CA2934682C - Mesenchymal stem cells and uses therefor - Google Patents

Mesenchymal stem cells and uses therefor Download PDF

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Publication number
CA2934682C
CA2934682C CA2934682A CA2934682A CA2934682C CA 2934682 C CA2934682 C CA 2934682C CA 2934682 A CA2934682 A CA 2934682A CA 2934682 A CA2934682 A CA 2934682A CA 2934682 C CA2934682 C CA 2934682C
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CA
Canada
Prior art keywords
mesenchymal stem
cells
stem cells
use according
mscs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2934682A
Other languages
English (en)
French (fr)
Other versions
CA2934682A1 (en
Inventor
Mark F. Pittenger
Sudeepta Aggarwal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mesoblast International SARL
Original Assignee
Mesoblast International SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mesoblast International SARL filed Critical Mesoblast International SARL
Priority to CA3135582A priority Critical patent/CA3135582A1/en
Publication of CA2934682A1 publication Critical patent/CA2934682A1/en
Application granted granted Critical
Publication of CA2934682C publication Critical patent/CA2934682C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2934682A 2004-03-22 2005-03-15 Mesenchymal stem cells and uses therefor Expired - Lifetime CA2934682C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3135582A CA3135582A1 (en) 2004-03-22 2005-03-15 Mesenchymal stem cells and uses therefor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55511804P 2004-03-22 2004-03-22
US60/555,118 2004-03-22
CA2868733A CA2868733C (en) 2004-03-22 2005-03-15 Mesenchymal stem cells for treating inflammation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2868733A Division CA2868733C (en) 2004-03-22 2005-03-15 Mesenchymal stem cells for treating inflammation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3135582A Division CA3135582A1 (en) 2004-03-22 2005-03-15 Mesenchymal stem cells and uses therefor

Publications (2)

Publication Number Publication Date
CA2934682A1 CA2934682A1 (en) 2005-10-06
CA2934682C true CA2934682C (en) 2021-12-07

Family

ID=46060822

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2934682A Expired - Lifetime CA2934682C (en) 2004-03-22 2005-03-15 Mesenchymal stem cells and uses therefor
CA2868733A Expired - Lifetime CA2868733C (en) 2004-03-22 2005-03-15 Mesenchymal stem cells for treating inflammation
CA3135582A Pending CA3135582A1 (en) 2004-03-22 2005-03-15 Mesenchymal stem cells and uses therefor

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2868733A Expired - Lifetime CA2868733C (en) 2004-03-22 2005-03-15 Mesenchymal stem cells for treating inflammation
CA3135582A Pending CA3135582A1 (en) 2004-03-22 2005-03-15 Mesenchymal stem cells and uses therefor

Country Status (5)

