A (ja) 2017-06-22
MX393818B (es) 2025-03-24
RU2708374C2 (ru) 2019-12-06
US11707448B2 (en) 2023-07-25
KR102535283B1 (ko) 2023-05-22
RU2016150650A3 (cg-RX-API-DMAC7.html) 2018-12-25
WO2015179615A1 (en) 2015-11-26
EP4656246A2 (en) 2025-12-03
IL249065A0 (en) 2017-01-31
SG11201609770TA (en) 2016-12-29
AU2015264102B2 (en) 2020-02-13
EP3134085A1 (en) 2017-03-01
US20170182003A1 (en) 2017-06-29
AU2015264102A1 (en) 2016-12-08
CN110354266A (zh) 2019-10-22
MA39906A (fr) 2017-03-01
KR20170017933A (ko) 2017-02-15
RU2016150650A (ru) 2018-06-26

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