CA2934682C - Cellules souches mesenchymateuses et leurs utilisations - Google Patents

Cellules souches mesenchymateuses et leurs utilisations Download PDF

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Publication number
CA2934682C
CA2934682C CA2934682A CA2934682A CA2934682C CA 2934682 C CA2934682 C CA 2934682C CA 2934682 A CA2934682 A CA 2934682A CA 2934682 A CA2934682 A CA 2934682A CA 2934682 C CA2934682 C CA 2934682C
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Prior art keywords
mesenchymal stem
cells
stem cells
use according
mscs
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CA2934682A
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CA2934682A1 (fr
Inventor
Mark F. Pittenger
Sudeepta Aggarwal
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Mesoblast International SARL
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Mesoblast International SARL
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Priority to CA3135582A priority Critical patent/CA3135582A1/fr
Publication of CA2934682A1 publication Critical patent/CA2934682A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne les cellules souches mésenchymateuses. Ces cellules sont utiles pour traiter linflammation intestinale ou hépatique en cas de maladie intestinale inflammatoire ou dhépatite chronique, car elles contrôlent la production des facteurs qui contrôlent certaines étapes du procédé de la réponse immunitaire.
CA2934682A 2004-03-22 2005-03-15 Cellules souches mesenchymateuses et leurs utilisations Active CA2934682C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3135582A CA3135582A1 (fr) 2004-03-22 2005-03-15 Cellules souches mesenchymateuses et leurs utilisations

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55511804P 2004-03-22 2004-03-22
US60/555,118 2004-03-22
CA2868733A CA2868733C (fr) 2004-03-22 2005-03-15 Cellules souches mesenchymateuses destinees au traitement de l'inflammation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2868733A Division CA2868733C (fr) 2004-03-22 2005-03-15 Cellules souches mesenchymateuses destinees au traitement de l'inflammation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3135582A Division CA3135582A1 (fr) 2004-03-22 2005-03-15 Cellules souches mesenchymateuses et leurs utilisations

Publications (2)

Publication Number Publication Date
CA2934682A1 CA2934682A1 (fr) 2005-10-06
CA2934682C true CA2934682C (fr) 2021-12-07

Family

ID=46060822

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2868733A Active CA2868733C (fr) 2004-03-22 2005-03-15 Cellules souches mesenchymateuses destinees au traitement de l'inflammation
CA2934682A Active CA2934682C (fr) 2004-03-22 2005-03-15 Cellules souches mesenchymateuses et leurs utilisations
CA3135582A Pending CA3135582A1 (fr) 2004-03-22 2005-03-15 Cellules souches mesenchymateuses et leurs utilisations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2868733A Active CA2868733C (fr) 2004-03-22 2005-03-15 Cellules souches mesenchymateuses destinees au traitement de l'inflammation

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3135582A Pending CA3135582A1 (fr) 2004-03-22 2005-03-15 Cellules souches mesenchymateuses et leurs utilisations

Country Status (6)