Country Link
JP (8) JP6114500B2 (enExample)
AT (1) ATE556134T1 (enExample)
CA (3) CA2934682C (enExample)
ES (7) ES2544689T3 (enExample)
TR (1) TR201901268T4 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2934682C (en) * 2004-03-22 2021-12-07 Mesoblast International Sarl Mesenchymal stem cells and uses therefor
EP2298861B1 (en) * 2004-03-22 2017-09-13 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
EP2849765A4 (en) * 2012-05-16 2015-12-02 Univ Johns Hopkins STEM CELLS AS INDIVIDUALIZED MATERNAL THERAPY FOR THE PREVENTION OF EARLY BIRTHS
JP2016210730A (ja) * 2015-05-08 2016-12-15 上田 実 医薬組成物及びその製造方法並びに医薬品
WO2018092769A1 (ja) 2016-11-15 2018-05-24 株式会社カネカ 胎児付属物に由来する間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物
CN112004923A (zh) 2017-11-22 2020-11-27 迈索布拉斯特国际有限公司 细胞组合物及治疗方法
WO2019132026A1 (ja) 2017-12-28 2019-07-04 株式会社カネカ 接着性幹細胞を含む細胞集団とその製造方法、及び医薬組成物
EP3984596A4 (en) 2019-06-14 2023-06-21 Kaneka Corporation POPULATION OF CELLS COMPRISING MESENCHYMATOUS CELLS, PHARMACEUTICAL COMPOSITION COMPRISING THEM AND METHOD FOR PRODUCTION THEREOF
EP4013856A1 (en) * 2019-08-15 2022-06-22 NextCell Pharma AB Allogeneic composition for treatment of cns disorders
CN113813288B (zh) * 2021-08-11 2024-02-13 谢岩 间充质干细胞及包含其的组合物用于制备治疗烧伤难愈创面的药物的用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0651641B2 (ja) * 1983-08-29 1994-07-06 株式会社ミドリ十字 ガンマ・インターフェロン組成物
JPH01501792A (ja) * 1986-03-17 1989-06-22 シェリング・コーポレーション γ型インターフェロンによる癌の治療
CA2191733A1 (en) * 1994-06-07 1995-12-21 Daniel A. Vallera Methods for inhibiting antigen specific t cell responses
US6497875B1 (en) * 1996-04-26 2002-12-24 Case Western Reserve University Multilayer skin or dermal equivalent having a layer containing mesenchymal stem cells
CA2320040C (en) * 1998-03-18 2007-05-22 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US6368636B1 (en) * 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US6797269B2 (en) * 1998-04-03 2004-09-28 Osiris Therapeutics, Inc. Mesenchymal stem cells as immunosuppressants
AU2001229254B2 (en) * 2000-01-19 2006-07-27 Gill, Parkash S. Pharmaceutical compositions and methods of treatment based on VEGF antisense oligonucleotides
ES2353061T5 (es) * 2000-04-25 2014-04-07 Osiris Therapeutics, Inc. Reparación de articulaciones utilizando células madre mesenquimatosas
MXPA04007426A (es) * 2002-02-01 2004-10-11 Schering Corp Usos de citosina de mamifero; reactivos relacionados.
JP3897343B2 (ja) * 2002-08-01 2007-03-22 株式会社林原生物化学研究所 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質
WO2004052177A2 (en) * 2002-12-05 2004-06-24 Case Western Reserve University Cell-based therapies for ischemia
CA2934682C (en) * 2004-03-22 2021-12-07 Mesoblast International Sarl Mesenchymal stem cells and uses therefor
EP2298861B1 (en) * 2004-03-22 2017-09-13 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor

Also Published As

Publication number Publication date
CA2868733A1 (en) 2005-10-06
ES2645018T3 (es) 2017-12-01
ES2385450T3 (es) 2012-07-25
JP2019014747A (ja) 2019-01-31
JP2012176948A (ja) 2012-09-13
JP6382360B2 (ja) 2018-08-29
ES2643076T3 (es) 2017-11-21
ATE556134T1 (de) 2012-05-15
TR201901268T4 (tr) 2019-02-21
JP2015061862A (ja) 2015-04-02
ES2544689T3 (es) 2015-09-02
JP6757383B2 (ja) 2020-09-16
JP2017080507A (ja) 2017-05-18
ES2708627T3 (es) 2019-04-10
ES2643030T3 (es) 2017-11-21
HK1205531A1 (en) 2015-12-18
ES2657382T5 (es) 2021-07-12
JP5997237B2 (ja) 2016-09-28
CA3135582A1 (en) 2005-10-06
CA2868733C (en) 2019-12-17
ES2657382T3 (es) 2018-03-05
JP2018009002A (ja) 2018-01-18
JP7546239B2 (ja) 2024-09-06
JP2021191771A (ja) 2021-12-16
JP2020111591A (ja) 2020-07-27
JP6114500B2 (ja) 2017-04-12
JP7033159B2 (ja) 2022-03-09
CA2934682A1 (en) 2005-10-06
JP6757300B2 (ja) 2020-09-16
JP2023065486A (ja) 2023-05-12
HK1205677A1 (en) 2015-12-24

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Effective date: 20160629