Country Link
JP (8) JP6114500B2 (fr)
AT (1) ATE556134T1 (fr)
CA (3) CA2868733C (fr)
ES (7) ES2645018T3 (fr)
HK (2) HK1205677A1 (fr)
TR (1) TR201901268T4 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2298862B1 (fr) * 2004-03-22 2017-08-30 Mesoblast International Sàrl Cellules souches mésenchymateuses et utilisations associées
TR201901268T4 (tr) * 2004-03-22 2019-02-21 Mesoblast Int Sarl Mezenkimal kök hücreleri ve bunların kullanımları.
EP2849765A4 (fr) * 2012-05-16 2015-12-02 Univ Johns Hopkins Cellules souches en tant que thérapie maternelle individualisée pour la prévention de la prématurité
JP2016210730A (ja) * 2015-05-08 2016-12-15 上田　実 医薬組成物及びその製造方法並びに医薬品
CN109952371A (zh) 2016-11-15 2019-06-28 株式会社钟化 包含来自胎儿附属物的间充质系干细胞的细胞群、其制备方法、以及医药组合物
CN111527198A (zh) 2017-12-28 2020-08-11 株式会社钟化 包含贴壁性干细胞的细胞群、其制造方法、以及医药组合物
WO2020251020A1 (fr) 2019-06-14 2020-12-17 株式会社カネカ Population de cellules comprenant des cellules mésenchymateuses, composition pharmaceutique la comprenant et son procédé de production
CA3148582A1 (fr) * 2019-08-15 2021-02-18 Nextcell Pharma Ab Composition allogenique pour le traitement de troubles du systeme nerveux central
CN113813288B (zh) * 2021-08-11 2024-02-13 谢岩 间充质干细胞及包含其的组合物用于制备治疗烧伤难愈创面的药物的用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0651641B2 (ja) * 1983-08-29 1994-07-06 株式会社ミドリ十字 ガンマ・インターフェロン組成物
JPH01501792A (ja) * 1986-03-17 1989-06-22 シェリング・コーポレーション γ型インターフェロンによる癌の治療
JPH10501815A (ja) * 1994-06-07 1998-02-17 リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ 抗原特異的ｔ細胞応答の阻害方法
WO1997041208A1 (fr) * 1996-04-26 1997-11-06 Case Western Reserve University Regeneration de la peau au moyen des cellules souches mesenchymateuses
WO2001052904A2 (fr) * 2000-01-19 2001-07-26 Gill Parkash S Compositions renfermant des oligonucleotides antisens diriges contre le vegf et methodes associees
PT1066052E (pt) * 1998-03-18 2006-06-30 Osiris Therapeutics Inc Celulas estaminais mesenquimatosas para a prevencao e tratamento
US6368636B1 (en) * 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US6797269B2 (en) 1998-04-03 2004-09-28 Osiris Therapeutics, Inc. Mesenchymal stem cells as immunosuppressants
JP5090604B2 (ja) * 2000-04-25 2012-12-05 オシリス セラピューティクス，インコーポレイテッド 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法
DK2311869T3 (da) * 2002-02-01 2013-03-18 Merck Sharp & Dohme Anvendelse af pattedyrcytokinrelaterede reagenser
JP3897343B2 (ja) * 2002-08-01 2007-03-22 株式会社林原生物化学研究所 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質
WO2004052177A2 (fr) * 2002-12-05 2004-06-24 Case Western Reserve University Therapies a base de cellules pour ischemie.
TR201901268T4 (tr) * 2004-03-22 2019-02-21 Mesoblast Int Sarl Mezenkimal kök hücreleri ve bunların kullanımları.
EP2298862B1 (fr) * 2004-03-22 2017-08-30 Mesoblast International Sàrl Cellules souches mésenchymateuses et utilisations associées

Also Published As

Publication number Publication date
ES2645018T3 (es) 2017-12-01
TR201901268T4 (tr) 2019-02-21
JP7033159B2 (ja) 2022-03-09
ES2544689T3 (es) 2015-09-02
JP6114500B2 (ja) 2017-04-12
ES2708627T3 (es) 2019-04-10
ATE556134T1 (de) 2012-05-15
ES2657382T3 (es) 2018-03-05
HK1205677A1 (en) 2015-12-24
JP2017080507A (ja) 2017-05-18
ES2657382T5 (es) 2021-07-12
JP2012176948A (ja) 2012-09-13
CA3135582A1 (fr) 2005-10-06
CA2868733C (fr) 2019-12-17
JP6757300B2 (ja) 2020-09-16
JP6757383B2 (ja) 2020-09-16
CA2868733A1 (fr) 2005-10-06
ES2643030T3 (es) 2017-11-21
JP5997237B2 (ja) 2016-09-28
JP2015061862A (ja) 2015-04-02
CA2934682A1 (fr) 2005-10-06
JP2018009002A (ja) 2018-01-18
JP2021191771A (ja) 2021-12-16
JP2023065486A (ja) 2023-05-12
JP2020111591A (ja) 2020-07-27
JP2019014747A (ja) 2019-01-31
JP6382360B2 (ja) 2018-08-29
JP7546239B2 (ja) 2024-09-06
HK1205531A1 (en) 2015-12-18
ES2385450T3 (es) 2012-07-25
ES2643076T3 (es) 2017-11-21

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